New dual-drug strategy blocks triple-negative breast cancer growth
Triple-negative breast cancer (TNBC) has a frustrating ability to adapt. Although this aggressive form of breast cancer can…
Newly discovered protein pathway limits spinal cord injury damage
Spinal cord injury begins with immediate mechanical damage, but much of the lasting neurological loss develops during the…
Combination therapy overcomes ferroptosis resistance in β-catenin-mutant hepatocellular carcinoma
Background and aims The aberrant activation of the mTOR pathway and its crosstalk with other signaling cascades represent…
Researchers find a new genetic vulnerability in acute myeloid leukemia
A study published in Nature Cell Biology reports a new vulnerability in acute myeloid leukemia (AML) that might…
Cell death crosstalk network drives acute respiratory distress syndrome
Acute respiratory distress syndrome (ARDS) remains one of the deadliest complications of severe infections, sepsis, trauma, and viral…
Evolutionary noncoding RNAs reveal new targets for cancer therapy
In cancer research, one person’s junk is increasingly becoming another person’s treasure. Scientists have now uncovered new evidence…
Review links iron-dependent cell death to pathogenesis of Friedreich’s Ataxia
Published in the open-access journal Ferroptosis and Oxidative Stress, the review by Giovanni Cravin and Giorgio Cozza from the University of…
Engineered silica nanoparticles destroy prostate tumors in preclinical study
Prostate-targeted, engineered nanoparticles made of amorphous silica are effective in killing prostate tumors directly while enhancing anti-tumor immunity,…
Study shows how TAF1 regulates ferroptosis in cancer cells
Ferroptosis has become a promising area in cancer research because it may provide a way to target tumor…
Tumor microenvironment drives resistance to ferroptosis in pancreatic cancer
Tumors driven by cancer-driving KRAS mutations are often susceptible to ferroptosis, a type of cell death that can…
Vitamin B2 metabolism helps cancer cells resist ferroptosis
A lack of vitamin B2 makes tumor cells more susceptible to a unique form of cell death. This…
Tiny plastic particles may interfere with brain processes implicated in Parkinson’s disease
From protein misfolding to gut–brain signalling, emerging evidence suggests that everyday plastic exposure may intersect with key biological…