Embryonic reproductive cells reveal striking genomic architecture before development
Researchers at the MRC Laboratory of Medical Sciences (LMS) and Imperial College London have shown for the first…
Data-driven modeling uncovers dynamic genome folding in three dimensions
Chromosomes are masters of organization. These long strings of DNA fold down into an ensemble of compact structures…
Epigenetic plasticity in germinal center B cells may help explain lymphoma origins
Immune cells called B cells make antibodies that fight off invading bacteria, viruses and other foreign substances. During…
Researchers create the most detailed 3D maps of the human genome
In a landmark effort to understand how the physical structure of our DNA influences human biology, Northwestern investigators…
Alzheimer’s breakthrough reveals how tweaking one gene shields brain connections
Scientists have uncovered a microglial switch that transforms these immune cells from plaque-promoting to plaque-protective, offering a new…
iNOME-seq: in vivo simultaneous genome-wide mapping of chromatin accessibility, nucleosome positioning, DNA-binding protein sites, and DNA methylation in Arabidopsis | Genome Biology
Plant lines and growth conditions The plant lines used in this study were derived from A. thaliana wild-type…
MRI age clocks reveal how each organ ages differently and predict who develops disease or lives longer
By decoding age gaps across the brain, heart, liver, and more, scientists show that no two organs grow…
In a surprising discovery, scientists find tiny loops in the genomes of dividing cells | MIT News
Before cells can divide, they first need to replicate all of their chromosomes, so that each of the…
Study shows how early-life epigenetic ‘memory’ can adult brain inflammation
Why do some people remain healthy through childhood yet become more vulnerable to brain disorders such as dementia…