{"id":152680,"date":"2025-11-25T09:53:06","date_gmt":"2025-11-25T09:53:06","guid":{"rendered":"https:\/\/www.newsbeep.com\/nz\/152680\/"},"modified":"2025-11-25T09:53:06","modified_gmt":"2025-11-25T09:53:06","slug":"association-of-growth-differentiation-factor-15-with-renal-disease-outcomes-and-all-cause-death-in-type-1-and-type-2-diabetic-patients-a-meta-analysis-bmc-nephrology","status":"publish","type":"post","link":"https:\/\/www.newsbeep.com\/nz\/152680\/","title":{"rendered":"Association of growth differentiation factor-15 with renal disease outcomes and all-cause death in type 1 and type 2 diabetic patients: a meta-analysis | BMC Nephrology"},"content":{"rendered":"<p class=\"c-article-references__text\" id=\"ref-CR1\">Collaborators GBDD. Global, regional, and National burden of diabetes from 1990 to 2021, with projections of prevalence to 2050: a systematic analysis for the global burden of disease study 2021. Lancet. 2023;402(10397):203\u201334. <a href=\"https:\/\/doi.org\/10.1016\/S0140-6736(23)01301-6\" data-track=\"click_references\" data-track-action=\"external reference\" data-track-value=\"external reference\" data-track-label=\"10.1016\/S0140-6736(23)01301-6\" rel=\"nofollow noopener\" target=\"_blank\">https:\/\/doi.org\/10.1016\/S0140-6736(23)01301-6<\/a>.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 1\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Global%2C%20regional%2C%20and%20National%20burden%20of%20diabetes%20from%201990%20to%202021%2C%20with%20projections%20of%20prevalence%20to%202050%3A%20a%20systematic%20analysis%20for%20the%20global%20burden%20of%20disease%20study%202021&amp;journal=Lancet&amp;doi=10.1016%2FS0140-6736%2823%2901301-6&amp;volume=402&amp;issue=10397&amp;pages=203-34&amp;publication_year=2023&amp;author=Collaborators%2CGBDD\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR2\">ElSayed NA, Aleppo G, Aroda VR, Bannuru RR, Brown FM, Bruemmer D, Collins BS, Hilliard ME, Isaacs D, Johnson EL, Kahan S, Khunti K, Leon J, Lyons SK, Perry ML, Prahalad P, Pratley RE, Seley JJ, Stanton RC, Gabbay RA, on behalf of the American Diabetes A. 2. Classification and diagnosis of diabetes: standards of care in Diabetes-2023. Diabetes Care. 2023;46(Suppl 1):S19\u201340. <a href=\"https:\/\/doi.org\/10.2337\/dc23-S002\" data-track=\"click_references\" data-track-action=\"external reference\" data-track-value=\"external reference\" data-track-label=\"10.2337\/dc23-S002\" rel=\"nofollow noopener\" target=\"_blank\">https:\/\/doi.org\/10.2337\/dc23-S002<\/a>.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 2\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=2.%20Classification%20and%20diagnosis%20of%20diabetes%3A%20standards%20of%20care%20in%20Diabetes-2023&amp;journal=Diabetes%20Care&amp;doi=10.2337%2Fdc23-S002&amp;volume=46&amp;issue=Suppl%201&amp;pages=S19-40&amp;publication_year=2023&amp;author=ElSayed%2CNA&amp;author=Aleppo%2CG&amp;author=Aroda%2CVR&amp;author=Bannuru%2CRR&amp;author=Brown%2CFM&amp;author=Bruemmer%2CD&amp;author=Collins%2CBS&amp;author=Hilliard%2CME&amp;author=Isaacs%2CD&amp;author=Johnson%2CEL&amp;author=Kahan%2CS&amp;author=Khunti%2CK&amp;author=Leon%2CJ&amp;author=Lyons%2CSK&amp;author=Perry%2CML&amp;author=Prahalad%2CP&amp;author=Pratley%2CRE&amp;author=Seley%2CJJ&amp;author=Stanton%2CRC&amp;author=Gabbay%2CRA\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR3\">Antar SA, Ashour NA, Sharaky M, Khattab M, Ashour NA, Zaid RT, Roh EJ, Elkamhawy A, Al-Karmalawy AA. Diabetes mellitus: Classification, mediators, and complications; A gate to identify potential targets for the development of new effective treatments. Biomed Pharmacother. 2023;168:115734. <a href=\"https:\/\/doi.org\/10.1016\/j.biopha.2023.115734\" data-track=\"click_references\" data-track-action=\"external reference\" data-track-value=\"external reference\" data-track-label=\"10.1016\/j.biopha.2023.115734\" rel=\"nofollow noopener\" target=\"_blank\">https:\/\/doi.org\/10.1016\/j.biopha.2023.115734<\/a>.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 3\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Diabetes%20mellitus%3A%20Classification%2C%20mediators%2C%20and%20complications%3B%20A%20gate%20to%20identify%20potential%20targets%20for%20the%20development%20of%20new%20effective%20treatments&amp;journal=Biomed%20Pharmacother&amp;doi=10.1016%2Fj.biopha.2023.115734&amp;volume=168&amp;publication_year=2023&amp;author=Antar%2CSA&amp;author=Ashour%2CNA&amp;author=Sharaky%2CM&amp;author=Khattab%2CM&amp;author=Ashour%2CNA&amp;author=Zaid%2CRT&amp;author=Roh%2CEJ&amp;author=Elkamhawy%2CA&amp;author=Al-Karmalawy%2CAA\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR4\">Gupta S, Dominguez M, Golestaneh L. Diabetic kidney disease: an update. Med Clin North Am. 2023;107(4):689\u2013705. <a href=\"https:\/\/doi.org\/10.1016\/j.mcna.2023.03.004\" data-track=\"click_references\" data-track-action=\"external reference\" data-track-value=\"external reference\" data-track-label=\"10.1016\/j.mcna.2023.03.004\" rel=\"nofollow noopener\" target=\"_blank\">https:\/\/doi.org\/10.1016\/j.mcna.2023.03.004<\/a>.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 4\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Diabetic%20kidney%20disease%3A%20an%20update&amp;journal=Med%20Clin%20North%20Am&amp;doi=10.1016%2Fj.mcna.2023.03.004&amp;volume=107&amp;issue=4&amp;pages=689-705&amp;publication_year=2023&amp;author=Gupta%2CS&amp;author=Dominguez%2CM&amp;author=Golestaneh%2CL\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR5\">Ricciardi CA, Gnudi L. Kidney disease in diabetes: from mechanisms to clinical presentation and treatment strategies. Metabolism. 2021;124:154890. <a href=\"https:\/\/doi.org\/10.1016\/j.metabol.2021.154890\" data-track=\"click_references\" data-track-action=\"external reference\" data-track-value=\"external reference\" data-track-label=\"10.1016\/j.metabol.2021.154890\" rel=\"nofollow noopener\" target=\"_blank\">https:\/\/doi.org\/10.1016\/j.metabol.2021.154890<\/a>.