Generative AI aids discovery of ISM3830’s novel scaffold
Casitas B-lineage lymphoma-b (CBLB) is an E3 ubiquitin–protein ligase that functions as an intracellular checkpoint and master negative…
Inflammation control can protect against AMD-like retinal damage
University of Minnesota Medical School researchers have shown that reducing chronic inflammation can significantly protect against age-related macular…
Scientists uncover molecular mechanism behind chemotherapy-induced peripheral neuropathy
Chemotherapy activates a stress sensor in immune cells, triggering inflammation and nerve damage, which may help explain why…
RNA-based cocktail shows promise against glioblastoma
A patented RNA-based cocktail developed at the Italian Institute of Technology (IIT-Istituto Italiano di Tecnologia) has emerged as…
Breakthrough in FcγRI inhibition opens path to safer autoimmune therapies
An international research group directed by UMC Utrecht have developed and characterized two first-in-class antibodies that specifically block…
Preclinical study shows aged garlic extract improves memory and reduces anxiety
New findings show that aged garlic extract reshapes brain pathways tied to memory and emotion, revealing a promising…
Innovative research reveals FGD3 as a key player in breast cancer cell death
A naturally occurring protein that tends to be expressed at higher levels in breast cancer cells boosts the…
Low-dose THC mitigates harmful side effects and inflammation caused by HIV treatment
Long-term, low doses of THC mitigate many harmful side effects and inflammation caused by HIV and antiretroviral therapy…
Resistance exercise may offer greater benefits for preventing diabetes and obesity
Running may help burn calories, but when it comes to preventing diabetes and obesity, pumping iron might have…
Northwestern team develops antibody to expose hidden pancreatic cancer cells
Pancreatic cancer is notoriously hard to treat and often resists the most advanced immunotherapies. Northwestern Medicine scientists have…
Lactate and lactylation drive metabolic, epigenetic reprogramming in gynecological cancers
Lactate, once considered a metabolic waste product, is now recognized as a key regulator of cellular homeostasis and…
Thiostrepton suppresses rhabdomyosarcoma progression by targeting the PI3K–AKT pathway
Rhabdomyosarcoma (RMS) accounts for up to 10% of childhood cancers and nearly half of pediatric soft tissue sarcomas.…