Mitochondria and lysosomes work together to control regulatory T cell activation
Metabolism guides the activation states of regulatory T cells, the immune cells that prevent inappropriate activation of the…
Epigenetic editing enables safer and more effective T cell therapies
Arc Institute, Gladstone Institutes, and University of California, San Francisco, scientists have developed an epigenetic editing platform that…
Researchers develop a novel approach to monitor CD8⁺ T cell activity over time
The ability of immune cells-particularly CD8+ T cells-to launch a rapid burst of proliferation inside tumors is key…
How The Shutdown Impacts Healthcare
In this week’s edition of InnovationRx, we look at the shutdown’s impact on healthcare, the Nobel Prize winners…
Early antiviral treatment following gammaherpesvirus-68 infection of the central nervous system prevents subsequent multiple sclerosis-like disease | Journal of Neuroinflammation
Dendrou CA, Fugger L, Friese MA. Immunopathology of multiple sclerosis. Nat Rev Immunol. 2015;15(9):545–58. CAS PubMed Google Scholar …
Common food additives may trigger childhood asthma
A recent study published in Frontiers in Immunology utilized metabolomics to investigate the mechanisms underlying the association between food…
World’s first vaccine trial against elephant endotheliotropic herpesvirus proves safe and effective
The world’s first vaccine trial against elephant endotheliotropic herpesvirus (EEHV) – a leading cause of death in young…
Study identifies PTX-3 as potential marker for long COVID and tissue damage
A research team working at MedUni Vienna has demonstrated that a specific component of the immune system (PTX-3)…
Microglial glycolytic reprogramming in alzheimer’s disease: association with impaired phagocytic function and altered vascular proximity | Journal of Neuroinflammation
In this study, we analysed HP‒EC tissue from 8 AD patients (mean age: 86.5 years, 5 males, 3…
Boosting the immune system to prevent cancer recurrence and improve survival
In experiments with mouse models of breast, pancreatic, and muscle cancers, researchers at Johns Hopkins All Children’s Hospital…
New T cell therapy targets CTNNB1 cancer mutation with promising results in animal studies
Researchers at the University of Oslo and Oslo University Hospital have developed a promising new immunotherapy targeting the…
Understanding how lipids activate LC3-associated phagocytosis
LC3-associated phagocytosis (LAP) is a specialized process for degrading dead cells, microbes or other particles. It plays a…