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 5\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Kidney%20disease%20in%20diabetes%3A%20from%20mechanisms%20to%20clinical%20presentation%20and%20treatment%20strategies&amp;journal=Metabolism&amp;doi=10.1016%2Fj.metabol.2021.154890&amp;volume=124&amp;publication_year=2021&amp;author=Ricciardi%2CCA&amp;author=Gnudi%2CL\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR6\">Selby NM, Taal MW. An updated overview of diabetic nephropathy: Diagnosis, prognosis, treatment goals and latest guidelines. Diabetes Obes Metab. 2020;22(Suppl 1):3\u201315. <a href=\"https:\/\/doi.org\/10.1111\/dom.14007\" data-track=\"click_references\" data-track-action=\"external reference\" data-track-value=\"external reference\" data-track-label=\"10.1111\/dom.14007\" rel=\"nofollow noopener\" target=\"_blank\">https:\/\/doi.org\/10.1111\/dom.14007<\/a>.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 6\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=An%20updated%20overview%20of%20diabetic%20nephropathy%3A%20Diagnosis%2C%20prognosis%2C%20treatment%20goals%20and%20latest%20guidelines&amp;journal=Diabetes%20Obes%20Metab&amp;doi=10.1111%2Fdom.14007&amp;volume=22&amp;issue=Suppl%201&amp;pages=3-15&amp;publication_year=2020&amp;author=Selby%2CNM&amp;author=Taal%2CMW\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR7\">Ali MK, Pearson-Stuttard J, Selvin E, Gregg EW. Interpreting global trends in type 2 diabetes complications and mortality. Diabetologia. 2022;65(1):3\u201313. <a href=\"https:\/\/doi.org\/10.1007\/s00125-021-05585-2\" data-track=\"click_references\" data-track-action=\"external reference\" data-track-value=\"external reference\" data-track-label=\"10.1007\/s00125-021-05585-2\" rel=\"nofollow noopener\" target=\"_blank\">https:\/\/doi.org\/10.1007\/s00125-021-05585-2<\/a>.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 7\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Interpreting%20global%20trends%20in%20type%202%20diabetes%20complications%20and%20mortality&amp;journal=Diabetologia&amp;doi=10.1007%2Fs00125-021-05585-2&amp;volume=65&amp;issue=1&amp;pages=3-13&amp;publication_year=2022&amp;author=Ali%2CMK&amp;author=Pearson-Stuttard%2CJ&amp;author=Selvin%2CE&amp;author=Gregg%2CEW\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR8\">Su B, Wang Y, Dong Y, Hu G, Xu Y, Peng X, Wang Q, Zheng X. Trends in diabetes mortality in urban and rural China, 1987\u20132019: A joinpoint regression analysis. Front Endocrinol (Lausanne). 2021;12:777654. <a href=\"https:\/\/doi.org\/10.3389\/fendo.2021.777654\" data-track=\"click_references\" data-track-action=\"external reference\" data-track-value=\"external reference\" data-track-label=\"10.3389\/fendo.2021.777654\" rel=\"nofollow noopener\" target=\"_blank\">https:\/\/doi.org\/10.3389\/fendo.2021.777654<\/a>.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 8\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Trends%20in%20diabetes%20mortality%20in%20urban%20and%20rural%20China%2C%201987%E2%80%932019%3A%20A%20joinpoint%20regression%20analysis&amp;journal=Front%20Endocrinol%20%28Lausanne%29&amp;doi=10.3389%2Ffendo.2021.777654&amp;volume=12&amp;publication_year=2021&amp;author=Su%2CB&amp;author=Wang%2CY&amp;author=Dong%2CY&amp;author=Hu%2CG&amp;author=Xu%2CY&amp;author=Peng%2CX&amp;author=Wang%2CQ&amp;author=Zheng%2CX\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR9\">Pearson-Stuttard J, Buckley J, Cicek M, Gregg EW. The changing nature of mortality and morbidity in patients with diabetes. Endocrinol Metab Clin North Am. 2021;50(3):357\u201368. <a href=\"https:\/\/doi.org\/10.1016\/j.ecl.2021.05.001\" data-track=\"click_references\" data-track-action=\"external reference\" data-track-value=\"external reference\" data-track-label=\"10.1016\/j.ecl.2021.05.001\" rel=\"nofollow noopener\" target=\"_blank\">https:\/\/doi.org\/10.1016\/j.ecl.2021.05.001<\/a>.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 9\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=The%20changing%20nature%20of%20mortality%20and%20morbidity%20in%20patients%20with%20diabetes&amp;journal=Endocrinol%20Metab%20Clin%20North%20Am&amp;doi=10.1016%2Fj.ecl.2021.05.001&amp;volume=50&amp;issue=3&amp;pages=357-68&amp;publication_year=2021&amp;author=Pearson-Stuttard%2CJ&amp;author=Buckley%2CJ&amp;author=Cicek%2CM&amp;author=Gregg%2CEW\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR10\">Eddy AC, Trask AJ. Growth differentiation factor-15 and its role in diabetes and cardiovascular disease. Cytokine Growth Factor Rev. 2021;57:11\u20138. <a href=\"https:\/\/doi.org\/10.1016\/j.cytogfr.2020.11.002\" data-track=\"click_references\" data-track-action=\"external reference\" data-track-value=\"external reference\" data-track-label=\"10.1016\/j.cytogfr.2020.11.002\" rel=\"nofollow noopener\" target=\"_blank\">https:\/\/doi.org\/10.1016\/j.cytogfr.2020.11.002<\/a>.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 10\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Growth%20differentiation%20factor-15%20and%20its%20role%20in%20diabetes%20and%20cardiovascular%20disease&amp;journal=Cytokine%20Growth%20Factor%20Rev&amp;doi=10.1016%2Fj.cytogfr.2020.11.002&amp;volume=57&amp;pages=11-8&amp;publication_year=2021&amp;author=Eddy%2CAC&amp;author=Trask%2CAJ\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR11\">Tang Y, Liu T, Sun S, Peng Y, Huang X, Wang S, Zhou Z. Role and mechanism of growth differentiation factor 15 in chronic kidney disease. J Inflamm Res. 2024;17:2861\u201371. <a href=\"https:\/\/doi.org\/10.2147\/JIR.S451398\" data-track=\"click_references\" data-track-action=\"external reference\" data-track-value=\"external reference\" data-track-label=\"10.2147\/JIR.S451398\" rel=\"nofollow noopener\" target=\"_blank\">https:\/\/doi.org\/10.2147\/JIR.S451398<\/a>.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 11\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Role%20and%20mechanism%20of%20growth%20differentiation%20factor%2015%20in%20chronic%20kidney%20disease&amp;journal=J%20Inflamm%20Res&amp;doi=10.2147%2FJIR.S451398&amp;volume=17&amp;pages=2861-71&amp;publication_year=2024&amp;author=Tang%2CY&amp;author=Liu%2CT&amp;author=Sun%2CS&amp;author=Peng%2CY&amp;author=Huang%2CX&amp;author=Wang%2CS&amp;author=Zhou%2CZ\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR12\">Lajer M, Jorsal A, Tarnow L, Parving HH, Rossing P. Plasma growth differentiation factor-15 independently predicts all-cause and cardiovascular mortality as well as deterioration of kidney function in type 1 diabetic patients with nephropathy. Diabetes Care. 2010;33(7):1567\u201372. <a href=\"https:\/\/doi.org\/10.2337\/dc09-2174\" data-track=\"click_references\" data-track-action=\"external reference\" data-track-value=\"external reference\" data-track-label=\"10.2337\/dc09-2174\" rel=\"nofollow noopener\" target=\"_blank\">https:\/\/doi.org\/10.2337\/dc09-2174<\/a>.