{"id":108475,"date":"2025-10-30T07:56:06","date_gmt":"2025-10-30T07:56:06","guid":{"rendered":"https:\/\/www.newsbeep.com\/nz\/108475\/"},"modified":"2025-10-30T07:56:06","modified_gmt":"2025-10-30T07:56:06","slug":"context-dependent-impact-of-type-i-interferon-signaling-in-cancer-molecular-cancer","status":"publish","type":"post","link":"https:\/\/www.newsbeep.com\/nz\/108475\/","title":{"rendered":"Context-dependent impact of type I interferon signaling in cancer | Molecular Cancer"},"content":{"rendered":"<p class=\"c-article-references__text\" id=\"ref-CR1\">Hardy MP, Owczarek CM, Jermiin LS, Ejdeb\u00e4ck M, Hertzog PJ. Characterization of the type I interferon locus and identification of novel genes. Genomics. 2004;84:331\u201345.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BD2cXltlyhtbg%3D\" aria-label=\"CAS reference 1\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=15233997\" aria-label=\"PubMed reference 1\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 1\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Characterization%20of%20the%20type%20I%20interferon%20locus%20and%20identification%20of%20novel%20genes&amp;journal=Genomics&amp;volume=84&amp;pages=331-45&amp;publication_year=2004&amp;author=Hardy%2CMP&amp;author=Owczarek%2CCM&amp;author=Jermiin%2CLS&amp;author=Ejdeb%C3%A4ck%2CM&amp;author=Hertzog%2CPJ\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR2\">Paludan SR, Pradeu T, Masters SL, Mogensen TH. Constitutive immune mechanisms: mediators of host defence and immune regulation. Nat Rev Immunol. 2021;21:137\u201350.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BB3cXhsFOlsb%2FP\" aria-label=\"CAS reference 2\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=32782357\" aria-label=\"PubMed reference 2\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 2\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Constitutive%20immune%20mechanisms%3A%20mediators%20of%20host%20defence%20and%20immune%20regulation&amp;journal=Nat%20Rev%20Immunol&amp;volume=21&amp;pages=137-50&amp;publication_year=2021&amp;author=Paludan%2CSR&amp;author=Pradeu%2CT&amp;author=Masters%2CSL&amp;author=Mogensen%2CTH\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR3\">Vanpouille-Box C, Hoffmann JA, Galluzzi L. Pharmacological modulation of nucleic acid sensors &#8211; therapeutic potential and persisting Obstacles. Nat Rev Drug Discov. 2019;18:845\u201367.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BC1MXhvVCmurnM\" aria-label=\"CAS reference 3\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=31554927\" aria-label=\"PubMed reference 3\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 3\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Pharmacological%20modulation%20of%20nucleic%20acid%20sensors%20-%20therapeutic%20potential%20and%20persisting%20Obstacles&amp;journal=Nat%20Rev%20Drug%20Discov&amp;volume=18&amp;pages=845-67&amp;publication_year=2019&amp;author=Vanpouille-Box%2CC&amp;author=Hoffmann%2CJA&amp;author=Galluzzi%2CL\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR4\">Brubaker SW, Bonham KS, Zanoni I, Kagan JC. Innate immune pattern recognition: a cell biological perspective. Annu Rev Immunol. 2015;33:257\u201390.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BC2MXhsVSisL3O\" aria-label=\"CAS reference 4\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=25581309\" aria-label=\"PubMed reference 4\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5146691\" aria-label=\"PubMed Central reference 4\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 4\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Innate%20immune%20pattern%20recognition%3A%20a%20cell%20biological%20perspective&amp;journal=Annu%20Rev%20Immunol&amp;volume=33&amp;pages=257-90&amp;publication_year=2015&amp;author=Brubaker%2CSW&amp;author=Bonham%2CKS&amp;author=Zanoni%2CI&amp;author=Kagan%2CJC\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR5\">Lind NA, Rael VE, Pestal K, Liu B, Barton GM. Regulation of the nucleic acid-sensing Toll-like receptors. Nat Rev Immunol. 2022;22:224\u201335.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BB3MXhsFyhtbnN\" aria-label=\"CAS reference 5\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=34272507\" aria-label=\"PubMed reference 5\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 5\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Regulation%20of%20the%20nucleic%20acid-sensing%20Toll-like%20receptors&amp;journal=Nat%20Rev%20Immunol&amp;volume=22&amp;pages=224-35&amp;publication_year=2022&amp;author=Lind%2CNA&amp;author=Rael%2CVE&amp;author=Pestal%2CK&amp;author=Liu%2CB&amp;author=Barton%2CGM\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR6\">Rehwinkel J, Gack MU. RIG-I-like receptors: their regulation and roles in RNA sensing. Nat Rev Immunol. 2020;20:537\u201351.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BB3cXkvFCgtbY%3D\" aria-label=\"CAS reference 6\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=32203325\" aria-label=\"PubMed reference 6\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC7094958\" aria-label=\"PubMed Central reference 6\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 6\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=RIG-I-like%20receptors%3A%20their%20regulation%20and%20roles%20in%20RNA%20sensing&amp;journal=Nat%20Rev%20Immunol&amp;volume=20&amp;pages=537-51&amp;publication_year=2020&amp;author=Rehwinkel%2CJ&amp;author=Gack%2CMU\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR7\">Zhang Z, Zhang C. Regulation of cGAS-STING signalling and its diversity of cellular outcomes. Nat Rev Immunol. 2025;25:425\u201344.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BB2MXotVCntA%3D%3D\" aria-label=\"CAS reference 7\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=39774812\" aria-label=\"PubMed reference 7\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 7\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Regulation%20of%20cGAS-STING%20signalling%20and%20its%20diversity%20of%20cellular%20outcomes&amp;journal=Nat%20Rev%20Immunol&amp;volume=25&amp;pages=425-44&amp;publication_year=2025&amp;author=Zhang%2CZ&amp;author=Zhang%2CC\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR8\">Tenoever BR, Ng SL, Chua MA, McWhirter SM, Garc\u00eda-Sastre A, Maniatis T. Multiple functions of the IKK-related kinase IKKepsilon in interferon-mediated antiviral immunity. Science. 2007;315:1274\u20138.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BD2sXitFChsrc%3D\" aria-label=\"CAS reference 8\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=17332413\" aria-label=\"PubMed reference 8\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 8\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Multiple%20functions%20of%20the%20IKK-related%20kinase%20IKKepsilon%20in%20interferon-mediated%20antiviral%20immunity&amp;journal=Science&amp;volume=315&amp;pages=1274-8&amp;publication_year=2007&amp;author=Tenoever%2CBR&amp;author=Ng%2CSL&amp;author=Chua%2CMA&amp;author=McWhirter%2CSM&amp;author=Garc%C3%ADa-Sastre%2CA&amp;author=Maniatis%2CT\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR9\">M\u00fcller M, Briscoe J, Laxton C, Guschin D, Ziemiecki A, Silvennoinen O, Harpur AG, Barbieri G, Witthuhn BA, Schindler C, et al. The protein tyrosine kinase JAK1 complements defects in interferon-alpha\/beta and -gamma signal transduction. Nature. 1993;366:129\u201335.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=8232552\" aria-label=\"PubMed reference 9\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 9\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=The%20protein%20tyrosine%20kinase%20JAK1%20complements%20defects%20in%20interferon-alpha%2Fbeta%20and%20-gamma%20signal%20transduction&amp;journal=Nature&amp;volume=366&amp;pages=129-35&amp;publication_year=1993&amp;author=M%C3%BCller%2CM&amp;author=Briscoe%2CJ&amp;author=Laxton%2CC&amp;author=Guschin%2CD&amp;author=Ziemiecki%2CA&amp;author=Silvennoinen%2CO&amp;author=Harpur%2CAG&amp;author=Barbieri%2CG&amp;author=Witthuhn%2CBA&amp;author=Schindler%2CC\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR10\">Shuai K, Ziemiecki A, Wilks AF, Harpur AG, Sadowski HB, Gilman MZ, Darnell JE. Polypeptide signalling to the nucleus through tyrosine phosphorylation of Jak and stat proteins. Nature. 1993;366:580\u20133.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:STN:280:DyaK2c%2FnslWrsQ%3D%3D\" aria-label=\"CAS reference 10\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=7504784\" aria-label=\"PubMed reference 10\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 10\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Polypeptide%20signalling%20to%20the%20nucleus%20through%20tyrosine%20phosphorylation%20of%20Jak%20and%20stat%20proteins&amp;journal=Nature&amp;volume=366&amp;pages=580-3&amp;publication_year=1993&amp;author=Shuai%2CK&amp;author=Ziemiecki%2CA&amp;author=Wilks%2CAF&amp;author=Harpur%2CAG&amp;author=Sadowski%2CHB&amp;author=Gilman%2CMZ&amp;author=Darnell%2CJE\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR11\">Silvennoinen O, Ihle JN, Schlessinger J, Levy DE. Interferon-induced nuclear signalling by Jak protein tyrosine kinases. Nature. 1993;366:583\u20135.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DyaK2cXnsFWntA%3D%3D\" aria-label=\"CAS reference 11\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=7504785\" aria-label=\"PubMed reference 11\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 11\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Interferon-induced%20nuclear%20signalling%20by%20Jak%20protein%20tyrosine%20kinases&amp;journal=Nature&amp;volume=366&amp;pages=583-5&amp;publication_year=1993&amp;author=Silvennoinen%2CO&amp;author=Ihle%2CJN&amp;author=Schlessinger%2CJ&amp;author=Levy%2CDE\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR12\">Colamonici O, Yan H, Domanski P, Handa R, Smalley D, Mullersman J, Witte M, Krishnan K, Krolewski J. Direct binding to and tyrosine phosphorylation of the alpha subunit of the type I interferon receptor by p135tyk2 tyrosine kinase. Mol Cell Biol. 1994;14:8133\u201342.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DyaK2MXisVWgtLo%3D\" aria-label=\"CAS reference 12\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=7526154\" aria-label=\"PubMed reference 12\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC359352\" aria-label=\"PubMed Central reference 12\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 12\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Direct%20binding%20to%20and%20tyrosine%20phosphorylation%20of%20the%20alpha%20subunit%20of%20the%20type%20I%20interferon%20receptor%20by%20p135tyk2%20tyrosine%20kinase&amp;journal=Mol%20Cell%20Biol&amp;volume=14&amp;pages=8133-42&amp;publication_year=1994&amp;author=Colamonici%2CO&amp;author=Yan%2CH&amp;author=Domanski%2CP&amp;author=Handa%2CR&amp;author=Smalley%2CD&amp;author=Mullersman%2CJ&amp;author=Witte%2CM&amp;author=Krishnan%2CK&amp;author=Krolewski%2CJ\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR13\">Kessler DS, Veals SA, Fu XY, Levy DE. Interferon-alpha regulates nuclear translocation and DNA-binding affinity of ISGF3, a multimeric transcriptional activator. Genes Dev. 1990;4:1753\u201365.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DyaK3cXmtVOjsr8%3D\" aria-label=\"CAS reference 13\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=2249773\" aria-label=\"PubMed reference 13\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 13\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Interferon-alpha%20regulates%20nuclear%20translocation%20and%20DNA-binding%20affinity%20of%20ISGF3%2C%20a%20multimeric%20transcriptional%20activator&amp;journal=Genes%20Dev&amp;volume=4&amp;pages=1753-65&amp;publication_year=1990&amp;author=Kessler%2CDS&amp;author=Veals%2CSA&amp;author=Fu%2CXY&amp;author=Levy%2CDE\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR14\">Fu XY, Kessler DS, Veals SA, Levy DE, Darnell JE Jr. ISGF3, the transcriptional activator induced by interferon alpha, consists of multiple interacting polypeptide chains. Proc Natl Acad Sci U S A. 1990;87:8555\u20139.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DyaK3MXks1Ck\" aria-label=\"CAS reference 14\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=2236065\" aria-label=\"PubMed reference 14\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC54995\" aria-label=\"PubMed Central reference 14\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 14\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=ISGF3%2C%20the%20transcriptional%20activator%20induced%20by%20interferon%20alpha%2C%20consists%20of%20multiple%20interacting%20polypeptide%20chains&amp;journal=Proc%20Natl%20Acad%20Sci%20U%20S%20A&amp;volume=87&amp;pages=8555-9&amp;publication_year=1990&amp;author=Fu%2CXY&amp;author=Kessler%2CDS&amp;author=Veals%2CSA&amp;author=Levy%2CDE&amp;author=Darnell%2CJE\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR15\">Fu XY, Schindler C, Improta T, Aebersold R, Darnell JE Jr. The proteins of ISGF-3, the interferon alpha-induced transcriptional activator, define a gene family involved in signal transduction. Proc Natl Acad Sci U S A. 1992;89:7840\u20133.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DyaK3sXkt1Knt7w%3D\" aria-label=\"CAS reference 15\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=1502204\" aria-label=\"PubMed reference 15\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC49807\" aria-label=\"PubMed Central reference 15\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 15\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=The%20proteins%20of%20ISGF-3%2C%20the%20interferon%20alpha-induced%20transcriptional%20activator%2C%20define%20a%20gene%20family%20involved%20in%20signal%20transduction&amp;journal=Proc%20Natl%20Acad%20Sci%20U%20S%20A&amp;volume=89&amp;pages=7840-3&amp;publication_year=1992&amp;author=Fu%2CXY&amp;author=Schindler%2CC&amp;author=Improta%2CT&amp;author=Aebersold%2CR&amp;author=Darnell%2CJE\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR16\">Schindler C, Fu XY, Improta T, Aebersold R, Darnell JE Jr. Proteins of transcription factor ISGF-3: one gene encodes the 91-and 84-kDa ISGF-3 proteins that are activated by interferon alpha. Proc Natl Acad Sci U S A. 1992;89:7836\u20139.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DyaK3sXkt1Knt78%3D\" aria-label=\"CAS reference 16\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=1502203\" aria-label=\"PubMed reference 16\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC49806\" aria-label=\"PubMed Central reference 16\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 16\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Proteins%20of%20transcription%20factor%20ISGF-3%3A%20one%20gene%20encodes%20the%2091-and%2084-kDa%20ISGF-3%20proteins%20that%20are%20activated%20by%20interferon%20alpha&amp;journal=Proc%20Natl%20Acad%20Sci%20U%20S%20A&amp;volume=89&amp;pages=7836-9&amp;publication_year=1992&amp;author=Schindler%2CC&amp;author=Fu%2CXY&amp;author=Improta%2CT&amp;author=Aebersold%2CR&amp;author=Darnell%2CJE\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR17\">Schneider WM, Chevillotte MD, Rice CM. Interferon-stimulated genes: a complex web of host defenses. Annu Rev Immunol. 2014;32:513\u201345.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BC2cXovVemt7c%3D\" aria-label=\"CAS reference 17\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=24555472\" aria-label=\"PubMed reference 17\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4313732\" aria-label=\"PubMed Central reference 17\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 17\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Interferon-stimulated%20genes%3A%20a%20complex%20web%20of%20host%20defenses&amp;journal=Annu%20Rev%20Immunol&amp;volume=32&amp;pages=513-45&amp;publication_year=2014&amp;author=Schneider%2CWM&amp;author=Chevillotte%2CMD&amp;author=Rice%2CCM\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR18\">Ivashkiv LB, Donlin LT. Regulation of type I interferon responses. Nat Rev Immunol. 2014;14:36\u201349.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BC3sXhvFOltLvJ\" aria-label=\"CAS reference 18\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=24362405\" aria-label=\"PubMed reference 18\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4084561\" aria-label=\"PubMed Central reference 18\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 18\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Regulation%20of%20type%20I%20interferon%20responses&amp;journal=Nat%20Rev%20Immunol&amp;volume=14&amp;pages=36-49&amp;publication_year=2014&amp;author=Ivashkiv%2CLB&amp;author=Donlin%2CLT\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR19\">Samarajiwa SA, Forster S, Auchettl K, Hertzog PJ. INTERFEROME: the database of interferon regulated genes. Nucleic Acids Res. 2009;37:D852\u2013857.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BD1cXhsFejt7jE\" aria-label=\"CAS reference 19\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=18996892\" aria-label=\"PubMed reference 19\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 19\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=INTERFEROME%3A%20the%20database%20of%20interferon%20regulated%20genes&amp;journal=Nucleic%20Acids%20Res&amp;volume=37&amp;pages=D852-857&amp;publication_year=2009&amp;author=Samarajiwa%2CSA&amp;author=Forster%2CS&amp;author=Auchettl%2CK&amp;author=Hertzog%2CPJ\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR20\">Porritt RA, Hertzog PJ. Dynamic control of type I IFN signalling by an integrated network of negative regulators. Trends Immunol. 2015;36:150\u201360.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BC2MXivFaiu7g%3D\" aria-label=\"CAS reference 20\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=25725583\" aria-label=\"PubMed reference 20\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 20\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Dynamic%20control%20of%20type%20I%20IFN%20signalling%20by%20an%20integrated%20network%20of%20negative%20regulators&amp;journal=Trends%20Immunol&amp;volume=36&amp;pages=150-60&amp;publication_year=2015&amp;author=Porritt%2CRA&amp;author=Hertzog%2CPJ\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR21\">Yamazaki T, Kirchmair A, Sato A, Buque A, Rybstein M, Petroni G, Bloy N, Finotello F, Stafford L, Navarro Manzano E, et al. Mitochondrial DNA drives abscopal responses to radiation that are inhibited by autophagy. Nat Immunol. 2020;21:1160\u201371.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BB3cXhsFWiurjL\" aria-label=\"CAS reference 21\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=32747819\" aria-label=\"PubMed reference 21\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 21\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Mitochondrial%20DNA%20drives%20abscopal%20responses%20to%20radiation%20that%20are%20inhibited%20by%20autophagy&amp;journal=Nat%20Immunol&amp;volume=21&amp;pages=1160-71&amp;publication_year=2020&amp;author=Yamazaki%2CT&amp;author=Kirchmair%2CA&amp;author=Sato%2CA&amp;author=Buque%2CA&amp;author=Rybstein%2CM&amp;author=Petroni%2CG&amp;author=Bloy%2CN&amp;author=Finotello%2CF&amp;author=Stafford%2CL&amp;author=Navarro%20Manzano%2CE\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR22\">Bartsch K, Knittler K, Borowski C, Rudnik S, Damme M, Aden K, Spehlmann ME, Frey N, Saftig P, Chalaris A, Rabe B. Absence of RNase H2 triggers generation of Immunogenic micronuclei removed by autophagy. Hum Mol Genet. 2017;26:3960\u201372.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BC1cXps1ygu7c%3D\" aria-label=\"CAS reference 22\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=29016854\" aria-label=\"PubMed reference 22\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 22\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Absence%20of%20RNase%20H2%20triggers%20generation%20of%20Immunogenic%20micronuclei%20removed%20by%20autophagy&amp;journal=Hum%20Mol%20Genet&amp;volume=26&amp;pages=3960-72&amp;publication_year=2017&amp;author=Bartsch%2CK&amp;author=Knittler%2CK&amp;author=Borowski%2CC&amp;author=Rudnik%2CS&amp;author=Damme%2CM&amp;author=Aden%2CK&amp;author=Spehlmann%2CME&amp;author=Frey%2CN&amp;author=Saftig%2CP&amp;author=Chalaris%2CA&amp;author=Rabe%2CB\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR23\">Gutierrez MG, Master SS, Singh SB, Taylor GA, Colombo MI, Deretic V. Autophagy is a defense mechanism inhibiting BCG and Mycobacterium tuberculosis survival in infected macrophages. Cell. 2004;119:753\u201366.