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<\/a>Intestinal nervous system: A central health hub<\/p>\nLead researchers from Charit\u00e9, Universit\u00e4tsmedizin Berlin, and Bern, Germany, explain that the intestinal nervous system is made up of mucosa, immune cells, and the microbiome, which protects the gut from its own contents. The intestinal mucosa also protects against pathogens.<\/p>\n
The finding, dubbed a \u201cfirst,\u201d also reveals that intestinal nerve cells use VIP to communicate directly with intestinal stem cells. It ensures these cells do not grow too fast into tuft cells.<\/p>\n
\u201cOur findings show that the intestinal nervous system is a decisive factor in preserving a healthy intestinal mucosa, regulating immune responses, and ultimately maintaining an intact intestinal barrier,\u201d explains study first author Dr. Manuel Jakob from the Department of Visceral Surgery and Medicine at Inselspital, research associate at the Department for BioMedical Research at the University of Bern and scientist at Charit\u00e9.\u00a0<\/p>\n
\u201cOur \u2018gut brain\u2019 is far more than a facilitator of digestion. It acts as a central hub for health, immunity, and potentially for conditions that affect large parts of the population. Interestingly, the results suggest that the effect may be shaped by the diet, i.e., the formulation of the food.\u201d<\/p>\n
The study <\/a>underscores the importance of a healthy gut microbiome and a regulated immune response to prevent disease.\u00a0<\/p>\n The team plans to study how nutrition could be used to support the nerve-gut axis to support intestinal health.<\/p>\n \u201cThe mechanism we have uncovered may help explain why some individuals are particularly sensitive in the gut and how we might intervene more precisely in the future,\u201d explains senior author professor Christoph Klose, head of the Neuroimmune Interaction research group at Charit\u00e9\u2019s Institute of Microbiology, Infectious Diseases and Immunology.<\/p>\n \u201cBy deepening our understanding of how nerves, cells, and immune responses interact in the gut, we can develop more targeted and personalized therapies \u2014 for example, for allergies, irritable bowel syndrome, or chronic inflammatory bowel diseases.\u201d<\/p>\n Related news\u00a0<\/p>\n In other news on allergies, gut health, and immunity, researchers identified a \u201cdisturbing\u201d gut microbiome trend<\/a> in US infants. Many babies were missing Bifidobacteria, driving allergies, asthma, and eczema.<\/p>\n