Targeted approach of immunotherapy improves sepsis outcomes
Immunotherapy for sepsis is effective when doctors tailor the treatment precisely to the patient’s immune system condition. While…
Serious side effects after CAR T cell therapy for multiple myeloma share a common immune root cause
Serious side effects, including neurotoxicity and intestinal inflammation, that appear weeks or months after patients receive CAR T…
Generative AI aids discovery of ISM3830’s novel scaffold
Casitas B-lineage lymphoma-b (CBLB) is an E3 ubiquitin–protein ligase that functions as an intracellular checkpoint and master negative…
Neoantigens-loaded DC vaccines show strong potential to overcome tumor resistance
Despite the success of immune checkpoint inhibitors in revolutionizing oncology, their benefits remain limited to a small fraction…
New antibody strategy shows promise for halting cyst growth in polycystic kidney disease
Polycystic kidney disease (PKD) is a debilitating hereditary condition in which fluid-filled sacs form and proliferate in the…
Innovative research reveals FGD3 as a key player in breast cancer cell death
A naturally occurring protein that tends to be expressed at higher levels in breast cancer cells boosts the…
Study reveals tumor defense mechanisms in colorectal cancer
Colorectal cancer is one of the leading causes of cancer death worldwide. In recent years, immunotherapies-treatments that reactivate…
Bowel cancer’s “Big Bang” moment reveals how the disease takes shape
Like the astronomical explosion that kickstarted the universe, bowel cancer has a “Big Bang” moment which determines how…
Northwestern team develops antibody to expose hidden pancreatic cancer cells
Pancreatic cancer is notoriously hard to treat and often resists the most advanced immunotherapies. Northwestern Medicine scientists have…
Lactate and lactylation drive metabolic, epigenetic reprogramming in gynecological cancers
Lactate, once considered a metabolic waste product, is now recognized as a key regulator of cellular homeostasis and…
Mitochondria and lysosomes work together to control regulatory T cell activation
Metabolism guides the activation states of regulatory T cells, the immune cells that prevent inappropriate activation of the…
How COVID mRNA vaccines may make cancer treatments more effective
A new study reveals that SARS-CoV-2 mRNA vaccines can amplify immune checkpoint therapy in lung and skin cancers…