Pediatric rheumatic diseases have unique genetic architecture compared to adults
Researchers from Children’s Hospital of Philadelphia (CHOP) have found that pediatric-onset rheumatic and inflammatory diseases have distinct genetic…
SLC7A11 deficiency exacerbates systemic lupus erythematosus by inducing instability and ferroptosis in regulatory T cells
Systemic lupus erythematosus (SLE) is an autoimmune disease posing a significant threat to human health. Regulatory T cells…
Review finds vitamin D lacks disease-modifying effect in rheumatic diseases
A new review from the International Osteoporosis Foundation (IOF) Osteoimmunology Working Group, published in Osteoporosis International, provides a…
Exploring melatonin therapeutic potential in systemic lupus erythematosus
A recent review published in Current Molecular Pharmacology explores the therapeutic potential of melatonin in systemic lupus erythematosus…
Single-cell RNA sequencing uncovers diverse CD4⁺ T-cell subtypes in pediatric lupus
Detailed mapping of CD4⁺ T cells from children with systemic lupus erythematosus (SLE) has revealed distinct immune cell…
Breakthrough in FcγRI inhibition opens path to safer autoimmune therapies
An international research group directed by UMC Utrecht have developed and characterized two first-in-class antibodies that specifically block…
Study links common Epstein-Barr virus to autoimmune lupus
One of humanity’s most ubiquitous infectious pathogens bears the blame for the chronic autoimmune condition called systemic lupus…