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 12\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Plasma%20growth%20differentiation%20factor-15%20independently%20predicts%20all-cause%20and%20cardiovascular%20mortality%20as%20well%20as%20deterioration%20of%20kidney%20function%20in%20type%201%20diabetic%20patients%20with%20nephropathy&amp;journal=Diabetes%20Care&amp;doi=10.2337%2Fdc09-2174&amp;volume=33&amp;issue=7&amp;pages=1567-72&amp;publication_year=2010&amp;author=Lajer%2CM&amp;author=Jorsal%2CA&amp;author=Tarnow%2CL&amp;author=Parving%2CHH&amp;author=Rossing%2CP\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR13\">Bidadkosh A, Lambooy SPH, Heerspink HJ, Pena MJ, Henning RH, Buikema H, Deelman LE. Predictive properties of biomarkers GDF-15, NTproBNP, and hs-TnT for morbidity and mortality in patients with type 2 diabetes with nephropathy. Diabetes Care. 2017;40(6):784\u201392. <a href=\"https:\/\/doi.org\/10.2337\/dc16-2175\" data-track=\"click_references\" data-track-action=\"external reference\" data-track-value=\"external reference\" data-track-label=\"10.2337\/dc16-2175\" rel=\"nofollow noopener\" target=\"_blank\">https:\/\/doi.org\/10.2337\/dc16-2175<\/a>.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 13\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Predictive%20properties%20of%20biomarkers%20GDF-15%2C%20NTproBNP%2C%20and%20hs-TnT%20for%20morbidity%20and%20mortality%20in%20patients%20with%20type%202%20diabetes%20with%20nephropathy&amp;journal=Diabetes%20Care&amp;doi=10.2337%2Fdc16-2175&amp;volume=40&amp;issue=6&amp;pages=784-92&amp;publication_year=2017&amp;author=Bidadkosh%2CA&amp;author=Lambooy%2CSPH&amp;author=Heerspink%2CHJ&amp;author=Pena%2CMJ&amp;author=Henning%2CRH&amp;author=Buikema%2CH&amp;author=Deelman%2CLE\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR14\">Carlsson AC, Nowak C, Lind L, Ostgren CJ, Nystrom FH, Sundstrom J, Carrero JJ, Riserus U, Ingelsson E, Fall T, Arnlov J. Growth differentiation factor 15 (GDF-15) is a potential biomarker of both diabetic kidney disease and future cardiovascular events in cohorts of individuals with type 2 diabetes: a proteomics approach. Ups J Med Sci. 2020;125(1):37\u201343. <a href=\"https:\/\/doi.org\/10.1080\/03009734.2019.1696430\" data-track=\"click_references\" data-track-action=\"external reference\" data-track-value=\"external reference\" data-track-label=\"10.1080\/03009734.2019.1696430\" rel=\"nofollow noopener\" target=\"_blank\">https:\/\/doi.org\/10.1080\/03009734.2019.1696430<\/a>.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 14\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Growth%20differentiation%20factor%2015%20%28GDF-15%29%20is%20a%20potential%20biomarker%20of%20both%20diabetic%20kidney%20disease%20and%20future%20cardiovascular%20events%20in%20cohorts%20of%20individuals%20with%20type%202%20diabetes%3A%20a%20proteomics%20approach&amp;journal=Ups%20J%20Med%20Sci&amp;doi=10.1080%2F03009734.2019.1696430&amp;volume=125&amp;issue=1&amp;pages=37-43&amp;publication_year=2020&amp;author=Carlsson%2CAC&amp;author=Nowak%2CC&amp;author=Lind%2CL&amp;author=Ostgren%2CCJ&amp;author=Nystrom%2CFH&amp;author=Sundstrom%2CJ&amp;author=Carrero%2CJJ&amp;author=Riserus%2CU&amp;author=Ingelsson%2CE&amp;author=Fall%2CT&amp;author=Arnlov%2CJ\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR15\">Sen T, Li J, Neuen BL, Arnott C, Neal B, Perkovic V, Mahaffey KW, Shaw W, Canovatchel W, Hansen MK, Heerspink HJL. Association between Circulating GDF-15 and Cardio-Renal outcomes and effect of canagliflozin: results from the CANVAS trial. J Am Heart Assoc. 2021;10(23):e021661. <a href=\"https:\/\/doi.org\/10.1161\/JAHA.121.021661\" data-track=\"click_references\" data-track-action=\"external reference\" data-track-value=\"external reference\" data-track-label=\"10.1161\/JAHA.121.021661\" rel=\"nofollow noopener\" target=\"_blank\">https:\/\/doi.org\/10.1161\/JAHA.121.021661<\/a>.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 15\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Association%20between%20Circulating%20GDF-15%20and%20Cardio-Renal%20outcomes%20and%20effect%20of%20canagliflozin%3A%20results%20from%20the%20CANVAS%20trial&amp;journal=J%20Am%20Heart%20Assoc&amp;doi=10.1161%2FJAHA.121.021661&amp;volume=10&amp;issue=23&amp;publication_year=2021&amp;author=Sen%2CT&amp;author=Li%2CJ&amp;author=Neuen%2CBL&amp;author=Arnott%2CC&amp;author=Neal%2CB&amp;author=Perkovic%2CV&amp;author=Mahaffey%2CKW&amp;author=Shaw%2CW&amp;author=Canovatchel%2CW&amp;author=Hansen%2CMK&amp;author=Heerspink%2CHJL\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR16\">Xie S, Li Q, Luk AOY, Lan HY, Chan PKS, Bayes-Genis A, Chan FKL, Fung E. Major adverse cardiovascular events and mortality prediction by Circulating GDF-15 in patients with type 2 diabetes: a systematic review and meta-analysis. Biomolecules. 2022;12(7). <a href=\"https:\/\/doi.org\/10.3390\/biom12070934\" data-track=\"click_references\" data-track-action=\"external reference\" data-track-value=\"external reference\" data-track-label=\"10.3390\/biom12070934\" rel=\"nofollow noopener\" target=\"_blank\">https:\/\/doi.org\/10.3390\/biom12070934<\/a>.<\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR17\">Zeng X, Zhang Y, Kwong JS, Zhang C, Li S, Sun F, Niu Y, Du L. The methodological quality assessment tools for preclinical and clinical studies, systematic review and meta-analysis, and clinical practice guideline: a systematic review. J Evid Based Med. 2015;8(1):2\u201310. <a href=\"https:\/\/doi.org\/10.1111\/jebm.12141\" data-track=\"click_references\" data-track-action=\"external reference\" data-track-value=\"external reference\" data-track-label=\"10.1111\/jebm.12141\" rel=\"nofollow noopener\" target=\"_blank\">https:\/\/doi.org\/10.1111\/jebm.12141<\/a>.