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Browsing Tag

gene

344 posts
HHealth
Brain circuit identified as key to repetitive and compulsive behaviors in mice
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High-resolution study maps molecular differences across six human cortical regions

  • April 17, 2026
A new analysis of individual brain cells across several human brain regions reveals subtle but widespread differences in…
HHealth
Innate immune activation and microglial transition during neurodegeneration. (A) During neurodegeneration, distressed neurons release DAMPs such as mtDNA, ROS, HMGB1, aberrant proteins, and pTau–bound RNA. These signals activate resident microglia and astrocytes, which then recruit peripheral immune cells. As shown in more detail in B, activated microglia upregulate PRRs, including TLRs, RAGE, and cGAS, enabling detection of neuron-derived DAMPs. Engagement of PRRs induces proinflammatory gene expression programs and activates inflammasome pathways that promote release of chemokines and cytokines into the CNS parenchyma. As microglia transition from homeostatic to reactive states in a TREM2-dependent manner, damage-associated microglia increase MHC-II expression to support antigen presentation and coordination of adaptive immune responses that attempt to limit neurodegeneration.
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How the immune system may influence Alzheimer’s, Parkinson’s, and related diseases

  • April 17, 2026
A sweeping review shows how the brain’s immune defenses can both fight and fuel neurodegeneration, revealing why timing,…
HHealth
NYU Langone strengthens world-leading GI cancer program with renowned leaders
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Epigenetic changes allow cancer cells to shift identity and survive drugs

  • April 16, 2026
Cancer drugs are designed to shut tumors down. But sometimes, in the very act of attacking a tumor,…
SScience
A precise tool to halt viral protein production
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New CRISPR tool selectively cuts tumor DNA while sparing healthy cells

  • April 15, 2026
Apr 15 2026 Cancer cells excel at evading detection, but subtle chemical differences set them apart from healthy…
HHealth
Infection or stressful events during pregnancy may increase anxiety risk in offspring
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Study identifies new genes linked to severe pregnancy sickness

  • April 15, 2026
The USC research team that recently identified the hormone-encoding gene GDF15 as a key driver of pregnancy sickness has identified…
HHealth
Brain circuit identified as key to repetitive and compulsive behaviors in mice
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Alzheimer’s risk gene APOE4 impacts bone health in females

  • April 14, 2026
Scientists at the Buck Institute for Research on Aging, along with collaborators at UC San Francisco, have discovered…
SSpace
“It Was Survival Mode”: The Lunar Mission That Nearly Ended in Disaster
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“It Was Survival Mode”: The Lunar Mission That Nearly Ended in Disaster

  • April 11, 2026
Griffin: During entry, there’s what we call a blackout, which is when it gets so hot that you…
HHealth
Machine learning unlocks blood test secrets for spinal cord injury
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Dynamic AI models detect body tipping points to forecast disease before symptoms

  • April 10, 2026
The editorial, “Dynamics-driven medical big data mining: dynamic approaches to early disease forecasting and individualized care,” published in…
HHealth
Unlocking the secrets of oral bacteria to fight tooth decay
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Vibrio cholerae acquires antiviral defenses through horizontal gene transfer

  • April 10, 2026
Like most bacteria, Vibrio cholerae lives under constant attack from viruses. To survive, bacteria equip themselves with antiviral…
HHealth
Study provides first worldwide validation of new GLIS model in older patients with heart failure
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Toxic RNA drives progressive heart damage in myotonic dystrophy

  • April 4, 2026
Myotonic dystrophy type 1 (DM1) is the most common cause of adult-onset muscular dystrophy, a genetic disorder that…
HHealth
Brain circuit identified as key to repetitive and compulsive behaviors in mice
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Researchers uncover a chain of molecular events behind early brain changes in Alzheimer’s

  • April 3, 2026
For the millions of people who carry the gene APOE4, the strongest known genetic risk factor for Alzheimer’s…
HHealth
Biallelic variants in RNU2-2 cause the most prevalent known recessive neurodevelopmental disorder
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Study identifies a common hidden genetic cause of neurodevelopmental disorder in children

  • April 3, 2026
A major genetic study has uncovered a surprisingly common recessive cause of neurodevelopmental disorder, revealing how hidden changes…
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