{"id":152610,"date":"2025-11-25T08:44:07","date_gmt":"2025-11-25T08:44:07","guid":{"rendered":"https:\/\/www.newsbeep.com\/nz\/152610\/"},"modified":"2025-11-25T08:44:07","modified_gmt":"2025-11-25T08:44:07","slug":"restoration-of-bap1-activity-via-base-editing-suppresses-anchorage-independent-survival-in-kidney-cancer-cancer-cell-international","status":"publish","type":"post","link":"https:\/\/www.newsbeep.com\/nz\/152610\/","title":{"rendered":"Restoration of BAP1 activity via base editing suppresses anchorage-independent survival in kidney cancer | Cancer Cell International"},"content":{"rendered":"<p class=\"c-article-references__text\" id=\"ref-CR1\">Jensen DE, Proctor M, Marquis ST, Gardner HP, Ha SI, Chodosh LA, Ishov AM, Tommerup N, Vissing H, Sekido Y, et al. BAP1: a novel ubiquitin hydrolase which binds to the BRCA1 RING finger and enhances BRCA1-mediated cell growth suppression. Oncogene. 1998;16(9):1097\u2013112.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 1\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=BAP1%3A%20a%20novel%20ubiquitin%20hydrolase%20which%20binds%20to%20the%20BRCA1%20RING%20finger%20and%20enhances%20BRCA1-mediated%20cell%20growth%20suppression&amp;journal=Oncogene&amp;volume=16&amp;issue=9&amp;pages=1097-112&amp;publication_year=1998&amp;author=Jensen%2CDE&amp;author=Proctor%2CM&amp;author=Marquis%2CST&amp;author=Gardner%2CHP&amp;author=Ha%2CSI&amp;author=Chodosh%2CLA&amp;author=Ishov%2CAM&amp;author=Tommerup%2CN&amp;author=Vissing%2CH&amp;author=Sekido%2CY\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR2\">Carbone M, Yang H, Pass HI, Krausz T, Testa JR, Gaudino G. BAP1 and cancer. Nat Rev Cancer. 2013;13(3):153\u20139.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 2\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=BAP1%20and%20cancer&amp;journal=Nat%20Rev%20Cancer&amp;volume=13&amp;issue=3&amp;pages=153-9&amp;publication_year=2013&amp;author=Carbone%2CM&amp;author=Yang%2CH&amp;author=Pass%2CHI&amp;author=Krausz%2CT&amp;author=Testa%2CJR&amp;author=Gaudino%2CG\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR3\">Misaghi S, Ottosen S, Izrael-Tomasevic A, Arnott D, Lamkanfi M, Lee J, Liu J, O\u2019Rourke K, Dixit VM, Wilson AC. Association of C-terminal ubiquitin hydrolase BRCA1-associated protein 1 with cell cycle regulator host cell factor 1. Mol Cell Biol. 2009;29(8):2181\u201392.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 3\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Association%20of%20C-terminal%20ubiquitin%20hydrolase%20BRCA1-associated%20protein%201%20with%20cell%20cycle%20regulator%20host%20cell%20factor%201&amp;journal=Mol%20Cell%20Biol&amp;volume=29&amp;issue=8&amp;pages=2181-92&amp;publication_year=2009&amp;author=Misaghi%2CS&amp;author=Ottosen%2CS&amp;author=Izrael-Tomasevic%2CA&amp;author=Arnott%2CD&amp;author=Lamkanfi%2CM&amp;author=Lee%2CJ&amp;author=Liu%2CJ&amp;author=O%E2%80%99Rourke%2CK&amp;author=Dixit%2CVM&amp;author=Wilson%2CAC\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR4\">Machida YJ, Machida Y, Vashisht AA, Wohlschlegel JA, Dutta A. The deubiquitinating enzyme BAP1 regulates cell growth via interaction with HCF-1. J Biol Chem. 2009;284(49):34179\u201388.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 4\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=The%20deubiquitinating%20enzyme%20BAP1%20regulates%20cell%20growth%20via%20interaction%20with%20HCF-1&amp;journal=J%20Biol%20Chem&amp;volume=284&amp;issue=49&amp;pages=34179-88&amp;publication_year=2009&amp;author=Machida%2CYJ&amp;author=Machida%2CY&amp;author=Vashisht%2CAA&amp;author=Wohlschlegel%2CJA&amp;author=Dutta%2CA\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR5\">Lee HS, Lee SA, Hur SK, Seo JW, Kwon J. Stabilization and targeting of INO80 to replication forks by BAP1 during normal DNA synthesis. Nat Commun. 2014;5:5128.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 5\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Stabilization%20and%20targeting%20of%20INO80%20to%20replication%20forks%20by%20BAP1%20during%20normal%20DNA%20synthesis&amp;journal=Nat%20Commun&amp;volume=5&amp;publication_year=2014&amp;author=Lee%2CHS&amp;author=Lee%2CSA&amp;author=Hur%2CSK&amp;author=Seo%2CJW&amp;author=Kwon%2CJ\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR6\">Lee HS, Seo HR, Lee SA, Choi S, Kang D, Kwon J. BAP1 promotes stalled fork restart and cell survival via INO80 in response to replication stress. Biochem J. 2019;476(20):3053\u201366.