Transcription factor HOXD13 drives melanoma growth and immune evasion
A molecule that helps regulate gene activity has also been shown to drive skin cancer growth and tumors’…
IRF7 reshapes the behavior of vascular smooth muscle cells during atherosclerosis
Atherosclerosis underlies most heart attacks and strokes and is now recognized as a chronic inflammatory disease rather than…
Scientists uncover new mechanism initiating gene transcription
Scientists at IOCB Prague are uncovering new details of gene transcription. They have identified a previously unknown molecular…
New findings show why the human intestine uniquely presents gluten to T cells
New evidence shows that human M cells act as fully fledged antigen-presenting cells, processing and presenting gluten peptides…
Breakthrough platform reveals the choreography of mammalian transcription
Life’s instructions are written in DNA, but it is the enzyme RNA polymerase II (Pol II) that reads…
Study explores how elevated growth hormone levels contribute to liver aging
A new research paper was published in Volume 17, Issue 10 of Aging-US on October 3, 2025, titled “Growth hormone excess…
Breast cancer cells use a molecular switch to survive stress
Cells are regularly faced with environmental stresses that may damage or destroy them. To survive, they quickly adjust…
Study links common Epstein-Barr virus to autoimmune lupus
One of humanity’s most ubiquitous infectious pathogens bears the blame for the chronic autoimmune condition called systemic lupus…
New insights reveal how TCF and LEF proteins control Wnt signaling and disease progression
Researchers have unveiled the intricate molecular mechanisms governing TCF/LEF-mediated transcription in the canonical Wnt pathway, identifying these proteins…
Comprehensive kinase atlas reveals new insights into cell signaling and disease
The enzyme RNA polymerase II transcribes genes into messenger RNA. This process is guided by modifications to the enzyme’s…
Alzheimer’s breakthrough reveals how tweaking one gene shields brain connections
Scientists have uncovered a microglial switch that transforms these immune cells from plaque-promoting to plaque-protective, offering a new…
Thiostrepton suppresses rhabdomyosarcoma progression by targeting the PI3K–AKT pathway
Rhabdomyosarcoma (RMS) accounts for up to 10% of childhood cancers and nearly half of pediatric soft tissue sarcomas.…