New nanoparticle therapy overcomes T cell exhaustion in solid tumors
Engineers at the University of Pennsylvania have developed a new type of lipid nanoparticle (LNP) that could one…
New insights highlight multifaceted roles of CD4+ T cells in tumor immunity
For decades, cancer immunotherapy has focused primarily on CD8+ cytotoxic T lymphocytes as the main executors of tumor…
Study finds cockroach allergy often driven by shared proteins across arthropods
A new molecular analysis reveals that many patients labeled as cockroach-allergic may actually be reacting to shared proteins…
Remote-controlled CAR T cells offer safer cancer therapy
Among the most promising tools of cancer therapy, engineered immune cells known as chimeric antigen-receptor (CAR) T cells…
Preoperative combination treatment shows promise for some patients with pancreatic cancer
A new UCLA investigator-initiated study sponsored by the UCLA Health Jonsson Comprehensive Cancer Center has found that adding immunotherapy to…
Chronic inflammation shapes cancer progression and immunotherapy response
Chronic inflammation is both a driver and suppressor of cancer depending on context. Key players-NF-κB, IL-6, STAT3, TAMs,…
Rising lung cancer in never smokers demands urgent research focus
Lung cancer patients who have never smoked make up a significant and growing share of global lung cancer…
Alzheimer’s plaques decline after CAR-T immune cell treatment in preclinical study
A novel CAR-T cell approach targets amyloid plaques in preclinical Alzheimer models, raising the possibility that engineered immune…
MHC class II marks stronger immune response and longer survival in ovarian cancer
A new study sheds light on why some patients with the most aggressive form of ovarian cancer respond…
Stage IV lung cancer survivor: ‘Go straight to MD Anderson’
By the time I was diagnosed with stage IV lung cancer in the fall of 2024, it had spread all over my body. Scans showed the cancer was in…
Regulating microglial phagocytosis through immunotherapy could slow Parkinson’s disease progression
By analyzing tissue from patients with Parkinson’s disease, and animal and cellular models of the disease, a research…
Treating desmoplastic melanoma with immunotherapy before surgery can shrink or eliminate tumors
New results from a clinical trial co-led by UCLA investigators demonstrate how treating desmoplastic melanoma, a rare and…