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Browsing Tag

Inflammasome

5 posts
HHealth
Smoking reprograms immune cells to accelerate cardiovascular disease
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Smoking reprograms immune cells to accelerate cardiovascular disease

  • June 30, 2026
Scientists at the University of Oklahoma have identified a previously unrecognized immune system pathway that helps explain how…
MMedication
Study: Statins promote muscle metabolic danger and NLRP3-mediated myopathy via lower protein-prenylation and YAP. Image Credit: pimpampix / Shutterstock
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Statins may trigger muscle side effects by activating inflammatory danger signals

  • June 25, 2026
New experimental findings reveal how statins may push vulnerable muscle cells into a stress state, suggesting future strategies…
HHealth
Innate immune activation and microglial transition during neurodegeneration. (A) During neurodegeneration, distressed neurons release DAMPs such as mtDNA, ROS, HMGB1, aberrant proteins, and pTau–bound RNA. These signals activate resident microglia and astrocytes, which then recruit peripheral immune cells. As shown in more detail in B, activated microglia upregulate PRRs, including TLRs, RAGE, and cGAS, enabling detection of neuron-derived DAMPs. Engagement of PRRs induces proinflammatory gene expression programs and activates inflammasome pathways that promote release of chemokines and cytokines into the CNS parenchyma. As microglia transition from homeostatic to reactive states in a TREM2-dependent manner, damage-associated microglia increase MHC-II expression to support antigen presentation and coordination of adaptive immune responses that attempt to limit neurodegeneration.
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How the immune system may influence Alzheimer’s, Parkinson’s, and related diseases

  • April 17, 2026
A sweeping review shows how the brain’s immune defenses can both fight and fuel neurodegeneration, revealing why timing,…
HHealth
NYU Langone strengthens world-leading GI cancer program with renowned leaders
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Chronic inflammation shapes cancer progression and immunotherapy response

  • February 16, 2026
Chronic inflammation is both a driver and suppressor of cancer depending on context. Key players-NF-κB, IL-6, STAT3, TAMs,…
HHealth
NYU Langone strengthens world-leading GI cancer program with renowned leaders
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New NIH grants fuel research in oral cancer treatment and pain relief

  • November 8, 2025
Researchers at the School of Dentistry at UT Health San Antonio, the academic health center of The University…
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