Genomic landscape and clinicopathologic significance of POLE mutant colorectal carcinoma
Background and objectives DNA polymerase epsilon catalytic subunit A (POLE) gene plays a crucial role in DNA repair…
Researchers reveal why SuperAgers retain youthful brain cell signatures into their 80s
A multiomic atlas of the aging human hippocampus uncovers how epigenetic regulation of neural stem cells and immature…
Novel lipid bubble delivery shows promise for ALS treatment
A researcher at the University of Missouri has made a promising breakthrough in the quest to help people…
Stilbenoid gaylussacin modulates particulate matter-induced chromatin remodeling in macrophages to suppress chronic obstructive pulmonary disease
Chronic obstructive pulmonary disease (COPD), a leading cause of mortality worldwide, is characterized by chronic bronchitis and emphysema.1…
Study identifies PPP2R5C blood marker that may detect Alzheimer’s disease earlier
Researchers report that declining PPP2R5C levels in blood may signal early Alzheimer’s pathology, offering new insight into tau…
FDA-approved anti-seizure drug could help fight Alzheimer’s disease
While physicians and scientists have long known Alzheimer’s disease involves the buildup of toxic protein fragments in the…
Alzheimer’s plaques decline after CAR-T immune cell treatment in preclinical study
A novel CAR-T cell approach targets amyloid plaques in preclinical Alzheimer models, raising the possibility that engineered immune…
New prevention strategy can reduce deadly ovarian cancer risk by nearly 80%
A prevention strategy developed by Canadian researchers can reduce the risk of the most common and deadly form of ovarian cancer by nearly…
Combination therapy improves cognition in Alzheimer’s models
In recent years, research into cannabis and its main psychoactive ingredient, Δ⁹-tetrahydrocannabinol (THC), has unearthed medical benefits including…
Immune system dysfunction may fuel progressive heart failure after heart attacks
When the heart’s muscle is weakened or injured due to a heart attack, it can make it hard…
Tiny plastic particles may interfere with brain processes implicated in Parkinson’s disease
From protein misfolding to gut–brain signalling, emerging evidence suggests that everyday plastic exposure may intersect with key biological…
Architectural Genocide – Malignant Cognition Review
It’s gotta be tough being inspired by genre giants. For bands like Incantation or Autopsy, it can be…