New mechanism linked to septic heart injury protection uncovered
Sepsis triggers widespread inflammation, circulatory failure and metabolic stress, and cardiac dysfunction is a common complication associated with…
Statins may trigger muscle side effects by activating inflammatory danger signals
New experimental findings reveal how statins may push vulnerable muscle cells into a stress state, suggesting future strategies…
Modified lipid nanoparticles boost mRNA vaccines while reducing side effects
The most common side effects of mRNA vaccines like the COVID-19 shot are well known: soreness, mild fever…
Study reveals dual role of PFK enzyme in metabolism and cell cycle progression
A metabolic enzyme studied for over seven decades has a hidden second function – it can unwind RNA…
Lactate and lactylation drive metabolic, epigenetic reprogramming in gynecological cancers
Lactate, once considered a metabolic waste product, is now recognized as a key regulator of cellular homeostasis and…
Microglial glycolytic reprogramming in alzheimer’s disease: association with impaired phagocytic function and altered vascular proximity | Journal of Neuroinflammation
In this study, we analysed HP‒EC tissue from 8 AD patients (mean age: 86.5 years, 5 males, 3…
Targeting metabolic reprogramming to overcome immune suppression in head and neck cancer
Head and neck cancer remains a major global health challenge, ranking among the six most common cancers worldwide…