New technique synthesizes non-natural amino acids for advanced peptide therapeutics
Ozempic has been making headlines for its remarkable success in treating obesity and diabetes. Yet it is just…
Systematic Discovery of Molecular Glues Targets Protein Degradation in Leukemia
Molecular structure of the leukemia protein ENL in the degradation complex introduced by the molecular glue dHTC1 [Miquel…
Blood metabolites reveal who will develop type 2 diabetes years before diagnosis
A decades-long study shows how patterns in circulating metabolites, shaped by genes and lifestyle, can identify people at…
UK Biobank releases the world’s largest metabolomic dataset for disease research
UK Biobank has today [Thursday 20 November] released the final set of data on nearly 250 metabolites – the molecules in our blood produced by…
Two microbial metabolites compete to control the cells’ protein building machinery
The microbiome-the trillions of bacteria, viruses, and fungi that live quietly in our body-plays a crucial role in…
Scientists uncover how amino acids stabilize proteins in solution
For decades, amino acids have been added to medical formulations like insulin as stabilizers: these small molecules keep…
Unlocking hidden soil microbes for new antibiotics
Most bacteria cannot be cultured in the lab-and that’s been bad news for medicine. Many of our frontline…