Prospective evaluation of a large language model clinical decision support system in the emergency department
Hoot, N. R. & Aronsky, D. Systematic review of emergency department crowding: causes, effects, and solutions. Ann. Emerg.…
Psilocybin-assisted therapy for treatment-resistant major depressive disorder in a public healthcare setting: a randomized controlled trial
This study of psilocybin assisted-therapy for TRD—to our knowledge, the first RCT in this population to assess feasibility…
Divergent impacts of explainable AI for dermatological diagnosis on clinicians versus lay people
Study design We designed two complementary large-scale experiments to evaluate human−AI collaborative diagnostic performance across expertise levels (Fig.…
Integrated care pathway in individuals with Long COVID: STIMULATE-ICP, a cluster-randomized, phase 3 trial
Trial design and oversight The STIMULATE-ICP trial aimed to investigate the efficacy of an enhanced ICP for LC,…
Mechanistic and evolutionary determinants of cefiderocol resistance in KPC-producing Pseudomonas aeruginosa
Cefiderocol (FDC), a siderophore cephalosporin, shows potent activity against difficult-to-treat Pseudomonas aeruginosa. We analyzed 25 clinical KPC-variant-producing P.…
Genomas Brasil program: building precision public health within Brazil’s Unified Health System
Patel, H. N. et al. J. Pharm. Bioallied Sci. 17, S1101–S3 (2025). Article PubMed PubMed Central Google Scholar …
Health system learning enables generalist neuroimaging models
Health system learning We define ‘health system learning’ as learning directly from uncurated data generated during routine clinical…
Generative AI-enabled clinical decision support system in primary care: a pragmatic, cluster-randomized trial
Design We conducted a pragmatic, multicenter, parallel-group cluster-randomized controlled trial across a network of 16 primary care facilities…
Evaluating the robustness and readiness of large frontier models in health AI applications
Singhal, K. et al. Large language models encode clinical knowledge. Nature 620, 172–180 (2023). Article CAS PubMed PubMed…
General-purpose chatbots outperform clinical AI tools on physicians’ real-world questions
Publisher’s note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. This…
Implications of wait times for sentinel node biopsy on melanoma disease progression, micrometastatic tumour burden and survival outcomes in the modern treatment era
The data confirms that our service began to struggle to achieve a waiting time of 90 days or…
Advancing ferroptosis-targeted therapies
RESEARCH HIGHLIGHT 10 June 2026 ]]> Ferroptosis is a form of regulated cell death characterised by iron accumulation…