Dysregulation of immune regulator NF-κB drives major human diseases
The NF‑κB family is a master regulator of innate and adaptive immunity. Its aberrant activation-via canonical or non‑canonical…
New viral library helps scientists study thousands of proteins
To prevent viruses from sickening or killing us – whether it’s an individual case of hepatitis B or…
Generative AI aids discovery of ISM3830’s novel scaffold
Casitas B-lineage lymphoma-b (CBLB) is an E3 ubiquitin–protein ligase that functions as an intracellular checkpoint and master negative…
Lactate and lactylation drive metabolic, epigenetic reprogramming in gynecological cancers
Lactate, once considered a metabolic waste product, is now recognized as a key regulator of cellular homeostasis and…