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BD2MXmsFym\" aria-label=\"CAS reference 23\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=15607973\" aria-label=\"PubMed reference 23\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 23\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Autophagy%20is%20a%20defense%20mechanism%20inhibiting%20BCG%20and%20Mycobacterium%20tuberculosis%20survival%20in%20infected%20macrophages&amp;journal=Cell&amp;volume=119&amp;pages=753-66&amp;publication_year=2004&amp;author=Gutierrez%2CMG&amp;author=Master%2CSS&amp;author=Singh%2CSB&amp;author=Taylor%2CGA&amp;author=Colombo%2CMI&amp;author=Deretic%2CV\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR24\">Lindqvist LM, Frank D, McArthur K, Dite TA, Lazarou M, Oakhill JS, Kile BT, Vaux DL. Autophagy induced during apoptosis degrades mitochondria and inhibits type I interferon secretion. Cell Death Differ. 2018;25:784\u201396.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=29229994\" aria-label=\"PubMed reference 24\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 24\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Autophagy%20induced%20during%20apoptosis%20degrades%20mitochondria%20and%20inhibits%20type%20I%20interferon%20secretion&amp;journal=Cell%20Death%20Differ&amp;volume=25&amp;pages=784-96&amp;publication_year=2018&amp;author=Lindqvist%2CLM&amp;author=Frank%2CD&amp;author=McArthur%2CK&amp;author=Dite%2CTA&amp;author=Lazarou%2CM&amp;author=Oakhill%2CJS&amp;author=Kile%2CBT&amp;author=Vaux%2CDL\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR25\">Stetson DB, Ko JS, Heidmann T, Medzhitov R. Trex1 prevents cell-intrinsic initiation of autoimmunity. Cell. 2008;134:587\u201398.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BD1cXhtVGqtrnK\" aria-label=\"CAS reference 25\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=18724932\" aria-label=\"PubMed reference 25\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC2626626\" aria-label=\"PubMed Central reference 25\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 25\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Trex1%20prevents%20cell-intrinsic%20initiation%20of%20autoimmunity&amp;journal=Cell&amp;volume=134&amp;pages=587-98&amp;publication_year=2008&amp;author=Stetson%2CDB&amp;author=Ko%2CJS&amp;author=Heidmann%2CT&amp;author=Medzhitov%2CR\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR26\">Mannion NM, Greenwood SM, Young R, Cox S, Brindle J, Read D, Nell\u00e5ker C, Vesely C, Ponting CP, McLaughlin PJ, et al. The RNA-editing enzyme ADAR1 controls innate immune responses to RNA. Cell Rep. 2014;9:1482\u201394.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BC2cXhvFGisbfI\" aria-label=\"CAS reference 26\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=25456137\" aria-label=\"PubMed reference 26\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4542304\" aria-label=\"PubMed Central reference 26\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 26\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=The%20RNA-editing%20enzyme%20ADAR1%20controls%20innate%20immune%20responses%20to%20RNA&amp;journal=Cell%20Rep&amp;volume=9&amp;pages=1482-94&amp;publication_year=2014&amp;author=Mannion%2CNM&amp;author=Greenwood%2CSM&amp;author=Young%2CR&amp;author=Cox%2CS&amp;author=Brindle%2CJ&amp;author=Read%2CD&amp;author=Nell%C3%A5ker%2CC&amp;author=Vesely%2CC&amp;author=Ponting%2CCP&amp;author=McLaughlin%2CPJ\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR27\">Song MM, Shuai K. The suppressor of cytokine signaling (SOCS) 1 and SOCS3 but not SOCS2 proteins inhibit interferon-mediated antiviral and antiproliferative activities. J Biol Chem. 1998;273:35056\u201362.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DyaK1MXisFaisQ%3D%3D\" aria-label=\"CAS reference 27\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=9857039\" aria-label=\"PubMed reference 27\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 27\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=The%20suppressor%20of%20cytokine%20signaling%20%28SOCS%29%201%20and%20SOCS3%20but%20not%20SOCS2%20proteins%20inhibit%20interferon-mediated%20antiviral%20and%20antiproliferative%20activities&amp;journal=J%20Biol%20Chem&amp;volume=273&amp;pages=35056-62&amp;publication_year=1998&amp;author=Song%2CMM&amp;author=Shuai%2CK\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR28\">Kinjyo I, Hanada T, Inagaki-Ohara K, Mori H, Aki D, Ohishi M, Yoshida H, Kubo M, Yoshimura A. SOCS1\/JAB is a negative regulator of LPS-induced macrophage activation. Immunity. 2002;17:583\u201391.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BD38XovF2lsro%3D\" aria-label=\"CAS reference 28\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=12433365\" aria-label=\"PubMed reference 28\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 28\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=SOCS1%2FJAB%20is%20a%20negative%20regulator%20of%20LPS-induced%20macrophage%20activation&amp;journal=Immunity&amp;volume=17&amp;pages=583-91&amp;publication_year=2002&amp;author=Kinjyo%2CI&amp;author=Hanada%2CT&amp;author=Inagaki-Ohara%2CK&amp;author=Mori%2CH&amp;author=Aki%2CD&amp;author=Ohishi%2CM&amp;author=Yoshida%2CH&amp;author=Kubo%2CM&amp;author=Yoshimura%2CA\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR29\">Malakhova OA, Yan M, Malakhov MP, Yuan Y, Ritchie KJ, Kim KI, Peterson LF, Shuai K, Zhang DE. Protein isgylation modulates the JAK-STAT signaling pathway. Genes Dev. 2003;17:455\u201360.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BD3sXhslCqtbk%3D\" aria-label=\"CAS reference 29\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=12600939\" aria-label=\"PubMed reference 29\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC195994\" aria-label=\"PubMed Central reference 29\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 29\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Protein%20isgylation%20modulates%20the%20JAK-STAT%20signaling%20pathway&amp;journal=Genes%20Dev&amp;volume=17&amp;pages=455-60&amp;publication_year=2003&amp;author=Malakhova%2COA&amp;author=Yan%2CM&amp;author=Malakhov%2CMP&amp;author=Yuan%2CY&amp;author=Ritchie%2CKJ&amp;author=Kim%2CKI&amp;author=Peterson%2CLF&amp;author=Shuai%2CK&amp;author=Zhang%2CDE\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR30\">Jov\u00e9 V, Wheeler H, Lee CW, Healy DR, Levine K, Ralph EC, Yamaguchi M, Jiang ZK, Cabral E, Xu Y, et al. Type I interferon regulation by USP18 is a key vulnerability in cancer. iScience. 2024;27:109593.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=38632987\" aria-label=\"PubMed reference 30\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC11022047\" aria-label=\"PubMed Central reference 30\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 30\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Type%20I%20interferon%20regulation%20by%20USP18%20is%20a%20key%20vulnerability%20in%20cancer&amp;journal=iScience&amp;volume=27&amp;publication_year=2024&amp;author=Jov%C3%A9%2CV&amp;author=Wheeler%2CH&amp;author=Lee%2CCW&amp;author=Healy%2CDR&amp;author=Levine%2CK&amp;author=Ralph%2CEC&amp;author=Yamaguchi%2CM&amp;author=Jiang%2CZK&amp;author=Cabral%2CE&amp;author=Xu%2CY\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR31\">Hida S, Ogasawara K, Sato K, Abe M, Takayanagi H, Yokochi T, Sato T, Hirose S, Shirai T, Taki S, Taniguchi T. CD8(+) T cell-mediated skin disease in mice lacking IRF-2, the transcriptional attenuator of interferon-alpha\/beta signaling. Immunity. 2000;13:643\u201355.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BD3cXovV2ht7o%3D\" aria-label=\"CAS reference 31\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=11114377\" aria-label=\"PubMed reference 31\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 31\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=CD8%28%2B%29%20T%20cell-mediated%20skin%20disease%20in%20mice%20lacking%20IRF-2%2C%20the%20transcriptional%20attenuator%20of%20interferon-alpha%2Fbeta%20signaling&amp;journal=Immunity&amp;volume=13&amp;pages=643-55&amp;publication_year=2000&amp;author=Hida%2CS&amp;author=Ogasawara%2CK&amp;author=Sato%2CK&amp;author=Abe%2CM&amp;author=Takayanagi%2CH&amp;author=Yokochi%2CT&amp;author=Sato%2CT&amp;author=Hirose%2CS&amp;author=Shirai%2CT&amp;author=Taki%2CS&amp;author=Taniguchi%2CT\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR32\">Faget J, Biota C, Bachelot T, Gobert M, Treilleux I, Goutagny N, Durand I, L\u00e9on-Goddard S, Blay JY, Caux C, M\u00e9n\u00e9trier-Caux C. Early detection of tumor cells by innate immune cells leads to T(reg) recruitment through CCL22 production by tumor cells. Cancer Res. 2011;71:6143\u201352.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BC3MXht1ChtLrN\" aria-label=\"CAS reference 32\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=21852386\" aria-label=\"PubMed reference 32\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 32\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Early%20detection%20of%20tumor%20cells%20by%20innate%20immune%20cells%20leads%20to%20T%28reg%29%20recruitment%20through%20CCL22%20production%20by%20tumor%20cells&amp;journal=Cancer%20Res&amp;volume=71&amp;pages=6143-52&amp;publication_year=2011&amp;author=Faget%2CJ&amp;author=Biota%2CC&amp;author=Bachelot%2CT&amp;author=Gobert%2CM&amp;author=Treilleux%2CI&amp;author=Goutagny%2CN&amp;author=Durand%2CI&amp;author=L%C3%A9on-Goddard%2CS&amp;author=Blay%2CJY&amp;author=Caux%2CC&amp;author=M%C3%A9n%C3%A9trier-Caux%2CC\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR33\">Rusinova I, Forster S, Yu S, Kannan A, Masse M, Cumming H, Chapman R, Hertzog PJ. Interferome v2.0: an updated database of annotated interferon-regulated genes. Nucleic Acids Res. 2013;41:D1040\u20131046.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BC38XhvV2ksbfJ\" aria-label=\"CAS reference 33\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=23203888\" aria-label=\"PubMed reference 33\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 33\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Interferome%20v2.0%3A%20an%20updated%20database%20of%20annotated%20interferon-regulated%20genes&amp;journal=Nucleic%20Acids%20Res&amp;volume=41&amp;pages=D1040-1046&amp;publication_year=2013&amp;author=Rusinova%2CI&amp;author=Forster%2CS&amp;author=Yu%2CS&amp;author=Kannan%2CA&amp;author=Masse%2CM&amp;author=Cumming%2CH&amp;author=Chapman%2CR&amp;author=Hertzog%2CPJ\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR34\">Boukhaled GM, Harding S, Brooks DG. Opposing roles of type I interferons in cancer immunity. Annu Rev Pathol. 2021;16:167\u201398.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BB3cXisVOntL7N\" aria-label=\"CAS reference 34\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=33264572\" aria-label=\"PubMed reference 34\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 34\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Opposing%20roles%20of%20type%20I%20interferons%20in%20cancer%20immunity&amp;journal=Annu%20Rev%20Pathol&amp;volume=16&amp;pages=167-98&amp;publication_year=2021&amp;author=Boukhaled%2CGM&amp;author=Harding%2CS&amp;author=Brooks%2CDG\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR35\">Vanpouille-Box C, Demaria S, Formenti SC, Galluzzi L. Cytosolic DNA sensing in organismal tumor control. Cancer Cell. 2018;34:361\u201378.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BC1cXht1Cis7nL\" aria-label=\"CAS reference 35\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=30216189\" aria-label=\"PubMed reference 35\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 35\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Cytosolic%20DNA%20sensing%20in%20organismal%20tumor%20control&amp;journal=Cancer%20Cell&amp;volume=34&amp;pages=361-78&amp;publication_year=2018&amp;author=Vanpouille-Box%2CC&amp;author=Demaria%2CS&amp;author=Formenti%2CSC&amp;author=Galluzzi%2CL\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR36\">Holicek P, Guilbaud E, Klapp V, Truxova I, Spisek R, Galluzzi L, Fucikova J. Type I interferon and cancer. Immunol Rev. 2024;321:115\u201327.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BB3sXhvVegs7nL\" aria-label=\"CAS reference 36\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=37667466\" aria-label=\"PubMed reference 36\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 36\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Type%20I%20interferon%20and%20cancer&amp;journal=Immunol%20Rev&amp;volume=321&amp;pages=115-27&amp;publication_year=2024&amp;author=Holicek%2CP&amp;author=Guilbaud%2CE&amp;author=Klapp%2CV&amp;author=Truxova%2CI&amp;author=Spisek%2CR&amp;author=Galluzzi%2CL&amp;author=Fucikova%2CJ\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR37\">Zitvogel L, Galluzzi L, Kepp O, Smyth MJ, Kroemer G. Type I interferons in anticancer immunity. Nat Rev Immunol. 2015;15:405\u201314.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BC2MXhtFeju7zK\" aria-label=\"CAS reference 37\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=26027717\" aria-label=\"PubMed reference 37\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 37\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Type%20I%20interferons%20in%20anticancer%20immunity&amp;journal=Nat%20Rev%20Immunol&amp;volume=15&amp;pages=405-14&amp;publication_year=2015&amp;author=Zitvogel%2CL&amp;author=Galluzzi%2CL&amp;author=Kepp%2CO&amp;author=Smyth%2CMJ&amp;author=Kroemer%2CG\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR38\">Kureshi CT, Dougan SK. Cytokines in cancer. Cancer Cell. 2025;43:15\u201335.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BB2cXislOhtr3M\" aria-label=\"CAS reference 38\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=39672170\" aria-label=\"PubMed reference 38\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 38\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Cytokines%20in%20cancer&amp;journal=Cancer%20Cell&amp;volume=43&amp;pages=15-35&amp;publication_year=2025&amp;author=Kureshi%2CCT&amp;author=Dougan%2CSK\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR39\">Petroni G, Buqu\u00e9 A, Coussens LM, Galluzzi L. Targeting oncogene and non-oncogene addiction to inflame the tumour microenvironment. Nat Rev Drug Discov. 2022;21:440\u201362.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BB38Xnt1yitLs%3D\" aria-label=\"CAS reference 39\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=35292771\" aria-label=\"PubMed reference 39\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 39\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Targeting%20oncogene%20and%20non-oncogene%20addiction%20to%20inflame%20the%20tumour%20microenvironment&amp;journal=Nat%20Rev%20Drug%20Discov&amp;volume=21&amp;pages=440-62&amp;publication_year=2022&amp;author=Petroni%2CG&amp;author=Buqu%C3%A9%2CA&amp;author=Coussens%2CLM&amp;author=Galluzzi%2CL\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR40\">Galluzzi L, Guilbaud E, Schmidt D, Kroemer G, Marincola FM. Targeting Immunogenic cell stress and death for cancer therapy. Nat Rev Drug Discov. 2024;23:445\u201360.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BB2cXotlGrsb0%3D\" aria-label=\"CAS reference 40\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=38622310\" aria-label=\"PubMed reference 40\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC11153000\" aria-label=\"PubMed Central reference 40\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 40\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Targeting%20Immunogenic%20cell%20stress%20and%20death%20for%20cancer%20therapy&amp;journal=Nat%20Rev%20Drug%20Discov&amp;volume=23&amp;pages=445-60&amp;publication_year=2024&amp;author=Galluzzi%2CL&amp;author=Guilbaud%2CE&amp;author=Schmidt%2CD&amp;author=Kroemer%2CG&amp;author=Marincola%2CFM\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR41\">Landolfo S, Guarini A, Riera L, Gariglio M, Gribaudo G, Cignetti A, Cordone I, Montefusco E, Mandelli F, Foa R. Chronic myeloid leukemia cells resistant to interferon-alpha lack STAT1 expression. Hematol J. 2000;1:7\u201314.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:STN:280:DC%2BD387oslCltA%3D%3D\" aria-label=\"CAS reference 41\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=11920164\" aria-label=\"PubMed reference 41\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 41\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Chronic%20myeloid%20leukemia%20cells%20resistant%20to%20interferon-alpha%20lack%20STAT1%20expression&amp;journal=Hematol%20J&amp;volume=1&amp;pages=7-14&amp;publication_year=2000&amp;author=Landolfo%2CS&amp;author=Guarini%2CA&amp;author=Riera%2CL&amp;author=Gariglio%2CM&amp;author=Gribaudo%2CG&amp;author=Cignetti%2CA&amp;author=Cordone%2CI&amp;author=Montefusco%2CE&amp;author=Mandelli%2CF&amp;author=Foa%2CR\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR42\">Zaretsky JM, Garcia-Diaz A, Shin DS, Escuin-Ordinas H, Hugo W, Hu-Lieskovan S, Torrejon DY, Abril-Rodriguez G, Sandoval S, Barthly L, et al. Mutations associated with acquired resistance to PD-1 Blockade in melanoma. N Engl J Med. 2016;375:819\u201329.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BC28XhvF2ks7%2FP\" aria-label=\"CAS reference 42\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=27433843\" aria-label=\"PubMed reference 42\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5007206\" aria-label=\"PubMed Central reference 42\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 42\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Mutations%20associated%20with%20acquired%20resistance%20to%20PD-1%20Blockade%20in%20melanoma&amp;journal=N%20Engl%20J%20Med&amp;volume=375&amp;pages=819-29&amp;publication_year=2016&amp;author=Zaretsky%2CJM&amp;author=Garcia-Diaz%2CA&amp;author=Shin%2CDS&amp;author=Escuin-Ordinas%2CH&amp;author=Hugo%2CW&amp;author=Hu-Lieskovan%2CS&amp;author=Torrejon%2CDY&amp;author=Abril-Rodriguez%2CG&amp;author=Sandoval%2CS&amp;author=Barthly%2CL\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR43\">Shin DS, Zaretsky JM, Escuin-Ordinas H, Garcia-Diaz A, Hu-Lieskovan S, Kalbasi A, Grasso CS, Hugo W, Sandoval S, Torrejon DY, et al. Primary resistance to PD-1 Blockade mediated by JAK1\/2 mutations. Cancer Discov. 2017;7:188\u2013201.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BC2sXitVCjsr0%3D\" aria-label=\"CAS reference 43\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=27903500\" aria-label=\"PubMed reference 43\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 43\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Primary%20resistance%20to%20PD-1%20Blockade%20mediated%20by%20JAK1%2F2%20mutations&amp;journal=Cancer%20Discov&amp;volume=7&amp;pages=188-201&amp;publication_year=2017&amp;author=Shin%2CDS&amp;author=Zaretsky%2CJM&amp;author=Escuin-Ordinas%2CH&amp;author=Garcia-Diaz%2CA&amp;author=Hu-Lieskovan%2CS&amp;author=Kalbasi%2CA&amp;author=Grasso%2CCS&amp;author=Hugo%2CW&amp;author=Sandoval%2CS&amp;author=Torrejon%2CDY\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR44\">Chin YE, Kitagawa M, Su WC, You ZH, Iwamoto Y, Fu XY. Cell growth arrest and induction of cyclin-dependent kinase inhibitor p21 WAF1\/CIP1 mediated by STAT1. Science. 1996;272:719\u201322.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DyaK28Xislamtrs%3D\" aria-label=\"CAS reference 44\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=8614832\" aria-label=\"PubMed reference 44\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 44\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Cell%20growth%20arrest%20and%20induction%20of%20cyclin-dependent%20kinase%20inhibitor%20p21%20WAF1%2FCIP1%20mediated%20by%20STAT1&amp;journal=Science&amp;volume=272&amp;pages=719-22&amp;publication_year=1996&amp;author=Chin%2CYE&amp;author=Kitagawa%2CM&amp;author=Su%2CWC&amp;author=You%2CZH&amp;author=Iwamoto%2CY&amp;author=Fu%2CXY\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR45\">Kuniyasu H, Yasui W, Kitahara K, Naka K, Yokozaki H, Akama Y, Hamamoto T, Tahara H, Tahara E. Growth inhibitory effect of interferon-beta is associated with the induction of cyclin-dependent kinase inhibitor p27Kip1 in a human gastric carcinoma cell line. Cell Growth Differ. 1997;8:47\u201352.