Targeting lipid enzymes triggers starvation states in aggressive tumor cells
While many American adults are trying to reduce cholesterol levels, certain cancerous tumors have a relentless appetite for…
Scientists uncover why genome guardian p53 protein is uniquely prone to collapse
The protein p53 is often called the guardian of the genome for its central role in preventing cancer.…
AI model reads genetic code to trace evolutionary history
Researchers at the University of Oregon have developed an artificial intelligence tool that can read genetic code the…
JMIR Publications’ new article showcases the transformative potential of precision oncology
JMIR Publications today announced the release of a timely new article in its News and Perspectives section, showcasing…
Toxic RNA drives progressive heart damage in myotonic dystrophy
Myotonic dystrophy type 1 (DM1) is the most common cause of adult-onset muscular dystrophy, a genetic disorder that…
Genomic study advances prioritization of variants in cancer diagnostics
Hiroshima University researchers have developed a practical framework to identify candidate pathogenic variants hidden among the large number…
Clinical trial tests a newer, targeted therapy for IDH mutant astrocytoma
A new clinical trial led by the Alliance for Clinical Trials in Oncology will investigate if a combination…
Gene mutation that aids high-altitude survival could repair myelin sheath damage
A genetic mutation that helps animals like yaks and Tibetan antelopes survive at high altitudes may hold the key to repairing…
Combined CDK4/6 and EGFR inhibition improves pancreatic cancer therapy
Clinically available KRAS inhibitors mainly target G12C, which is rare in PDAC and often acquires resistance. Oncogenic KRAS…
Transposable elements cause majority of lethal mutations in fruit flies
Most lethal mutations in wild fruit flies are driven by newly transferred jumping genes, not small DNA errors,…
AI trained on 9 trillion DNA letters predicts harmful mutations and designs new genomes
Trained on genomic data spanning the tree of life, Evo 2 reveals how artificial intelligence can decode the…
Genomic landscape and clinicopathologic significance of POLE mutant colorectal carcinoma
Background and objectives DNA polymerase epsilon catalytic subunit A (POLE) gene plays a crucial role in DNA repair…