Aging brains struggle to recycle synaptic proteins
As we age, we begin to lose the connections that wire up our brains-and neuroscientists aren’t sure why. …
Regulating microglial phagocytosis through immunotherapy could slow Parkinson’s disease progression
By analyzing tissue from patients with Parkinson’s disease, and animal and cellular models of the disease, a research…
Study shows DHPS enzyme controls macrophage maturation across multiple organs
A new study led by researchers at the Johns Hopkins Kimmel Cancer Center, its Bloomberg~Kimmel Institute for Cancer Immunotherapy and the Johns…
Brain immune cells drive persistent negative emotions after repeated binge drinking
New research has identified that neuroinflammation driven by microglia (immune cells in the brain) is a primary underlying…
Switching APOE4 to APOE2 in adult mice reduces Alzheimer’s pathology and improves memory
By flipping a single genetic switch from APOE4 to APOE2 in adult mice, researchers reversed key Alzheimer’s-like changes…
Alzheimer’s breakthrough reveals how tweaking one gene shields brain connections
Scientists have uncovered a microglial switch that transforms these immune cells from plaque-promoting to plaque-protective, offering a new…
MIT researchers invent new human brain model to enable disease research, drug discovery | MIT News
A new 3D human brain tissue platform developed by MIT researchers is the first to integrate all major…
Disruption of glial circadian rhythms linked to Alzheimer’s disease progression
Alzheimer’s disease is notorious for scrambling patients’ daily rhythms. Restless nights with little sleep and increased napping during…
Early antiviral treatment following gammaherpesvirus-68 infection of the central nervous system prevents subsequent multiple sclerosis-like disease | Journal of Neuroinflammation
Dendrou CA, Fugger L, Friese MA. Immunopathology of multiple sclerosis. Nat Rev Immunol. 2015;15(9):545–58. CAS PubMed Google Scholar …
Microglial glycolytic reprogramming in alzheimer’s disease: association with impaired phagocytic function and altered vascular proximity | Journal of Neuroinflammation
In this study, we analysed HP‒EC tissue from 8 AD patients (mean age: 86.5 years, 5 males, 3…
Mount Sinai study maps protein networks driving Alzheimer’s disease pathogenesis
A new study led by the Icahn School of Medicine at Mount Sinai offers one of the most…
New Biomarker Could Detect Alzheimer’s Years Before Symptoms Appear
A new study suggests that TSPO, a key biomarker of brain inflammation, may reveal the earliest stages of…