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 6\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=BAP1%20promotes%20stalled%20fork%20restart%20and%20cell%20survival%20via%20INO80%20in%20response%20to%20replication%20stress&amp;journal=Biochem%20J&amp;volume=476&amp;issue=20&amp;pages=3053-66&amp;publication_year=2019&amp;author=Lee%2CHS&amp;author=Seo%2CHR&amp;author=Lee%2CSA&amp;author=Choi%2CS&amp;author=Kang%2CD&amp;author=Kwon%2CJ\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR7\">Yu H, Pak H, Hammond-Martel I, Ghram M, Rodrigue A, Daou S, et al. Tumor suppressor and deubiquitinase BAP1 promotes DNA double-strand break repair. Proc Natl Acad Sci U S A. 2014;111(1):285\u201390.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 7\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Tumor%20suppressor%20and%20deubiquitinase%20BAP1%20promotes%20DNA%20double-strand%20break%20repair&amp;journal=Proc%20Natl%20Acad%20Sci%20U%20S%20A&amp;volume=111&amp;issue=1&amp;pages=285-290&amp;publication_year=2014&amp;author=Yu%2CH&amp;author=Pak%2CH&amp;author=Hammond-Martel%2CI&amp;author=Ghram%2CM&amp;author=Rodrigue%2CA&amp;author=Daou%2CS&amp;author=Barbour%2CH&amp;author=Corbeil%2CL&amp;author=Hebert%2CJ&amp;author=Drobetsky%2CE\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR8\">Szczepanski AP, Wang L. Emerging multifaceted roles of BAP1 complexes in biological processes. Cell Death Discov. 2021;7(1):20.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 8\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Emerging%20multifaceted%20roles%20of%20BAP1%20complexes%20in%20biological%20processes&amp;journal=Cell%20Death%20Discov&amp;volume=7&amp;issue=1&amp;publication_year=2021&amp;author=Szczepanski%2CAP&amp;author=Wang%2CL\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR9\">Seo HR, Jeong D, Lee S, Lee HS, Lee SA, Kang SW, et al. CHIP and BAP1 act in concert to regulate INO80 ubiquitination and stability for DNA replication. Molecules Cells. 2021;44(2):101\u201315.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 9\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=CHIP%20and%20BAP1%20act%20in%20concert%20to%20regulate%20INO80%20ubiquitination%20and%20stability%20for%20DNA%20replication&amp;journal=Molecules%20Cells&amp;volume=44&amp;issue=2&amp;pages=101-115&amp;publication_year=2021&amp;author=Seo%2CHR&amp;author=Jeong%2CD&amp;author=Lee%2CS&amp;author=Lee%2CHS&amp;author=Lee%2CSA&amp;author=Kang%2CSW&amp;author=Kwon%2CJ\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR10\">Daou S, Hammond-Martel I, Mashtalir N, Barbour H, Gagnon J, Iannantuono NV, Nkwe NS, Motorina A, Pak H, Yu H, et al. The BAP1\/ASXL2 histone H2A deubiquitinase complex regulates cell proliferation and is disrupted in cancer. J Biol Chem. 2015;290(48):28643\u201363.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 10\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=The%20BAP1%2FASXL2%20histone%20H2A%20deubiquitinase%20complex%20regulates%20cell%20proliferation%20and%20is%20disrupted%20in%20cancer&amp;journal=J%20Biol%20Chem&amp;volume=290&amp;issue=48&amp;pages=28643-63&amp;publication_year=2015&amp;author=Daou%2CS&amp;author=Hammond-Martel%2CI&amp;author=Mashtalir%2CN&amp;author=Barbour%2CH&amp;author=Gagnon%2CJ&amp;author=Iannantuono%2CNV&amp;author=Nkwe%2CNS&amp;author=Motorina%2CA&amp;author=Pak%2CH&amp;author=Yu%2CH\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR11\">Zhang Y, Shi J, Liu X, Feng L, Gong Z, Koppula P, Sirohi K, Li X, Wei Y, Lee H, et al. BAP1 links metabolic regulation of ferroptosis to tumour suppression. Nat Cell Biol. 2018;20(10):1181\u201392.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 11\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=BAP1%20links%20metabolic%20regulation%20of%20ferroptosis%20to%20tumour%20suppression&amp;journal=Nat%20Cell%20Biol&amp;volume=20&amp;issue=10&amp;pages=1181-92&amp;publication_year=2018&amp;author=Zhang%2CY&amp;author=Shi%2CJ&amp;author=Liu%2CX&amp;author=Feng%2CL&amp;author=Gong%2CZ&amp;author=Koppula%2CP&amp;author=Sirohi%2CK&amp;author=Li%2CX&amp;author=Wei%2CY&amp;author=Lee%2CH\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR12\">Kuznetsov JN, Aguero TH, Owens DA, Kurtenbach S, Field MG, Durante MA, et al. BAP1 regulates epigenetic switch from pluripotency to differentiation in developmental lineages giving rise to BAP1-mutant cancers. Sci Adv. 2019;5(9):eaax1738.