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DyaK2sXltVWgsw%3D%3D\" aria-label=\"CAS reference 45\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=8993833\" aria-label=\"PubMed reference 45\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 45\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Growth%20inhibitory%20effect%20of%20interferon-beta%20is%20associated%20with%20the%20induction%20of%20cyclin-dependent%20kinase%20inhibitor%20p27Kip1%20in%20a%20human%20gastric%20carcinoma%20cell%20line&amp;journal=Cell%20Growth%20Differ&amp;volume=8&amp;pages=47-52&amp;publication_year=1997&amp;author=Kuniyasu%2CH&amp;author=Yasui%2CW&amp;author=Kitahara%2CK&amp;author=Naka%2CK&amp;author=Yokozaki%2CH&amp;author=Akama%2CY&amp;author=Hamamoto%2CT&amp;author=Tahara%2CH&amp;author=Tahara%2CE\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR46\">Sangfelt O, Erickson S, Einhorn S, Grand\u00e9r D. Induction of Cip\/Kip and Ink4 Cyclin dependent kinase inhibitors by interferon-alpha in hematopoietic cell lines. Oncogene. 1997;14:415\u201323.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DyaK2sXht1ensbw%3D\" aria-label=\"CAS reference 46\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=9053838\" aria-label=\"PubMed reference 46\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 46\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Induction%20of%20Cip%2FKip%20and%20Ink4%20Cyclin%20dependent%20kinase%20inhibitors%20by%20interferon-alpha%20in%20hematopoietic%20cell%20lines&amp;journal=Oncogene&amp;volume=14&amp;pages=415-23&amp;publication_year=1997&amp;author=Sangfelt%2CO&amp;author=Erickson%2CS&amp;author=Einhorn%2CS&amp;author=Grand%C3%A9r%2CD\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR47\">Huang YF, Wee S, Gunaratne J, Lane DP, Bulavin DV. Isg15 controls p53 stability and functions. Cell Cycle. 2014;13:2200\u201310.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=24844324\" aria-label=\"PubMed reference 47\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 47\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Isg15%20controls%20p53%20stability%20and%20functions&amp;journal=Cell%20Cycle&amp;volume=13&amp;pages=2200-10&amp;publication_year=2014&amp;author=Huang%2CYF&amp;author=Wee%2CS&amp;author=Gunaratne%2CJ&amp;author=Lane%2CDP&amp;author=Bulavin%2CDV\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR48\">Forys JT, Kuzmicki CE, Saporita AJ, Winkeler CL, Maggi LB Jr., Weber JD. ARF and p53 coordinate tumor suppression of an oncogenic IFN-\u03b2-STAT1-ISG15 signaling axis. Cell Rep. 2014;7:514\u201326.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BC2cXmtVCkurc%3D\" aria-label=\"CAS reference 48\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=24726362\" aria-label=\"PubMed reference 48\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4157460\" aria-label=\"PubMed Central reference 48\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 48\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=ARF%20and%20p53%20coordinate%20tumor%20suppression%20of%20an%20oncogenic%20IFN-%CE%B2-STAT1-ISG15%20signaling%20axis&amp;journal=Cell%20Rep&amp;volume=7&amp;pages=514-26&amp;publication_year=2014&amp;author=Forys%2CJT&amp;author=Kuzmicki%2CCE&amp;author=Saporita%2CAJ&amp;author=Winkeler%2CCL&amp;author=Maggi%2CLB&amp;author=Weber%2CJD\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR49\">Selleri C, Sato T, Del Vecchio L, Luciano L, Barrett AJ, Rotoli B, Young NS, Maciejewski JP. Involvement of Fas-mediated apoptosis in the inhibitory effects of interferon-alpha in chronic myelogenous leukemia. Blood. 1997;89:957\u201364.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DyaK2sXptV2gsg%3D%3D\" aria-label=\"CAS reference 49\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=9028327\" aria-label=\"PubMed reference 49\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 49\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Involvement%20of%20Fas-mediated%20apoptosis%20in%20the%20inhibitory%20effects%20of%20interferon-alpha%20in%20chronic%20myelogenous%20leukemia&amp;journal=Blood&amp;volume=89&amp;pages=957-64&amp;publication_year=1997&amp;author=Selleri%2CC&amp;author=Sato%2CT&amp;author=Vecchio%2CL&amp;author=Luciano%2CL&amp;author=Barrett%2CAJ&amp;author=Rotoli%2CB&amp;author=Young%2CNS&amp;author=Maciejewski%2CJP\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR50\">Gisslinger H, Kurzrock R, Gisslinger B, Jiang S, Li S, Virgolini I, Woloszczuk W, Andreeff M, Talpaz M. Autocrine cell suicide in a Burkitt lymphoma cell line (Daudi) induced by interferon alpha: involvement of tumor necrosis factor as ligand for the CD95 receptor. Blood. 2001;97:2791\u20137.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BD3MXjtlShsr4%3D\" aria-label=\"CAS reference 50\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=11313273\" aria-label=\"PubMed reference 50\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 50\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Autocrine%20cell%20suicide%20in%20a%20Burkitt%20lymphoma%20cell%20line%20%28Daudi%29%20induced%20by%20interferon%20alpha%3A%20involvement%20of%20tumor%20necrosis%20factor%20as%20ligand%20for%20the%20CD95%20receptor&amp;journal=Blood&amp;volume=97&amp;pages=2791-7&amp;publication_year=2001&amp;author=Gisslinger%2CH&amp;author=Kurzrock%2CR&amp;author=Gisslinger%2CB&amp;author=Jiang%2CS&amp;author=Li%2CS&amp;author=Virgolini%2CI&amp;author=Woloszczuk%2CW&amp;author=Andreeff%2CM&amp;author=Talpaz%2CM\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR51\">Chen Q, Gong B, Mahmoud-Ahmed AS, Zhou A, Hsi ED, Hussein M, Almasan A. Apo2L\/TRAIL and Bcl-2-related proteins regulate type I interferon-induced apoptosis in multiple myeloma. Blood. 2001;98:2183\u201392.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BD3MXnsVChtrY%3D\" aria-label=\"CAS reference 51\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=11568006\" aria-label=\"PubMed reference 51\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 51\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Apo2L%2FTRAIL%20and%20Bcl-2-related%20proteins%20regulate%20type%20I%20interferon-induced%20apoptosis%20in%20multiple%20myeloma&amp;journal=Blood&amp;volume=98&amp;pages=2183-92&amp;publication_year=2001&amp;author=Chen%2CQ&amp;author=Gong%2CB&amp;author=Mahmoud-Ahmed%2CAS&amp;author=Zhou%2CA&amp;author=Hsi%2CED&amp;author=Hussein%2CM&amp;author=Almasan%2CA\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR52\">de Luj\u00e1n Alvarez M, Cerliani JP, Monti J, Carnovale C, Ronco MT, Pisani G, Lugano MC, Carrillo MC. The in vivo apoptotic effect of interferon alfa-2b on rat preneoplastic liver involves Bax protein. Hepatology. 2002;35:824\u201333.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=11915028\" aria-label=\"PubMed reference 52\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 52\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=The%20in%20vivo%20apoptotic%20effect%20of%20interferon%20alfa-2b%20on%20rat%20preneoplastic%20liver%20involves%20Bax%20protein&amp;journal=Hepatology&amp;volume=35&amp;pages=824-33&amp;publication_year=2002&amp;author=Luj%C3%A1n%20Alvarez%2CM&amp;author=Cerliani%2CJP&amp;author=Monti%2CJ&amp;author=Carnovale%2CC&amp;author=Ronco%2CMT&amp;author=Pisani%2CG&amp;author=Lugano%2CMC&amp;author=Carrillo%2CMC\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR53\">Schiavoni G, Sistigu A, Valentini M, Mattei F, Sestili P, Spadaro F, Sanchez M, Lorenzi S, D\u2019Urso MT, Belardelli F, et al. Cyclophosphamide synergizes with type I interferons through systemic dendritic cell reactivation and induction of Immunogenic tumor apoptosis. Cancer Res. 2011;71:768\u201378.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BC3MXhsVCisb8%3D\" aria-label=\"CAS reference 53\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=21156650\" aria-label=\"PubMed reference 53\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 53\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Cyclophosphamide%20synergizes%20with%20type%20I%20interferons%20through%20systemic%20dendritic%20cell%20reactivation%20and%20induction%20of%20Immunogenic%20tumor%20apoptosis&amp;journal=Cancer%20Res&amp;volume=71&amp;pages=768-78&amp;publication_year=2011&amp;author=Schiavoni%2CG&amp;author=Sistigu%2CA&amp;author=Valentini%2CM&amp;author=Mattei%2CF&amp;author=Sestili%2CP&amp;author=Spadaro%2CF&amp;author=Sanchez%2CM&amp;author=Lorenzi%2CS&amp;author=D%E2%80%99Urso%2CMT&amp;author=Belardelli%2CF\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR54\">Bernardo AR, Cosgaya JM, Aranda A, Jim\u00e9nez-Lara AM. Synergy between RA and TLR3 promotes type I IFN-dependent apoptosis through upregulation of TRAIL pathway in breast cancer cells. Cell Death Dis. 2013;4:e479.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:STN:280:DC%2BC3szksVCnsg%3D%3D\" aria-label=\"CAS reference 54\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=23370279\" aria-label=\"PubMed reference 54\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3564005\" aria-label=\"PubMed Central reference 54\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 54\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Synergy%20between%20RA%20and%20TLR3%20promotes%20type%20I%20IFN-dependent%20apoptosis%20through%20upregulation%20of%20TRAIL%20pathway%20in%20breast%20cancer%20cells&amp;journal=Cell%20Death%20Dis&amp;volume=4&amp;publication_year=2013&amp;author=Bernardo%2CAR&amp;author=Cosgaya%2CJM&amp;author=Aranda%2CA&amp;author=Jim%C3%A9nez-Lara%2CAM\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR55\">Jin WJ, Zangl LM, Hyun M, Massoud E, Schroeder K, Alexandridis RA, et al. ATM inhibition augments type I interferon response and antitumor T-cell immunity when combined with radiation therapy in murine tumor models. J Immunother Cancer. 2023;11:e007474.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=37730275\" aria-label=\"PubMed reference 55\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC10510866\" aria-label=\"PubMed Central reference 55\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 55\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=ATM%20inhibition%20augments%20type%20I%20interferon%20response%20and%20antitumor%20T-cell%20immunity%20when%20combined%20with%20radiation%20therapy%20in%20murine%20tumor%20models&amp;journal=J%20Immunother%20Cancer&amp;volume=11&amp;publication_year=2023&amp;author=Jin%2CWJ&amp;author=Zangl%2CLM&amp;author=Hyun%2CM&amp;author=Massoud%2CE&amp;author=Schroeder%2CK&amp;author=Alexandridis%2CRA&amp;author=Morris%2CZS\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR56\">Huber M, Suprunenko T, Ashhurst T, Marbach F, Raifer H, Wolff S, Strecker T, Viengkhou B, Jung SR, Obermann HL, et al. IRF9 prevents CD8(+) T cell exhaustion in an extrinsic manner during acute lymphocytic choriomeningitis virus infection. J Virol. 2017;91:e01219\u201301217.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=28878077\" aria-label=\"PubMed reference 56\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5660491\" aria-label=\"PubMed Central reference 56\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 56\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=IRF9%20prevents%20CD8%28%2B%29%20T%20cell%20exhaustion%20in%20an%20extrinsic%20manner%20during%20acute%20lymphocytic%20choriomeningitis%20virus%20infection&amp;journal=J%20Virol&amp;volume=91&amp;pages=e01219-01217&amp;publication_year=2017&amp;author=Huber%2CM&amp;author=Suprunenko%2CT&amp;author=Ashhurst%2CT&amp;author=Marbach%2CF&amp;author=Raifer%2CH&amp;author=Wolff%2CS&amp;author=Strecker%2CT&amp;author=Viengkhou%2CB&amp;author=Jung%2CSR&amp;author=Obermann%2CHL\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR57\">Crouse J, Bedenikovic G, Wiesel M, Ibberson M, Xenarios I, Von Laer D, et al. Type I interferons protect T cells against NK cell attack mediated by the activating receptor NCR1. Immunity. 2014;40:961\u201373.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BC2cXps1Citb4%3D\" aria-label=\"CAS reference 57\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=24909889\" aria-label=\"PubMed reference 57\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 57\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Type%20I%20interferons%20protect%20T%20cells%20against%20NK%20cell%20attack%20mediated%20by%20the%20activating%20receptor%20NCR1&amp;journal=Immunity&amp;volume=40&amp;pages=961-73&amp;publication_year=2014&amp;author=Crouse%2CJ&amp;author=Bedenikovic%2CG&amp;author=Wiesel%2CM&amp;author=Ibberson%2CM&amp;author=Xenarios%2CI&amp;author=Von%20Laer%2CD&amp;author=Kalinke%2CU&amp;author=Vivier%2CE&amp;author=Jonjic%2CS&amp;author=Oxenius%2CA\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR58\">Nicolai CJ, Wolf N, Chang IC, Kirn G, Marcus A, Ndubaku CO, et al. NK cells mediate clearance of CD8(+) T cell-resistant tumors in response to STING agonists. Sci Immunol. 2020;5:eaaz2738.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BB3cXmsV2gur8%3D\" aria-label=\"CAS reference 58\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=32198222\" aria-label=\"PubMed reference 58\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC7228660\" aria-label=\"PubMed Central reference 58\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 58\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=NK%20cells%20mediate%20clearance%20of%20CD8%28%2B%29%20T%20cell-resistant%20tumors%20in%20response%20to%20STING%20agonists&amp;journal=Sci%20Immunol&amp;volume=5&amp;publication_year=2020&amp;author=Nicolai%2CCJ&amp;author=Wolf%2CN&amp;author=Chang%2CIC&amp;author=Kirn%2CG&amp;author=Marcus%2CA&amp;author=Ndubaku%2CCO&amp;author=McWhirter%2CSM&amp;author=Raulet%2CDH\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR59\">Brodeur MN, Dopeso H, Zhu Y, Longhini ALF, Gazzo A, Sun S, et al. Interferon response and epigenetic modulation by SMARCA4 mutations drive ovarian tumor immunogenicity. Sci Adv. 2024;10:eadk4851.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BB2cXislKks7nM\" aria-label=\"CAS reference 59\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=39630912\" aria-label=\"PubMed reference 59\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC11616711\" aria-label=\"PubMed Central reference 59\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 59\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Interferon%20response%20and%20epigenetic%20modulation%20by%20SMARCA4%20mutations%20drive%20ovarian%20tumor%20immunogenicity&amp;journal=Sci%20Adv&amp;volume=10&amp;publication_year=2024&amp;author=Brodeur%2CMN&amp;author=Dopeso%2CH&amp;author=Zhu%2CY&amp;author=Longhini%2CALF&amp;author=Gazzo%2CA&amp;author=Sun%2CS&amp;author=Koche%2CRP&amp;author=Qu%2CR&amp;author=Rosenberg%2CL&amp;author=Hamard%2CPJ\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR60\">Dufva O, Gandolfi S, Huuhtanen J, Dashevsky O, Du\u00e0n H, Saeed K, Klievink J, Nygren P, Bouhlal J, Lahtela J, et al. Single-cell functional genomics reveals determinants of sensitivity and resistance to natural killer cells in blood cancers. Immunity. 2023;56:2816\u2013e28352813.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BB3sXis1WntLfF\" aria-label=\"CAS reference 60\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=38091953\" aria-label=\"PubMed reference 60\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 60\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Single-cell%20functional%20genomics%20reveals%20determinants%20of%20sensitivity%20and%20resistance%20to%20natural%20killer%20cells%20in%20blood%20cancers&amp;journal=Immunity&amp;volume=56&amp;pages=2816-e28352813&amp;publication_year=2023&amp;author=Dufva%2CO&amp;author=Gandolfi%2CS&amp;author=Huuhtanen%2CJ&amp;author=Dashevsky%2CO&amp;author=Du%C3%A0n%2CH&amp;author=Saeed%2CK&amp;author=Klievink%2CJ&amp;author=Nygren%2CP&amp;author=Bouhlal%2CJ&amp;author=Lahtela%2CJ\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR61\">Diamond MS, Kinder M, Matsushita H, Mashayekhi M, Dunn GP, Archambault JM, et al. Type I interferon is selectively required by dendritic cells for immune rejection of tumors. J Exp Med. 2011;208:1989\u20132003.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BC3MXht1KjsbnL\" aria-label=\"CAS reference 61\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=21930769\" aria-label=\"PubMed reference 61\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3182061\" aria-label=\"PubMed Central reference 61\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 61\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Type%20I%20interferon%20is%20selectively%20required%20by%20dendritic%20cells%20for%20immune%20rejection%20of%20tumors&amp;journal=J%20Exp%20Med&amp;volume=208&amp;pages=1989-2003&amp;publication_year=2011&amp;author=Diamond%2CMS&amp;author=Kinder%2CM&amp;author=Matsushita%2CH&amp;author=Mashayekhi%2CM&amp;author=Dunn%2CGP&amp;author=Archambault%2CJM&amp;author=Lee%2CH&amp;author=Arthur%2CCD&amp;author=White%2CJM&amp;author=Kalinke%2CU\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR62\">Cauwels A, Van Lint S, Paul F, Garcin G, De Koker S, Van Parys A, Wueest T, Gerlo S, Van der Heyden J, Bordat Y, et al. Delivering type I interferon to dendritic cells empowers tumor eradication and immune combination treatments. Cancer Res. 2018;78:463\u201374.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BC1cXoslCntw%3D%3D\" aria-label=\"CAS reference 62\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=29187401\" aria-label=\"PubMed reference 62\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 62\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Delivering%20type%20I%20interferon%20to%20dendritic%20cells%20empowers%20tumor%20eradication%20and%20immune%20combination%20treatments&amp;journal=Cancer%20Res&amp;volume=78&amp;pages=463-74&amp;publication_year=2018&amp;author=Cauwels%2CA&amp;author=Lint%2CS&amp;author=Paul%2CF&amp;author=Garcin%2CG&amp;author=Koker%2CS&amp;author=Parys%2CA&amp;author=Wueest%2CT&amp;author=Gerlo%2CS&amp;author=Heyden%2CJ&amp;author=Bordat%2CY\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR63\">Pantel A, Teixeira A, Haddad E, Wood EG, Steinman RM, Longhi MP. Direct type i IFN but not MDA5\/TLR3 activation of dendritic cells is required for maturation and metabolic shift to glycolysis after poly IC stimulation. PLoS Biol. 2014;12:e1001759.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=24409099\" aria-label=\"PubMed reference 63\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3883643\" aria-label=\"PubMed Central reference 63\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 63\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Direct%20type%20i%20IFN%20but%20not%20MDA5%2FTLR3%20activation%20of%20dendritic%20cells%20is%20required%20for%20maturation%20and%20metabolic%20shift%20to%20glycolysis%20after%20poly%20IC%20stimulation&amp;journal=PLoS%20Biol&amp;volume=12&amp;publication_year=2014&amp;author=Pantel%2CA&amp;author=Teixeira%2CA&amp;author=Haddad%2CE&amp;author=Wood%2CEG&amp;author=Steinman%2CRM&amp;author=Longhi%2CMP\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR64\">Wu D, Sanin DE, Everts B, Chen Q, Qiu J, Buck MD, et al. Type 1 interferons induce changes in core metabolism that are critical for immune function. Immunity. 2016;44:1325\u201336.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BC28XhtVKhs7bI\" aria-label=\"CAS reference 64\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=27332732\" aria-label=\"PubMed reference 64\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5695232\" aria-label=\"PubMed Central reference 64\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 64\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Type%201%20interferons%20induce%20changes%20in%20core%20metabolism%20that%20are%20critical%20for%20immune%20function&amp;journal=Immunity&amp;volume=44&amp;pages=1325-36&amp;publication_year=2016&amp;author=Wu%2CD&amp;author=Sanin%2CDE&amp;author=Everts%2CB&amp;author=Chen%2CQ&amp;author=Qiu%2CJ&amp;author=Buck%2CMD&amp;author=Patterson%2CA&amp;author=Smith%2CAM&amp;author=Chang%2CCH&amp;author=Liu%2CZ\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR65\">Longhi MP, Trumpfheller C, Idoyaga J, Caskey M, Matos I, Kluger C, Salazar AM, Colonna M, Steinman RM. Dendritic cells require a systemic type I interferon response to mature and induce CD4\u2009+\u2009Th1 immunity with Poly IC as adjuvant. J Exp Med. 2009;206:1589\u2013602.