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 17\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=The%20methodological%20quality%20assessment%20tools%20for%20preclinical%20and%20clinical%20studies%2C%20systematic%20review%20and%20meta-analysis%2C%20and%20clinical%20practice%20guideline%3A%20a%20systematic%20review&amp;journal=J%20Evid%20Based%20Med&amp;doi=10.1111%2Fjebm.12141&amp;volume=8&amp;issue=1&amp;pages=2-10&amp;publication_year=2015&amp;author=Zeng%2CX&amp;author=Zhang%2CY&amp;author=Kwong%2CJS&amp;author=Zhang%2CC&amp;author=Li%2CS&amp;author=Sun%2CF&amp;author=Niu%2CY&amp;author=Du%2CL\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR18\">Sterne JA, Hernan MA, Reeves BC, Savovic J, Berkman ND, Viswanathan M, Henry D, Altman DG, Ansari MT, Boutron I, Carpenter JR, Chan AW, Churchill R, Deeks JJ, Hrobjartsson A, Kirkham J, Juni P, Loke YK, Pigott TD, Ramsay CR, Regidor D, Rothstein HR, Sandhu L, Santaguida PL, Schunemann HJ, Shea B, Shrier I, Tugwell P, Turner L, Valentine JC, Waddington H, Waters E, Wells GA, Whiting PF, Higgins JP. ROBINS-I: a tool for assessing risk of bias in non-randomised studies of interventions. BMJ. 2016;355:i4919. <a href=\"https:\/\/doi.org\/10.1136\/bmj.i4919\" data-track=\"click_references\" data-track-action=\"external reference\" data-track-value=\"external reference\" data-track-label=\"10.1136\/bmj.i4919\" rel=\"nofollow noopener\" target=\"_blank\">https:\/\/doi.org\/10.1136\/bmj.i4919<\/a>.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 18\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=ROBINS-I%3A%20a%20tool%20for%20assessing%20risk%20of%20bias%20in%20non-randomised%20studies%20of%20interventions&amp;journal=BMJ&amp;doi=10.1136%2Fbmj.i4919&amp;volume=355&amp;publication_year=2016&amp;author=Sterne%2CJA&amp;author=Hernan%2CMA&amp;author=Reeves%2CBC&amp;author=Savovic%2CJ&amp;author=Berkman%2CND&amp;author=Viswanathan%2CM&amp;author=Henry%2CD&amp;author=Altman%2CDG&amp;author=Ansari%2CMT&amp;author=Boutron%2CI&amp;author=Carpenter%2CJR&amp;author=Chan%2CAW&amp;author=Churchill%2CR&amp;author=Deeks%2CJJ&amp;author=Hrobjartsson%2CA&amp;author=Kirkham%2CJ&amp;author=Juni%2CP&amp;author=Loke%2CYK&amp;author=Pigott%2CTD&amp;author=Ramsay%2CCR&amp;author=Regidor%2CD&amp;author=Rothstein%2CHR&amp;author=Sandhu%2CL&amp;author=Santaguida%2CPL&amp;author=Schunemann%2CHJ&amp;author=Shea%2CB&amp;author=Shrier%2CI&amp;author=Tugwell%2CP&amp;author=Turner%2CL&amp;author=Valentine%2CJC&amp;author=Waddington%2CH&amp;author=Waters%2CE&amp;author=Wells%2CGA&amp;author=Whiting%2CPF&amp;author=Higgins%2CJP\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR19\">Higgins JP, Altman DG, Gotzsche PC, Juni P, Moher D, Oxman AD, Savovic J, Schulz KF, Weeks L, Sterne JA, Cochrane Bias Methods G, Statistical Cochrane G. The Cochrane collaboration\u2019s tool for assessing risk of bias in randomised trials. BMJ. 2011;343:d5928. <a href=\"https:\/\/doi.org\/10.1136\/bmj.d5928\" data-track=\"click_references\" data-track-action=\"external reference\" data-track-value=\"external reference\" data-track-label=\"10.1136\/bmj.d5928\" rel=\"nofollow noopener\" target=\"_blank\">https:\/\/doi.org\/10.1136\/bmj.d5928<\/a>.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 19\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=The%20Cochrane%20collaboration%E2%80%99s%20tool%20for%20assessing%20risk%20of%20bias%20in%20randomised%20trials&amp;journal=BMJ&amp;doi=10.1136%2Fbmj.d5928&amp;volume=343&amp;publication_year=2011&amp;author=Higgins%2CJP&amp;author=Altman%2CDG&amp;author=Gotzsche%2CPC&amp;author=Juni%2CP&amp;author=Moher%2CD&amp;author=Oxman%2CAD&amp;author=Savovic%2CJ&amp;author=Schulz%2CKF&amp;author=Weeks%2CL&amp;author=Sterne%2CJA&amp;author=Cochrane%20Bias%20Methods%2CG&amp;author=Cochrane%2CG\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR20\">Guyatt G, Oxman AD, Akl EA, Kunz R, Vist G, Brozek J, Norris S, Falck-Ytter Y, Glasziou P, DeBeer H, Jaeschke R, Rind D, Meerpohl J, Dahm P, Schunemann HJ. GRADE guidelines: 1. Introduction-GRADE evidence profiles and summary of findings tables. J Clin Epidemiol. 2011;64(4):383\u201394. <a href=\"https:\/\/doi.org\/10.1016\/j.jclinepi.2010.04.026\" data-track=\"click_references\" data-track-action=\"external reference\" data-track-value=\"external reference\" data-track-label=\"10.1016\/j.jclinepi.2010.04.026\" rel=\"nofollow noopener\" target=\"_blank\">https:\/\/doi.org\/10.1016\/j.jclinepi.2010.04.026<\/a>.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 20\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=GRADE%20guidelines%3A%201.%20Introduction-GRADE%20evidence%20profiles%20and%20summary%20of%20findings%20tables&amp;journal=J%20Clin%20Epidemiol&amp;doi=10.1016%2Fj.jclinepi.2010.04.026&amp;volume=64&amp;issue=4&amp;pages=383-94&amp;publication_year=2011&amp;author=Guyatt%2CG&amp;author=Oxman%2CAD&amp;author=Akl%2CEA&amp;author=Kunz%2CR&amp;author=Vist%2CG&amp;author=Brozek%2CJ&amp;author=Norris%2CS&amp;author=Falck-Ytter%2CY&amp;author=Glasziou%2CP&amp;author=DeBeer%2CH&amp;author=Jaeschke%2CR&amp;author=Rind%2CD&amp;author=Meerpohl%2CJ&amp;author=Dahm%2CP&amp;author=Schunemann%2CHJ\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR21\">Frimodt-Moller M, von Scholten BJ, Reinhard H, Jacobsen PK, Hansen TW, Persson FI, Parving HH, Rossing P. Growth differentiation factor-15 and fibroblast growth factor-23 are associated with mortality in type 2 diabetes &#8211; An observational follow-up study. PLoS ONE. 2018;13(4):e0196634. <a href=\"https:\/\/doi.org\/10.1371\/journal.pone.0196634\" data-track=\"click_references\" data-track-action=\"external reference\" data-track-value=\"external reference\" data-track-label=\"10.1371\/journal.pone.0196634\" rel=\"nofollow noopener\" target=\"_blank\">https:\/\/doi.org\/10.1371\/journal.pone.0196634<\/a>.