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 12\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=BAP1%20regulates%20epigenetic%20switch%20from%20pluripotency%20to%20differentiation%20in%20developmental%20lineages%20giving%20rise%20to%20BAP1-mutant%20cancers&amp;journal=Sci%20Adv&amp;volume=5&amp;issue=9&amp;publication_year=2019&amp;author=Kuznetsov%2CJN&amp;author=Aguero%2CTH&amp;author=Owens%2CDA&amp;author=Kurtenbach%2CS&amp;author=Field%2CMG&amp;author=Durante%2CMA&amp;author=Rodriguez%2CDA&amp;author=King%2CML&amp;author=Harbour%2CJW\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR13\">Dey A, Seshasayee D, Noubade R, French DM, Liu J, Chaurushiya MS, Kirkpatrick DS, Pham VC, Lill JR, Bakalarski CE, et al. Loss of the tumor suppressor BAP1 causes myeloid transformation. Science. 2012;337(6101):1541\u20136.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 13\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Loss%20of%20the%20tumor%20suppressor%20BAP1%20causes%20myeloid%20transformation&amp;journal=Science&amp;volume=337&amp;issue=6101&amp;pages=1541-6&amp;publication_year=2012&amp;author=Dey%2CA&amp;author=Seshasayee%2CD&amp;author=Noubade%2CR&amp;author=French%2CDM&amp;author=Liu%2CJ&amp;author=Chaurushiya%2CMS&amp;author=Kirkpatrick%2CDS&amp;author=Pham%2CVC&amp;author=Lill%2CJR&amp;author=Bakalarski%2CCE\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR14\">Bononi A, Giorgi C, Patergnani S, Larson D, Verbruggen K, Tanji M, et al. BAP1 regulates IP3R3-mediated Ca(2+) flux to mitochondria suppressing cell transformation. Nature. 2017;546(7659):549\u201353.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 14\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=BAP1%20regulates%20IP3R3-mediated%20Ca%282%2B%29%20flux%20to%20mitochondria%20suppressing%20cell%20transformation&amp;journal=Nature&amp;volume=546&amp;issue=7659&amp;pages=549-553&amp;publication_year=2017&amp;author=Bononi%2CA&amp;author=Giorgi%2CC&amp;author=Patergnani%2CS&amp;author=Larson%2CD&amp;author=Verbruggen%2CK&amp;author=Tanji%2CM&amp;author=Pellegrini%2CL&amp;author=Signorato%2CV&amp;author=Olivetto%2CF&amp;author=Pastorino%2CS\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR15\">Masclef L, Ahmed O, Estavoyer B, Larrivee B, Labrecque N, Nijnik A, Affar EB. Roles and mechanisms of BAP1 deubiquitinase in tumor suppression. Cell Death Differ. 2021;28(2):606\u201325.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 15\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Roles%20and%20mechanisms%20of%20BAP1%20deubiquitinase%20in%20tumor%20suppression&amp;journal=Cell%20Death%20Differ&amp;volume=28&amp;issue=2&amp;pages=606-25&amp;publication_year=2021&amp;author=Masclef%2CL&amp;author=Ahmed%2CO&amp;author=Estavoyer%2CB&amp;author=Larrivee%2CB&amp;author=Labrecque%2CN&amp;author=Nijnik%2CA&amp;author=Affar%2CEB\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR16\">Qin J, Zhou Z, Chen W, Wang C, Zhang H, Ge G, Shao M, You D, Fan Z, Xia H, et al. BAP1 promotes breast cancer cell proliferation and metastasis by deubiquitinating KLF5. Nat Commun. 2015;6:8471.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 16\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=BAP1%20promotes%20breast%20cancer%20cell%20proliferation%20and%20metastasis%20by%20deubiquitinating%20KLF5&amp;journal=Nat%20Commun&amp;volume=6&amp;publication_year=2015&amp;author=Qin%2CJ&amp;author=Zhou%2CZ&amp;author=Chen%2CW&amp;author=Wang%2CC&amp;author=Zhang%2CH&amp;author=Ge%2CG&amp;author=Shao%2CM&amp;author=You%2CD&amp;author=Fan%2CZ&amp;author=Xia%2CH\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR17\">Kang M, Park SG, Lee SA, Kim S, Lee D, Shirbhate ME, Youn SY, Kim KM, Cha SS, Kwon J. Targeting BAP1 with small compound inhibitor for colon cancer treatment. Sci Rep. 2023;13(1):2264.