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BD1MXos1eisLc%3D\" aria-label=\"CAS reference 65\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=19564349\" aria-label=\"PubMed reference 65\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC2715098\" aria-label=\"PubMed Central reference 65\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 65\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Dendritic%20cells%20require%20a%20systemic%20type%20I%20interferon%20response%20to%20mature%20and%20induce%20CD4%E2%80%89%2B%E2%80%89Th1%20immunity%20with%20Poly%20IC%20as%20adjuvant&amp;journal=J%20Exp%20Med&amp;volume=206&amp;pages=1589-602&amp;publication_year=2009&amp;author=Longhi%2CMP&amp;author=Trumpfheller%2CC&amp;author=Idoyaga%2CJ&amp;author=Caskey%2CM&amp;author=Matos%2CI&amp;author=Kluger%2CC&amp;author=Salazar%2CAM&amp;author=Colonna%2CM&amp;author=Steinman%2CRM\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR66\">Luri-Rey C, Teijeira \u00c1, Wculek SK, de Andrea C, Herrero C, Lopez-Janeiro A, Rodr\u00edguez-Ruiz ME, Heras I, Aggelakopoulou M, Berraondo P, et al. Cross-priming in cancer immunology and immunotherapy. Nat Rev Cancer. 2025;25:249\u201373.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BB2MXisFKqsb0%3D\" aria-label=\"CAS reference 66\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=39881005\" aria-label=\"PubMed reference 66\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 66\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Cross-priming%20in%20cancer%20immunology%20and%20immunotherapy&amp;journal=Nat%20Rev%20Cancer&amp;volume=25&amp;pages=249-73&amp;publication_year=2025&amp;author=Luri-Rey%2CC&amp;author=Teijeira%2C%C3%81&amp;author=Wculek%2CSK&amp;author=Andrea%2CC&amp;author=Herrero%2CC&amp;author=Lopez-Janeiro%2CA&amp;author=Rodr%C3%ADguez-Ruiz%2CME&amp;author=Heras%2CI&amp;author=Aggelakopoulou%2CM&amp;author=Berraondo%2CP\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR67\">Borst J, Ahrends T, B\u0105ba\u0142a N, Melief CJM, Kastenm\u00fcller W. CD4(+) T cell help in cancer immunology and immunotherapy. Nat Rev Immunol. 2018;18:635\u201347.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BC1cXhsVShtbrP\" aria-label=\"CAS reference 67\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=30057419\" aria-label=\"PubMed reference 67\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 67\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=CD4%28%2B%29%20T%20cell%20help%20in%20cancer%20immunology%20and%20immunotherapy&amp;journal=Nat%20Rev%20Immunol&amp;volume=18&amp;pages=635-47&amp;publication_year=2018&amp;author=Borst%2CJ&amp;author=Ahrends%2CT&amp;author=B%C4%85ba%C5%82a%2CN&amp;author=Melief%2CCJM&amp;author=Kastenm%C3%BCller%2CW\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR68\">Whitmore MM, DeVeer MJ, Edling A, Oates RK, Simons B, Lindner D, Williams BR. Synergistic activation of innate immunity by double-stranded RNA and CpG DNA promotes enhanced antitumor activity. Cancer Res. 2004;64:5850\u201360.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BD2cXmslaks7o%3D\" aria-label=\"CAS reference 68\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=15313929\" aria-label=\"PubMed reference 68\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 68\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Synergistic%20activation%20of%20innate%20immunity%20by%20double-stranded%20RNA%20and%20CpG%20DNA%20promotes%20enhanced%20antitumor%20activity&amp;journal=Cancer%20Res&amp;volume=64&amp;pages=5850-60&amp;publication_year=2004&amp;author=Whitmore%2CMM&amp;author=DeVeer%2CMJ&amp;author=Edling%2CA&amp;author=Oates%2CRK&amp;author=Simons%2CB&amp;author=Lindner%2CD&amp;author=Williams%2CBR\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR69\">Reynolds MB, Klein B, McFadden MJ, Judge NK, Navarrete HE, Michmerhuizen BC, Awad D, Schultz TL, Harms PW, Zhang L, et al. Type I interferon governs immunometabolic checkpoints that coordinate inflammation during Staphylococcal infection. Cell Rep. 2024;43:114607.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BB2cXhslamsrbM\" aria-label=\"CAS reference 69\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=39126652\" aria-label=\"PubMed reference 69\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC11590196\" aria-label=\"PubMed Central reference 69\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 69\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Type%20I%20interferon%20governs%20immunometabolic%20checkpoints%20that%20coordinate%20inflammation%20during%20Staphylococcal%20infection&amp;journal=Cell%20Rep&amp;volume=43&amp;publication_year=2024&amp;author=Reynolds%2CMB&amp;author=Klein%2CB&amp;author=McFadden%2CMJ&amp;author=Judge%2CNK&amp;author=Navarrete%2CHE&amp;author=Michmerhuizen%2CBC&amp;author=Awad%2CD&amp;author=Schultz%2CTL&amp;author=Harms%2CPW&amp;author=Zhang%2CL\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR70\">Zemek RM, Chin WL, Fear VS, Wylie B, Casey TH, Forbes C, Tilsed CM, Boon L, Guo BB, Bosco A, et al. Temporally restricted activation of IFNbeta signaling underlies response to immune checkpoint therapy in mice. Nat Commun. 2022;13:4895.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BB38Xit1SlurbI\" aria-label=\"CAS reference 70\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=35986006\" aria-label=\"PubMed reference 70\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9390963\" aria-label=\"PubMed Central reference 70\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 70\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Temporally%20restricted%20activation%20of%20IFNbeta%20signaling%20underlies%20response%20to%20immune%20checkpoint%20therapy%20in%20mice&amp;journal=Nat%20Commun&amp;volume=13&amp;publication_year=2022&amp;author=Zemek%2CRM&amp;author=Chin%2CWL&amp;author=Fear%2CVS&amp;author=Wylie%2CB&amp;author=Casey%2CTH&amp;author=Forbes%2CC&amp;author=Tilsed%2CCM&amp;author=Boon%2CL&amp;author=Guo%2CBB&amp;author=Bosco%2CA\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR71\">Le Bon A, Durand V, Kamphuis E, Thompson C, Bulfone-Paus S, Rossmann C, Kalinke U, Tough DF. Direct stimulation of T cells by type I IFN enhances the CD8\u2009+\u2009T cell response during cross-priming. J Immunol. 2006;176:4682\u20139.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=16585561\" aria-label=\"PubMed reference 71\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 71\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Direct%20stimulation%20of%20T%20cells%20by%20type%20I%20IFN%20enhances%20the%20CD8%E2%80%89%2B%E2%80%89T%20cell%20response%20during%20cross-priming&amp;journal=J%20Immunol&amp;volume=176&amp;pages=4682-9&amp;publication_year=2006&amp;author=Bon%2CA&amp;author=Durand%2CV&amp;author=Kamphuis%2CE&amp;author=Thompson%2CC&amp;author=Bulfone-Paus%2CS&amp;author=Rossmann%2CC&amp;author=Kalinke%2CU&amp;author=Tough%2CDF\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR72\">Suthar MS, Ramos HJ, Brassil MM, Netland J, Chappell CP, Blahnik G, McMillan A, Diamond MS, Clark EA, Bevan MJ, Gale M Jr. The RIG-I-like receptor LGP2 controls CD8(+) T cell survival and fitness. Immunity. 2012;37:235\u201348.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BC38XhtFShurrJ\" aria-label=\"CAS reference 72\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=22841161\" aria-label=\"PubMed reference 72\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3910444\" aria-label=\"PubMed Central reference 72\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 72\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=The%20RIG-I-like%20receptor%20LGP2%20controls%20CD8%28%2B%29%20T%20cell%20survival%20and%20fitness&amp;journal=Immunity&amp;volume=37&amp;pages=235-48&amp;publication_year=2012&amp;author=Suthar%2CMS&amp;author=Ramos%2CHJ&amp;author=Brassil%2CMM&amp;author=Netland%2CJ&amp;author=Chappell%2CCP&amp;author=Blahnik%2CG&amp;author=McMillan%2CA&amp;author=Diamond%2CMS&amp;author=Clark%2CEA&amp;author=Bevan%2CMJ&amp;author=Gale%2CM\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR73\">Eriksen KW, Lovato P, Skov L, Krejsgaard T, Kaltoft K, Geisler C, \u00d8dum N. Increased sensitivity to interferon-alpha in psoriatic T cells. J Invest Dermatol. 2005;125:936\u201344.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BD2MXht1Grtr3K\" aria-label=\"CAS reference 73\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=16297193\" aria-label=\"PubMed reference 73\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 73\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Increased%20sensitivity%20to%20interferon-alpha%20in%20psoriatic%20T%20cells&amp;journal=J%20Invest%20Dermatol&amp;volume=125&amp;pages=936-44&amp;publication_year=2005&amp;author=Eriksen%2CKW&amp;author=Lovato%2CP&amp;author=Skov%2CL&amp;author=Krejsgaard%2CT&amp;author=Kaltoft%2CK&amp;author=Geisler%2CC&amp;author=%C3%98dum%2CN\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR74\">Lu C, Klement JD, Ibrahim ML, Xiao W, Redd PS, Nayak-Kapoor A, Zhou G, Liu K. Type I interferon suppresses tumor growth through activating the STAT3-granzyme B pathway in tumor-infiltrating cytotoxic T lymphocytes. J Immunother Cancer. 2019;7:157.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=31228946\" aria-label=\"PubMed reference 74\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC6589175\" aria-label=\"PubMed Central reference 74\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 74\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Type%20I%20interferon%20suppresses%20tumor%20growth%20through%20activating%20the%20STAT3-granzyme%20B%20pathway%20in%20tumor-infiltrating%20cytotoxic%20T%20lymphocytes&amp;journal=J%20Immunother%20Cancer&amp;volume=7&amp;publication_year=2019&amp;author=Lu%2CC&amp;author=Klement%2CJD&amp;author=Ibrahim%2CML&amp;author=Xiao%2CW&amp;author=Redd%2CPS&amp;author=Nayak-Kapoor%2CA&amp;author=Zhou%2CG&amp;author=Liu%2CK\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR75\">Starbeck-Miller GR, Xue HH, Harty JT. IL-12 and type I interferon prolong the division of activated CD8 T cells by maintaining high-affinity IL-2 signaling in vivo. J Exp Med. 2014;211:105\u201320.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BC2cXpvVWitw%3D%3D\" aria-label=\"CAS reference 75\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=24367005\" aria-label=\"PubMed reference 75\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3892973\" aria-label=\"PubMed Central reference 75\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 75\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=IL-12%20and%20type%20I%20interferon%20prolong%20the%20division%20of%20activated%20CD8%20T%20cells%20by%20maintaining%20high-affinity%20IL-2%20signaling%20in%20vivo&amp;journal=J%20Exp%20Med&amp;volume=211&amp;pages=105-20&amp;publication_year=2014&amp;author=Starbeck-Miller%2CGR&amp;author=Xue%2CHH&amp;author=Harty%2CJT\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR76\">Lacalle RA, Blanco R, Carmona-Rodr\u00edguez L, Mart\u00edn-Leal A, Mira E, Ma\u00f1es S. Chemokine receptor signaling and the hallmarks of cancer. Int Rev Cell Mol Biol. 2017;331:181\u2013244.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BB3cXhsFWqsL3K\" aria-label=\"CAS reference 76\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=28325212\" aria-label=\"PubMed reference 76\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 76\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Chemokine%20receptor%20signaling%20and%20the%20hallmarks%20of%20cancer&amp;journal=Int%20Rev%20Cell%20Mol%20Biol&amp;volume=331&amp;pages=181-244&amp;publication_year=2017&amp;author=Lacalle%2CRA&amp;author=Blanco%2CR&amp;author=Carmona-Rodr%C3%ADguez%2CL&amp;author=Mart%C3%ADn-Leal%2CA&amp;author=Mira%2CE&amp;author=Ma%C3%B1es%2CS\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR77\">Mowat C, Mosley SR, Namdar A, Schiller D, Baker K. Anti-tumor immunity in mismatch repair-deficient colorectal cancers requires type I IFN-driven CCL5 and CXCL10. J Exp Med. 2021;218:e20210108.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BB3MXhvFOitLrL\" aria-label=\"CAS reference 77\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=34297038\" aria-label=\"PubMed reference 77\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC8313406\" aria-label=\"PubMed Central reference 77\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 77\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Anti-tumor%20immunity%20in%20mismatch%20repair-deficient%20colorectal%20cancers%20requires%20type%20I%20IFN-driven%20CCL5%20and%20CXCL10&amp;journal=J%20Exp%20Med&amp;volume=218&amp;publication_year=2021&amp;author=Mowat%2CC&amp;author=Mosley%2CSR&amp;author=Namdar%2CA&amp;author=Schiller%2CD&amp;author=Baker%2CK\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR78\">Gallucci S, Lolkema M, Matzinger P. Natural adjuvants: endogenous activators of dendritic cells. Nat Med. 1999;5:1249\u201355.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DyaK1MXnt1ynsbk%3D\" aria-label=\"CAS reference 78\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=10545990\" aria-label=\"PubMed reference 78\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 78\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Natural%20adjuvants%3A%20endogenous%20activators%20of%20dendritic%20cells&amp;journal=Nat%20Med&amp;volume=5&amp;pages=1249-55&amp;publication_year=1999&amp;author=Gallucci%2CS&amp;author=Lolkema%2CM&amp;author=Matzinger%2CP\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR79\">Galassi C, Chan TA, Vitale I, Galluzzi L. The hallmarks of cancer immune evasion. Cancer Cell. 2024;42:1825\u201363.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BB2cXitF2nsLzI\" aria-label=\"CAS reference 79\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=39393356\" aria-label=\"PubMed reference 79\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 79\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=The%20hallmarks%20of%20cancer%20immune%20evasion&amp;journal=Cancer%20Cell&amp;volume=42&amp;pages=1825-63&amp;publication_year=2024&amp;author=Galassi%2CC&amp;author=Chan%2CTA&amp;author=Vitale%2CI&amp;author=Galluzzi%2CL\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR80\">Gangaplara A, Martens C, Dahlstrom E, Metidji A, Gokhale AS, Glass DD, Lopez-Ocasio M, Baur R, Kanakabandi K, Porcella SF, Shevach EM. Type I interferon signaling attenuates regulatory T cell function in viral infection and in the tumor microenvironment. PLoS Pathog. 2018;14:e1006985.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=29672594\" aria-label=\"PubMed reference 80\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5929570\" aria-label=\"PubMed Central reference 80\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 80\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Type%20I%20interferon%20signaling%20attenuates%20regulatory%20T%20cell%20function%20in%20viral%20infection%20and%20in%20the%20tumor%20microenvironment&amp;journal=PLoS%20Pathog&amp;volume=14&amp;publication_year=2018&amp;author=Gangaplara%2CA&amp;author=Martens%2CC&amp;author=Dahlstrom%2CE&amp;author=Metidji%2CA&amp;author=Gokhale%2CAS&amp;author=Glass%2CDD&amp;author=Lopez-Ocasio%2CM&amp;author=Baur%2CR&amp;author=Kanakabandi%2CK&amp;author=Porcella%2CSF&amp;author=Shevach%2CEM\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR81\">Bacher N, Raker V, Hofmann C, Graulich E, Schwenk M, Baumgrass R, Bopp T, Zechner U, Merten L, Becker C, Steinbrink K. Interferon-\u03b1 suppresses cAMP to disarm human regulatory T cells. Cancer Res. 2013;73:5647\u201356.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BC3sXhsVCqs7nI\" aria-label=\"CAS reference 81\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=23878189\" aria-label=\"PubMed reference 81\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 81\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Interferon-%CE%B1%20suppresses%20cAMP%20to%20disarm%20human%20regulatory%20T%20cells&amp;journal=Cancer%20Res&amp;volume=73&amp;pages=5647-56&amp;publication_year=2013&amp;author=Bacher%2CN&amp;author=Raker%2CV&amp;author=Hofmann%2CC&amp;author=Graulich%2CE&amp;author=Schwenk%2CM&amp;author=Baumgrass%2CR&amp;author=Bopp%2CT&amp;author=Zechner%2CU&amp;author=Merten%2CL&amp;author=Becker%2CC&amp;author=Steinbrink%2CK\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR82\">Yofe I, Landsberger T, Yalin A, Solomon I, Costoya C, Demane DF, Shah M, David E, Borenstein C, Barboy O, et al. Anti-CTLA-4 antibodies drive myeloid activation and reprogram the tumor microenvironment through Fc\u03b3R engagement and type I interferon signaling. Nat Cancer. 2022;3:1336\u201350.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BB38XislyqsLvM\" aria-label=\"CAS reference 82\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=36302895\" aria-label=\"PubMed reference 82\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 82\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Anti-CTLA-4%20antibodies%20drive%20myeloid%20activation%20and%20reprogram%20the%20tumor%20microenvironment%20through%20Fc%CE%B3R%20engagement%20and%20type%20I%20interferon%20signaling&amp;journal=Nat%20Cancer&amp;volume=3&amp;pages=1336-50&amp;publication_year=2022&amp;author=Yofe%2CI&amp;author=Landsberger%2CT&amp;author=Yalin%2CA&amp;author=Solomon%2CI&amp;author=Costoya%2CC&amp;author=Demane%2CDF&amp;author=Shah%2CM&amp;author=David%2CE&amp;author=Borenstein%2CC&amp;author=Barboy%2CO\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR83\">Togashi Y, Shitara K, Nishikawa H. Regulatory T cells in cancer immunosuppression &#8211; implications for anticancer therapy. Nat Rev Clin Oncol. 2019;16:356\u201371.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BC1MXhtVyjtr3E\" aria-label=\"CAS reference 83\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=30705439\" aria-label=\"PubMed reference 83\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 83\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Regulatory%20T%20cells%20in%20cancer%20immunosuppression%20-%20implications%20for%20anticancer%20therapy&amp;journal=Nat%20Rev%20Clin%20Oncol&amp;volume=16&amp;pages=356-71&amp;publication_year=2019&amp;author=Togashi%2CY&amp;author=Shitara%2CK&amp;author=Nishikawa%2CH\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR84\">U\u2019Ren L, Guth A, Kamstock D, Dow S. Type I interferons inhibit the generation of tumor-associated macrophages. Cancer Immunol Immunother. 2010;59:587\u201398.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=19826812\" aria-label=\"PubMed reference 84\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 84\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Type%20I%20interferons%20inhibit%20the%20generation%20of%20tumor-associated%20macrophages&amp;journal=Cancer%20Immunol%20Immunother&amp;volume=59&amp;pages=587-98&amp;publication_year=2010&amp;author=U%E2%80%99Ren%2CL&amp;author=Guth%2CA&amp;author=Kamstock%2CD&amp;author=Dow%2CS\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR85\">Ming-Chin Lee K, Achuthan AA, De Souza DP, Lupancu TJ, Binger KJ, Lee MKS, Xu Y, McConville MJ, de Weerd NA, Dragoljevic D, et al. Type I interferon antagonism of the JMJD3-IRF4 pathway modulates macrophage activation and polarization. Cell Rep. 2022;39:110719.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BB38XhtVGhsL7L\" aria-label=\"CAS reference 85\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=35443173\" aria-label=\"PubMed reference 85\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 85\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Type%20I%20interferon%20antagonism%20of%20the%20JMJD3-IRF4%20pathway%20modulates%20macrophage%20activation%20and%20polarization&amp;journal=Cell%20Rep&amp;volume=39&amp;publication_year=2022&amp;author=Ming-Chin%20Lee%2CK&amp;author=Achuthan%2CAA&amp;author=Souza%2CDP&amp;author=Lupancu%2CTJ&amp;author=Binger%2CKJ&amp;author=Lee%2CMKS&amp;author=Xu%2CY&amp;author=McConville%2CMJ&amp;author=Weerd%2CNA&amp;author=Dragoljevic%2CD\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR86\">Vitale I, Manic G, Coussens LM, Kroemer G, Galluzzi L. Macrophages and metabolism in the tumor microenvironment. Cell Metab. 2019;30:36\u201350.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BC1MXhtlWns7rN\" aria-label=\"CAS reference 86\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=31269428\" aria-label=\"PubMed reference 86\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 86\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Macrophages%20and%20metabolism%20in%20the%20tumor%20microenvironment&amp;journal=Cell%20Metab&amp;volume=30&amp;pages=36-50&amp;publication_year=2019&amp;author=Vitale%2CI&amp;author=Manic%2CG&amp;author=Coussens%2CLM&amp;author=Kroemer%2CG&amp;author=Galluzzi%2CL\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR87\">Mantovani A, Allavena P, Marchesi F, Garlanda C. Macrophages as tools and targets in cancer therapy. Nat Rev Drug Discov. 2022;21:799\u2013820.