New skin-permeable polymer delivers insulin without needles
A breakthrough zwitterionic polymer slips through the skin’s toughest barriers, carrying insulin deep into tissue and normalizing blood…
Calcium-activated switch improves delivery and potency of cancer-fighting drugs
Cancer-fighting antibody drugs are designed to penetrate tumor cells and release a lethal payload deep within, but too…
Study finds GLP-1 drugs improve strength and reverse aging biology in mice
New multi-omic data reveal that GLP-1 signaling in the brain can drive body-wide rejuvenation, offering a potential weight-neutral…
New signaling molecule drives development of tissue resident memory T cells
We owe a lot to tissue resident memory T cells (TRM). These specialized immune cells are among the…
Study compares GLP-1 drug benefits and finds substantial variation in clinical effects
A new umbrella review reveals how GLP-1 therapies shape cardiovascular, renal, and metabolic outcomes in type 2 diabetes…
Breakthrough in FcγRI inhibition opens path to safer autoimmune therapies
An international research group directed by UMC Utrecht have developed and characterized two first-in-class antibodies that specifically block…
New antibody strategy shows promise for halting cyst growth in polycystic kidney disease
Polycystic kidney disease (PKD) is a debilitating hereditary condition in which fluid-filled sacs form and proliferate in the…
Breast cancer cells use a molecular switch to survive stress
Cells are regularly faced with environmental stresses that may damage or destroy them. To survive, they quickly adjust…
Understanding leptin’s dual function in MAFLD pathogenesis
Metabolic dysfunction-associated fatty liver disease (MAFLD) has emerged as a predominant chronic liver condition globally, intricately linked with…
Off-label GLP-1 use highlights the cultural pressures driving body anxieties
A new sociomedical perspective shows how off-label use of GLP-1 drugs for slimness is redefining what counts as…
Innovative research reveals FGD3 as a key player in breast cancer cell death
A naturally occurring protein that tends to be expressed at higher levels in breast cancer cells boosts the…
Switching APOE4 to APOE2 in adult mice reduces Alzheimer’s pathology and improves memory
By flipping a single genetic switch from APOE4 to APOE2 in adult mice, researchers reversed key Alzheimer’s-like changes…