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 17\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Targeting%20BAP1%20with%20small%20compound%20inhibitor%20for%20colon%20cancer%20treatment&amp;journal=Sci%20Rep&amp;volume=13&amp;issue=1&amp;publication_year=2023&amp;author=Kang%2CM&amp;author=Park%2CSG&amp;author=Lee%2CSA&amp;author=Kim%2CS&amp;author=Lee%2CD&amp;author=Shirbhate%2CME&amp;author=Youn%2CSY&amp;author=Kim%2CKM&amp;author=Cha%2CSS&amp;author=Kwon%2CJ\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR18\">Bononi A, Yang H, Giorgi C, Patergnani S, Pellegrini L, Su M, Xie G, Signorato V, Pastorino S, Morris P, et al. Germline BAP1 mutations induce a Warburg effect. Cell Death Differ. 2017;24(10):1694\u2013704.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 18\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Germline%20BAP1%20mutations%20induce%20a%20Warburg%20effect&amp;journal=Cell%20Death%20Differ&amp;volume=24&amp;issue=10&amp;pages=1694-704&amp;publication_year=2017&amp;author=Bononi%2CA&amp;author=Yang%2CH&amp;author=Giorgi%2CC&amp;author=Patergnani%2CS&amp;author=Pellegrini%2CL&amp;author=Su%2CM&amp;author=Xie%2CG&amp;author=Signorato%2CV&amp;author=Pastorino%2CS&amp;author=Morris%2CP\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR19\">Mashtalir N, Daou S, Barbour H, Sen NN, Gagnon J, Hammond-Martel I, Dar HH, Therrien M. Affar El B: autodeubiquitination protects the tumor suppressor BAP1 from cytoplasmic sequestration mediated by the atypical ubiquitin ligase UBE2O. Mol Cell. 2014;54(3):392\u2013406.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 19\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Affar%20El%20B%3A%20autodeubiquitination%20protects%20the%20tumor%20suppressor%20BAP1%20from%20cytoplasmic%20sequestration%20mediated%20by%20the%20atypical%20ubiquitin%20ligase%20UBE2O&amp;journal=Mol%20Cell&amp;volume=54&amp;issue=3&amp;pages=392-406&amp;publication_year=2014&amp;author=Mashtalir%2CN&amp;author=Daou%2CS&amp;author=Barbour%2CH&amp;author=Sen%2CNN&amp;author=Gagnon%2CJ&amp;author=Hammond-Martel%2CI&amp;author=Dar%2CHH&amp;author=Therrien%2CM\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR20\">Scheuermann JC, de Ayala Alonso AG, Oktaba K, Ly-Hartig N, McGinty RK, Fraterman S, et al. Histone H2A deubiquitinase activity of the Polycomb repressive complex PR-DUB. Nature. 2010;465(7295):243\u20137.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 20\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Histone%20H2A%20deubiquitinase%20activity%20of%20the%20Polycomb%20repressive%20complex%20PR-DUB&amp;journal=Nature&amp;volume=465&amp;issue=7295&amp;pages=243-247&amp;publication_year=2010&amp;author=Scheuermann%2CJC&amp;author=Ayala%20Alonso%2CAG&amp;author=Oktaba%2CK&amp;author=Ly-Hartig%2CN&amp;author=McGinty%2CRK&amp;author=Fraterman%2CS&amp;author=Wilm%2CM&amp;author=Muir%2CTW&amp;author=Muller%2CJ\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR21\">Harbour JW, Onken MD, Roberson ED, Duan S, Cao L, Worley LA, Council ML, Matatall KA, Helms C, Bowcock AM. Frequent mutation of BAP1 in metastasizing uveal melanomas. Science. 2010;330(6009):1410\u20133.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 21\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Frequent%20mutation%20of%20BAP1%20in%20metastasizing%20uveal%20melanomas&amp;journal=Science&amp;volume=330&amp;issue=6009&amp;pages=1410-3&amp;publication_year=2010&amp;author=Harbour%2CJW&amp;author=Onken%2CMD&amp;author=Roberson%2CED&amp;author=Duan%2CS&amp;author=Cao%2CL&amp;author=Worley%2CLA&amp;author=Council%2CML&amp;author=Matatall%2CKA&amp;author=Helms%2CC&amp;author=Bowcock%2CAM\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR22\">Testa JR, Cheung M, Pei J, Below JE, Tan Y, Sementino E, Cox NJ, Dogan AU, Pass HI, Trusa S, et al. Germline BAP1 mutations predispose to malignant mesothelioma. Nat Genet. 2011;43(10):1022\u20135.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 22\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Germline%20BAP1%20mutations%20predispose%20to%20malignant%20mesothelioma&amp;journal=Nat%20Genet&amp;volume=43&amp;issue=10&amp;pages=1022-5&amp;publication_year=2011&amp;author=Testa%2CJR&amp;author=Cheung%2CM&amp;author=Pei%2CJ&amp;author=Below%2CJE&amp;author=Tan%2CY&amp;author=Sementino%2CE&amp;author=Cox%2CNJ&amp;author=Dogan%2CAU&amp;author=Pass%2CHI&amp;author=Trusa%2CS\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR23\">Pena-Llopis S, Vega-Rubin-de-Celis S, Liao A, Leng N, Pavia-Jimenez A, Wang S, et al. BAP1 loss defines a new class of renal cell carcinoma. Nat Genet. 