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BB38XitFGjsrfI\" aria-label=\"CAS reference 87\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=35974096\" aria-label=\"PubMed reference 87\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9380983\" aria-label=\"PubMed Central reference 87\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 87\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Macrophages%20as%20tools%20and%20targets%20in%20cancer%20therapy&amp;journal=Nat%20Rev%20Drug%20Discov&amp;volume=21&amp;pages=799-820&amp;publication_year=2022&amp;author=Mantovani%2CA&amp;author=Allavena%2CP&amp;author=Marchesi%2CF&amp;author=Garlanda%2CC\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR88\">Alicea-Torres K, Sanseviero E, Gui J, Chen J, Veglia F, Yu Q, Donthireddy L, Kossenkov A, Lin C, Fu S, et al. Immune suppressive activity of myeloid-derived suppressor cells in cancer requires inactivation of the type I interferon pathway. Nat Commun. 2021;12:1717.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BB3MXntl2qsL0%3D\" aria-label=\"CAS reference 88\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=33741967\" aria-label=\"PubMed reference 88\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC7979850\" aria-label=\"PubMed Central reference 88\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 88\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Immune%20suppressive%20activity%20of%20myeloid-derived%20suppressor%20cells%20in%20cancer%20requires%20inactivation%20of%20the%20type%20I%20interferon%20pathway&amp;journal=Nat%20Commun&amp;volume=12&amp;publication_year=2021&amp;author=Alicea-Torres%2CK&amp;author=Sanseviero%2CE&amp;author=Gui%2CJ&amp;author=Chen%2CJ&amp;author=Veglia%2CF&amp;author=Yu%2CQ&amp;author=Donthireddy%2CL&amp;author=Kossenkov%2CA&amp;author=Lin%2CC&amp;author=Fu%2CS\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR89\">Wan S, Pestka S, Jubin RG, Lyu YL, Tsai YC, Liu LF. Chemotherapeutics and radiation stimulate MHC class I expression through elevated interferon-beta signaling in breast cancer cells. PLoS ONE. 2012;7:e32542.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BC38XjslOlu74%3D\" aria-label=\"CAS reference 89\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=22396773\" aria-label=\"PubMed reference 89\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3291570\" aria-label=\"PubMed Central reference 89\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 89\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Chemotherapeutics%20and%20radiation%20stimulate%20MHC%20class%20I%20expression%20through%20elevated%20interferon-beta%20signaling%20in%20breast%20cancer%20cells&amp;journal=PLoS%20ONE&amp;volume=7&amp;publication_year=2012&amp;author=Wan%2CS&amp;author=Pestka%2CS&amp;author=Jubin%2CRG&amp;author=Lyu%2CYL&amp;author=Tsai%2CYC&amp;author=Liu%2CLF\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR90\">Sistigu A, Yamazaki T, Vacchelli E, Chaba K, Enot DP, Adam J, Vitale I, Goubar A, Baracco EE, Remedios C, et al. Cancer cell-autonomous contribution of type I interferon signaling to the efficacy of chemotherapy. Nat Med. 2014;20:1301\u20139.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BC2cXhvVSqsbbM\" aria-label=\"CAS reference 90\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=25344738\" aria-label=\"PubMed reference 90\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 90\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Cancer%20cell-autonomous%20contribution%20of%20type%20I%20interferon%20signaling%20to%20the%20efficacy%20of%20chemotherapy&amp;journal=Nat%20Med&amp;volume=20&amp;pages=1301-9&amp;publication_year=2014&amp;author=Sistigu%2CA&amp;author=Yamazaki%2CT&amp;author=Vacchelli%2CE&amp;author=Chaba%2CK&amp;author=Enot%2CDP&amp;author=Adam%2CJ&amp;author=Vitale%2CI&amp;author=Goubar%2CA&amp;author=Baracco%2CEE&amp;author=Remedios%2CC\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR91\">Marchi S, Guilbaud E, Tait SWG, Yamazaki T, Galluzzi L. Mitochondrial control of inflammation. Nat Rev Immunol. 2023;23:159\u201373.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BB38XhvFGgtrrM\" aria-label=\"CAS reference 91\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=35879417\" aria-label=\"PubMed reference 91\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 91\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Mitochondrial%20control%20of%20inflammation&amp;journal=Nat%20Rev%20Immunol&amp;volume=23&amp;pages=159-73&amp;publication_year=2023&amp;author=Marchi%2CS&amp;author=Guilbaud%2CE&amp;author=Tait%2CSWG&amp;author=Yamazaki%2CT&amp;author=Galluzzi%2CL\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR92\">Anz D, Rapp M, Eiber S, Koelzer VH, Thaler R, Haubner S, Knott M, Nagel S, Golic M, Wiedemann GM, et al. Suppression of intratumoral CCL22 by type i interferon inhibits migration of regulatory T cells and blocks cancer progression. Cancer Res. 2015;75:4483\u201393.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BC2MXhslGnu7vE\" aria-label=\"CAS reference 92\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=26432403\" aria-label=\"PubMed reference 92\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 92\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Suppression%20of%20intratumoral%20CCL22%20by%20type%20i%20interferon%20inhibits%20migration%20of%20regulatory%20T%20cells%20and%20blocks%20cancer%20progression&amp;journal=Cancer%20Res&amp;volume=75&amp;pages=4483-93&amp;publication_year=2015&amp;author=Anz%2CD&amp;author=Rapp%2CM&amp;author=Eiber%2CS&amp;author=Koelzer%2CVH&amp;author=Thaler%2CR&amp;author=Haubner%2CS&amp;author=Knott%2CM&amp;author=Nagel%2CS&amp;author=Golic%2CM&amp;author=Wiedemann%2CGM\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR93\">Galluzzi L, Green DR. Autophagy-Independent functions of the autophagy machinery. Cell. 2019;177:1682\u201399.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BC1MXhtFOrsL7N\" aria-label=\"CAS reference 93\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=31199916\" aria-label=\"PubMed reference 93\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC7173070\" aria-label=\"PubMed Central reference 93\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 93\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Autophagy-Independent%20functions%20of%20the%20autophagy%20machinery&amp;journal=Cell&amp;volume=177&amp;pages=1682-99&amp;publication_year=2019&amp;author=Galluzzi%2CL&amp;author=Green%2CDR\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR94\">Zhou H, Wang W, Xu H, Liang Y, Ding J, Lv M, Ren B, Peng H, Fu YX, Zhu M. Metabolic reprograming mediated by tumor cell-intrinsic type I IFN signaling is required for CD47-SIRP\u03b1 Blockade efficacy. Nat Commun. 2024;15:5759.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BB2cXhsFOnt7bK\" aria-label=\"CAS reference 94\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=38982116\" aria-label=\"PubMed reference 94\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC11233683\" aria-label=\"PubMed Central reference 94\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 94\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Metabolic%20reprograming%20mediated%20by%20tumor%20cell-intrinsic%20type%20I%20IFN%20signaling%20is%20required%20for%20CD47-SIRP%CE%B1%20Blockade%20efficacy&amp;journal=Nat%20Commun&amp;volume=15&amp;publication_year=2024&amp;author=Zhou%2CH&amp;author=Wang%2CW&amp;author=Xu%2CH&amp;author=Liang%2CY&amp;author=Ding%2CJ&amp;author=Lv%2CM&amp;author=Ren%2CB&amp;author=Peng%2CH&amp;author=Fu%2CYX&amp;author=Zhu%2CM\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR95\">Campisi M, Sundararaman SK, Shelton SE, Knelson EH, Mahadevan NR, Yoshida R, Tani T, Ivanova E, Ca\u00f1adas I, Osaki T et al. Tumor-Derived cGAMP Regulates Activation of the Vasculature. Front Immunol. 2020, 11:2090.<\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR96\">Yang H, Lee WS, Kong SJ, Kim CG, Kim JH, Chang SK, Kim S, Kim G, Chon HJ, Kim C. STING activation reprograms tumor vasculatures and synergizes with VEGFR2 Blockade. J Clin Invest. 2019;129:4350\u201364.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=31343989\" aria-label=\"PubMed reference 96\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC6763266\" aria-label=\"PubMed Central reference 96\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 96\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=STING%20activation%20reprograms%20tumor%20vasculatures%20and%20synergizes%20with%20VEGFR2%20Blockade&amp;journal=J%20Clin%20Invest&amp;volume=129&amp;pages=4350-64&amp;publication_year=2019&amp;author=Yang%2CH&amp;author=Lee%2CWS&amp;author=Kong%2CSJ&amp;author=Kim%2CCG&amp;author=Kim%2CJH&amp;author=Chang%2CSK&amp;author=Kim%2CS&amp;author=Kim%2CG&amp;author=Chon%2CHJ&amp;author=Kim%2CC\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR97\">Carmona-Rodr\u00edguez L, Mart\u00ednez-Rey D, Fern\u00e1ndez-Ace\u00f1ero MJ, Gonz\u00e1lez-Mart\u00edn A, Paz-Cabezas M, Rodr\u00edguez-Rodr\u00edguez N, P\u00e9rez-Villamil B, S\u00e1ez ME, D\u00edaz-Rubio E, Mira E, Ma\u00f1es S. SOD3 induces a HIF-2\u03b1-dependent program in endothelial cells that provides a selective signal for tumor infiltration by T cells. J Immunother Cancer. 2020;8:e000432.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=32591431\" aria-label=\"PubMed reference 97\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC7319787\" aria-label=\"PubMed Central reference 97\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 97\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=SOD3%20induces%20a%20HIF-2%CE%B1-dependent%20program%20in%20endothelial%20cells%20that%20provides%20a%20selective%20signal%20for%20tumor%20infiltration%20by%20T%20cells&amp;journal=J%20Immunother%20Cancer&amp;volume=8&amp;publication_year=2020&amp;author=Carmona-Rodr%C3%ADguez%2CL&amp;author=Mart%C3%ADnez-Rey%2CD&amp;author=Fern%C3%A1ndez-Ace%C3%B1ero%2CMJ&amp;author=Gonz%C3%A1lez-Mart%C3%ADn%2CA&amp;author=Paz-Cabezas%2CM&amp;author=Rodr%C3%ADguez-Rodr%C3%ADguez%2CN&amp;author=P%C3%A9rez-Villamil%2CB&amp;author=S%C3%A1ez%2CME&amp;author=D%C3%ADaz-Rubio%2CE&amp;author=Mira%2CE&amp;author=Ma%C3%B1es%2CS\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR98\">Weichselbaum RR, Ishwaran H, Yoon T, Nuyten DS, Baker SW, Khodarev N, Su AW, Shaikh AY, Roach P, Kreike B, et al. An interferon-related gene signature for DNA damage resistance is a predictive marker for chemotherapy and radiation for breast cancer. Proc Natl Acad Sci U S A. 2008;105:18490\u20135.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BD1cXhsVOmsbfJ\" aria-label=\"CAS reference 98\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=19001271\" aria-label=\"PubMed reference 98\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC2587578\" aria-label=\"PubMed Central reference 98\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 98\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=An%20interferon-related%20gene%20signature%20for%20DNA%20damage%20resistance%20is%20a%20predictive%20marker%20for%20chemotherapy%20and%20radiation%20for%20breast%20cancer&amp;journal=Proc%20Natl%20Acad%20Sci%20U%20S%20A&amp;volume=105&amp;pages=18490-5&amp;publication_year=2008&amp;author=Weichselbaum%2CRR&amp;author=Ishwaran%2CH&amp;author=Yoon%2CT&amp;author=Nuyten%2CDS&amp;author=Baker%2CSW&amp;author=Khodarev%2CN&amp;author=Su%2CAW&amp;author=Shaikh%2CAY&amp;author=Roach%2CP&amp;author=Kreike%2CB\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR99\">Khodarev NN, Beckett M, Labay E, Darga T, Roizman B, Weichselbaum RR. STAT1 is overexpressed in tumors selected for radioresistance and confers protection from radiation in transduced sensitive cells. Proc Natl Acad Sci U S A. 2004;101:1714\u20139.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BD2cXhsFaqtLk%3D\" aria-label=\"CAS reference 99\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=14755057\" aria-label=\"PubMed reference 99\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC341831\" aria-label=\"PubMed Central reference 99\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 99\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=STAT1%20is%20overexpressed%20in%20tumors%20selected%20for%20radioresistance%20and%20confers%20protection%20from%20radiation%20in%20transduced%20sensitive%20cells&amp;journal=Proc%20Natl%20Acad%20Sci%20U%20S%20A&amp;volume=101&amp;pages=1714-9&amp;publication_year=2004&amp;author=Khodarev%2CNN&amp;author=Beckett%2CM&amp;author=Labay%2CE&amp;author=Darga%2CT&amp;author=Roizman%2CB&amp;author=Weichselbaum%2CRR\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR100\">Khodarev NN, Roach P, Pitroda SP, Golden DW, Bhayani M, Shao MY, Darga TE, Beveridge MG, Sood RF, Sutton HG, et al. STAT1 pathway mediates amplification of metastatic potential and resistance to therapy. PLoS ONE. 2009;4:e5821.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=19503789\" aria-label=\"PubMed reference 100\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC2688034\" aria-label=\"PubMed Central reference 100\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 100\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=STAT1%20pathway%20mediates%20amplification%20of%20metastatic%20potential%20and%20resistance%20to%20therapy&amp;journal=PLoS%20ONE&amp;volume=4&amp;publication_year=2009&amp;author=Khodarev%2CNN&amp;author=Roach%2CP&amp;author=Pitroda%2CSP&amp;author=Golden%2CDW&amp;author=Bhayani%2CM&amp;author=Shao%2CMY&amp;author=Darga%2CTE&amp;author=Beveridge%2CMG&amp;author=Sood%2CRF&amp;author=Sutton%2CHG\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR101\">Rodriguez-Ruiz ME, Buque A, Hensler M, Chen J, Bloy N, Petroni G, Sato A, Yamazaki T, Fucikova J, Galluzzi L. Apoptotic caspases inhibit abscopal responses to radiation and identify a new prognostic biomarker for breast cancer patients. Oncoimmunology. 2019;8:e1655964.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=31646105\" aria-label=\"PubMed reference 101\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC6791460\" aria-label=\"PubMed Central reference 101\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 101\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Apoptotic%20caspases%20inhibit%20abscopal%20responses%20to%20radiation%20and%20identify%20a%20new%20prognostic%20biomarker%20for%20breast%20cancer%20patients&amp;journal=Oncoimmunology&amp;volume=8&amp;publication_year=2019&amp;author=Rodriguez-Ruiz%2CME&amp;author=Buque%2CA&amp;author=Hensler%2CM&amp;author=Chen%2CJ&amp;author=Bloy%2CN&amp;author=Petroni%2CG&amp;author=Sato%2CA&amp;author=Yamazaki%2CT&amp;author=Fucikova%2CJ&amp;author=Galluzzi%2CL\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR102\">Kondratova AA, Cheon H, Dong B, Holvey-Bates EG, Hasipek M, Taran I, Gaughan C, Jha BK, Silverman RH, Stark GR. Suppressing parylation by 2\u2019,5\u2019-oligoadenylate synthetase 1 inhibits DNA damage-induced cell death. EMBO J. 2020;39:e101573.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BB3cXns1Cnurg%3D\" aria-label=\"CAS reference 102\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=32323871\" aria-label=\"PubMed reference 102\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC7265237\" aria-label=\"PubMed Central reference 102\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 102\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Suppressing%20parylation%20by%202%E2%80%99%2C5%E2%80%99-oligoadenylate%20synthetase%201%20inhibits%20DNA%20damage-induced%20cell%20death&amp;journal=EMBO%20J&amp;volume=39&amp;publication_year=2020&amp;author=Kondratova%2CAA&amp;author=Cheon%2CH&amp;author=Dong%2CB&amp;author=Holvey-Bates%2CEG&amp;author=Hasipek%2CM&amp;author=Taran%2CI&amp;author=Gaughan%2CC&amp;author=Jha%2CBK&amp;author=Silverman%2CRH&amp;author=Stark%2CGR\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR103\">Jacquelot N, Yamazaki T, Roberti MP, Duong CPM, Andrews MC, Verlingue L, Ferrere G, Becharef S, V\u00e9tizou M, Daill\u00e8re R, et al. Sustained type I interferon signaling as a mechanism of resistance to PD-1 Blockade. Cell Res. 2019;29:846\u201361.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BC1MXhslajsb%2FJ\" aria-label=\"CAS reference 103\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=31481761\" aria-label=\"PubMed reference 103\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC6796942\" aria-label=\"PubMed Central reference 103\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 103\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Sustained%20type%20I%20interferon%20signaling%20as%20a%20mechanism%20of%20resistance%20to%20PD-1%20Blockade&amp;journal=Cell%20Res&amp;volume=29&amp;pages=846-61&amp;publication_year=2019&amp;author=Jacquelot%2CN&amp;author=Yamazaki%2CT&amp;author=Roberti%2CMP&amp;author=Duong%2CCPM&amp;author=Andrews%2CMC&amp;author=Verlingue%2CL&amp;author=Ferrere%2CG&amp;author=Becharef%2CS&amp;author=V%C3%A9tizou%2CM&amp;author=Daill%C3%A8re%2CR\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR104\">Benci JL, Xu B, Qiu Y, Wu TJ, Dada H, Twyman-Saint Victor C, Cucolo L, Lee DSM, Pauken KE, Huang AC, et al. Tumor interferon signaling regulates a Multigenic resistance program to immune checkpoint Blockade. Cell. 2016;167:1540\u2013e15541512.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BC28XitVSms7bF\" aria-label=\"CAS reference 104\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=27912061\" aria-label=\"PubMed reference 104\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5385895\" aria-label=\"PubMed Central reference 104\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 104\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Tumor%20interferon%20signaling%20regulates%20a%20Multigenic%20resistance%20program%20to%20immune%20checkpoint%20Blockade&amp;journal=Cell&amp;volume=167&amp;pages=1540-e15541512&amp;publication_year=2016&amp;author=Benci%2CJL&amp;author=Xu%2CB&amp;author=Qiu%2CY&amp;author=Wu%2CTJ&amp;author=Dada%2CH&amp;author=Twyman-Saint%20Victor%2CC&amp;author=Cucolo%2CL&amp;author=Lee%2CDSM&amp;author=Pauken%2CKE&amp;author=Huang%2CAC\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR105\">Bakhoum SF, Ngo B, Laughney AM, Cavallo JA, Murphy CJ, Ly P, Shah P, Sriram RK, Watkins TBK, Taunk NK, et al. Chromosomal instability drives metastasis through a cytosolic DNA response. Nature. 2018;553:467\u201372.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BC1cXhtVOisb0%3D\" aria-label=\"CAS reference 105\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=29342134\" aria-label=\"PubMed reference 105\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5785464\" aria-label=\"PubMed Central reference 105\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 105\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Chromosomal%20instability%20drives%20metastasis%20through%20a%20cytosolic%20DNA%20response&amp;journal=Nature&amp;volume=553&amp;pages=467-72&amp;publication_year=2018&amp;author=Bakhoum%2CSF&amp;author=Ngo%2CB&amp;author=Laughney%2CAM&amp;author=Cavallo%2CJA&amp;author=Murphy%2CCJ&amp;author=Ly%2CP&amp;author=Shah%2CP&amp;author=Sriram%2CRK&amp;author=Watkins%2CTBK&amp;author=Taunk%2CNK\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR106\">Hong C, Schubert M, Tijhuis AE, Requesens M, Roorda M, van den Brink A, Ruiz LA, Bakker PL, van der Sluis T, Pieters W, et al. cGAS-STING drives the IL-6-dependent survival of chromosomally instable cancers. Nature. 2022;607:366\u201373.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BB38XhsFaktrjO\" aria-label=\"CAS reference 106\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=35705809\" aria-label=\"PubMed reference 106\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 106\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=cGAS-STING%20drives%20the%20IL-6-dependent%20survival%20of%20chromosomally%20instable%20cancers&amp;journal=Nature&amp;volume=607&amp;pages=366-73&amp;publication_year=2022&amp;author=Hong%2CC&amp;author=Schubert%2CM&amp;author=Tijhuis%2CAE&amp;author=Requesens%2CM&amp;author=Roorda%2CM&amp;author=Brink%2CA&amp;author=Ruiz%2CLA&amp;author=Bakker%2CPL&amp;author=Sluis%2CT&amp;author=Pieters%2CW\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR107\">Li J, Hubisz MJ, Earlie EM, Duran MA, Hong C, Varela AA, Lettera E, Deyell M, Tavora B, Havel JJ, et al. Non-cell-autonomous cancer progression from chromosomal instability. Nature. 2023;620:1080\u20138.