{"id":181100,"date":"2025-12-13T01:10:03","date_gmt":"2025-12-13T01:10:03","guid":{"rendered":"https:\/\/www.newsbeep.com\/nz\/181100\/"},"modified":"2025-12-13T01:10:03","modified_gmt":"2025-12-13T01:10:03","slug":"exploring-melatonin-therapeutic-potential-in-systemic-lupus-erythematosus","status":"publish","type":"post","link":"https:\/\/www.newsbeep.com\/nz\/181100\/","title":{"rendered":"Exploring melatonin therapeutic potential in systemic lupus erythematosus"},"content":{"rendered":"<p>A recent review published in Current Molecular Pharmacology explores the therapeutic potential of melatonin in systemic lupus erythematosus (SLE), a complex autoimmune disease affecting multiple organs. The study, led by researchers from Iran University of Medical Sciences and UT Health San Antonio, suggests that melatonin-primarily known for regulating sleep-may also play a significant role in managing SLE and its severe complication, lupus nephritis.<\/p>\n<p>Melatonin, produced by the pineal gland and other tissues, exhibits strong antioxidant and <a href=\"https:\/\/www.news-medical.net\/health\/What-Does-Inflammation-Do-to-the-Body.aspx#3\" class=\"linked-term\" rel=\"nofollow noopener\" target=\"_blank\">anti-inflammatory<\/a> effects. The review highlights that SLE patients often have lower serum melatonin levels, which may correlate with increased disease activity. &#8220;Our findings suggest that melatonin could serve as both a diagnostic marker and a therapeutic agent,&#8221; said co-author Azam Hosseinzadeh.<\/p>\n<p>Preclinical studies show melatonin can reduce renal <a href=\"https:\/\/www.news-medical.net\/health\/What-Does-Inflammation-Do-to-the-Body.aspx\" class=\"linked-term\" rel=\"nofollow noopener\" target=\"_blank\">inflammation<\/a> and oxidative stress in lupus models. Clinical trials, including a randomized double-blind study, reported decreased oxidative stress markers like malondialdehyde (MDA) in SLE patients taking melatonin supplements. However, its impact on overall disease activity remains inconclusive.<\/p>\n<p>Despite promising lab results, the authors caution that more robust, long-term clinical trials are needed. &#8220;Melatonin&#8217;s safety profile and multifaceted effects make it a compelling candidate for adjunctive therapy, but we need to understand optimal dosing and timing,&#8221; noted co-author Mohammad Sheibani.<\/p>\n<p>The review also emphasizes the importance of standardized sampling protocols, as melatonin levels fluctuate with circadian rhythms. Future research should explore melatonin&#8217;s role in preventing organ damage and improving quality of life in lupus patients.<\/p>\n<p>Source:<\/p>\n<p>Journal reference:<\/p>\n<p>DOI:\u00a0<a href=\"http:\/\/dx.doi.org\/10.1016\/j.cmp.2025.11.001\" rel=\"noopener nofollow\" target=\"_blank\">10.1016\/j.cmp.2025.11.001<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"A recent review published in Current Molecular Pharmacology explores the therapeutic potential of melatonin in systemic lupus erythematosus&hellip;\n","protected":false},"author":2,"featured_media":181101,"comment_status":"","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[10],"tags":[41689,2285,70141,134,41690,29367,90824,90827,43135,111,139,69,17192,8323,14374,2859,18760,3405,90829,3422],"class_list":["post-181100","post","type-post","status-publish","format-standard","has-post-thumbnail","category-health","tag-cytokines","tag-diagnostic","tag-growth-factor","tag-health","tag-interleukin","tag-intracellular","tag-lupus","tag-lupus-erythematosus","tag-melatonin","tag-new-zealand","tag-newzealand","tag-nz","tag-oxidative-stress","tag-oxygen","tag-pharmacology","tag-protein","tag-receptor","tag-stress","tag-systemic-lupus-erythematosus","tag-therapy"],"_links":{"self":[{"href":"https:\/\/www.newsbeep.com\/nz\/wp-json\/wp\/v2\/posts\/181100","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.newsbeep.com\/nz\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.newsbeep.com\/nz\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/nz\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/nz\/wp-json\/wp\/v2\/comments?post=181100"}],"version-history":[{"count":0,"href":"https:\/\/www.newsbeep.com\/nz\/wp-json\/wp\/v2\/posts\/181100\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/nz\/wp-json\/wp\/v2\/media\/181101"}],"wp:attachment":[{"href":"https:\/\/www.newsbeep.com\/nz\/wp-json\/wp\/v2\/media?parent=181100"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.newsbeep.com\/nz\/wp-json\/wp\/v2\/categories?post=181100"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.newsbeep.com\/nz\/wp-json\/wp\/v2\/tags?post=181100"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}