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 21\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Growth%20differentiation%20factor-15%20and%20fibroblast%20growth%20factor-23%20are%20associated%20with%20mortality%20in%20type%202%20diabetes%20-%20An%20observational%20follow-up%20study&amp;journal=PLoS%20ONE&amp;doi=10.1371%2Fjournal.pone.0196634&amp;volume=13&amp;issue=4&amp;publication_year=2018&amp;author=Frimodt-Moller%2CM&amp;author=Scholten%2CBJ&amp;author=Reinhard%2CH&amp;author=Jacobsen%2CPK&amp;author=Hansen%2CTW&amp;author=Persson%2CFI&amp;author=Parving%2CHH&amp;author=Rossing%2CP\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR22\">Januzzi JL, Mohebi R, Liu Y, Sattar N, Heerspink HJL, Tefera E, Vaduganathan M, Butler J, Yavin Y, Li J, Pollock CA, Perkovic V, Neal B, Hansen MK. Cardiorenal Biomarkers, Canagliflozin, and outcomes in diabetic kidney disease: the CREDENCE trial. Circulation. 2023;148(8):651\u201360. <a href=\"https:\/\/doi.org\/10.1161\/CIRCULATIONAHA.123.065251\" data-track=\"click_references\" data-track-action=\"external reference\" data-track-value=\"external reference\" data-track-label=\"10.1161\/CIRCULATIONAHA.123.065251\" rel=\"nofollow noopener\" target=\"_blank\">https:\/\/doi.org\/10.1161\/CIRCULATIONAHA.123.065251<\/a>.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 22\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Cardiorenal%20Biomarkers%2C%20Canagliflozin%2C%20and%20outcomes%20in%20diabetic%20kidney%20disease%3A%20the%20CREDENCE%20trial&amp;journal=Circulation&amp;doi=10.1161%2FCIRCULATIONAHA.123.065251&amp;volume=148&amp;issue=8&amp;pages=651-60&amp;publication_year=2023&amp;author=Januzzi%2CJL&amp;author=Mohebi%2CR&amp;author=Liu%2CY&amp;author=Sattar%2CN&amp;author=Heerspink%2CHJL&amp;author=Tefera%2CE&amp;author=Vaduganathan%2CM&amp;author=Butler%2CJ&amp;author=Yavin%2CY&amp;author=Li%2CJ&amp;author=Pollock%2CCA&amp;author=Perkovic%2CV&amp;author=Neal%2CB&amp;author=Hansen%2CMK\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR23\">Shora HA, El-Deen IM, El-Lithy NM, Abo-Elmatty DM, Khirallah SM. Growth differentiation factor-15: A marker for diabetic kidney disease in patients with metabolic-associated fatty liver disease. J Diabetes Complications. 2025;39(6):109037. <a href=\"https:\/\/doi.org\/10.1016\/j.jdiacomp.2025.109037\" data-track=\"click_references\" data-track-action=\"external reference\" data-track-value=\"external reference\" data-track-label=\"10.1016\/j.jdiacomp.2025.109037\" rel=\"nofollow noopener\" target=\"_blank\">https:\/\/doi.org\/10.1016\/j.jdiacomp.2025.109037<\/a>.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 23\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Growth%20differentiation%20factor-15%3A%20A%20marker%20for%20diabetic%20kidney%20disease%20in%20patients%20with%20metabolic-associated%20fatty%20liver%20disease&amp;journal=J%20Diabetes%20Complications&amp;doi=10.1016%2Fj.jdiacomp.2025.109037&amp;volume=39&amp;issue=6&amp;publication_year=2025&amp;author=Shora%2CHA&amp;author=El-Deen%2CIM&amp;author=El-Lithy%2CNM&amp;author=Abo-Elmatty%2CDM&amp;author=Khirallah%2CSM\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR24\">Gohda T, Kamei N, Tanaka M, Furuhashi M, Sato T, Kubota M, Sanuki M, Koshida T, Hagiwara S, Suzuki Y, Murakoshi M. Association of difference between eGFR from Cystatin C and creatinine and serum GDF-15 with adverse outcomes in diabetes mellitus. J Cachexia Sarcopenia Muscle. 2025;16(4):e70011. <a href=\"https:\/\/doi.org\/10.1002\/jcsm.70011\" data-track=\"click_references\" data-track-action=\"external reference\" data-track-value=\"external reference\" data-track-label=\"10.1002\/jcsm.70011\" rel=\"nofollow noopener\" target=\"_blank\">https:\/\/doi.org\/10.1002\/jcsm.70011<\/a>.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 24\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Association%20of%20difference%20between%20eGFR%20from%20Cystatin%20C%20and%20creatinine%20and%20serum%20GDF-15%20with%20adverse%20outcomes%20in%20diabetes%20mellitus&amp;journal=J%20Cachexia%20Sarcopenia%20Muscle&amp;doi=10.1002%2Fjcsm.70011&amp;volume=16&amp;issue=4&amp;publication_year=2025&amp;author=Gohda%2CT&amp;author=Kamei%2CN&amp;author=Tanaka%2CM&amp;author=Furuhashi%2CM&amp;author=Sato%2CT&amp;author=Kubota%2CM&amp;author=Sanuki%2CM&amp;author=Koshida%2CT&amp;author=Hagiwara%2CS&amp;author=Suzuki%2CY&amp;author=Murakoshi%2CM\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR25\">Falkowski B, Rogowicz-Frontczak A, Szczepanek-Parulska E, Krygier A, Wrotkowska E, Uruska A, Araszkiewicz A, Ruchala M, Zozulinska-Ziolkiewicz D. Novel biochemical markers of neurovascular complications in type 1 diabetes patients. J Clin Med. 2020;9(1). <a href=\"https:\/\/doi.org\/10.3390\/jcm9010198\" data-track=\"click_references\" data-track-action=\"external reference\" data-track-value=\"external reference\" data-track-label=\"10.3390\/jcm9010198\" rel=\"nofollow noopener\" target=\"_blank\">https:\/\/doi.org\/10.3390\/jcm9010198<\/a>.<\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR26\">Zhu X, Zhang Y, Liang F, Yin J, Jiang L, Cai W, Lu J, Zhang C, Xiao Y, Teng H, Ge W, Hu Y, Lu Y, Su J, Zhang J, Wu M. Relationship between plasma growth differentiation factor 15 levels and complications of type 2 diabetes mellitus: A Cross-sectional study. Can J Diabetes. 2023;47(2):117\u2013e123117. <a href=\"https:\/\/doi.org\/10.1016\/j.jcjd.2022.09.116\" data-track=\"click_references\" data-track-action=\"external reference\" data-track-value=\"external reference\" data-track-label=\"10.1016\/j.jcjd.2022.09.116\" rel=\"nofollow noopener\" target=\"_blank\">https:\/\/doi.org\/10.1016\/j.jcjd.2022.09.116<\/a>.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 26\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Relationship%20between%20plasma%20growth%20differentiation%20factor%2015%20levels%20and%20complications%20of%20type%202%20diabetes%20mellitus%3A%20A%20Cross-sectional%20study&amp;journal=Can%20J%20Diabetes&amp;doi=10.1016%2Fj.jcjd.2022.09.116&amp;volume=47&amp;issue=2&amp;pages=117-e123117&amp;publication_year=2023&amp;author=Zhu%2CX&amp;author=Zhang%2CY&amp;author=Liang%2CF&amp;author=Yin%2CJ&amp;author=Jiang%2CL&amp;author=Cai%2CW&amp;author=Lu%2CJ&amp;author=Zhang%2CC&amp;author=Xiao%2CY&amp;author=Teng%2CH&amp;author=Ge%2CW&amp;author=Hu%2CY&amp;author=Lu%2CY&amp;author=Su%2CJ&amp;author=Zhang%2CJ&amp;author=Wu%2CM\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR27\">Zou LX, Hou ZL, Qian CH, Wang X, Sun L. Performance of novel biomarkers for prediction of diabetic kidney disease in patients with diabetes mellitus. Ann Med. 2025;57(1):2562996. <a href=\"https:\/\/doi.org\/10.1080\/07853890.2025.2562996\" data-track=\"click_references\" data-track-action=\"external reference\" data-track-value=\"external reference\" data-track-label=\"10.1080\/07853890.2025.2562996\" rel=\"nofollow noopener\" target=\"_blank\">https:\/\/doi.org\/10.1080\/07853890.2025.2562996<\/a>.