New nanoparticle therapy overcomes T cell exhaustion in solid tumors
Engineers at the University of Pennsylvania have developed a new type of lipid nanoparticle (LNP) that could one…
Chronic inflammation shapes cancer progression and immunotherapy response
Chronic inflammation is both a driver and suppressor of cancer depending on context. Key players-NF-κB, IL-6, STAT3, TAMs,…
Silica nanomatrix enhances immunotherapy for solid tumors
Cancer has long remained a leading cause of death worldwide and in Hong Kong, accounting for 30% of…
Reprogramming camp for immune cells shows early promise for autoimmune diseases
Scientists are trying a revolutionary new approach to treat rheumatoid arthritis, multiple sclerosis, lupus and other devastating autoimmune…
Generative AI aids discovery of ISM3830’s novel scaffold
Casitas B-lineage lymphoma-b (CBLB) is an E3 ubiquitin–protein ligase that functions as an intracellular checkpoint and master negative…
Single-cell RNA sequencing uncovers diverse CD4⁺ T-cell subtypes in pediatric lupus
Detailed mapping of CD4⁺ T cells from children with systemic lupus erythematosus (SLE) has revealed distinct immune cell…
Study identifies iron dysregulation in the spleen as a driver of immune aging
Researchers at the Technion – Israel Institute of Technology Faculty of Biology have identified a unique mechanism involved…
How is the FOXP3 Gene Regulated?
Original story from the Gladstone Institutes (CA, USA). Fine-tuning a gene centrally involved in regulating the immune system…
Mitochondria and lysosomes work together to control regulatory T cell activation
Metabolism guides the activation states of regulatory T cells, the immune cells that prevent inappropriate activation of the…
New T cell therapy targets CTNNB1 cancer mutation with promising results in animal studies
Researchers at the University of Oslo and Oslo University Hospital have developed a promising new immunotherapy targeting the…