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Browsing Tag

Neurodegeneration

32 posts
HHealth
Study analyzes alterations in the cerebral cortex in people with psychosis
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Study connects late-life psychosis to abnormal tau protein buildup

  • August 4, 2026
Hallucinations and delusions that appear for the first time in midlife or later are often treated as psychiatric…
HHealth
Study: AI-redesigned starting points and outcomes enhance protein evolution. Image Credit: Corona Borealis Studio / Shutterstock
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AI redesign helps enzymes evolve beyond natural limits

  • July 24, 2026
By stabilizing enzyme starting points before evolution, researchers opened new mutational routes for engineering highly specific proteases, including…
HHealth
Frequent TV watching links to higher white matter lesion volume
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Frequent TV watching links to higher white matter lesion volume

  • July 23, 2026
A 24-year ARIC analysis suggests that the setting in which people sit may matter for brain measures linked…
HHealth
SLIT2 protein levels in the eye and blood linked to cognitive function
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Sleeping longer may signal early Alzheimer’s-related brain changes

  • July 16, 2026
Regularly sleeping long hours each night is associated with higher levels of an Alzheimer’s-related protein in the blood,…
HHealth
Scientists reveal how cGAS-STING fuels brain inflammation and neurodegeneration
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Scientists reveal how cGAS-STING fuels brain inflammation and neurodegeneration

  • June 11, 2026
A major immune pathway once known for detecting DNA damage is now being linked to brain aging, glial…
HHealth
Brain circuit identified as key to repetitive and compulsive behaviors in mice
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Allen Institute launches global research initiative to accelerate new treatments for brain disorders

  • June 2, 2026
The Allen Institute, together with partner organizations, today launched the Brain Health accelerator: an ambitious global research initiative seeking to identify the specific brain cells and circuits affected in neurodegenerative disease and other brain disorders and use that…
HHealth
Brain circuit identified as key to repetitive and compulsive behaviors in mice
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Molecular map reveals how Down syndrome alters brain development

  • April 25, 2026
Scientists at UCLA have created one of the first cellular-resolution molecular maps detailing how Down syndrome alters human…
SScience
Neuroscience News logo for mobile.
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Glutathione Prevents Cellular Clogs – Neuroscience News

  • April 18, 2026
Summary: The endoplasmic reticulum (ER) is the cell’s busiest manufacturing hub, responsible for folding and exporting proteins. For…
HHealth
Innate immune activation and microglial transition during neurodegeneration. (A) During neurodegeneration, distressed neurons release DAMPs such as mtDNA, ROS, HMGB1, aberrant proteins, and pTau–bound RNA. These signals activate resident microglia and astrocytes, which then recruit peripheral immune cells. As shown in more detail in B, activated microglia upregulate PRRs, including TLRs, RAGE, and cGAS, enabling detection of neuron-derived DAMPs. Engagement of PRRs induces proinflammatory gene expression programs and activates inflammasome pathways that promote release of chemokines and cytokines into the CNS parenchyma. As microglia transition from homeostatic to reactive states in a TREM2-dependent manner, damage-associated microglia increase MHC-II expression to support antigen presentation and coordination of adaptive immune responses that attempt to limit neurodegeneration.
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How the immune system may influence Alzheimer’s, Parkinson’s, and related diseases

  • April 17, 2026
A sweeping review shows how the brain’s immune defenses can both fight and fuel neurodegeneration, revealing why timing,…
HHealth
Caregiver feeding elderly woman with soup in dining room.
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Gut microbiome changes improve memory in early cognitive decline

  • April 1, 2026
From Mediterranean diets to probiotics, scientists reveal how reshaping the gut microbiome could help protect brain function, while…
SScience
Neuroscience News logo for mobile.
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AI Links Brain Rhythms to Physical “Wiring” Across Lifespan

  • March 27, 2026
Summary: For the first time, a multinational research team has mapped how the brain’s electrical activity evolves from…
HHealth
Semaglutide Falls Short in Alzheimer’s Phase 3 Trials
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Semaglutide Falls Short in Alzheimer’s Phase 3 Trials

  • March 21, 2026
Phase 3 trials show oral semaglutide failed to slow early Alzheimer’s progression, potentially limiting its expansion beyond metabolic…
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