Combined CDK4/6 and EGFR inhibition improves pancreatic cancer therapy
Clinically available KRAS inhibitors mainly target G12C, which is rare in PDAC and often acquires resistance. Oncogenic KRAS…
FOXJ1 gene may drive resistance to taxane chemotherapy in advanced prostate cancer
A gene called FOXJ1 may drive resistance to taxane chemotherapy during treatment for advanced prostate cancer, according to…
New insights into a hidden process that protects cells from harmful mutations | MIT News
Some genetic mutations that are expected to completely stop a gene from working surprisingly cause only mild or…
MSU scientists map the neural circuitry of drug compulsion
When a cocaine addict relapses, it isn’t a matter of personal failure – it’s the biological result of…
Study maps how NF-κB regulates gene expression in cells
To further the quantitative understanding of cellular decision making, Dr. Gregory Reeves and his team in the chemical engineering department…
Researchers reveal why SuperAgers retain youthful brain cell signatures into their 80s
A multiomic atlas of the aging human hippocampus uncovers how epigenetic regulation of neural stem cells and immature…
Study reveals poxvirus’s unique DNA clamp for gene activation
A research team at the University of Würzburg has deciphered another aspect of poxviral gene activation. The study…
Transcription factor HOXD13 drives melanoma growth and immune evasion
A molecule that helps regulate gene activity has also been shown to drive skin cancer growth and tumors’…
IRF7 reshapes the behavior of vascular smooth muscle cells during atherosclerosis
Atherosclerosis underlies most heart attacks and strokes and is now recognized as a chronic inflammatory disease rather than…
Scientists uncover new mechanism initiating gene transcription
Scientists at IOCB Prague are uncovering new details of gene transcription. They have identified a previously unknown molecular…
New findings show why the human intestine uniquely presents gluten to T cells
New evidence shows that human M cells act as fully fledged antigen-presenting cells, processing and presenting gluten peptides…
Breakthrough platform reveals the choreography of mammalian transcription
Life’s instructions are written in DNA, but it is the enzyme RNA polymerase II (Pol II) that reads…