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 27\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Performance%20of%20novel%20biomarkers%20for%20prediction%20of%20diabetic%20kidney%20disease%20in%20patients%20with%20diabetes%20mellitus&amp;journal=Ann%20Med&amp;doi=10.1080%2F07853890.2025.2562996&amp;volume=57&amp;issue=1&amp;publication_year=2025&amp;author=Zou%2CLX&amp;author=Hou%2CZL&amp;author=Qian%2CCH&amp;author=Wang%2CX&amp;author=Sun%2CL\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR28\">Iglesias P, Silvestre RA, Diez JJ. Growth differentiation factor 15 (GDF-15) in endocrinology. Endocrine. 2023;81(3):419\u201331. <a href=\"https:\/\/doi.org\/10.1007\/s12020-023-03377-9\" data-track=\"click_references\" data-track-action=\"external reference\" data-track-value=\"external reference\" data-track-label=\"10.1007\/s12020-023-03377-9\" rel=\"nofollow noopener\" target=\"_blank\">https:\/\/doi.org\/10.1007\/s12020-023-03377-9<\/a>.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 28\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Growth%20differentiation%20factor%2015%20%28GDF-15%29%20in%20endocrinology&amp;journal=Endocrine&amp;doi=10.1007%2Fs12020-023-03377-9&amp;volume=81&amp;issue=3&amp;pages=419-31&amp;publication_year=2023&amp;author=Iglesias%2CP&amp;author=Silvestre%2CRA&amp;author=Diez%2CJJ\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR29\">Mazagova M, Buikema H, van Buiten A, Duin M, Goris M, Sandovici M, Henning RH, Deelman LE. Genetic deletion of growth differentiation factor 15 augments renal damage in both type 1 and type 2 models of diabetes. Am J Physiol Ren Physiol. 2013;305(9):F1249\u20131264. <a href=\"https:\/\/doi.org\/10.1152\/ajprenal.00387.2013\" data-track=\"click_references\" data-track-action=\"external reference\" data-track-value=\"external reference\" data-track-label=\"10.1152\/ajprenal.00387.2013\" rel=\"nofollow noopener\" target=\"_blank\">https:\/\/doi.org\/10.1152\/ajprenal.00387.2013<\/a>.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 29\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Genetic%20deletion%20of%20growth%20differentiation%20factor%2015%20augments%20renal%20damage%20in%20both%20type%201%20and%20type%202%20models%20of%20diabetes&amp;journal=Am%20J%20Physiol%20Ren%20Physiol&amp;doi=10.1152%2Fajprenal.00387.2013&amp;volume=305&amp;issue=9&amp;pages=F1249-1264&amp;publication_year=2013&amp;author=Mazagova%2CM&amp;author=Buikema%2CH&amp;author=Buiten%2CA&amp;author=Duin%2CM&amp;author=Goris%2CM&amp;author=Sandovici%2CM&amp;author=Henning%2CRH&amp;author=Deelman%2CLE\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR30\">Kim YI, Shin HW, Chun YS, Park JW. CST3 and GDF15 ameliorate renal fibrosis by inhibiting fibroblast growth and activation. Biochem Biophys Res Commun. 2018;500(2):288\u201395. <a href=\"https:\/\/doi.org\/10.1016\/j.bbrc.2018.04.061\" data-track=\"click_references\" data-track-action=\"external reference\" data-track-value=\"external reference\" data-track-label=\"10.1016\/j.bbrc.2018.04.061\" rel=\"nofollow noopener\" target=\"_blank\">https:\/\/doi.org\/10.1016\/j.bbrc.2018.04.061<\/a>.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 30\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=CST3%20and%20GDF15%20ameliorate%20renal%20fibrosis%20by%20inhibiting%20fibroblast%20growth%20and%20activation&amp;journal=Biochem%20Biophys%20Res%20Commun&amp;doi=10.1016%2Fj.bbrc.2018.04.061&amp;volume=500&amp;issue=2&amp;pages=288-95&amp;publication_year=2018&amp;author=Kim%2CYI&amp;author=Shin%2CHW&amp;author=Chun%2CYS&amp;author=Park%2CJW\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR31\">von Rauchhaupt E, Klaus M, Ribeiro A, Honarpisheh M, Li C, Liu M, Kohler P, Adamowicz K, Schmaderer C, Lindenmeyer M, Steiger S, Anders HJ, Lech M. GDF-15 suppresses puromycin aminonucleoside-Induced podocyte injury by reducing Endoplasmic reticulum stress and glomerular inflammation. Cells. 2024;13(7). <a href=\"https:\/\/doi.org\/10.3390\/cells13070637\" data-track=\"click_references\" data-track-action=\"external reference\" data-track-value=\"external reference\" data-track-label=\"10.3390\/cells13070637\" rel=\"nofollow noopener\" target=\"_blank\">https:\/\/doi.org\/10.3390\/cells13070637<\/a>.<\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR32\">Delrue C, Speeckaert R, Delanghe JR, Speeckaert MM. Growth differentiation factor 15 (GDF-15) in kidney diseases. Adv Clin Chem. 2023;114:1\u201346. <a href=\"https:\/\/doi.org\/10.1016\/bs.acc.2023.02.003\" data-track=\"click_references\" data-track-action=\"external reference\" data-track-value=\"external reference\" data-track-label=\"10.1016\/bs.acc.2023.02.003\" rel=\"nofollow noopener\" target=\"_blank\">https:\/\/doi.org\/10.1016\/bs.acc.2023.02.003<\/a>.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 32\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Growth%20differentiation%20factor%2015%20%28GDF-15%29%20in%20kidney%20diseases&amp;journal=Adv%20Clin%20Chem&amp;doi=10.1016%2Fbs.acc.2023.02.003&amp;volume=114&amp;pages=1-46&amp;publication_year=2023&amp;author=Delrue%2CC&amp;author=Speeckaert%2CR&amp;author=Delanghe%2CJR&amp;author=Speeckaert%2CMM\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR33\">Lasaad S, Crambert G. GDF15, an emerging player in renal physiology and pathophysiology. Int J Mol Sci. 2024;25(11). <a href=\"https:\/\/doi.org\/10.3390\/ijms25115956\" data-track=\"click_references\" data-track-action=\"external reference\" data-track-value=\"external reference\" data-track-label=\"10.3390\/ijms25115956\" rel=\"nofollow noopener\" target=\"_blank\">https:\/\/doi.org\/10.3390\/ijms25115956<\/a>.