Genomic landscape and clinicopathologic significance of POLE mutant colorectal carcinoma
Background and objectives DNA polymerase epsilon catalytic subunit A (POLE) gene plays a crucial role in DNA repair…
New laser technique ensures integrity of mRNA therapeutics
Messenger RNA (mRNA) technology is transforming medicine by providing our cells with genetic instructions to produce proteins that…
Jumping DNA fragments found to destabilize cancer genome
A study published today in the journal Science reveals how jumping fragments of human DNA, a type of genetic parasite,…
Neanderthal DNA loss tied to ancient interbreeding dynamics
The human genome is a rich, complex record of migration, encounters, and inheritance written over thousands of millennia.…
Vitamin B3 shows promise for treating rare genetic disorder
Scientists at Gladstone Institutes have flipped the traditional approach to finding potential treatments for deadly diseases. Instead of…
New Pico C technology maps genome structure before activation
For decades, scientists viewed the genome of a newly fertilised egg as a structural ‘blank slate’ – a…
WashU Medicine receives 80 million to study exceptional longevity
Researchers at Washington University School of Medicine in St. Louis have received an $80 million grant to continue…
Ion channel TRPV4 found to regulate relief after scratching an itch
When you scratch an itch, something tells your brain when to stop. That moment of relief, when scratching…
Neutral polymer enables safer DNA delivery into cells
Researchers from Tokyo Metropolitan University have created a new molecule which carries DNA into biological cells, to treat…
Genetic mismatch identified as major risk factor in cord blood transplantation
A Japanese study of more than 7,400 patients has identified a genetic mismatch that sharply increases the risk…
Embryonic reproductive cells reveal striking genomic architecture before development
Researchers at the MRC Laboratory of Medical Sciences (LMS) and Imperial College London have shown for the first…
New AI-based analysis method can accurately classify and monitor brain tumors
An international research team, with significant involvement from the Medical University of Vienna, has developed a new AI-based…