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Browsing Tag

Preclinical

30 posts
HHealth
First FDA-approved islet transplant at UI Health ends insulin dependence
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UC Irvine receives funding for clinical trial of neural stem cell therapy for Huntington’s disease

  • December 13, 2025
Leslie M. Thompson, Donald Bren Professor of psychiatry and human behavior as well as neurobiology and behavior at…
HHealth
Study: Dietary restriction reprograms CD8+ T cell fate to enhance anti-tumour immunity and immunotherapy responses. Image Credit: Corona Borealis Studio / Shutterstock
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Dietary restriction boosts antitumour immunity by rewiring T cell metabolism

  • December 11, 2025
By elevating ketone-driven energy pathways inside CD8+ T cells, dietary restriction steers them away from exhaustion and toward…
HHealth
Study: Maternal allergy and neonatal RSV infection synergize via FcR-mediated allergen uptake to promote the development of asthma in early life. Image Credit: Art_Photo  / Shutterstock
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Early RSV infection turns maternal allergy into a powerful driver of childhood asthma

  • December 9, 2025
By combining nationwide health data with elegant immunology experiments, researchers reveal how RSV infection in infancy hijacks maternal…
HHealth
Regular mammograms linked to longer survival in women over 80
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Novel antibody suppresses primary tumor growth and spread of triple-negative breast cancer

  • December 5, 2025
Triple-negative breast cancer (TNBC) is one of the most aggressive and treatment-resistant forms of breast cancer. It grows…
HHealth
COMBINEDBrain and MUSC join forces to launch pediatric CNS biorepository
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Generative AI aids discovery of ISM3830’s novel scaffold

  • December 2, 2025
Casitas B-lineage lymphoma-b (CBLB) is an E3 ubiquitin–protein ligase that functions as an intracellular checkpoint and master negative…
HHealth
Reversing age-related vision loss with retinal lipid therapy
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Inflammation control can protect against AMD-like retinal damage

  • November 22, 2025
University of Minnesota Medical School researchers have shown that reducing chronic inflammation can significantly protect against age-related macular…
HHealth
Adjuvant chemo-immunotherapy may benefit patients with resected stage IB–IIIA NSCLC, trial suggests
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Scientists uncover molecular mechanism behind chemotherapy-induced peripheral neuropathy

  • November 21, 2025
Chemotherapy activates a stress sensor in immune cells, triggering inflammation and nerve damage, which may help explain why…
TTechnology
Personalized brain stimulation approach shows promise for patients with drug-resistant epilepsy
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RNA-based cocktail shows promise against glioblastoma

  • November 21, 2025
A patented RNA-based cocktail developed at the Italian Institute of Technology (IIT-Istituto Italiano di Tecnologia) has emerged as…
HHealth
Integrating physicochemical laws into future AI models for better drug design
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Breakthrough in FcγRI inhibition opens path to safer autoimmune therapies

  • November 19, 2025
An international research group directed by UMC Utrecht have developed and characterized two first-in-class antibodies that specifically block…
HHealth
Study: Supplementation of aged garlic extract attenuates age-associated memory impairment and cognitive decline: Involvement of molecular pathways in the cortex and hippocampus. Image Credit: New Africa / Shutterstock
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Preclinical study shows aged garlic extract improves memory and reduces anxiety

  • November 17, 2025
New findings show that aged garlic extract reshapes brain pathways tied to memory and emotion, revealing a promising…
HHealth
Regular mammograms linked to longer survival in women over 80
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Innovative research reveals FGD3 as a key player in breast cancer cell death

  • November 13, 2025
A naturally occurring protein that tends to be expressed at higher levels in breast cancer cells boosts the…
HHealth
Researchers uncover how HIV-1 uses RNA:DNA hybrids to integrate into the genome
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Low-dose THC mitigates harmful side effects and inflammation caused by HIV treatment

  • November 6, 2025
Long-term, low doses of THC mitigate many harmful side effects and inflammation caused by HIV and antiretroviral therapy…
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