Cigarette smoke alters lung stem cells to drive specific cancers
Chronic exposure to cigarette smoke may reprogram different populations of lung stem cells, which maintain and repair lung…
Baseline liver fibrosis severity predicts treatment response in patients with HBeAg-positive CHB
Background and aims The impact of baseline liver fibrosis severity on the effectiveness of pegylated interferon (Peg-IFN) combined…
Study uncovers how interferon-alpha treats rare blood cancers
The biologic drug interferon-alpha can benefit patients with blood cancers called myeloproliferative neoplasms by forcing mutant blood stem…
Could scorpion venom inspire new treatments for liver disease?
From blocking inflammatory immune pathways to disrupting hepatitis viruses, scorpion-derived peptides are attracting attention as potential drug candidates,…
Scientists reveal how cGAS-STING fuels brain inflammation and neurodegeneration
A major immune pathway once known for detecting DNA damage is now being linked to brain aging, glial…
Gut microbiota-derived metabolite directly shapes immune responses in bacterial pneumonia
Sepsis and severe pneumonia are frequently accompanied by disruption of the gut microbiota, leading to immune dysfunction and…
Study identifies antiviral protein IFN-γ as a potential biomarker for Long COVID fatigue
SARS-CoV-2 triggers the production of the antiviral protein IFN-γ, which is associated with fatigue, muscle ache and depression.…
Study reveals coffee triggers distinct cytokine responses compared with pure caffeine
A controlled human study reveals that coffee’s complex chemical matrix may shape immune responses differently than pure caffeine,…
Macrophage immune memory depends on lingering interferon gamma
Researchers from the University of California, Los Angeles, have discovered that immune cells known as macrophages remain poised…
New findings show why the human intestine uniquely presents gluten to T cells
New evidence shows that human M cells act as fully fledged antigen-presenting cells, processing and presenting gluten peptides…
Novel antibody suppresses primary tumor growth and spread of triple-negative breast cancer
Triple-negative breast cancer (TNBC) is one of the most aggressive and treatment-resistant forms of breast cancer. It grows…
Alzheimer’s breakthrough reveals how tweaking one gene shields brain connections
Scientists have uncovered a microglial switch that transforms these immune cells from plaque-promoting to plaque-protective, offering a new…