2012;44(7):751\u20139.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 23\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=BAP1%20loss%20defines%20a%20new%20class%20of%20renal%20cell%20carcinoma&amp;journal=Nat%20Genet&amp;volume=44&amp;issue=7&amp;pages=751-759&amp;publication_year=2012&amp;author=Pena-Llopis%2CS&amp;author=Vega-Rubin-de-Celis%2CS&amp;author=Liao%2CA&amp;author=Leng%2CN&amp;author=Pavia-Jimenez%2CA&amp;author=Wang%2CS&amp;author=Yamasaki%2CT&amp;author=Zhrebker%2CL&amp;author=Sivanand%2CS&amp;author=Spence%2CP\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR24\">Carbone M, Harbour JW, Brugarolas J, Bononi A, Pagano I, Dey A, Krausz T, Pass HI, Yang H, Gaudino G. Biological mechanisms and clinical significance of BAP1 mutations in human cancer. Cancer Discov. 2020;10(8):1103\u201320.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 24\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Biological%20mechanisms%20and%20clinical%20significance%20of%20BAP1%20mutations%20in%20human%20cancer&amp;journal=Cancer%20Discov&amp;volume=10&amp;issue=8&amp;pages=1103-20&amp;publication_year=2020&amp;author=Carbone%2CM&amp;author=Harbour%2CJW&amp;author=Brugarolas%2CJ&amp;author=Bononi%2CA&amp;author=Pagano%2CI&amp;author=Dey%2CA&amp;author=Krausz%2CT&amp;author=Pass%2CHI&amp;author=Yang%2CH&amp;author=Gaudino%2CG\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR25\">Carbone M, Adusumilli PS, Alexander HR Jr., Baas P, Bardelli F, Bononi A, et al. Mesothelioma: scientific clues for prevention, diagnosis, and therapy. CA Cancer J Clin. 2019;69(5):402\u201329.<\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR26\">Kwon J, Lee D, Lee SA. BAP1 as a guardian of genome stability: implications in human cancer. Exp Mol Med. 2023;55(4):745\u201354.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 26\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=BAP1%20as%20a%20guardian%20of%20genome%20stability%3A%20implications%20in%20human%20cancer&amp;journal=Exp%20Mol%20Med&amp;volume=55&amp;issue=4&amp;pages=745-54&amp;publication_year=2023&amp;author=Kwon%2CJ&amp;author=Lee%2CD&amp;author=Lee%2CSA\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR27\">Lee SA, Lee D, Kang M, Kim S, Kwon SJ, Lee HS, et al. BAP1 promotes the repair of UV-induced DNA damage via PARP1-mediated recruitment to damage sites and control of activity and stability. Cell Death Differ. 2022. <a href=\"https:\/\/doi.org\/10.1038\/s41418-022-01024-w\" data-track=\"click_references\" data-track-action=\"external reference\" data-track-value=\"external reference\" data-track-label=\"10.1038\/s41418-022-01024-w\" rel=\"nofollow noopener\" target=\"_blank\">https:\/\/doi.org\/10.1038\/s41418-022-01024-w<\/a>.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 27\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=BAP1%20promotes%20the%20repair%20of%20UV-induced%20DNA%20damage%20via%20PARP1-mediated%20recruitment%20to%20damage%20sites%20and%20control%20of%20activity%20and%20stability&amp;journal=Cell%20Death%20Differ&amp;doi=10.1038%2Fs41418-022-01024-w&amp;publication_year=2022&amp;author=Lee%2CSA&amp;author=Lee%2CD&amp;author=Kang%2CM&amp;author=Kim%2CS&amp;author=Kwon%2CSJ&amp;author=Lee%2CHS&amp;author=Seo%2CHR&amp;author=Kaushal%2CP&amp;author=Lee%2CNS&amp;author=Kim%2CH\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR28\">Pickar-Oliver A, Gersbach CA. The next generation of CRISPR-Cas technologies and applications. Nat Rev Mol Cell Biol. 2019;20(8):490\u2013507.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 28\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=The%20next%20generation%20of%20CRISPR-Cas%20technologies%20and%20applications&amp;journal=Nat%20Rev%20Mol%20Cell%20Biol&amp;volume=20&amp;issue=8&amp;pages=490-507&amp;publication_year=2019&amp;author=Pickar-Oliver%2CA&amp;author=Gersbach%2CCA\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR29\">Anzalone AV, Koblan LW, Liu DR. Genome editing with CRISPR-Cas nucleases, base editors, transposases and prime editors. Nat Biotechnol. 2020;38(7):824\u201344.