Reframing the role of MCL1 in cancer signaling and metabolism
A study by the Mildred Scheel Early Career Center group led by Dr. Mohamed Elgendy at the TUD…
How diabetes medications may influence cancer risk and progression
Diabetes, particularly Type 2 Diabetes (T2DM), has been linked to an increased risk of various cancers, including liver,…
Study finds a new protein target against KRAS-driven non-small cell lung cancer
Lung cancer is the second-most common cancer and the leading cause of cancer death in the United States.…
Bifunctional biomaterials for postoperative management of osteosarcoma
Background Osteosarcoma is the most prevalent primary malignant bone tumor in children and adolescents. The current standard treatment…
Using sound waves to soften tumors and boost chemotherapy
Cancer is one of the leading causes of death in the U.S., second only to heart disease. But…
New findings show why the human intestine uniquely presents gluten to T cells
New evidence shows that human M cells act as fully fledged antigen-presenting cells, processing and presenting gluten peptides…
Dietary restriction boosts antitumour immunity by rewiring T cell metabolism
By elevating ketone-driven energy pathways inside CD8+ T cells, dietary restriction steers them away from exhaustion and toward…
Novel antibody suppresses primary tumor growth and spread of triple-negative breast cancer
Triple-negative breast cancer (TNBC) is one of the most aggressive and treatment-resistant forms of breast cancer. It grows…
AR3-based optogenetic strategy shows high efficacy in inducing apoptosis and antitumor effects
One of the hallmarks of cancer cells is their ability to evade apoptosis, or programmed cell death, through…
Innate immunity and metabolic stress drive a unique form of cell death
In several disease conditions, including infections and cancers, innate immune activation and nutrient scarcity occur together. A study…
Generative AI aids discovery of ISM3830’s novel scaffold
Casitas B-lineage lymphoma-b (CBLB) is an E3 ubiquitin–protein ligase that functions as an intracellular checkpoint and master negative…
Study reveals ATM kinase as the key driver of replicative senescence
After a finite number of divisions, cells simply give up. As each round of replication trims their telomeres-the…