Combination therapy overcomes ferroptosis resistance in β-catenin-mutant hepatocellular carcinoma
Background and aims The aberrant activation of the mTOR pathway and its crosstalk with other signaling cascades represent…
Scientists uncover shared gene signatures that reveal how mammals age
A sweeping study across four mammalian species shows that aging leaves a shared molecular fingerprint, opening new ways…
Disappointing results from the first rapamycin-plus-exercise trial
Rapamycin has had a bruising couple of weeks in the longevity press. The RAPA-EX-01 trial was the first…
Food timing may shape how T cells respond to infection and therapy
A new study reveals how lipids released after a meal can durably boost T cell metabolism, translation, and…
UT San Antonio study evaluates rapamycin’s potential to promote healthy aging
UT Health San Antonio, the academic health center of The University of Texas at San Antonio (UT San Antonio) is…
ARPA-H-funded PROSPR program focuses on the biological hallmarks of aging
Columbia University Mailman School of Public Health has received an award as part of the PROactive Solutions for Prolonging Resilience (PROSPR) program within the Advanced…
Engineered extracellular vesicles enable antigen-specific regulatory T cell induction
A research team at the Nano Life Science Institute (WPI-NanoLSI) and the Faculty of Medicine at Kanazawa University…
Study finds GLP-1 drugs improve strength and reverse aging biology in mice
New multi-omic data reveal that GLP-1 signaling in the brain can drive body-wide rejuvenation, offering a potential weight-neutral…
New TOR inhibitor rapalink-1 prolongs chronological lifespan in fission yeast
Researchers from Queen Mary University of London’s School of Biological and Behavioural Sciences, using the simple fission yeast…