FDA clears trial of dual-targeted CAR T-cell therapy for cancer
The U.S. Food and Drug Administration this week granted permission for investigators at the University of Colorado Anschutz to…
Scientists traced a hidden immune route that may worsen tau-linked brain damage
Researchers traced an immune pathway from brain-draining lymph nodes to tau-affected tissue, revealing how peripheral immune activity may…
New study redefines high risk criteria for multiple myeloma
Researchers have found that with new treatments for multiple myeloma, a serious type of blood cancer, clinicians should…
Why H2N2 flu is back on the pandemic preparedness radar
Decades after H2N2 vanished from humans, declining immunity and persistent animal reservoirs are renewing calls for stockpile-ready vaccines…
Researchers uncover new mechanism linking metabolism, immunity, and skeletal health
Obesity alters bone health not only through increased body weight but also by reshaping the bone marrow environment.…
Scientists find unexpected immune pathways for mRNA cancer vaccines
The advent of mRNA vaccines against SARS-CoV-2 in 2020 changed the course of the COVID-19 pandemic. Now, the…
Clusterin inhibition offers new hope for treating cervical gastric-type adenocarcinoma
Gastric-type adenocarcinoma (GAS) is one of the most aggressive non-human papillomavirus (HPV)-associated cervical adenocarcinomas and remains especially difficult…
New nanoparticle therapy overcomes T cell exhaustion in solid tumors
Engineers at the University of Pennsylvania have developed a new type of lipid nanoparticle (LNP) that could one…
Chronic inflammation shapes cancer progression and immunotherapy response
Chronic inflammation is both a driver and suppressor of cancer depending on context. Key players-NF-κB, IL-6, STAT3, TAMs,…
Silica nanomatrix enhances immunotherapy for solid tumors
Cancer has long remained a leading cause of death worldwide and in Hong Kong, accounting for 30% of…
Reprogramming camp for immune cells shows early promise for autoimmune diseases
Scientists are trying a revolutionary new approach to treat rheumatoid arthritis, multiple sclerosis, lupus and other devastating autoimmune…
Generative AI aids discovery of ISM3830’s novel scaffold
Casitas B-lineage lymphoma-b (CBLB) is an E3 ubiquitin–protein ligase that functions as an intracellular checkpoint and master negative…