Study uncovers role of mechanical forces in human gastrulation
Only two weeks after fertilization, the first sign of the formation of the 3 axes of the human…
Breast cancer cells use a molecular switch to survive stress
Cells are regularly faced with environmental stresses that may damage or destroy them. To survive, they quickly adjust…
One-time CRISPR therapy safely lowers cholesterol and triglycerides in early trial
In a 15-patient, Phase 1 one, first-in-human trial, a one-time, CRISPR-Cas9 gene-editing therapy safely reduced LDL cholesterol and…
Alzheimer’s breakthrough reveals how tweaking one gene shields brain connections
Scientists have uncovered a microglial switch that transforms these immune cells from plaque-promoting to plaque-protective, offering a new…
Thiostrepton suppresses rhabdomyosarcoma progression by targeting the PI3K–AKT pathway
Rhabdomyosarcoma (RMS) accounts for up to 10% of childhood cancers and nearly half of pediatric soft tissue sarcomas.…
Understanding the role of m6A methylation in acute lung injury pathogenesis
Acute lung injury (ALI) is a critical clinical condition characterized by diffuse inflammation of the lung parenchyma and…
Eating peanuts while pregnant may influence how a child’s genes respond to breastfeeding
Researchers found that mothers who ate both peanuts and peanut butter during pregnancy had children with distinct DNA…
Mitochondria and lysosomes work together to control regulatory T cell activation
Metabolism guides the activation states of regulatory T cells, the immune cells that prevent inappropriate activation of the…
Disruption of glial circadian rhythms linked to Alzheimer’s disease progression
Alzheimer’s disease is notorious for scrambling patients’ daily rhythms. Restless nights with little sleep and increased napping during…
Twenty years of genome-wide association studies: Health translation challenges and AI opportunities
Southam L, Zeggini E. Twenty years of genome-wide association studies. Nature. 2025;641:47–9. Article PubMed CAS Google Scholar Klein…
Torino Identifies mRNA Isoforms in Disease-Related Gene Expression
Credit: libre de droit / Getty Images Different variants of a gene, known as isoforms, can be transcribed…
The genetic influence of sex on gene expression for blood in pigs | BMC Genomics
Data summary We collected 386 blood samples with matched genotype and gene expression data from the PigGTEx project…