Faulty myelin-making brain cells may help drive cognitive decline with age
A rare combination of lifelong cognitive tracking, postmortem brain analysis, and targeted mouse experiments reveals unexpected changes in…
Shared protein pathology redefines treatment for multiple neurodegenerative diseases
On the surface, amyotrophic lateral sclerosis (ALS), frontotemporal dementia (FTD) and limbic-predominant age-related TDP-43 encephalopathy (LATE) might seem…
Lancet review examines possible amyloid-beta transmission through blood transfusions
A review and opinion piece published in The Lancet and led by UCL (University College London) and UCLH…
New genetic mutations linked to malaria drug resistance discovered
Researchers searching for genetic clues to the growing problem of malaria drug resistance identified new mutations associated with…
Alzheimer’s markers show crucial differences across diverse global populations
Established Alzheimer’s markers are also detected in blood samples from Nigeria and Tanzania. But other proteins in the…
Study connects late-life psychosis to abnormal tau protein buildup
Hallucinations and delusions that appear for the first time in midlife or later are often treated as psychiatric…
Using DNA sequencing for accurate identification of microbial infections in cystic fibrosis patients
Lung infections are a constant risk for people living with cystic fibrosis (CF), a life-threatening genetic disorder which…
Gut microbiome shifts may begin before Alzheimer’s symptoms appear
A new review traces how diet, gut bacteria, and their metabolites may intersect with the silent biological changes…
A closer look at Parkinson’s brains finds tau where standard tests saw little
By examining six brain regions at single-molecule resolution, researchers identified a layer of tau pathology that conventional tissue…
Prenatal use of certain medications can harm developing fetal brain
A review article by a University of Nebraska Medical Center/Child Health Research Institute research team underscores and describes…
New tumor organoids strengthen precision oncology research
Significant advances have been made in the development of patient-derived tumor “organoids” for preclinical research, in two new…
Blood p-tau217 levels signal cognitive impairment risk years before symptoms emerge
A six-cohort analysis links higher baseline p-tau217 to rising 5- and 10-year risks, bringing presymptomatic risk models closer…