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 29\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Genome%20editing%20with%20CRISPR-Cas%20nucleases%2C%20base%20editors%2C%20transposases%20and%20prime%20editors&amp;journal=Nat%20Biotechnol&amp;volume=38&amp;issue=7&amp;pages=824-44&amp;publication_year=2020&amp;author=Anzalone%2CAV&amp;author=Koblan%2CLW&amp;author=Liu%2CDR\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR30\">Koblan LW, Erdos MR, Wilson C, Cabral WA, Levy JM, Xiong ZM, Tavarez UL, Davison LM, Gete YG, Mao X, et al. In vivo base editing rescues Hutchinson-Gilford Progeria syndrome in mice. Nature. 2021;589(7843):608\u201314.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 30\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=In%20vivo%20base%20editing%20rescues%20Hutchinson-Gilford%20Progeria%20syndrome%20in%20mice&amp;journal=Nature&amp;volume=589&amp;issue=7843&amp;pages=608-14&amp;publication_year=2021&amp;author=Koblan%2CLW&amp;author=Erdos%2CMR&amp;author=Wilson%2CC&amp;author=Cabral%2CWA&amp;author=Levy%2CJM&amp;author=Xiong%2CZM&amp;author=Tavarez%2CUL&amp;author=Davison%2CLM&amp;author=Gete%2CYG&amp;author=Mao%2CX\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR31\">Paoli P, Giannoni E, Chiarugi P. Anoikis molecular pathways and its role in cancer progression. Biochim Biophys Acta. 2013;1833(12):3481\u201398.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 31\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Anoikis%20molecular%20pathways%20and%20its%20role%20in%20cancer%20progression&amp;journal=Biochim%20Biophys%20Acta&amp;volume=1833&amp;issue=12&amp;pages=3481-98&amp;publication_year=2013&amp;author=Paoli%2CP&amp;author=Giannoni%2CE&amp;author=Chiarugi%2CP\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR32\">Gerstberger S, Jiang Q, Ganesh K. Metastasis. Cell. 2023;186(8):1564\u201379.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 32\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Metastasis&amp;journal=Cell&amp;volume=186&amp;issue=8&amp;pages=1564-1579&amp;publication_year=2023&amp;author=Gerstberger%2CS&amp;author=Jiang%2CQ&amp;author=Ganesh%2CK\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR33\">Suskiewicz MJ, Prokhorova E, Rack JGM, Ahel I. ADP-ribosylation from molecular mechanisms to therapeutic implications. Cell. 2023;186(21):4475\u201395.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 33\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=ADP-ribosylation%20from%20molecular%20mechanisms%20to%20therapeutic%20implications&amp;journal=Cell&amp;volume=186&amp;issue=21&amp;pages=4475-95&amp;publication_year=2023&amp;author=Suskiewicz%2CMJ&amp;author=Prokhorova%2CE&amp;author=Rack%2CJGM&amp;author=Ahel%2CI\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR34\">van Roy F. Beyond E-cadherin: roles of other cadherin superfamily members in cancer. Nat Rev Cancer. 2014;14(2):121\u201334.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 34\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Beyond%20E-cadherin%3A%20roles%20of%20other%20cadherin%20superfamily%20members%20in%20cancer&amp;journal=Nat%20Rev%20Cancer&amp;volume=14&amp;issue=2&amp;pages=121-34&amp;publication_year=2014&amp;author=Roy%2CF\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR35\">Mrozik KM, Blaschuk OW, Cheong CM, Zannettino ACW, Vandyke K. N-cadherin in cancer metastasis, its emerging role in haematological malignancies and potential as a therapeutic target in cancer. BMC Cancer. 2018;18(1):939.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 35\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=N-cadherin%20in%20cancer%20metastasis%2C%20its%20emerging%20role%20in%20haematological%20malignancies%20and%20potential%20as%20a%20therapeutic%20target%20in%20cancer&amp;journal=BMC%20Cancer&amp;volume=18&amp;issue=1&amp;publication_year=2018&amp;author=Mrozik%2CKM&amp;author=Blaschuk%2COW&amp;author=Cheong%2CCM&amp;author=Zannettino%2CACW&amp;author=Vandyke%2CK\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR36\">Pecina-Slaus N. Wnt signal transduction pathway and apoptosis: a review. Cancer Cell Int. 2010;10:22.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 36\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Wnt%20signal%20transduction%20pathway%20and%20apoptosis%3A%20a%20review&amp;journal=Cancer%20Cell%20Int&amp;volume=10&amp;publication_year=2010&amp;author=Pecina-Slaus%2CN\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR37\">Polakis P. Wnt signaling and cancer. Genes Dev. 2000;14(15):1837\u201351.