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Browsing Tag

gene expression

70 posts
HHealth
Brain circuit identified as key to repetitive and compulsive behaviors in mice
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High-resolution study maps molecular differences across six human cortical regions

  • April 17, 2026
A new analysis of individual brain cells across several human brain regions reveals subtle but widespread differences in…
HHealth
Innate immune activation and microglial transition during neurodegeneration. (A) During neurodegeneration, distressed neurons release DAMPs such as mtDNA, ROS, HMGB1, aberrant proteins, and pTau–bound RNA. These signals activate resident microglia and astrocytes, which then recruit peripheral immune cells. As shown in more detail in B, activated microglia upregulate PRRs, including TLRs, RAGE, and cGAS, enabling detection of neuron-derived DAMPs. Engagement of PRRs induces proinflammatory gene expression programs and activates inflammasome pathways that promote release of chemokines and cytokines into the CNS parenchyma. As microglia transition from homeostatic to reactive states in a TREM2-dependent manner, damage-associated microglia increase MHC-II expression to support antigen presentation and coordination of adaptive immune responses that attempt to limit neurodegeneration.
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How the immune system may influence Alzheimer’s, Parkinson’s, and related diseases

  • April 17, 2026
A sweeping review shows how the brain’s immune defenses can both fight and fuel neurodegeneration, revealing why timing,…
HHealth
Biallelic variants in RNU2-2 cause the most prevalent known recessive neurodevelopmental disorder
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Study identifies a common hidden genetic cause of neurodevelopmental disorder in children

  • April 3, 2026
A major genetic study has uncovered a surprisingly common recessive cause of neurodevelopmental disorder, revealing how hidden changes…
HHealth
Study: Bisphenol a exposure and major depressive disorder: an integrative analysis combining network toxicology, molecular docking, genetic epidemiology, and transcriptomic validation. Image Credit: monticello / Shutterstock
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How could bisphenol A raise depression risk? Study identifies six key molecular targets

  • April 1, 2026
Researchers combined genetic epidemiology, transcriptomics, molecular docking, and mouse experiments to show how a common endocrine-disrupting chemical may…
HHealth
New study reveals a 25-year rise in alcohol-induced mortality
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Alcohol impacts gene expression differently across brain regions

  • March 31, 2026
Erica Periandri and Gabor Egervari, from Washington University in St. Louis, led a study to explore how alcohol exposure in male mice influences gene expression…
HHealth
Brain circuit identified as key to repetitive and compulsive behaviors in mice
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Scientists identify common molecular program across multiple brain tumor types

  • March 6, 2026
Research uncovering the origin of pineoblastoma, a rare pediatric brain tumor, has also revealed a dependency across multiple…
HHealth
Researchers uncover how HIV-1 uses RNA:DNA hybrids to integrate into the genome
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New HIV-seq tool advances understanding of persistent viral reservoirs

  • March 4, 2026
For people living with human immunodeficiency virus (HIV), life-saving antiretroviral therapy keeps their HIV-infected immune cells from making…
SScience
Brain circuit identified as key to repetitive and compulsive behaviors in mice
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Scientists put forward a new theory of brain development

  • March 2, 2026
Your brain begins as a single cell. When all is said and done, it will house an incredibly…
HHealth
Neuroscience News logo for mobile.
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New Tech Tracks Living Brain Activity Noninvasively

  • March 1, 2026
Summary: Unlocking the secrets of the living brain often requires invasive surgery or expensive, static imaging. However, a…
HHealth
A multi-dimensional framework for establishing and managing a genomic newborn screening program
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A multi-dimensional framework for establishing and managing a genomic newborn screening program

  • March 1, 2026
The above-described methodology resulted in a multi-dimensional framework for a gNBS program consisting of 18 screening criteria (Table 1)…
HHealth
Rare ABCA7 gene variants linked to Alzheimer’s risk
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Study maps how NF-κB regulates gene expression in cells

  • February 28, 2026
To further the quantitative understanding of cellular decision making, Dr. Gregory Reeves and his team in the chemical engineering department…
HHealth
Athletes may gain health and performance advantages from time-restricted eating
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NIH’s continued investment fuels TMJ pain research

  • February 28, 2026
Chronic pain is one of the most common health conditions worldwide. Back pain is the most frequently reported…
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