Clinical trial tests a newer, targeted therapy for IDH mutant astrocytoma
A new clinical trial led by the Alliance for Clinical Trials in Oncology will investigate if a combination…
Gene mutation that aids high-altitude survival could repair myelin sheath damage
A genetic mutation that helps animals like yaks and Tibetan antelopes survive at high altitudes may hold the key to repairing…
Combined CDK4/6 and EGFR inhibition improves pancreatic cancer therapy
Clinically available KRAS inhibitors mainly target G12C, which is rare in PDAC and often acquires resistance. Oncogenic KRAS…
Transposable elements cause majority of lethal mutations in fruit flies
Most lethal mutations in wild fruit flies are driven by newly transferred jumping genes, not small DNA errors,…
AI trained on 9 trillion DNA letters predicts harmful mutations and designs new genomes
Trained on genomic data spanning the tree of life, Evo 2 reveals how artificial intelligence can decode the…
Genomic landscape and clinicopathologic significance of POLE mutant colorectal carcinoma
Background and objectives DNA polymerase epsilon catalytic subunit A (POLE) gene plays a crucial role in DNA repair…
Novel lipid bubble delivery shows promise for ALS treatment
A researcher at the University of Missouri has made a promising breakthrough in the quest to help people…
MULTI-evolve accelerates protein engineering with machine learning
The search space for protein engineering grows exponentially with complexity. A protein of just 100 amino acids has…
Antibody feedback reshapes B cell selection during immune response
 A collaborative study published in Immunity from the Batista Lab and Liu Lab at the Ragon Institute, together…
Zebrafish can play a decisive role in clinical interpretation of spinal muscular atrophy
The tiny zebrafish is helping researchers rapidly determine whether a newborn’s genetic mutation is likely to cause spinal…
Single-cell technique maps pre-malignant gene mutations in solid tissues
A new single-cell profiling technique has mapped pre-malignant gene mutations and their effects in solid tissues for the…
DNA analysis of colorectal polyps improves diagnosis and treatment
In about 5–10% of colorectal cancer patients, hereditary factors play a role, with higher percentages among younger patients.…