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 37\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Wnt%20signaling%20and%20cancer&amp;journal=Genes%20Dev&amp;volume=14&amp;issue=15&amp;pages=1837-51&amp;publication_year=2000&amp;author=Polakis%2CP\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR38\">Kalluri R, Weinberg RA. The basics of epithelial-mesenchymal transition. J Clin Invest. 2009;119(6):1420\u20138.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 38\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=The%20basics%20of%20epithelial-mesenchymal%20transition&amp;journal=J%20Clin%20Invest&amp;volume=119&amp;issue=6&amp;pages=1420-8&amp;publication_year=2009&amp;author=Kalluri%2CR&amp;author=Weinberg%2CRA\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR39\">Cotta BH, Choueiri TK, Cieslik M, Ghatalia P, Mehra R, Morgan TM, et al. Current landscape of genomic biomarkers in clear cell renal cell carcinoma. Eur Urol. 2023;84(2):166\u201375.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 39\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Current%20landscape%20of%20genomic%20biomarkers%20in%20clear%20cell%20renal%20cell%20carcinoma&amp;journal=Eur%20Urol&amp;volume=84&amp;issue=2&amp;pages=166-175&amp;publication_year=2023&amp;author=Cotta%2CBH&amp;author=Choueiri%2CTK&amp;author=Cieslik%2CM&amp;author=Ghatalia%2CP&amp;author=Mehra%2CR&amp;author=Morgan%2CTM&amp;author=Palapattu%2CGS&amp;author=Shuch%2CB&amp;author=Vaishampayan%2CU&amp;author=Van%20Allen%2CE\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR40\">Webster BR, Gopal N, Ball MW. Tumorigenesis mechanisms found in hereditary renal cell carcinoma: a review. Genes (Basel). 2022. <a href=\"https:\/\/doi.org\/10.3390\/genes13112122\" data-track=\"click_references\" data-track-action=\"external reference\" data-track-value=\"external reference\" data-track-label=\"10.3390\/genes13112122\" rel=\"nofollow noopener\" target=\"_blank\">https:\/\/doi.org\/10.3390\/genes13112122<\/a>.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 40\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Tumorigenesis%20mechanisms%20found%20in%20hereditary%20renal%20cell%20carcinoma%3A%20a%20review&amp;journal=Genes%20%28Basel%29&amp;doi=10.3390%2Fgenes13112122&amp;publication_year=2022&amp;author=Webster%2CBR&amp;author=Gopal%2CN&amp;author=Ball%2CMW\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR41\">Escuder-Rodriguez JJ, Rodriguez-Alonso A, Jove L, Quiroga M, Alfonsin G, Figueroa A. Beyond destruction: emerging roles of the E3 ubiquitin ligase Hakai. Cell Mol Biol Lett. 2025;30(1):9.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 41\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Beyond%20destruction%3A%20emerging%20roles%20of%20the%20E3%20ubiquitin%20ligase%20Hakai&amp;journal=Cell%20Mol%20Biol%20Lett&amp;volume=30&amp;issue=1&amp;publication_year=2025&amp;author=Escuder-Rodriguez%2CJJ&amp;author=Rodriguez-Alonso%2CA&amp;author=Jove%2CL&amp;author=Quiroga%2CM&amp;author=Alfonsin%2CG&amp;author=Figueroa%2CA\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR42\">Seo T, Lowery AM, Xu H, Giang W, Troyanovsky SM, Vincent PA, et al. MARCH family E3 ubiquitin ligases selectively target and degrade cadherin family proteins. PLoS ONE. 2024;19(5):e0290485.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 42\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=MARCH%20family%20E3%20ubiquitin%20ligases%20selectively%20target%20and%20degrade%20cadherin%20family%20proteins&amp;journal=PLoS%20ONE&amp;volume=19&amp;issue=5&amp;publication_year=2024&amp;author=Seo%2CT&amp;author=Lowery%2CAM&amp;author=Xu%2CH&amp;author=Giang%2CW&amp;author=Troyanovsky%2CSM&amp;author=Vincent%2CPA&amp;author=Kowalczyk%2CAP\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR43\">Winston JT, Strack P, Beer-Romero P, Chu CY, Elledge SJ, Harper JW. The SCFbeta-TRCP-ubiquitin ligase complex associates specifically with phosphorylated destruction motifs in IkappaBalpha and beta-catenin and stimulates IkappaBalpha ubiquitination in vitro. Genes Dev. 1999;13(3):270\u201383.