{"id":294939,"date":"2026-02-21T09:18:08","date_gmt":"2026-02-21T09:18:08","guid":{"rendered":"https:\/\/www.newsbeep.com\/nz\/294939\/"},"modified":"2026-02-21T09:18:08","modified_gmt":"2026-02-21T09:18:08","slug":"sildenafil-use-and-risk-of-serous-retinal-detachment-in-men-with-erectile-dysfunction-in-us","status":"publish","type":"post","link":"https:\/\/www.newsbeep.com\/nz\/294939\/","title":{"rendered":"Sildenafil use and risk of serous retinal detachment in men with erectile dysfunction in US"},"content":{"rendered":"<p>Phosphodiesterase type 5 inhibitors (PDE5i) are widely used for erectile dysfunction. Case reports and claims-based cohort studies have suggested associations between PDE5i use and ocular adverse events, including serous retinal detachment (SRD), retinal vascular occlusion (RVO), and ischemic optic neuropathy (ION) [<a data-track=\"click\" data-track-action=\"reference anchor\" data-track-label=\"link\" data-test=\"citation-ref\" aria-label=\"Reference 1\" title=\"Etminan M, Sodhi M, Mikelberg FS, Maberley D. Risk of Ocular Adverse Events Associated With Use of Phosphodiesterase 5 Inhibitors in Men in the US. JAMA Ophthalmol. 2022;140:480&#x2013;4. &#010;                https:\/\/doi.org\/10.1001\/jamaophthalmol.2022.0663&#010;                &#010;              .\" href=\"http:\/\/www.nature.com\/articles\/s41433-026-04326-2#ref-CR1\" id=\"ref-link-section-d76663590e328\" rel=\"nofollow noopener\" target=\"_blank\">1<\/a>]. However, large multicentre evidence specific to sildenafil in real-world data is limited.<\/p>\n<p>We conducted a retrospective cohort study using the TriNetX US collaborative network, a federated database of de-identified electronic health records from over 129 million patients across over 70 health systems. Men aged \u226518 years with an ICD-10 diagnosis of erectile dysfunction (N52) were included. Exposure was defined as documented of sildenafil use (RxNorm 136411); the control cohort comprised patients with erectile dysfunction and no recorded sildenafil exposure. Patients with a prior history of SRD, RVO, ION, other ocular disease history, or other PDE5i exposure (Tadalafil RxNorm 358263; Avanafil RxNorm 1291301; Vardenafil RxNorm 306674) were excluded from the analyses.<\/p>\n","protected":false},"excerpt":{"rendered":"Phosphodiesterase type 5 inhibitors (PDE5i) are widely used for erectile dysfunction. Case reports and claims-based cohort studies have&hellip;\n","protected":false},"author":2,"featured_media":294940,"comment_status":"","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[7],"tags":[5384,2294,130380,14214,111,139,69,3532,28256,130381,147,6290,31499],"class_list":["post-294939","post","type-post","status-publish","format-standard","has-post-thumbnail","category-science","tag-epidemiology","tag-general","tag-laboratory-medicine","tag-medicine-public-health","tag-new-zealand","tag-newzealand","tag-nz","tag-ophthalmology","tag-outcomes-research","tag-pharmaceutical-sciences-technology","tag-science","tag-surgery","tag-surgical-oncology"],"_links":{"self":[{"href":"https:\/\/www.newsbeep.com\/nz\/wp-json\/wp\/v2\/posts\/294939","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.newsbeep.com\/nz\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.newsbeep.com\/nz\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/nz\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/nz\/wp-json\/wp\/v2\/comments?post=294939"}],"version-history":[{"count":0,"href":"https:\/\/www.newsbeep.com\/nz\/wp-json\/wp\/v2\/posts\/294939\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/nz\/wp-json\/wp\/v2\/media\/294940"}],"wp:attachment":[{"href":"https:\/\/www.newsbeep.com\/nz\/wp-json\/wp\/v2\/media?parent=294939"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.newsbeep.com\/nz\/wp-json\/wp\/v2\/categories?post=294939"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.newsbeep.com\/nz\/wp-json\/wp\/v2\/tags?post=294939"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}