Updated EULAR recommendations guide treatment decisions for rheumatoid arthritis
First published in 2010, the EULAR recommendations for the management of RA, the most frequent inflammatory rheumatic disease,…
Combined CDK4/6 and EGFR inhibition improves pancreatic cancer therapy
Clinically available KRAS inhibitors mainly target G12C, which is rare in PDAC and often acquires resistance. Oncogenic KRAS…
Unmasking the hyper-active circuitry of early Alzheimer’s
Neuroscientists at King’s College London have pinpointed a mechanism behind the increased neural connectivity observed in the very early stages of Alzheimer’s…
How somatic mutations shape disease and reveal new drug targets
Scientists reveal how evolution within our own tissues can drive disease, protect cells, and uncover hidden therapeutic targets…
Identifying the core catalyst for muscle energy production
Researchers have investigated the role of a certain enzyme in regulating energy in muscle and exercise performance for…
Tumor-targeted chimeric drug increases efficacy and limits side effects
Wistar scientists have combined a promising cancer therapy with a molecule that targets tumors to treat cancer more…
Tiny plastic particles may interfere with brain processes implicated in Parkinson’s disease
From protein misfolding to gut–brain signalling, emerging evidence suggests that everyday plastic exposure may intersect with key biological…
Gut microbe metabolite TMA improves blood sugar by shutting down a key inflammatory switch
A microbial metabolite long linked to cardiovascular risk emerges as a surprising ally against metabolic inflammation, revealing how…
New method reveals how human cells initiate DNA replication
When cells proliferate, genomic DNA is precisely duplicated once per cell cycle. Abnormalities in this DNA replication process…
Study reveals ATM kinase as the key driver of replicative senescence
After a finite number of divisions, cells simply give up. As each round of replication trims their telomeres-the…
Comprehensive kinase atlas reveals new insights into cell signaling and disease
The enzyme RNA polymerase II transcribes genes into messenger RNA. This process is guided by modifications to the enzyme’s…
Lactate and lactylation drive metabolic, epigenetic reprogramming in gynecological cancers
Lactate, once considered a metabolic waste product, is now recognized as a key regulator of cellular homeostasis and…