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 43\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=The%20SCFbeta-TRCP-ubiquitin%20ligase%20complex%20associates%20specifically%20with%20phosphorylated%20destruction%20motifs%20in%20IkappaBalpha%20and%20beta-catenin%20and%20stimulates%20IkappaBalpha%20ubiquitination%20in%20vitro&amp;journal=Genes%20Dev&amp;volume=13&amp;issue=3&amp;pages=270-83&amp;publication_year=1999&amp;author=Winston%2CJT&amp;author=Strack%2CP&amp;author=Beer-Romero%2CP&amp;author=Chu%2CCY&amp;author=Elledge%2CSJ&amp;author=Harper%2CJW\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR44\">Liu C, Kato Y, Zhang Z, Do VM, Yankner BA, He X. Beta-Trcp couples beta-catenin phosphorylation-degradation and regulates xenopus axis formation. Proc Natl Acad Sci U S A. 1999;96(11):6273\u20138.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 44\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Beta-Trcp%20couples%20beta-catenin%20phosphorylation-degradation%20and%20regulates%20xenopus%20axis%20formation&amp;journal=Proc%20Natl%20Acad%20Sci%20U%20S%20A&amp;volume=96&amp;issue=11&amp;pages=6273-8&amp;publication_year=1999&amp;author=Liu%2CC&amp;author=Kato%2CY&amp;author=Zhang%2CZ&amp;author=Do%2CVM&amp;author=Yankner%2CBA&amp;author=He%2CX\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR45\">Xue J, Chen Y, Wu Y, Wang Z, Zhou A, Zhang S, Lin K, Aldape K, Majumder S, Lu Z, et al. Tumour suppressor TRIM33 targets nuclear beta-catenin degradation. Nat Commun. 2015;6:6156.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 45\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Tumour%20suppressor%20TRIM33%20targets%20nuclear%20beta-catenin%20degradation&amp;journal=Nat%20Commun&amp;volume=6&amp;publication_year=2015&amp;author=Xue%2CJ&amp;author=Chen%2CY&amp;author=Wu%2CY&amp;author=Wang%2CZ&amp;author=Zhou%2CA&amp;author=Zhang%2CS&amp;author=Lin%2CK&amp;author=Aldape%2CK&amp;author=Majumder%2CS&amp;author=Lu%2CZ\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR46\">Estavoyer B, Messmer C, Echbicheb M, Rudd CE, Milot E, Affar EB. Mechanisms orchestrating the enzymatic activity and cellular functions of deubiquitinases. J Biol Chem. 2022;298(8):102198.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 46\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Mechanisms%20orchestrating%20the%20enzymatic%20activity%20and%20cellular%20functions%20of%20deubiquitinases&amp;journal=J%20Biol%20Chem&amp;volume=298&amp;issue=8&amp;publication_year=2022&amp;author=Estavoyer%2CB&amp;author=Messmer%2CC&amp;author=Echbicheb%2CM&amp;author=Rudd%2CCE&amp;author=Milot%2CE&amp;author=Affar%2CEB\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n","protected":false},"excerpt":{"rendered":"Jensen DE, Proctor M, Marquis ST, Gardner HP, Ha SI, Chodosh LA, Ishov AM, Tommerup N, Vissing H,&hellip;\n","protected":false},"author":2,"featured_media":152611,"comment_status":"","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[6],"tags":[101607,25487,101606,6472,5300,101608,68586,111,139,69,145],"class_list":{"0":"post-152610","1":"post","2":"type-post","3":"status-publish","4":"format-standard","5":"has-post-thumbnail","7":"category-technology","8":"tag-anchorage-dependent-growth","9":"tag-apoptosis","10":"tag-bap1-tumor-suppressor","11":"tag-cancer-research","12":"tag-cell-biology","13":"tag-crispr-cas9-mediated-adenine-base-editing","14":"tag-kidney-cancer","15":"tag-new-zealand","16":"tag-newzealand","17":"tag-nz","18":"tag-technology"},"_links":{"self":[{"href":"https:\/\/www.newsbeep.com\/nz\/wp-json\/wp\/v2\/posts\/152610","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.newsbeep.com\/nz\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.newsbeep.com\/nz\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/nz\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/nz\/wp-json\/wp\/v2\/comments?post=152610"}],"version-history":[{"count":0,"href":"https:\/\/www.newsbeep.com\/nz\/wp-json\/wp\/v2\/posts\/152610\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/nz\/wp-json\/wp\/v2\/media\/152611"}],"wp:attachment":[{"href":"https:\/\/www.newsbeep.com\/nz\/wp-json\/wp\/v2\/media?parent=152610"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.newsbeep.com\/nz\/wp-json\/wp\/v2\/categories?post=152610"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.newsbeep.com\/nz\/wp-json\/wp\/v2\/tags?post=152610"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}