<\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR34\">Lu Q, Wang WW, Zhang MZ, Ma ZX, Qiu XR, Shen M, Yin XX. ROS induces epithelial-mesenchymal transition via the TGF-beta1\/PI3K\/Akt\/mTOR pathway in diabetic nephropathy. Exp Ther Med. 2019;17(1):835\u201346. <a href=\"https:\/\/doi.org\/10.3892\/etm.2018.7014\" data-track=\"click_references\" data-track-action=\"external reference\" data-track-value=\"external reference\" data-track-label=\"10.3892\/etm.2018.7014\" rel=\"nofollow noopener\" target=\"_blank\">https:\/\/doi.org\/10.3892\/etm.2018.7014<\/a>.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 34\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=ROS%20induces%20epithelial-mesenchymal%20transition%20via%20the%20TGF-beta1%2FPI3K%2FAkt%2FmTOR%20pathway%20in%20diabetic%20nephropathy&amp;journal=Exp%20Ther%20Med&amp;doi=10.3892%2Fetm.2018.7014&amp;volume=17&amp;issue=1&amp;pages=835-46&amp;publication_year=2019&amp;author=Lu%2CQ&amp;author=Wang%2CWW&amp;author=Zhang%2CMZ&amp;author=Ma%2CZX&amp;author=Qiu%2CXR&amp;author=Shen%2CM&amp;author=Yin%2CXX\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR35\">Tuttle KR, Jones CR, Daratha KB, Koyama AK, Nicholas SB, Alicic RZ, Duru OK, Neumiller JJ, Norris KC, Rios Burrows N, Pavkov ME. Incidence of chronic kidney disease among adults with Diabetes, 2015\u20132020. N Engl J Med. 2022;387(15):1430\u20131. <a href=\"https:\/\/doi.org\/10.1056\/NEJMc2207018\" data-track=\"click_references\" data-track-action=\"external reference\" data-track-value=\"external reference\" data-track-label=\"10.1056\/NEJMc2207018\" rel=\"nofollow noopener\" target=\"_blank\">https:\/\/doi.org\/10.1056\/NEJMc2207018<\/a>.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 35\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Incidence%20of%20chronic%20kidney%20disease%20among%20adults%20with%20Diabetes%2C%202015%E2%80%932020&amp;journal=N%20Engl%20J%20Med&amp;doi=10.1056%2FNEJMc2207018&amp;volume=387&amp;issue=15&amp;pages=1430-1&amp;publication_year=2022&amp;author=Tuttle%2CKR&amp;author=Jones%2CCR&amp;author=Daratha%2CKB&amp;author=Koyama%2CAK&amp;author=Nicholas%2CSB&amp;author=Alicic%2CRZ&amp;author=Duru%2COK&amp;author=Neumiller%2CJJ&amp;author=Norris%2CKC&amp;author=Rios%20Burrows%2CN&amp;author=Pavkov%2CME\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR36\">Kaze AD, Jaar BG, Fonarow GC, Echouffo-Tcheugui JB. Diabetic kidney disease and risk of incident stroke among adults with type 2 diabetes. BMC Med. 2022;20(1):127. <a href=\"https:\/\/doi.org\/10.1186\/s12916-022-02317-0\" data-track=\"click_references\" data-track-action=\"external reference\" data-track-value=\"external reference\" data-track-label=\"10.1186\/s12916-022-02317-0\" rel=\"nofollow noopener\" target=\"_blank\">https:\/\/doi.org\/10.1186\/s12916-022-02317-0<\/a>.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 36\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Diabetic%20kidney%20disease%20and%20risk%20of%20incident%20stroke%20among%20adults%20with%20type%202%20diabetes&amp;journal=BMC%20Med&amp;doi=10.1186%2Fs12916-022-02317-0&amp;volume=20&amp;issue=1&amp;publication_year=2022&amp;author=Kaze%2CAD&amp;author=Jaar%2CBG&amp;author=Fonarow%2CGC&amp;author=Echouffo-Tcheugui%2CJB\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR37\">Koye DN, Magliano DJ, Nelson RG, Pavkov ME. The global epidemiology of diabetes and kidney disease. Adv Chronic Kidney Dis. 2018;25(2):121\u201332. <a href=\"https:\/\/doi.org\/10.1053\/j.ackd.2017.10.011\" data-track=\"click_references\" data-track-action=\"external reference\" data-track-value=\"external reference\" data-track-label=\"10.1053\/j.ackd.2017.10.011\" rel=\"nofollow noopener\" target=\"_blank\">https:\/\/doi.org\/10.1053\/j.ackd.2017.10.011<\/a>.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 37\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=The%20global%20epidemiology%20of%20diabetes%20and%20kidney%20disease&amp;journal=Adv%20Chronic%20Kidney%20Dis&amp;doi=10.1053%2Fj.ackd.2017.10.011&amp;volume=25&amp;issue=2&amp;pages=121-32&amp;publication_year=2018&amp;author=Koye%2CDN&amp;author=Magliano%2CDJ&amp;author=Nelson%2CRG&amp;author=Pavkov%2CME\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR38\">Zhou Z, Liu H, Ju H, Chen H, Jin H, Sun M. Circulating GDF-15 in relation to the progression and prognosis of chronic kidney disease: A systematic review and dose-response meta-analysis. Eur J Intern Med. 2023;110:77\u201385. <a href=\"https:\/\/doi.org\/10.1016\/j.ejim.2023.01.026\" data-track=\"click_references\" data-track-action=\"external reference\" data-track-value=\"external reference\" data-track-label=\"10.1016\/j.ejim.2023.01.026\" rel=\"nofollow noopener\" target=\"_blank\">https:\/\/doi.org\/10.1016\/j.ejim.2023.01.026<\/a>.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 38\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Circulating%20GDF-15%20in%20relation%20to%20the%20progression%20and%20prognosis%20of%20chronic%20kidney%20disease%3A%20A%20systematic%20review%20and%20dose-response%20meta-analysis&amp;journal=Eur%20J%20Intern%20Med&amp;doi=10.1016%2Fj.ejim.2023.01.026&amp;volume=110&amp;pages=77-85&amp;publication_year=2023&amp;author=Zhou%2CZ&amp;author=Liu%2CH&amp;author=Ju%2CH&amp;author=Chen%2CH&amp;author=Jin%2CH&amp;author=Sun%2CM\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR39\">Li T, Chen Y, Ye T, Zheng L, Chen L, Fan Y, Lin B. Association of growth differentiation factor-15 level with adverse outcomes in patients with stable coronary artery disease: A meta-analysis. Atheroscler Plus. 2022;47:1\u20137. <a href=\"https:\/\/doi.org\/10.1016\/j.athplu.2021.11.003\" data-track=\"click_references\" data-track-action=\"external reference\" data-track-value=\"external reference\" data-track-label=\"10.1016\/j.athplu.2021.11.003\" rel=\"nofollow noopener\" target=\"_blank\">https:\/\/doi.org\/10.1016\/j.athplu.2021.11.003<\/a>.