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BB3sXhslGrs7nL\" aria-label=\"CAS reference 107\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=37612508\" aria-label=\"PubMed reference 107\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC10468402\" aria-label=\"PubMed Central reference 107\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 107\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Non-cell-autonomous%20cancer%20progression%20from%20chromosomal%20instability&amp;journal=Nature&amp;volume=620&amp;pages=1080-8&amp;publication_year=2023&amp;author=Li%2CJ&amp;author=Hubisz%2CMJ&amp;author=Earlie%2CEM&amp;author=Duran%2CMA&amp;author=Hong%2CC&amp;author=Varela%2CAA&amp;author=Lettera%2CE&amp;author=Deyell%2CM&amp;author=Tavora%2CB&amp;author=Havel%2CJJ\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR108\">Zeng Q, Yao C, Zhang S, Mao Y, Wang J, Wang Z, Sheng C, Chen S. ORMDL3 restrains type I interferon signaling and anti-tumor immunity by promoting RIG-I degradation. Elife. 2025;13:RP101973.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=40126553\" aria-label=\"PubMed reference 108\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC11932694\" aria-label=\"PubMed Central reference 108\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 108\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=ORMDL3%20restrains%20type%20I%20interferon%20signaling%20and%20anti-tumor%20immunity%20by%20promoting%20RIG-I%20degradation&amp;journal=Elife&amp;volume=13&amp;publication_year=2025&amp;author=Zeng%2CQ&amp;author=Yao%2CC&amp;author=Zhang%2CS&amp;author=Mao%2CY&amp;author=Wang%2CJ&amp;author=Wang%2CZ&amp;author=Sheng%2CC&amp;author=Chen%2CS\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR109\">Lai P, Liu L, Bancaro N, Troiani M, Cal\u00ec B, Li Y, Chen J, Singh PK, Arzola RA, Attanasio G, et al. Mitochondrial DNA released by senescent tumor cells enhances PMN-MDSC-driven immunosuppression through the cGAS-STING pathway. Immunity. 2025;58:811\u2013e825817.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BB2MXotlaktL8%3D\" aria-label=\"CAS reference 109\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=40203808\" aria-label=\"PubMed reference 109\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 109\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Mitochondrial%20DNA%20released%20by%20senescent%20tumor%20cells%20enhances%20PMN-MDSC-driven%20immunosuppression%20through%20the%20cGAS-STING%20pathway&amp;journal=Immunity&amp;volume=58&amp;pages=811-e825817&amp;publication_year=2025&amp;author=Lai%2CP&amp;author=Liu%2CL&amp;author=Bancaro%2CN&amp;author=Troiani%2CM&amp;author=Cal%C3%AC%2CB&amp;author=Li%2CY&amp;author=Chen%2CJ&amp;author=Singh%2CPK&amp;author=Arzola%2CRA&amp;author=Attanasio%2CG\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR110\">Chen J, Cao Y, Markelc B, Kaeppler J, Vermeer JA, Muschel RJ. Type I IFN protects cancer cells from CD8\u2009+\u2009T cell-mediated cytotoxicity after radiation. J Clin Invest. 2019;129:4224\u201338.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=31483286\" aria-label=\"PubMed reference 110\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC6763250\" aria-label=\"PubMed Central reference 110\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 110\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Type%20I%20IFN%20protects%20cancer%20cells%20from%20CD8%E2%80%89%2B%E2%80%89T%20cell-mediated%20cytotoxicity%20after%20radiation&amp;journal=J%20Clin%20Invest&amp;volume=129&amp;pages=4224-38&amp;publication_year=2019&amp;author=Chen%2CJ&amp;author=Cao%2CY&amp;author=Markelc%2CB&amp;author=Kaeppler%2CJ&amp;author=Vermeer%2CJA&amp;author=Muschel%2CRJ\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR111\">Galassi C, Esteller M, Vitale I, Galluzzi L. Epigenetic control of immunoevasion in cancer stem cells. Trends Cancer. 2024;10:1052\u201371.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BB2cXhvFartLjM\" aria-label=\"CAS reference 111\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=39244477\" aria-label=\"PubMed reference 111\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 111\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Epigenetic%20control%20of%20immunoevasion%20in%20cancer%20stem%20cells&amp;journal=Trends%20Cancer&amp;volume=10&amp;pages=1052-71&amp;publication_year=2024&amp;author=Galassi%2CC&amp;author=Esteller%2CM&amp;author=Vitale%2CI&amp;author=Galluzzi%2CL\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR112\">Qadir AS, Ceppi P, Brockway S, Law C, Mu L, Khodarev NN, Kim J, Zhao JC, Putzbach W, Murmann AE, et al. CD95\/Fas increases stemness in cancer cells by inducing a STAT1-Dependent type I interferon response. Cell Rep. 2017;18:2373\u201386.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BC2sXjvF2hsbw%3D\" aria-label=\"CAS reference 112\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=28273453\" aria-label=\"PubMed reference 112\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5474321\" aria-label=\"PubMed Central reference 112\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 112\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=CD95%2FFas%20increases%20stemness%20in%20cancer%20cells%20by%20inducing%20a%20STAT1-Dependent%20type%20I%20interferon%20response&amp;journal=Cell%20Rep&amp;volume=18&amp;pages=2373-86&amp;publication_year=2017&amp;author=Qadir%2CAS&amp;author=Ceppi%2CP&amp;author=Brockway%2CS&amp;author=Law%2CC&amp;author=Mu%2CL&amp;author=Khodarev%2CNN&amp;author=Kim%2CJ&amp;author=Zhao%2CJC&amp;author=Putzbach%2CW&amp;author=Murmann%2CAE\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR113\">Musella M, Guarracino A, Manduca N, Galassi C, Ruggiero E, Potenza A, Maccafeo E, Manic G, Mattiello L, Soliman Abdel Rehim S, et al. Type I IFNs promote cancer cell stemness by triggering the epigenetic regulator KDM1B. Nat Immunol. 2022;23:1379\u201392.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BB38Xit1WqtrjJ\" aria-label=\"CAS reference 113\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=36002648\" aria-label=\"PubMed reference 113\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9477743\" aria-label=\"PubMed Central reference 113\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 113\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Type%20I%20IFNs%20promote%20cancer%20cell%20stemness%20by%20triggering%20the%20epigenetic%20regulator%20KDM1B&amp;journal=Nat%20Immunol&amp;volume=23&amp;pages=1379-92&amp;publication_year=2022&amp;author=Musella%2CM&amp;author=Guarracino%2CA&amp;author=Manduca%2CN&amp;author=Galassi%2CC&amp;author=Ruggiero%2CE&amp;author=Potenza%2CA&amp;author=Maccafeo%2CE&amp;author=Manic%2CG&amp;author=Mattiello%2CL&amp;author=Soliman%20Abdel%20Rehim%2CS\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR114\">Qiu J, Xu B, Ye D, Ren D, Wang S, Benci JL, Xu Y, Ishwaran H, Beltra JC, Wherry EJ, et al. Cancer cells resistant to immune checkpoint Blockade acquire interferon-associated epigenetic memory to sustain T cell dysfunction. Nat Cancer. 2023;4:43\u201361.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BB3sXhslKhs7o%3D\" aria-label=\"CAS reference 114\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=36646856\" aria-label=\"PubMed reference 114\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 114\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Cancer%20cells%20resistant%20to%20immune%20checkpoint%20Blockade%20acquire%20interferon-associated%20epigenetic%20memory%20to%20sustain%20T%20cell%20dysfunction&amp;journal=Nat%20Cancer&amp;volume=4&amp;pages=43-61&amp;publication_year=2023&amp;author=Qiu%2CJ&amp;author=Xu%2CB&amp;author=Ye%2CD&amp;author=Ren%2CD&amp;author=Wang%2CS&amp;author=Benci%2CJL&amp;author=Xu%2CY&amp;author=Ishwaran%2CH&amp;author=Beltra%2CJC&amp;author=Wherry%2CEJ\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR115\">Kamada R, Yang W, Zhang Y, Patel MC, Yang Y, Ouda R, Dey A, Wakabayashi Y, Sakaguchi K, Fujita T, et al. Interferon stimulation creates chromatin marks and establishes transcriptional memory. Proc Natl Acad Sci U S A. 2018;115:E9162\u201371.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BC1cXhvVGisL3E\" aria-label=\"CAS reference 115\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=30201712\" aria-label=\"PubMed reference 115\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC6166839\" aria-label=\"PubMed Central reference 115\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 115\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Interferon%20stimulation%20creates%20chromatin%20marks%20and%20establishes%20transcriptional%20memory&amp;journal=Proc%20Natl%20Acad%20Sci%20U%20S%20A&amp;volume=115&amp;pages=E9162-71&amp;publication_year=2018&amp;author=Kamada%2CR&amp;author=Yang%2CW&amp;author=Zhang%2CY&amp;author=Patel%2CMC&amp;author=Yang%2CY&amp;author=Ouda%2CR&amp;author=Dey%2CA&amp;author=Wakabayashi%2CY&amp;author=Sakaguchi%2CK&amp;author=Fujita%2CT\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR116\">Cheon H, Wang Y, Wightman SM, Jackson MW, Stark GR. How cancer cells make and respond to interferon-I. Trends Cancer. 2023;9:83\u201392.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BB38Xis1aisbfO\" aria-label=\"CAS reference 116\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=36216730\" aria-label=\"PubMed reference 116\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 116\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=How%20cancer%20cells%20make%20and%20respond%20to%20interferon-I&amp;journal=Trends%20Cancer&amp;volume=9&amp;pages=83-92&amp;publication_year=2023&amp;author=Cheon%2CH&amp;author=Wang%2CY&amp;author=Wightman%2CSM&amp;author=Jackson%2CMW&amp;author=Stark%2CGR\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR117\">Rothenfusser S, Goutagny N, DiPerna G, Gong M, Monks BG, Schoenemeyer A, Yamamoto M, Akira S, Fitzgerald KA. The RNA helicase Lgp2 inhibits TLR-independent sensing of viral replication by retinoic acid-inducible gene-I. J Immunol. 2005;175:5260\u20138.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BD2MXhtVylsbbE\" aria-label=\"CAS reference 117\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=16210631\" aria-label=\"PubMed reference 117\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 117\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=The%20RNA%20helicase%20Lgp2%20inhibits%20TLR-independent%20sensing%20of%20viral%20replication%20by%20retinoic%20acid-inducible%20gene-I&amp;journal=J%20Immunol&amp;volume=175&amp;pages=5260-8&amp;publication_year=2005&amp;author=Rothenfusser%2CS&amp;author=Goutagny%2CN&amp;author=DiPerna%2CG&amp;author=Gong%2CM&amp;author=Monks%2CBG&amp;author=Schoenemeyer%2CA&amp;author=Yamamoto%2CM&amp;author=Akira%2CS&amp;author=Fitzgerald%2CKA\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR118\">Yonesaka K, Kurosaki T, Tanizaki J, Kawakami H, Tanaka K, Maenishi O, Takamura S, Sakai K, Chiba Y, Teramura T, et al. Chromosomal instability is associated with cGAS-STING activation in EGFR-TKI refractory Non-Small-Cell lung cancer. Cells. 2025;14:447.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BB2MXns1KmtL4%3D\" aria-label=\"CAS reference 118\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=40136696\" aria-label=\"PubMed reference 118\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC11941500\" aria-label=\"PubMed Central reference 118\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 118\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Chromosomal%20instability%20is%20associated%20with%20cGAS-STING%20activation%20in%20EGFR-TKI%20refractory%20Non-Small-Cell%20lung%20cancer&amp;journal=Cells&amp;volume=14&amp;publication_year=2025&amp;author=Yonesaka%2CK&amp;author=Kurosaki%2CT&amp;author=Tanizaki%2CJ&amp;author=Kawakami%2CH&amp;author=Tanaka%2CK&amp;author=Maenishi%2CO&amp;author=Takamura%2CS&amp;author=Sakai%2CK&amp;author=Chiba%2CY&amp;author=Teramura%2CT\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR119\">Benci JL, Johnson LR, Choa R, Xu Y, Qiu J, Zhou Z, Xu B, Ye D, Nathanson KL, June CH, et al. Opposing functions of interferon coordinate adaptive and innate immune responses to cancer immune checkpoint Blockade. Cell. 2019;178:933\u2013e948914.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BC1MXhsFKktrjP\" aria-label=\"CAS reference 119\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=31398344\" aria-label=\"PubMed reference 119\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC6830508\" aria-label=\"PubMed Central reference 119\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 119\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Opposing%20functions%20of%20interferon%20coordinate%20adaptive%20and%20innate%20immune%20responses%20to%20cancer%20immune%20checkpoint%20Blockade&amp;journal=Cell&amp;volume=178&amp;pages=933-e948914&amp;publication_year=2019&amp;author=Benci%2CJL&amp;author=Johnson%2CLR&amp;author=Choa%2CR&amp;author=Xu%2CY&amp;author=Qiu%2CJ&amp;author=Zhou%2CZ&amp;author=Xu%2CB&amp;author=Ye%2CD&amp;author=Nathanson%2CKL&amp;author=June%2CCH\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR120\">Ma W, Oliveira-Nunes MC, Xu K, Kossenkov A, Reiner BC, Crist RC, Hayden J, Chen Q. Type I interferon response in astrocytes promotes brain metastasis by enhancing monocytic myeloid cell recruitment. Nat Commun. 2023;14:2632.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BB3sXpsV2is7w%3D\" aria-label=\"CAS reference 120\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=37149684\" aria-label=\"PubMed reference 120\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC10163863\" aria-label=\"PubMed Central reference 120\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 120\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Type%20I%20interferon%20response%20in%20astrocytes%20promotes%20brain%20metastasis%20by%20enhancing%20monocytic%20myeloid%20cell%20recruitment&amp;journal=Nat%20Commun&amp;volume=14&amp;publication_year=2023&amp;author=Ma%2CW&amp;author=Oliveira-Nunes%2CMC&amp;author=Xu%2CK&amp;author=Kossenkov%2CA&amp;author=Reiner%2CBC&amp;author=Crist%2CRC&amp;author=Hayden%2CJ&amp;author=Chen%2CQ\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR121\">Dikopoulos N, Bertoletti A, Kr\u00f6ger A, Hauser H, Schirmbeck R, Reimann J. Type I IFN negatively regulates CD8\u2009+\u2009T cell responses through IL-10-producing CD4\u2009+\u2009T regulatory 1 cells. J Immunol. 2005;174:99\u2013109.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BD2cXhtFaiu7%2FF\" aria-label=\"CAS reference 121\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=15611232\" aria-label=\"PubMed reference 121\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 121\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Type%20I%20IFN%20negatively%20regulates%20CD8%E2%80%89%2B%E2%80%89T%20cell%20responses%20through%20IL-10-producing%20CD4%E2%80%89%2B%E2%80%89T%20regulatory%201%20cells&amp;journal=J%20Immunol&amp;volume=174&amp;pages=99-109&amp;publication_year=2005&amp;author=Dikopoulos%2CN&amp;author=Bertoletti%2CA&amp;author=Kr%C3%B6ger%2CA&amp;author=Hauser%2CH&amp;author=Schirmbeck%2CR&amp;author=Reimann%2CJ\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR122\">Chen W, Teo JMN, Yau SW, Wong MY, Lok CN, Che CM, Javed A, Huang Y, Ma S, Ling GS. Chronic type I interferon signaling promotes lipid-peroxidation-driven terminal CD8(+) T cell exhaustion and curtails anti-PD-1 efficacy. Cell Rep. 2022;41:111647.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BB38XivV2ltL3F\" aria-label=\"CAS reference 122\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=36384131\" aria-label=\"PubMed reference 122\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 122\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Chronic%20type%20I%20interferon%20signaling%20promotes%20lipid-peroxidation-driven%20terminal%20CD8%28%2B%29%20T%20cell%20exhaustion%20and%20curtails%20anti-PD-1%20efficacy&amp;journal=Cell%20Rep&amp;volume=41&amp;publication_year=2022&amp;author=Chen%2CW&amp;author=Teo%2CJMN&amp;author=Yau%2CSW&amp;author=Wong%2CMY&amp;author=Lok%2CCN&amp;author=Che%2CCM&amp;author=Javed%2CA&amp;author=Huang%2CY&amp;author=Ma%2CS&amp;author=Ling%2CGS\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR123\">Fridman WH, Zitvogel L, Saut\u00e8s-Fridman C, Kroemer G. The immune contexture in cancer prognosis and treatment. Nat Rev Clin Oncol. 2017;14:717\u201334.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BC2sXht1akt7bM\" aria-label=\"CAS reference 123\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=28741618\" aria-label=\"PubMed reference 123\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 123\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=The%20immune%20contexture%20in%20cancer%20prognosis%20and%20treatment&amp;journal=Nat%20Rev%20Clin%20Oncol&amp;volume=14&amp;pages=717-34&amp;publication_year=2017&amp;author=Fridman%2CWH&amp;author=Zitvogel%2CL&amp;author=Saut%C3%A8s-Fridman%2CC&amp;author=Kroemer%2CG\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR124\">Teijaro JR, Ng C, Lee AM, Sullivan BM, Sheehan KC, Welch M, Schreiber RD, de la Torre JC, Oldstone MB. Persistent LCMV infection is controlled by Blockade of type I interferon signaling. Science. 2013;340:207\u201311.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BC3sXlsFWktLk%3D\" aria-label=\"CAS reference 124\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=23580529\" aria-label=\"PubMed reference 124\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3640797\" aria-label=\"PubMed Central reference 124\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 124\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Persistent%20LCMV%20infection%20is%20controlled%20by%20Blockade%20of%20type%20I%20interferon%20signaling&amp;journal=Science&amp;volume=340&amp;pages=207-11&amp;publication_year=2013&amp;author=Teijaro%2CJR&amp;author=Ng%2CC&amp;author=Lee%2CAM&amp;author=Sullivan%2CBM&amp;author=Sheehan%2CKC&amp;author=Welch%2CM&amp;author=Schreiber%2CRD&amp;author=Torre%2CJC&amp;author=Oldstone%2CMB\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR125\">Wilson EB, Yamada DH, Elsaesser H, Herskovitz J, Deng J, Cheng G, Aronow BJ, Karp CL, Brooks DG. Blockade of chronic type I interferon signaling to control persistent LCMV infection. Science. 2013;340:202\u20137.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BC3sXlsFWktLs%3D\" aria-label=\"CAS reference 125\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=23580528\" aria-label=\"PubMed reference 125\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3704950\" aria-label=\"PubMed Central reference 125\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 125\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Blockade%20of%20chronic%20type%20I%20interferon%20signaling%20to%20control%20persistent%20LCMV%20infection&amp;journal=Science&amp;volume=340&amp;pages=202-7&amp;publication_year=2013&amp;author=Wilson%2CEB&amp;author=Yamada%2CDH&amp;author=Elsaesser%2CH&amp;author=Herskovitz%2CJ&amp;author=Deng%2CJ&amp;author=Cheng%2CG&amp;author=Aronow%2CBJ&amp;author=Karp%2CCL&amp;author=Brooks%2CDG\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR126\">Mathew D, Marmarelis ME, Foley C, Bauml JM, Ye D, Ghinnagow R, Ngiow SF, Klapholz M, Jun S, Zhang Z, et al. Combined JAK Inhibition and PD-1 immunotherapy for non-small cell lung cancer patients. Science. 2024;384:eadf1329.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BB2cXitVenurjL\" aria-label=\"CAS reference 126\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=38900877\" aria-label=\"PubMed reference 126\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC11327955\" aria-label=\"PubMed Central reference 126\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 126\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Combined%20JAK%20Inhibition%20and%20PD-1%20immunotherapy%20for%20non-small%20cell%20lung%20cancer%20patients&amp;journal=Science&amp;volume=384&amp;publication_year=2024&amp;author=Mathew%2CD&amp;author=Marmarelis%2CME&amp;author=Foley%2CC&amp;author=Bauml%2CJM&amp;author=Ye%2CD&amp;author=Ghinnagow%2CR&amp;author=Ngiow%2CSF&amp;author=Klapholz%2CM&amp;author=Jun%2CS&amp;author=Zhang%2CZ\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR127\">Zak J, Pratumchai I, Marro BS, Marquardt KL, Zavareh RB, Lairson LL, Oldstone MBA, Varner JA, Hegerova L, Cao Q, et al. JAK Inhibition enhances checkpoint Blockade immunotherapy in patients with hodgkin lymphoma. Science. 2024;384:eade8520.