New nanoparticle system boosts scalable production of therapeutic exosomes
Researchers from Xi’an Jiaotong-Liverpool University (XJTLU) in China have developed a streamlined process that makes it easier to…
CSF1R T567M mutation induces microglial dysfunction and synaptic impairment in patient iPSC-derived cerebral organoids of CSF1R-related disorder
Ayrignac X, Carra-Dalliere C, Codjia P, Mouzat K, Castelnovo G, Ellie E, et al. Evaluation of CSF1R-related adult…
Scientists discover how muscle stem cells “flip a switch” to rebuild damaged muscle
Scientists at the University of California, Irvine’s School of Pharmacy & Pharmaceutical Sciences have discovered how muscle stem cells “flip…
Researchers reveal why SuperAgers retain youthful brain cell signatures into their 80s
A multiomic atlas of the aging human hippocampus uncovers how epigenetic regulation of neural stem cells and immature…
Alpha-Ketoglutarate Enhances Adipose-Derived Stem Cells Survival in Wound Healing by Hypoxia-Inducible Factor 1-Alpha-Mediated Redox Homeostasis and Glycogen-Dependent Bioenergetics
BACKGROUND Adipose-derived stem cells (ADSCs) hold significant therapeutic potential for regenerative medicine, particularly in wound healing, owing to…
Genetic mismatch identified as major risk factor in cord blood transplantation
A Japanese study of more than 7,400 patients has identified a genetic mismatch that sharply increases the risk…
New brain discovery could help reverse the effects of aging
The promise of reclaiming youthful cognitive function has long been a holy grail for neuroscientists, but researchers may…
Stem cell implants aim to restore dopamine in Parkinson’s disease
Parkinson’s disease is a progressive neurodegenerative disorder that affects more than one million people in the United States,…
Engineered mesenchymal and endothelial cell layers effectively mimic native lymph nodes
The rising incidence of cancer worldwide has led to an increasing number of surgeries that involve the removal…
Sperm RNA aging shift that may explain paternal age effects
A newly revealed “aging cliff” in sperm RNA marks a conserved molecular transition from youth to later life,…
Interferon response key to fighting rhinovirus infections in nasal passages
When a rhinovirus, the most frequent cause of the common cold, infects the lining of our nasal passages,…
New study exposes a targetable vulnerability in acute myeloid leukemia
New research co-led by Indiana University School of Medicine scientists has exposed a vulnerability in acute myeloid leukemia…