New signaling pathway enhances blood stem cell transplantation outcomes
Gene therapies are used to treat many different blood disorders. However, blood stem cells often fail to achieve…
Study identifies shared pathway driving cardiac fibrosis
Three adenosine receptor subtypes that normally send different signals were found to converge on a common pathway that…
Specialized blood vessel cells found to actively drive lung fibrosis
Millions of people worldwide are affected by diseases that cause scarring of the lungs, often leading to breathing…
Dysregulation of immune regulator NF-κB drives major human diseases
The NF‑κB family is a master regulator of innate and adaptive immunity. Its aberrant activation-via canonical or non‑canonical…
Stem cell study uncovers molecular pathway for enamel regeneration
Tooth enamel is the hardest substance in the human body, yet once damaged, it cannot regenerate naturally. To…
Astrocytes form complex networks across the mouse brain
Cells long thought to play a secondary role in brain function build their own far-reaching connections, a new…
Drugs targeting TIE2 protein could help prevent formation of cerebral cavernous malformations
Researchers in the Perelman School of Medicine at the University of Pennsylvania have identified a cell surface receptor…
Open Framework for Integrating Whole-Slide and Molecular Data
Cell detection with LazySlide in human colon tissue: Immune cells (green), connective tissue cells (blue) and epithelial cells…
FOXJ3 gene identified as the critical link between abnormal brain development and epilepsy
Researchers have discovered that mutations in the FOXJ3 gene act as a “master switch” failure, disrupting how the…
Gut microbiota-derived metabolite directly shapes immune responses in bacterial pneumonia
Sepsis and severe pneumonia are frequently accompanied by disruption of the gut microbiota, leading to immune dysfunction and…
UCF researcher explores insulin signaling as new target for diabetic neuropathy
Neuropathy – chronic pain, numbness and tingling in the hands and feet – is a challenging fact of…
New study exposes a targetable vulnerability in acute myeloid leukemia
New research co-led by Indiana University School of Medicine scientists has exposed a vulnerability in acute myeloid leukemia…