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 39\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Association%20of%20growth%20differentiation%20factor-15%20level%20with%20adverse%20outcomes%20in%20patients%20with%20stable%20coronary%20artery%20disease%3A%20A%20meta-analysis&amp;journal=Atheroscler%20Plus&amp;doi=10.1016%2Fj.athplu.2021.11.003&amp;volume=47&amp;pages=1-7&amp;publication_year=2022&amp;author=Li%2CT&amp;author=Chen%2CY&amp;author=Ye%2CT&amp;author=Zheng%2CL&amp;author=Chen%2CL&amp;author=Fan%2CY&amp;author=Lin%2CB\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR40\">Ma CX, Ma XN, Guan CH, Li YD, Mauricio D, Fu SB. Cardiovascular disease in type 2 diabetes mellitus: progress toward personalized management. Cardiovasc Diabetol. 2022;21(1):74. <a href=\"https:\/\/doi.org\/10.1186\/s12933-022-01516-6\" data-track=\"click_references\" data-track-action=\"external reference\" data-track-value=\"external reference\" data-track-label=\"10.1186\/s12933-022-01516-6\" rel=\"nofollow noopener\" target=\"_blank\">https:\/\/doi.org\/10.1186\/s12933-022-01516-6<\/a>.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 40\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Cardiovascular%20disease%20in%20type%202%20diabetes%20mellitus%3A%20progress%20toward%20personalized%20management&amp;journal=Cardiovasc%20Diabetol&amp;doi=10.1186%2Fs12933-022-01516-6&amp;volume=21&amp;issue=1&amp;publication_year=2022&amp;author=Ma%2CCX&amp;author=Ma%2CXN&amp;author=Guan%2CCH&amp;author=Li%2CYD&amp;author=Mauricio%2CD&amp;author=Fu%2CSB\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR41\">Teoh IH, Elisaus P, Schofield JD. Cardiovascular risk management in type 1 diabetes. Curr Diab Rep. 2021;21(9):29. <a href=\"https:\/\/doi.org\/10.1007\/s11892-021-01400-9\" data-track=\"click_references\" data-track-action=\"external reference\" data-track-value=\"external reference\" data-track-label=\"10.1007\/s11892-021-01400-9\" rel=\"nofollow noopener\" target=\"_blank\">https:\/\/doi.org\/10.1007\/s11892-021-01400-9<\/a>.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 41\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Cardiovascular%20risk%20management%20in%20type%201%20diabetes&amp;journal=Curr%20Diab%20Rep&amp;doi=10.1007%2Fs11892-021-01400-9&amp;volume=21&amp;issue=9&amp;publication_year=2021&amp;author=Teoh%2CIH&amp;author=Elisaus%2CP&amp;author=Schofield%2CJD\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR42\">Wang D, Day EA, Townsend LK, Djordjevic D, Jorgensen SB, Steinberg GR. GDF15: emerging biology and therapeutic applications for obesity and cardiometabolic disease. Nat Rev Endocrinol. 2021;17(10):592\u2013607. <a href=\"https:\/\/doi.org\/10.1038\/s41574-021-00529-7\" data-track=\"click_references\" data-track-action=\"external reference\" data-track-value=\"external reference\" data-track-label=\"10.1038\/s41574-021-00529-7\" rel=\"nofollow noopener\" target=\"_blank\">https:\/\/doi.org\/10.1038\/s41574-021-00529-7<\/a>.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 42\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=GDF15%3A%20emerging%20biology%20and%20therapeutic%20applications%20for%20obesity%20and%20cardiometabolic%20disease&amp;journal=Nat%20Rev%20Endocrinol&amp;doi=10.1038%2Fs41574-021-00529-7&amp;volume=17&amp;issue=10&amp;pages=592-607&amp;publication_year=2021&amp;author=Wang%2CD&amp;author=Day%2CEA&amp;author=Townsend%2CLK&amp;author=Djordjevic%2CD&amp;author=Jorgensen%2CSB&amp;author=Steinberg%2CGR\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR43\">Al-Kuraishy HM, Al-Gareeb AI, Alexiou A, Papadakis M, Nadwa EH, Albogami SM, Alorabi M, Saad HM, Batiha GE. Metformin and growth differentiation factor 15 (GDF15) in type 2 diabetes mellitus: A hidden treasure. J Diabetes. 2022;14(12):806\u201314. <a href=\"https:\/\/doi.org\/10.1111\/1753-0407.13334\" data-track=\"click_references\" data-track-action=\"external reference\" data-track-value=\"external reference\" data-track-label=\"10.1111\/1753-0407.13334\" rel=\"nofollow noopener\" target=\"_blank\">https:\/\/doi.org\/10.1111\/1753-0407.13334<\/a>.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 43\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Metformin%20and%20growth%20differentiation%20factor%2015%20%28GDF15%29%20in%20type%202%20diabetes%20mellitus%3A%20A%20hidden%20treasure&amp;journal=J%20Diabetes&amp;doi=10.1111%2F1753-0407.13334&amp;volume=14&amp;issue=12&amp;pages=806-14&amp;publication_year=2022&amp;author=Al-Kuraishy%2CHM&amp;author=Al-Gareeb%2CAI&amp;author=Alexiou%2CA&amp;author=Papadakis%2CM&amp;author=Nadwa%2CEH&amp;author=Albogami%2CSM&amp;author=Alorabi%2CM&amp;author=Saad%2CHM&amp;author=Batiha%2CGE\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n","protected":false},"excerpt":{"rendered":"Collaborators GBDD. Global, regional, and National burden of diabetes from 1990 to 2021, with projections of prevalence to&hellip;\n","protected":false},"author":2,"featured_media":146394,"comment_status":"","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[10],"tags":[101671,3535,101670,101668,134,3536,51824,111,139,69,101669],"class_list":{"0":"post-152680","1":"post","2":"type-post","3":"status-publish","4":"format-standard","5":"has-post-thumbnail","7":"category-health","8":"tag-all-cause-death","9":"tag-diabetes","10":"tag-diabetic-kidney-disease","11":"tag-growth-differentiation-factor-15","12":"tag-health","13":"tag-internal-medicine","14":"tag-nephrology","15":"tag-new-zealand","16":"tag-newzealand","17":"tag-nz","18":"tag-poor-renal-outcomes"},"_links":{"self":[{"href":"https:\/\/www.newsbeep.com\/nz\/wp-json\/wp\/v2\/posts\/152680","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.newsbeep.com\/nz\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.newsbeep.com\/nz\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/nz\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/nz\/wp-json\/wp\/v2\/comments?post=152680"}],"version-history":[{"count":0,"href":"https:\/\/www.newsbeep.com\/nz\/wp-json\/wp\/v2\/posts\/152680\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/nz\/wp-json\/wp\/v2\/media\/146394"}],"wp:attachment":[{"href":"https:\/\/www.newsbeep.com\/nz\/wp-json\/wp\/v2\/media?parent=152680"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.newsbeep.com\/nz\/wp-json\/wp\/v2\/categories?post=152680"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.newsbeep.com\/nz\/wp-json\/wp\/v2\/tags?post=152680"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}