Breast cancer cells use a molecular switch to survive stress
Cells are regularly faced with environmental stresses that may damage or destroy them. To survive, they quickly adjust…
Subtle changes in the composition of short tandem repeats may shape disease risk
Scientists at The Hospital for Sick Children (SickKids) have revealed a previously overlooked layer of genetic variation that…
Understanding leptin’s dual function in MAFLD pathogenesis
Metabolic dysfunction-associated fatty liver disease (MAFLD) has emerged as a predominant chronic liver condition globally, intricately linked with…
Study links common Epstein-Barr virus to autoimmune lupus
One of humanity’s most ubiquitous infectious pathogens bears the blame for the chronic autoimmune condition called systemic lupus…
Stanford scientists discover unexpected cancer resistance in aged mice
Old laboratory mice develop substantially fewer and less-aggressive lung tumors than younger animals in a new study led…
Switching APOE4 to APOE2 in adult mice reduces Alzheimer’s pathology and improves memory
By flipping a single genetic switch from APOE4 to APOE2 in adult mice, researchers reversed key Alzheimer’s-like changes…
One-time CRISPR therapy safely lowers cholesterol and triglycerides in early trial
In a 15-patient, Phase 1 one, first-in-human trial, a one-time, CRISPR-Cas9 gene-editing therapy safely reduced LDL cholesterol and…
TAU researchers develop groundbreaking gene therapy to treat hearing, balance disabilities
“These findings highlight the potential of self-complementary AAVs to reduce dose requirements, minimize toxicity, and broaden clinical use…
Multiple protein forms from a single gene offer fresh insight into rare disease mechanisms
Iain Cheeseman and colleagues reveal the underappreciated role of single genes producing multiple proteins in atypical presentations of…
Comprehensive kinase atlas reveals new insights into cell signaling and disease
The enzyme RNA polymerase II transcribes genes into messenger RNA. This process is guided by modifications to the enzyme’s…
Researchers refine tools to map DNA’s 3D structure inside cells
DNA isn’t just a long string of genetic code, but an intricate 3D structure folded inside each cell.…
Inflammation identified as a key driver in the earliest stages of lung cancer
By creating high-resolution cellular and molecular visual maps of lung cancer before and during development, researchers at The…