Taiwan Biobank data reveals ongoing natural selection in living humans
For more than a century, scientists have sought to reconstruct human evolution using diverse lines of evidence, including…
Scientists discover master molecular switch for ginseng saponin production
Sanchi ginseng (Panax notoginseng) is a cornerstone of traditional Chinese medicine, prized for its saponins-bioactive compounds with anti-inflammatory,…
Study reveals unexpected mechanism driving extreme antibiotic resistance
A patient with a severe infection is prescribed a potent antibiotic. Hopes for improvement are high, but just…
Occult hepatitis B mutations drive liver cancer growth via Akt mTOR pathway
Occult hepatitis B virus (OBI) infection presents a significant global health challenge, notoriously flying under the radar of…
Five epigenetic clocks reveal shared and distinct signals of aging
A large multi-omics study maps why epigenetic clocks capture different aspects of aging and shows how gene-expression scores…
Researchers identify new genetic pathway driving epilepsy and seizures
Researchers have uncovered a novel biological pathway that can lead to seizures when disrupted. The findings also provide…
New biological feedback loop helps the immune system attack colorectal cancers
A subset of cancers, known as microsatellite instability (MSI) and deficient DNA mismatch repair (dMMR) cancers, are more…
Pet gecko offers promising model for cancer research breakthroughs
A new study, led by experts at the University of Nottingham, suggests a pet gecko with an unusually…
Myotonia may play a much larger role in driving muscle damage than previously recognized
For decades, researchers studying myotonic dystrophy type 1 (DM1) have focused on the disease’s underlying genetic cause: a…
Genes follow a random switching principle, yet remain precise on average
Inside the cell nucleus, genes must be turned on and off with precision to regulate biological processes. The…
Dysregulation of immune regulator NF-κB drives major human diseases
The NF‑κB family is a master regulator of innate and adaptive immunity. Its aberrant activation-via canonical or non‑canonical…
New genetic reference map accelerates human stem cell research
A team led by bioengineers at the University of California San Diego has developed a genome-scale reference map…