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Browsing Tag

Microglia

23 posts
HHealth
Blood-based biomarkers reveal barriers to diversity in Alzheimer’s disease trials
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Comprehensive brain cell map opens new avenues for Alzheimer’s therapies

  • August 11, 2026
The brain’s immune cells are increasingly recognized as key players in Alzheimer’s disease, but exactly how they change…
HHealth
Brain circuit identified as key to repetitive and compulsive behaviors in mice
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Brain’s immune cells play key role in maintaining stability of neuronal networks in Alzheimer’s disease

  • July 16, 2026
Researchers at Trinity College Dublin have discovered that microglia – the main immune cells of the brain –…
HHealth
Decoding the purpose of fetal yawns in the womb
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Study compares different light therapies for treating Alzheimer’s disease

  • July 6, 2026
“We wanted to compare the two most common tPBM paradigms head‑to‑head in a well‑established AD mouse model,” explains…
HHealth
A hidden immune pathway may help explain why Alzheimer’s inflammation persists
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A hidden immune pathway may help explain why Alzheimer’s inflammation persists

  • June 11, 2026
A newly identified epigenetic pathway reveals how overactive microglia may sustain brain inflammation in Alzheimer’s, suggesting KAT7 as…
HHealth
Novel RNA target offers hope for improving outcomes in patients with chronic limb ischemia
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Cellular reprogramming helps outsmart progressive Alzheimers disease

  • June 2, 2026
A team led by researcher José Vicente Sánchez Mut at the Institute for Neurosciences (IN), a joint center…
HHealth
Brain circuit identified as key to repetitive and compulsive behaviors in mice
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Microglia actively shape glioblastoma growth and tumor spread

  • April 22, 2026
Glioblastoma, the most common and most aggressive brain tumor type in adults, remains difficult to treat because it…
HHealth
Innate immune activation and microglial transition during neurodegeneration. (A) During neurodegeneration, distressed neurons release DAMPs such as mtDNA, ROS, HMGB1, aberrant proteins, and pTau–bound RNA. These signals activate resident microglia and astrocytes, which then recruit peripheral immune cells. As shown in more detail in B, activated microglia upregulate PRRs, including TLRs, RAGE, and cGAS, enabling detection of neuron-derived DAMPs. Engagement of PRRs induces proinflammatory gene expression programs and activates inflammasome pathways that promote release of chemokines and cytokines into the CNS parenchyma. As microglia transition from homeostatic to reactive states in a TREM2-dependent manner, damage-associated microglia increase MHC-II expression to support antigen presentation and coordination of adaptive immune responses that attempt to limit neurodegeneration.
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How the immune system may influence Alzheimer’s, Parkinson’s, and related diseases

  • April 17, 2026
A sweeping review shows how the brain’s immune defenses can both fight and fuel neurodegeneration, revealing why timing,…
HHealth
Early warning signs of MS appear years before diagnosis and affect all communities in similar ways
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Enriched environments improve stroke recovery and reduce brain inflammation

  • April 12, 2026
Stroke is one of the leading causes of death worldwide. Its recovery is often challenging as most of…
HHealth
Microglia among neurons
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Affecting a Signaling Pathway Alleviates Alzheimer’s in Mice

  • April 10, 2026
A new study shows that the overexpression of somatostatin (SST), a neuropeptide produced in neurons and acting mostly…
HHealth
Neuroscience News logo for mobile.
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Single Immune Switch Drives Both Arthritis and Alzheimer’s

  • April 7, 2026
Summary: Inflammation is the body’s natural defense, but when it gets stuck in the “on” position, it drives…
HHealth
Antibody cocktail could change the way the world fights influenza
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Investigating microglia’s role in Alzheimer’s pathology

  • March 2, 2026
Announcing a new article publication for BIO Integration journal. Alzheimer’s disease (AD) is a neurodegenerative disorder and the…
HHealth
AI toolset reveals links between lung fibrosis and aging
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Aging brains struggle to recycle synaptic proteins

  • February 3, 2026
As we age, we begin to lose the connections that wire up our brains-and neuroscientists aren’t sure why. …
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