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BB2cXitVenurnM\" aria-label=\"CAS reference 127\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=38900864\" aria-label=\"PubMed reference 127\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC11283877\" aria-label=\"PubMed Central reference 127\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 127\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=JAK%20Inhibition%20enhances%20checkpoint%20Blockade%20immunotherapy%20in%20patients%20with%20hodgkin%20lymphoma&amp;journal=Science&amp;volume=384&amp;publication_year=2024&amp;author=Zak%2CJ&amp;author=Pratumchai%2CI&amp;author=Marro%2CBS&amp;author=Marquardt%2CKL&amp;author=Zavareh%2CRB&amp;author=Lairson%2CLL&amp;author=Oldstone%2CMBA&amp;author=Varner%2CJA&amp;author=Hegerova%2CL&amp;author=Cao%2CQ\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR128\">Fu T, Jin X, He M, Chen YY, Yang YS, Chen L, Zhang HY, Fan L, Wu J, Wang ZH, et al. Interferon-induced senescent CD8(+) T cells reduce anti-PD1 immunotherapy efficacy in early triple-negative breast cancer. Sci Transl Med. 2025;17:eadj7808.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BB2MXitlSmu7fO\" aria-label=\"CAS reference 128\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=40929245\" aria-label=\"PubMed reference 128\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 128\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Interferon-induced%20senescent%20CD8%28%2B%29%20T%20cells%20reduce%20anti-PD1%20immunotherapy%20efficacy%20in%20early%20triple-negative%20breast%20cancer&amp;journal=Sci%20Transl%20Med&amp;volume=17&amp;publication_year=2025&amp;author=Fu%2CT&amp;author=Jin%2CX&amp;author=He%2CM&amp;author=Chen%2CYY&amp;author=Yang%2CYS&amp;author=Chen%2CL&amp;author=Zhang%2CHY&amp;author=Fan%2CL&amp;author=Wu%2CJ&amp;author=Wang%2CZH\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR129\">Galluzzi L, Smith KN, Liston A, Garg AD. The diversity of CD8(+) T cell dysfunction in cancer and viral infection. Nat Rev Immunol. 2025;25:662\u201379.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BB2MXhvFOrsbnO\" aria-label=\"CAS reference 129\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=40216888\" aria-label=\"PubMed reference 129\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 129\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=The%20diversity%20of%20CD8%28%2B%29%20T%20cell%20dysfunction%20in%20cancer%20and%20viral%20infection&amp;journal=Nat%20Rev%20Immunol&amp;volume=25&amp;pages=662-79&amp;publication_year=2025&amp;author=Galluzzi%2CL&amp;author=Smith%2CKN&amp;author=Liston%2CA&amp;author=Garg%2CAD\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR130\">Mudla A, Jiang Y, Arimoto KI, Xu B, Rajesh A, Ryan AP, Wang W, Daugherty MD, Zhang DE, Hao N. Cell-cycle-gated feedback control mediates desensitization to interferon stimulation. Elife. 2020;9:e58825.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BB3cXisVegtLrK\" aria-label=\"CAS reference 130\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=32945770\" aria-label=\"PubMed reference 130\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC7500952\" aria-label=\"PubMed Central reference 130\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 130\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Cell-cycle-gated%20feedback%20control%20mediates%20desensitization%20to%20interferon%20stimulation&amp;journal=Elife&amp;volume=9&amp;publication_year=2020&amp;author=Mudla%2CA&amp;author=Jiang%2CY&amp;author=Arimoto%2CKI&amp;author=Xu%2CB&amp;author=Rajesh%2CA&amp;author=Ryan%2CAP&amp;author=Wang%2CW&amp;author=Daugherty%2CMD&amp;author=Zhang%2CDE&amp;author=Hao%2CN\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR131\">Kok F, Rosenblatt M, Teusel M, Nizharadze T, Gon\u00e7alves Magalh\u00e3es V, D\u00e4chert C, Maiwald T, Vlasov A, W\u00e4sch M, Tyufekchieva S, et al. Disentangling molecular mechanisms regulating sensitization of interferon alpha signal transduction. Mol Syst Biol. 2020;16:e8955.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BB3cXhsFWqurvI\" aria-label=\"CAS reference 131\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=32696599\" aria-label=\"PubMed reference 131\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC7373899\" aria-label=\"PubMed Central reference 131\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 131\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Disentangling%20molecular%20mechanisms%20regulating%20sensitization%20of%20interferon%20alpha%20signal%20transduction&amp;journal=Mol%20Syst%20Biol&amp;volume=16&amp;publication_year=2020&amp;author=Kok%2CF&amp;author=Rosenblatt%2CM&amp;author=Teusel%2CM&amp;author=Nizharadze%2CT&amp;author=Gon%C3%A7alves%20Magalh%C3%A3es%2CV&amp;author=D%C3%A4chert%2CC&amp;author=Maiwald%2CT&amp;author=Vlasov%2CA&amp;author=W%C3%A4sch%2CM&amp;author=Tyufekchieva%2CS\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR132\">Khodarev NN, Minn AJ, Efimova EV, Darga TE, Labay E, Beckett M, Mauceri HJ, Roizman B, Weichselbaum RR. Signal transducer and activator of transcription 1 regulates both cytotoxic and prosurvival functions in tumor cells. Cancer Res. 2007;67:9214\u201320.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BD2sXhtFSnurzI\" aria-label=\"CAS reference 132\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=17909027\" aria-label=\"PubMed reference 132\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 132\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Signal%20transducer%20and%20activator%20of%20transcription%201%20regulates%20both%20cytotoxic%20and%20prosurvival%20functions%20in%20tumor%20cells&amp;journal=Cancer%20Res&amp;volume=67&amp;pages=9214-20&amp;publication_year=2007&amp;author=Khodarev%2CNN&amp;author=Minn%2CAJ&amp;author=Efimova%2CEV&amp;author=Darga%2CTE&amp;author=Labay%2CE&amp;author=Beckett%2CM&amp;author=Mauceri%2CHJ&amp;author=Roizman%2CB&amp;author=Weichselbaum%2CRR\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR133\">Sung PS, Cheon H, Cho CH, Hong SH, Park DY, Seo HI, Park SH, Yoon SK, Stark GR, Shin EC. Roles of unphosphorylated ISGF3 in HCV infection and interferon responsiveness. Proc Natl Acad Sci U S A. 2015;112:10443\u20138.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BC2MXht1Crt7rK\" aria-label=\"CAS reference 133\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=26216956\" aria-label=\"PubMed reference 133\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4547285\" aria-label=\"PubMed Central reference 133\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 133\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Roles%20of%20unphosphorylated%20ISGF3%20in%20HCV%20infection%20and%20interferon%20responsiveness&amp;journal=Proc%20Natl%20Acad%20Sci%20U%20S%20A&amp;volume=112&amp;pages=10443-8&amp;publication_year=2015&amp;author=Sung%2CPS&amp;author=Cheon%2CH&amp;author=Cho%2CCH&amp;author=Hong%2CSH&amp;author=Park%2CDY&amp;author=Seo%2CHI&amp;author=Park%2CSH&amp;author=Yoon%2CSK&amp;author=Stark%2CGR&amp;author=Shin%2CEC\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR134\">Wang W, Yin Y, Xu L, Su J, Huang F, Wang Y, Boor PPC, Chen K, Wang W, Cao W, et al. Unphosphorylated ISGF3 drives constitutive expression of interferon-stimulated genes to protect against viral infections. Sci Signal. 2017;10:eaah4248.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=28442624\" aria-label=\"PubMed reference 134\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 134\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Unphosphorylated%20ISGF3%20drives%20constitutive%20expression%20of%20interferon-stimulated%20genes%20to%20protect%20against%20viral%20infections&amp;journal=Sci%20Signal&amp;volume=10&amp;publication_year=2017&amp;author=Wang%2CW&amp;author=Yin%2CY&amp;author=Xu%2CL&amp;author=Su%2CJ&amp;author=Huang%2CF&amp;author=Wang%2CY&amp;author=Boor%2CPPC&amp;author=Chen%2CK&amp;author=Wang%2CW&amp;author=Cao%2CW\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR135\">Zierhut C, Yamaguchi N, Paredes M, Luo JD, Carroll T, Funabiki H. The cytoplasmic DNA sensor cGAS promotes mitotic cell death. Cell. 2019;178:302\u2013e315323.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BC1MXhtlKlu7vP\" aria-label=\"CAS reference 135\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=31299200\" aria-label=\"PubMed reference 135\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC6693521\" aria-label=\"PubMed Central reference 135\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 135\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=The%20cytoplasmic%20DNA%20sensor%20cGAS%20promotes%20mitotic%20cell%20death&amp;journal=Cell&amp;volume=178&amp;pages=302-e315323&amp;publication_year=2019&amp;author=Zierhut%2CC&amp;author=Yamaguchi%2CN&amp;author=Paredes%2CM&amp;author=Luo%2CJD&amp;author=Carroll%2CT&amp;author=Funabiki%2CH\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR136\">Vitale I, Shema E, Loi S, Galluzzi L. Intratumoral heterogeneity in cancer progression and response to immunotherapy. Nat Med. 2021;27:212\u201324.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BB3MXjvVOnsb0%3D\" aria-label=\"CAS reference 136\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=33574607\" aria-label=\"PubMed reference 136\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 136\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Intratumoral%20heterogeneity%20in%20cancer%20progression%20and%20response%20to%20immunotherapy&amp;journal=Nat%20Med&amp;volume=27&amp;pages=212-24&amp;publication_year=2021&amp;author=Vitale%2CI&amp;author=Shema%2CE&amp;author=Loi%2CS&amp;author=Galluzzi%2CL\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR137\">Osokine I, Snell LM, Cunningham CR, Yamada DH, Wilson EB, Elsaesser HJ, de la Torre JC, Brooks D. Type I interferon suppresses de Novo virus-specific CD4 Th1 immunity during an established persistent viral infection. Proc Natl Acad Sci U S A. 2014;111:7409\u201314.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BC2cXnsVagsbo%3D\" aria-label=\"CAS reference 137\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=24799699\" aria-label=\"PubMed reference 137\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4034239\" aria-label=\"PubMed Central reference 137\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 137\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Type%20I%20interferon%20suppresses%20de%20Novo%20virus-specific%20CD4%20Th1%20immunity%20during%20an%20established%20persistent%20viral%20infection&amp;journal=Proc%20Natl%20Acad%20Sci%20U%20S%20A&amp;volume=111&amp;pages=7409-14&amp;publication_year=2014&amp;author=Osokine%2CI&amp;author=Snell%2CLM&amp;author=Cunningham%2CCR&amp;author=Yamada%2CDH&amp;author=Wilson%2CEB&amp;author=Elsaesser%2CHJ&amp;author=Torre%2CJC&amp;author=Brooks%2CD\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR138\">Cunningham CR, Champhekar A, Tullius MV, Dillon BJ, Zhen A, de la Fuente JR, Herskovitz J, Elsaesser H, Snell LM, Wilson EB, et al. Type I and type II interferon coordinately regulate suppressive dendritic cell fate and function during viral persistence. PLoS Pathog. 2016;12:e1005356.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=26808628\" aria-label=\"PubMed reference 138\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4726812\" aria-label=\"PubMed Central reference 138\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 138\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Type%20I%20and%20type%20II%20interferon%20coordinately%20regulate%20suppressive%20dendritic%20cell%20fate%20and%20function%20during%20viral%20persistence&amp;journal=PLoS%20Pathog&amp;volume=12&amp;publication_year=2016&amp;author=Cunningham%2CCR&amp;author=Champhekar%2CA&amp;author=Tullius%2CMV&amp;author=Dillon%2CBJ&amp;author=Zhen%2CA&amp;author=Fuente%2CJR&amp;author=Herskovitz%2CJ&amp;author=Elsaesser%2CH&amp;author=Snell%2CLM&amp;author=Wilson%2CEB\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR139\">Gebhardt T, Park SL, Parish IA. Stem-like exhausted and memory CD8(+) T cells in cancer. Nat Rev Cancer. 2023;23:780\u201398.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BB3sXitFWjtrfK\" aria-label=\"CAS reference 139\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=37821656\" aria-label=\"PubMed reference 139\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 139\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Stem-like%20exhausted%20and%20memory%20CD8%28%2B%29%20T%20cells%20in%20cancer&amp;journal=Nat%20Rev%20Cancer&amp;volume=23&amp;pages=780-98&amp;publication_year=2023&amp;author=Gebhardt%2CT&amp;author=Park%2CSL&amp;author=Parish%2CIA\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR140\">Broomfield BJ, Tan CW, Qin RZ, Abberger H, Duckworth BC, Alvarado C, Dalit L, Lee CL, Shandre Mugan R, Mazrad ZAI, et al. Transient Inhibition of type I interferon enhances CD8\u2009+\u2009T cell stemness and vaccine protection. J Exp Med. 2025;222:e20241148.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BB2MXpsVKntb4%3D\" aria-label=\"CAS reference 140\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=40062995\" aria-label=\"PubMed reference 140\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC11893171\" aria-label=\"PubMed Central reference 140\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 140\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Transient%20Inhibition%20of%20type%20I%20interferon%20enhances%20CD8%E2%80%89%2B%E2%80%89T%20cell%20stemness%20and%20vaccine%20protection&amp;journal=J%20Exp%20Med&amp;volume=222&amp;publication_year=2025&amp;author=Broomfield%2CBJ&amp;author=Tan%2CCW&amp;author=Qin%2CRZ&amp;author=Abberger%2CH&amp;author=Duckworth%2CBC&amp;author=Alvarado%2CC&amp;author=Dalit%2CL&amp;author=Lee%2CCL&amp;author=Shandre%20Mugan%2CR&amp;author=Mazrad%2CZAI\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR141\">Gauci L. Management of cancer patients receiving interferon alfa-2a. Int J Cancer Suppl. 1987;1:21\u201330.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:STN:280:DyaL2szgslSltA%3D%3D\" aria-label=\"CAS reference 141\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=3476474\" aria-label=\"PubMed reference 141\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 141\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Management%20of%20cancer%20patients%20receiving%20interferon%20alfa-2a&amp;journal=Int%20J%20Cancer%20Suppl&amp;volume=1&amp;pages=21-30&amp;publication_year=1987&amp;author=Gauci%2CL\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR142\">Nassar D, Blanpain C. Cancer stem cells: basic concepts and therapeutic implications. Annu Rev Pathol. 2016;11:47\u201376.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BC28XotF2qtLY%3D\" aria-label=\"CAS reference 142\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=27193450\" aria-label=\"PubMed reference 142\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 142\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Cancer%20stem%20cells%3A%20basic%20concepts%20and%20therapeutic%20implications&amp;journal=Annu%20Rev%20Pathol&amp;volume=11&amp;pages=47-76&amp;publication_year=2016&amp;author=Nassar%2CD&amp;author=Blanpain%2CC\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR143\">Alcal\u00e1 S, Sancho P, Martinelli P, Navarro D, Pedrero C, Mart\u00edn-Hijano L, Valle S, Earl J, Rodr\u00edguez-Serrano M, Ruiz-Ca\u00f1as L, et al. ISG15 and isgylation is required for pancreatic cancer stem cell mitophagy and metabolic plasticity. Nat Commun. 2020;11:2682.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=32472071\" aria-label=\"PubMed reference 143\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC7260233\" aria-label=\"PubMed Central reference 143\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 143\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=ISG15%20and%20isgylation%20is%20required%20for%20pancreatic%20cancer%20stem%20cell%20mitophagy%20and%20metabolic%20plasticity&amp;journal=Nat%20Commun&amp;volume=11&amp;publication_year=2020&amp;author=Alcal%C3%A1%2CS&amp;author=Sancho%2CP&amp;author=Martinelli%2CP&amp;author=Navarro%2CD&amp;author=Pedrero%2CC&amp;author=Mart%C3%ADn-Hijano%2CL&amp;author=Valle%2CS&amp;author=Earl%2CJ&amp;author=Rodr%C3%ADguez-Serrano%2CM&amp;author=Ruiz-Ca%C3%B1as%2CL\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR144\">Mills EL, Ryan DG, Prag HA, Dikovskaya D, Menon D, Zaslona Z, Jedrychowski MP, Costa ASH, Higgins M, Hams E, et al. Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1. Nature. 2018;556:113\u20137.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BC1cXmt1aqtL0%3D\" aria-label=\"CAS reference 144\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=29590092\" aria-label=\"PubMed reference 144\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC6047741\" aria-label=\"PubMed Central reference 144\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 144\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Itaconate%20is%20an%20anti-inflammatory%20metabolite%20that%20activates%20Nrf2%20via%20alkylation%20of%20KEAP1&amp;journal=Nature&amp;volume=556&amp;pages=113-7&amp;publication_year=2018&amp;author=Mills%2CEL&amp;author=Ryan%2CDG&amp;author=Prag%2CHA&amp;author=Dikovskaya%2CD&amp;author=Menon%2CD&amp;author=Zaslona%2CZ&amp;author=Jedrychowski%2CMP&amp;author=Costa%2CASH&amp;author=Higgins%2CM&amp;author=Hams%2CE\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR145\">Bourner LA, Chung LA, Long H, McGettrick AF, Xiao J, Roth K, Bailey JD, Strickland M, Tan B, Cunningham J, et al. Endogenously produced Itaconate negatively regulates innate-driven cytokine production and drives global ubiquitination in human macrophages. Cell Rep. 2024;43:114570.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BB2cXhs1OqsLbF\" aria-label=\"CAS reference 145\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=39093697\" aria-label=\"PubMed reference 145\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 145\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Endogenously%20produced%20Itaconate%20negatively%20regulates%20innate-driven%20cytokine%20production%20and%20drives%20global%20ubiquitination%20in%20human%20macrophages&amp;journal=Cell%20Rep&amp;volume=43&amp;publication_year=2024&amp;author=Bourner%2CLA&amp;author=Chung%2CLA&amp;author=Long%2CH&amp;author=McGettrick%2CAF&amp;author=Xiao%2CJ&amp;author=Roth%2CK&amp;author=Bailey%2CJD&amp;author=Strickland%2CM&amp;author=Tan%2CB&amp;author=Cunningham%2CJ\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR146\">Su C, Cheng T, Huang J, Zhang T, Yin H. 4-Octyl Itaconate restricts STING activation by blocking its palmitoylation. Cell Rep. 2023;42:113040.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BB3sXhslCnsbfM\" aria-label=\"CAS reference 146\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=37624697\" aria-label=\"PubMed reference 146\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 146\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=4-Octyl%20Itaconate%20restricts%20STING%20activation%20by%20blocking%20its%20palmitoylation&amp;journal=Cell%20Rep&amp;volume=42&amp;publication_year=2023&amp;author=Su%2CC&amp;author=Cheng%2CT&amp;author=Huang%2CJ&amp;author=Zhang%2CT&amp;author=Yin%2CH\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR147\">O\u2019Carroll SM, Peace CG, Toller-Kawahisa JE, Min Y, Hooftman A, Charki S, Kehoe L, O\u2019Sullivan MJ, Zoller A, McGettrick AF, et al. Itaconate drives mtRNA-mediated type I interferon production through Inhibition of succinate dehydrogenase. Nat Metab. 2024;6:2060\u20139.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=39406969\" aria-label=\"PubMed reference 147\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC12164541\" aria-label=\"PubMed Central reference 147\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 147\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Itaconate%20drives%20mtRNA-mediated%20type%20I%20interferon%20production%20through%20Inhibition%20of%20succinate%20dehydrogenase&amp;journal=Nat%20Metab&amp;volume=6&amp;pages=2060-9&amp;publication_year=2024&amp;author=O%E2%80%99Carroll%2CSM&amp;author=Peace%2CCG&amp;author=Toller-Kawahisa%2CJE&amp;author=Min%2CY&amp;author=Hooftman%2CA&amp;author=Charki%2CS&amp;author=Kehoe%2CL&amp;author=O%E2%80%99Sullivan%2CMJ&amp;author=Zoller%2CA&amp;author=McGettrick%2CAF\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR148\">Van Eyndhoven LC, Singh A, Tel J. Decoding the dynamics of multilayered stochastic antiviral IFN-I responses. Trends Immunol. 2021;42:824\u201339.