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Browsing Tag

Pathology

81 posts
TTechnology
Electrical stimulation predicts recovery potential after acute nerve injuries
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Pinecone-inspired conduit enables suture-free repair of nerve injuries

  • April 22, 2026
As the authors detail, PNI is a prevalent neurological condition that often causes permanent sensory and motor dysfunction,…
HHealth
Neurons in Alzheimer
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Alzheimer’s monoclonal antibodies fail to deliver meaningful results

  • April 21, 2026
Despite successfully removing amyloid plaques from the brain, widely anticipated antibody therapies fail to deliver meaningful cognitive improvements,…
HHealth
Innate immune activation and microglial transition during neurodegeneration. (A) During neurodegeneration, distressed neurons release DAMPs such as mtDNA, ROS, HMGB1, aberrant proteins, and pTau–bound RNA. These signals activate resident microglia and astrocytes, which then recruit peripheral immune cells. As shown in more detail in B, activated microglia upregulate PRRs, including TLRs, RAGE, and cGAS, enabling detection of neuron-derived DAMPs. Engagement of PRRs induces proinflammatory gene expression programs and activates inflammasome pathways that promote release of chemokines and cytokines into the CNS parenchyma. As microglia transition from homeostatic to reactive states in a TREM2-dependent manner, damage-associated microglia increase MHC-II expression to support antigen presentation and coordination of adaptive immune responses that attempt to limit neurodegeneration.
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How the immune system may influence Alzheimer’s, Parkinson’s, and related diseases

  • April 17, 2026
A sweeping review shows how the brain’s immune defenses can both fight and fuel neurodegeneration, revealing why timing,…
HHealth
NYU Langone strengthens world-leading GI cancer program with renowned leaders
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New biomarker predicts prognosis and treatment response in colorectal cancer

  • April 15, 2026
Determining the presence of a protein in non-tumor cells within the cancer microenvironment could be one of the keys to establishing prognosis…
HHealth
SLIT2 protein levels in the eye and blood linked to cognitive function
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Study reveals how tau tangles spread from one brain region to another in Alzheimer’s

  • April 8, 2026
Alzheimer’s disease is a progressive neurodegenerative disorder that slowly impairs memory, affects thinking skills, and eventually interferes with…
HHealth
Study provides first worldwide validation of new GLIS model in older patients with heart failure
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Toxic RNA drives progressive heart damage in myotonic dystrophy

  • April 4, 2026
Myotonic dystrophy type 1 (DM1) is the most common cause of adult-onset muscular dystrophy, a genetic disorder that…
NNew Zealand
Auckland woman offered stranger’s ovary instead of her own breast tissue at Anatomic Pathology Service
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Auckland woman offered stranger’s ovary instead of her own breast tissue at Anatomic Pathology Service

  • April 1, 2026
Both patients caught up in the errors had the same first name, and surnames weren’t checked – even…
HHealth
Researchers identify cellular drivers of gut scarring in Crohn’s disease
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Researchers identify cellular drivers of gut scarring in Crohn’s disease

  • March 16, 2026
As inflamed regions of the gut form scar tissue, the space within the gut lumen becomes smaller and…
TTechnology
NYU Langone strengthens world-leading GI cancer program with renowned leaders
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New AI system reduces pathologist workload while maintaining diagnostic accuracy

  • March 13, 2026
Artificial intelligence could make cancer diagnosis safer and fairer by learning when to defer to human pathologists without…
HHealth
Brain circuit identified as key to repetitive and compulsive behaviors in mice
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Study reveals a disease-relevant role for tanycytes in neurodegeneration

  • March 5, 2026
Accumulation of the protein tau in the brain is one of the hallmarks of Alzheimer’s disease. In a paper publishing March…
HHealth
NYU Langone strengthens world-leading GI cancer program with renowned leaders
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AI cancer tools may be using visual shortcuts rather than true biology

  • March 2, 2026
New research warns that popular deep learning systems trained for cancer pathology may be relying on hidden shortcuts rather…
HHealth
Antibody cocktail could change the way the world fights influenza
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Investigating microglia’s role in Alzheimer’s pathology

  • March 2, 2026
Announcing a new article publication for BIO Integration journal. Alzheimer’s disease (AD) is a neurodegenerative disorder and the…
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