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=34364820\" aria-label=\"PubMed reference 148\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 148\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Decoding%20the%20dynamics%20of%20multilayered%20stochastic%20antiviral%20IFN-I%20responses&amp;journal=Trends%20Immunol&amp;volume=42&amp;pages=824-39&amp;publication_year=2021&amp;author=Eyndhoven%2CLC&amp;author=Singh%2CA&amp;author=Tel%2CJ\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR149\">Drayman N, Patel P, Vistain L, Tay S. HSV-1 single-cell analysis reveals the activation of anti-viral and developmental programs in distinct sub-populations. Elife. 2019;8:e46339.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=31090537\" aria-label=\"PubMed reference 149\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC6570482\" aria-label=\"PubMed Central reference 149\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 149\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=HSV-1%20single-cell%20analysis%20reveals%20the%20activation%20of%20anti-viral%20and%20developmental%20programs%20in%20distinct%20sub-populations&amp;journal=Elife&amp;volume=8&amp;publication_year=2019&amp;author=Drayman%2CN&amp;author=Patel%2CP&amp;author=Vistain%2CL&amp;author=Tay%2CS\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR150\">Wimmers F, Subedi N, van Buuringen N, Heister D, Vivi\u00e9 J, Beeren-Reinieren I, Woestenenk R, Dolstra H, Piruska A, Jacobs JFM, et al. Single-cell analysis reveals that stochasticity and paracrine signaling control interferon-alpha production by plasmacytoid dendritic cells. Nat Commun. 2018;9:3317.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=30127440\" aria-label=\"PubMed reference 150\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC6102223\" aria-label=\"PubMed Central reference 150\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 150\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Single-cell%20analysis%20reveals%20that%20stochasticity%20and%20paracrine%20signaling%20control%20interferon-alpha%20production%20by%20plasmacytoid%20dendritic%20cells&amp;journal=Nat%20Commun&amp;volume=9&amp;publication_year=2018&amp;author=Wimmers%2CF&amp;author=Subedi%2CN&amp;author=Buuringen%2CN&amp;author=Heister%2CD&amp;author=Vivi%C3%A9%2CJ&amp;author=Beeren-Reinieren%2CI&amp;author=Woestenenk%2CR&amp;author=Dolstra%2CH&amp;author=Piruska%2CA&amp;author=Jacobs%2CJFM\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR151\">Hoekstra ME, Bornes L, Dijkgraaf FE, Philips D, Pardieck IN, Toebes M, Thommen DS, van Rheenen J, Schumacher TNM. Long-distance modulation of bystander tumor cells by CD8(+) T cell-secreted IFN\u03b3. Nat Cancer. 2020;1:291\u2013301.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BB38XjsFeit7Y%3D\" aria-label=\"CAS reference 151\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=32566933\" aria-label=\"PubMed reference 151\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC7305033\" aria-label=\"PubMed Central reference 151\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 151\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Long-distance%20modulation%20of%20bystander%20tumor%20cells%20by%20CD8%28%2B%29%20T%20cell-secreted%20IFN%CE%B3&amp;journal=Nat%20Cancer&amp;volume=1&amp;pages=291-301&amp;publication_year=2020&amp;author=Hoekstra%2CME&amp;author=Bornes%2CL&amp;author=Dijkgraaf%2CFE&amp;author=Philips%2CD&amp;author=Pardieck%2CIN&amp;author=Toebes%2CM&amp;author=Thommen%2CDS&amp;author=Rheenen%2CJ&amp;author=Schumacher%2CTNM\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR152\">Thibaut R, Bost P, Milo I, Cazaux M, Lema\u00eetre F, Garcia Z, Amit I, Breart B, Cornuot C, Schwikowski B, Bousso P. Bystander IFN-\u03b3 activity promotes widespread and sustained cytokine signaling altering the tumor microenvironment. Nat Cancer. 2020;1:302\u201314.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BB38XjsFeitLY%3D\" aria-label=\"CAS reference 152\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=32803171\" aria-label=\"PubMed reference 152\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC7115926\" aria-label=\"PubMed Central reference 152\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 152\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Bystander%20IFN-%CE%B3%20activity%20promotes%20widespread%20and%20sustained%20cytokine%20signaling%20altering%20the%20tumor%20microenvironment&amp;journal=Nat%20Cancer&amp;volume=1&amp;pages=302-14&amp;publication_year=2020&amp;author=Thibaut%2CR&amp;author=Bost%2CP&amp;author=Milo%2CI&amp;author=Cazaux%2CM&amp;author=Lema%C3%AEtre%2CF&amp;author=Garcia%2CZ&amp;author=Amit%2CI&amp;author=Breart%2CB&amp;author=Cornuot%2CC&amp;author=Schwikowski%2CB&amp;author=Bousso%2CP\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR153\">Burnette BC, Liang H, Lee Y, Chlewicki L, Khodarev NN, Weichselbaum RR, Fu YX, Auh SL. The efficacy of radiotherapy relies upon induction of type i interferon-dependent innate and adaptive immunity. Cancer Res. 2011;71:2488\u201396.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BC3MXktVOjtL4%3D\" aria-label=\"CAS reference 153\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=21300764\" aria-label=\"PubMed reference 153\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3070872\" aria-label=\"PubMed Central reference 153\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 153\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=The%20efficacy%20of%20radiotherapy%20relies%20upon%20induction%20of%20type%20i%20interferon-dependent%20innate%20and%20adaptive%20immunity&amp;journal=Cancer%20Res&amp;volume=71&amp;pages=2488-96&amp;publication_year=2011&amp;author=Burnette%2CBC&amp;author=Liang%2CH&amp;author=Lee%2CY&amp;author=Chlewicki%2CL&amp;author=Khodarev%2CNN&amp;author=Weichselbaum%2CRR&amp;author=Fu%2CYX&amp;author=Auh%2CSL\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR154\">Vanpouille-Box C, Alard A, Aryankalayil MJ, Sarfraz Y, Diamond JM, Schneider RJ, Inghirami G, Coleman CN, Formenti SC, Demaria S. DNA exonuclease Trex1 regulates radiotherapy-induced tumour immunogenicity. Nat Commun. 2017;8:15618.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=28598415\" aria-label=\"PubMed reference 154\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5472757\" aria-label=\"PubMed Central reference 154\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 154\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=DNA%20exonuclease%20Trex1%20regulates%20radiotherapy-induced%20tumour%20immunogenicity&amp;journal=Nat%20Commun&amp;volume=8&amp;publication_year=2017&amp;author=Vanpouille-Box%2CC&amp;author=Alard%2CA&amp;author=Aryankalayil%2CMJ&amp;author=Sarfraz%2CY&amp;author=Diamond%2CJM&amp;author=Schneider%2CRJ&amp;author=Inghirami%2CG&amp;author=Coleman%2CCN&amp;author=Formenti%2CSC&amp;author=Demaria%2CS\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR155\">Deng L, Liang H, Xu M, Yang X, Burnette B, Arina A, Li XD, Mauceri H, Beckett M, Darga T, et al. STING-Dependent cytosolic DNA sensing promotes Radiation-Induced type I Interferon-Dependent antitumor immunity in Immunogenic tumors. Immunity. 2014;41:843\u201352.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BC2cXhvFOitrbM\" aria-label=\"CAS reference 155\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=25517616\" aria-label=\"PubMed reference 155\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5155593\" aria-label=\"PubMed Central reference 155\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 155\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=STING-Dependent%20cytosolic%20DNA%20sensing%20promotes%20Radiation-Induced%20type%20I%20Interferon-Dependent%20antitumor%20immunity%20in%20Immunogenic%20tumors&amp;journal=Immunity&amp;volume=41&amp;pages=843-52&amp;publication_year=2014&amp;author=Deng%2CL&amp;author=Liang%2CH&amp;author=Xu%2CM&amp;author=Yang%2CX&amp;author=Burnette%2CB&amp;author=Arina%2CA&amp;author=Li%2CXD&amp;author=Mauceri%2CH&amp;author=Beckett%2CM&amp;author=Darga%2CT\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR156\">Klionsky DJ, Petroni G, Amaravadi RK, Baehrecke EH, Ballabio A, Boya P, Bravo-San Pedro JM, Cadwell K, Cecconi F, Choi AMK, et al. Autophagy in major human diseases. Embo J. 2021;40:e108863.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BB3MXhvFWqtLrO\" aria-label=\"CAS reference 156\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=34459017\" aria-label=\"PubMed reference 156\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC8488577\" aria-label=\"PubMed Central reference 156\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 156\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Autophagy%20in%20major%20human%20diseases&amp;journal=Embo%20J&amp;volume=40&amp;publication_year=2021&amp;author=Klionsky%2CDJ&amp;author=Petroni%2CG&amp;author=Amaravadi%2CRK&amp;author=Baehrecke%2CEH&amp;author=Ballabio%2CA&amp;author=Boya%2CP&amp;author=Bravo-San%20Pedro%2CJM&amp;author=Cadwell%2CK&amp;author=Cecconi%2CF&amp;author=Choi%2CAMK\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR157\">Xia H, Green DR, Zou W. Autophagy in tumour immunity and therapy. Nat Rev Cancer. 2021;21:281\u201397.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BB3MXntFymu7o%3D\" aria-label=\"CAS reference 157\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=33758415\" aria-label=\"PubMed reference 157\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC8087647\" aria-label=\"PubMed Central reference 157\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 157\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Autophagy%20in%20tumour%20immunity%20and%20therapy&amp;journal=Nat%20Rev%20Cancer&amp;volume=21&amp;pages=281-97&amp;publication_year=2021&amp;author=Xia%2CH&amp;author=Green%2CDR&amp;author=Zou%2CW\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR158\">Suvac A, Ashton J, Bristow RG. Tumour hypoxia in driving genomic instability and tumour evolution. Nat Rev Cancer. 2025;25:167\u201388.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BB2MXisFCntb8%3D\" aria-label=\"CAS reference 158\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=39875616\" aria-label=\"PubMed reference 158\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 158\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Tumour%20hypoxia%20in%20driving%20genomic%20instability%20and%20tumour%20evolution&amp;journal=Nat%20Rev%20Cancer&amp;volume=25&amp;pages=167-88&amp;publication_year=2025&amp;author=Suvac%2CA&amp;author=Ashton%2CJ&amp;author=Bristow%2CRG\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR159\">Qin W, Duan Y, Hu Z, Hou Y, Wen T, Ouyang Y, Wang Z, Sun X, Chen X, Wang KL, et al. PCK1 inhibits cGAS-STING activation by consumption of GTP to promote tumor immune evasion. J Exp Med. 2025;222:e20240902.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BB2MXpsVKnt70%3D\" aria-label=\"CAS reference 159\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=40048154\" aria-label=\"PubMed reference 159\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 159\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=PCK1%20inhibits%20cGAS-STING%20activation%20by%20consumption%20of%20GTP%20to%20promote%20tumor%20immune%20evasion&amp;journal=J%20Exp%20Med&amp;volume=222&amp;publication_year=2025&amp;author=Qin%2CW&amp;author=Duan%2CY&amp;author=Hu%2CZ&amp;author=Hou%2CY&amp;author=Wen%2CT&amp;author=Ouyang%2CY&amp;author=Wang%2CZ&amp;author=Sun%2CX&amp;author=Chen%2CX&amp;author=Wang%2CKL\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR160\">Mazure NM, Pouyss\u00e9gur J. Hypoxia-induced autophagy: cell death or cell survival? Curr Opin Cell Biol. 2010;22:177\u201380.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BC3cXks1Srtb8%3D\" aria-label=\"CAS reference 160\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=20022734\" aria-label=\"PubMed reference 160\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 160\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Hypoxia-induced%20autophagy%3A%20cell%20death%20or%20cell%20survival%3F&amp;journal=Curr%20Opin%20Cell%20Biol&amp;volume=22&amp;pages=177-80&amp;publication_year=2010&amp;author=Mazure%2CNM&amp;author=Pouyss%C3%A9gur%2CJ\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR161\">Vasquez Ayala A, Hsu CY, Oles RE, Matsuo K, Loomis LR, Buzun E, Carrillo Terrazas M, Gerner RR, Lu HH, Kim S, et al. Commensal bacteria promote type I interferon signaling to maintain immune tolerance in mice. J Exp Med. 2024;221:e20230063.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=38085267\" aria-label=\"PubMed reference 161\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 161\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Commensal%20bacteria%20promote%20type%20I%20interferon%20signaling%20to%20maintain%20immune%20tolerance%20in%20mice&amp;journal=J%20Exp%20Med&amp;volume=221&amp;publication_year=2024&amp;author=Vasquez%20Ayala%2CA&amp;author=Hsu%2CCY&amp;author=Oles%2CRE&amp;author=Matsuo%2CK&amp;author=Loomis%2CLR&amp;author=Buzun%2CE&amp;author=Carrillo%20Terrazas%2CM&amp;author=Gerner%2CRR&amp;author=Lu%2CHH&amp;author=Kim%2CS\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR162\">Porcari S, Ng SC, Zitvogel L, Sokol H, Weersma RK, Elinav E, Gasbarrini A, Cammarota G, Tilg H, Ianiro G. The Microbiome for clinicians. Cell. 2025;188:2836\u201344.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BB2MXht1GlurjM\" aria-label=\"CAS reference 162\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=40446358\" aria-label=\"PubMed reference 162\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 162\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=The%20Microbiome%20for%20clinicians&amp;journal=Cell&amp;volume=188&amp;pages=2836-44&amp;publication_year=2025&amp;author=Porcari%2CS&amp;author=Ng%2CSC&amp;author=Zitvogel%2CL&amp;author=Sokol%2CH&amp;author=Weersma%2CRK&amp;author=Elinav%2CE&amp;author=Gasbarrini%2CA&amp;author=Cammarota%2CG&amp;author=Tilg%2CH&amp;author=Ianiro%2CG\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR163\">Silva CAC, Fidelle M, Almonte AA, Derosa L, Zitvogel L. Gut Microbiota-Related biomarkers in Immuno-Oncology. Annu Rev Pharmacol Toxicol. 2025;65:333\u201354.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BB2MXit1alsbs%3D\" aria-label=\"CAS reference 163\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=39259979\" aria-label=\"PubMed reference 163\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 163\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Gut%20Microbiota-Related%20biomarkers%20in%20Immuno-Oncology&amp;journal=Annu%20Rev%20Pharmacol%20Toxicol&amp;volume=65&amp;pages=333-54&amp;publication_year=2025&amp;author=Silva%2CCAC&amp;author=Fidelle%2CM&amp;author=Almonte%2CAA&amp;author=Derosa%2CL&amp;author=Zitvogel%2CL\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR164\">Abraham S, Choi JG, Ortega NM, Zhang J, Shankar P, Swamy NM. Gene therapy with plasmids encoding IFN-\u03b2 or IFN-\u03b114 confers long-term resistance to HIV-1 in humanized mice. Oncotarget. 2016;7:78412\u201320.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=27729616\" aria-label=\"PubMed reference 164\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5346649\" aria-label=\"PubMed Central reference 164\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 164\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Gene%20therapy%20with%20plasmids%20encoding%20IFN-%CE%B2%20or%20IFN-%CE%B114%20confers%20long-term%20resistance%20to%20HIV-1%20in%20humanized%20mice&amp;journal=Oncotarget&amp;volume=7&amp;pages=78412-20&amp;publication_year=2016&amp;author=Abraham%2CS&amp;author=Choi%2CJG&amp;author=Ortega%2CNM&amp;author=Zhang%2CJ&amp;author=Shankar%2CP&amp;author=Swamy%2CNM\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR165\">Barnes SA, Audsley KM, Newnes HV, Fernandez S, de Jong E, Waithman J, Foley B. Type I interferon subtypes differentially activate the anti-leukaemic function of natural killer cells. Front Immunol. 2022;13:1050718.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BB3sXpsFSmtg%3D%3D\" aria-label=\"CAS reference 165\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=36505400\" aria-label=\"PubMed reference 165\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9731670\" aria-label=\"PubMed Central reference 165\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 165\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Type%20I%20interferon%20subtypes%20differentially%20activate%20the%20anti-leukaemic%20function%20of%20natural%20killer%20cells&amp;journal=Front%20Immunol&amp;volume=13&amp;publication_year=2022&amp;author=Barnes%2CSA&amp;author=Audsley%2CKM&amp;author=Newnes%2CHV&amp;author=Fernandez%2CS&amp;author=Jong%2CE&amp;author=Waithman%2CJ&amp;author=Foley%2CB\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR166\">Buzzai AC, Wagner T, Audsley KM, Newnes HV, Barrett LW, Barnes S, Wylie BC, Stone S, McDonnell A, Fear VS, et al. Diverse Anti-Tumor immune potential driven by individual IFN\u03b1 subtypes. Front Immunol. 2020;11:542.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BB3cXitVWnsbvP\" aria-label=\"CAS reference 166\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=32308653\" aria-label=\"PubMed reference 166\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC7145903\" aria-label=\"PubMed Central reference 166\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 166\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Diverse%20Anti-Tumor%20immune%20potential%20driven%20by%20individual%20IFN%CE%B1%20subtypes&amp;journal=Front%20Immunol&amp;volume=11&amp;publication_year=2020&amp;author=Buzzai%2CAC&amp;author=Wagner%2CT&amp;author=Audsley%2CKM&amp;author=Newnes%2CHV&amp;author=Barrett%2CLW&amp;author=Barnes%2CS&amp;author=Wylie%2CBC&amp;author=Stone%2CS&amp;author=McDonnell%2CA&amp;author=Fear%2CVS\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR167\">Newnes HV, Armitage JD, Buzzai AC, de Jong E, Audsley KM, Barnes SA, Srinivasan S, Serralha M, Fear VS, Guo BB, et al. Interleukin-4 modulates type I interferon to augment antitumor immunity. Sci Adv. 2025;11:eadt3618.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BB2MXhtFymtLnL\" aria-label=\"CAS reference 167\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=40367186\" aria-label=\"PubMed reference 167\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC12077506\" aria-label=\"PubMed Central reference 167\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 167\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Interleukin-4%20modulates%20type%20I%20interferon%20to%20augment%20antitumor%20immunity&amp;journal=Sci%20Adv&amp;volume=11&amp;publication_year=2025&amp;author=Newnes%2CHV&amp;author=Armitage%2CJD&amp;author=Buzzai%2CAC&amp;author=Jong%2CE&amp;author=Audsley%2CKM&amp;author=Barnes%2CSA&amp;author=Srinivasan%2CS&amp;author=Serralha%2CM&amp;author=Fear%2CVS&amp;author=Guo%2CBB\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n","protected":false},"excerpt":{"rendered":"Hardy MP, Owczarek CM, Jermiin LS, Ejdeb\u00e4ck M, Hertzog PJ. Characterization of the type I interferon locus and&hellip;\n","protected":false},"author":2,"featured_media":108476,"comment_status":"","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[6],"tags":[6472,78112,78114,78113,111,139,78115,69,6840,57437,145,78116],"class_list":{"0":"post-108475","1":"post","2":"type-post","3":"status-publish","4":"format-standard","5":"has-post-thumbnail","7":"category-technology","8":"tag-cancer-research","9":"tag-chromosomal-instability","10":"tag-immune-checkpoint-inhibitors","11":"tag-immunogenic-cell-death","12":"tag-new-zealand","13":"tag-newzealand","14":"tag-nf-b","15":"tag-nz","16":"tag-oncology","17":"tag-sting","18":"tag-technology","19":"tag-three-cs"},"_links":{"self":[{"href":"https:\/\/www.newsbeep.com\/nz\/wp-json\/wp\/v2\/posts\/108475","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.newsbeep.com\/nz\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.newsbeep.com\/nz\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/nz\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/nz\/wp-json\/wp\/v2\/comments?post=108475"}],"version-history":[{"count":0,"href":"https:\/\/www.newsbeep.com\/nz\/wp-json\/wp\/v2\/posts\/108475\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/nz\/wp-json\/wp\/v2\/media\/108476"}],"wp:attachment":[{"href":"https:\/\/www.newsbeep.com\/nz\/wp-json\/wp\/v2\/media?parent=108475"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.newsbeep.com\/nz\/wp-json\/wp\/v2\/categories?post=108475"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.newsbeep.com\/nz\/wp-json\/wp\/v2\/tags?post=108475"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}