{"id":311588,"date":"2026-03-03T22:27:12","date_gmt":"2026-03-03T22:27:12","guid":{"rendered":"https:\/\/www.newsbeep.com\/nz\/311588\/"},"modified":"2026-03-03T22:27:12","modified_gmt":"2026-03-03T22:27:12","slug":"what-full-body-mris-and-cancer-blood-tests-really-offer","status":"publish","type":"post","link":"https:\/\/www.newsbeep.com\/nz\/311588\/","title":{"rendered":"What Full Body MRIs and Cancer Blood Tests Really Offer"},"content":{"rendered":"<p data-journey-content=\"true\" data-node-id=\"0\" class=\"body-dropcap css-1xzgd0b emevuu60\">M<a href=\"https:\/\/guardanthealth.com\/products\/tests-for-cancer-screening\/\" target=\"_blank\" data-vars-ga-outbound-link=\"https:\/\/guardanthealth.com\/products\/tests-for-cancer-screening\/\" data-vars-ga-ux-element=\"Hyperlink\" data-vars-ga-call-to-action=\"https:\/\/guardanthealth.com\/pro...\" data-node-id=\"0.0.1\" class=\"body-link css-10fnnmt emevuu60\" rel=\"nofollow noopener\">https:\/\/guardanthealth.com\/pro&#8230;<\/a>Y BROTHER&#8217;S EYESIGHT started to fail in February 2024. The problem came on suddenly: Text messages were blurry, then faces. Soon he was afraid to drive. His eye doctor suspected a retina issue. But when the problem didn\u2019t resolve on its own, he sent him for an MRI \u201cto be safe,\u201d which felt anything but. The scan would reveal a small tumor growing on his brain stem, the part of the body that regulates vital functions like breath control and heart rate. It was also pressing on a cranial nerve, which explained the changes in his vision\u2014though that was a minor concern now.<\/p>\n<p data-journey-content=\"true\" data-node-id=\"1\" class=\"css-6wxqfj emevuu60\">Because of the tumor\u2019s location, a biopsy was deemed too risky, let alone surgery to remove it. And my brother, Jon, started chemotherapy and radiation within days. Surgery eventually followed, and then two separate clinical trials, but his deterioration continued unabated. It was devastating to watch. A walker (for balance) gave way to a wheelchair. And Jon, a former Division I athlete, eventually lost so much motor control that he needed his food cut up for him. Soon, he was sleeping in a hospital bed in what had been his family\u2019s guest room.<\/p>\n<p data-journey-content=\"true\" data-node-id=\"2\" class=\"css-6wxqfj emevuu60\">Eighteen months after his diagnosis, my brother was dead. He\u2019d turned 51 a week earlier, and there was still leftover birthday cake in the freezer, which we had to throw out to make room for all of the food people started sending, which I appreciated but couldn\u2019t bring myself to eat.<\/p>\n<p data-journey-content=\"true\" data-node-id=\"4\" class=\"css-6wxqfj emevuu60\">Before Jon got sick, I was never all that curious about my own health, a luxury of youth I was desperately clinging to despite all evidence to the contrary (the gray hair, that involuntary \u201coof\u201d sound one makes getting out of the car). I don\u2019t wear an Oura ring, and not just because I think they\u2019re hideous (though they are). I don\u2019t eat creatine chews or sit in an ice bath. And I run three days a week mostly so I don\u2019t have to learn what a macro is.<\/p>\n<p data-journey-content=\"true\" data-node-id=\"5\" class=\"css-6wxqfj emevuu60\">But in the wake of my brother\u2019s diagnosis, I largely stopped taking care of myself\u2014skipping my own doctor\u2019s appointments and eating garbage, which is a common refrain among caretakers. Who has the time? During Jon\u2019s treatment, I was shuttling back and forth between my home in L.A. and his house in New Jersey, where I slept in the basement and drove him to appointments, sitting in an endless string of beige waiting rooms, helpless to do for him what he\u2019d so effortlessly done for me: make me feel safe.<\/p>\n<p><img draggable=\"true\" alt=\"jon rapkin was co captain of the cornell men\u2019s tennis team from 1995 to 1996. the author with his brother jon and nephew corey in 2014\" title=\"jon rapkin was co captain of the cornell men\u2019s tennis team from 1995 to 1996. the author with his brother jon and nephew corey in 2014\" loading=\"lazy\" width=\"3474\" height=\"2148\" decoding=\"async\" data-nimg=\"1\" style=\"color:transparent;width:100%;height:auto;\"   src=\"https:\/\/www.newsbeep.com\/nz\/wp-content\/uploads\/2026\/03\/hlh099926-an1-mortality-00-699f20081c9f2.jpg\" class=\"css-0 e1g79fud0\"\/>Courtesy Mickey Rapkin<\/p>\n<p>Jon Rapkin was co-captain of the Cornell men\u2019s tennis team from 1995 to 1996. The author with his brother Jon and nephew Corey in 2014.<\/p>\n<p data-journey-content=\"true\" data-node-id=\"7\" class=\"css-6wxqfj emevuu60\">The one thing I could do was keep a steady supply of Carvel on hand, which I did, one of the few things that made him happy besides spending time with his wife and kids. But three months after burying my brother, I started to worry: Was I next?<\/p>\n<p data-journey-content=\"true\" data-node-id=\"8\" class=\"css-6wxqfj emevuu60\">There\u2019s a strange feeling of mortality that creeps up in middle age. It\u2019s not just that a bunch of famous people who are basically my age are dying. Though the list is disturbingly long: Dawson\u2019s Creek star James Van Der Beek (48, colorectal cancer) and Euphoria\u2019s Eric Dane (53, ALS). Then there are the guys fighting for their lives: Ben Sasse, the Republican former senator from Nebraska (53, stage IV pancreatic cancer); the NBA\u2019s Jason Collins (47, stage IV glioblastoma). No one wants to talk about it. But your late 40s is a time when people you know suddenly start to die\u2014like my friend Miles Bingham, who passed away at 46 from pulmonary fibrosis.<\/p>\n<p data-journey-content=\"true\" data-node-id=\"9\" class=\"css-6wxqfj emevuu60\">When I started reporting this story, a colleague expressed his condolences on the loss of my brother, though he pointed out 51 was not \u201ctragically young.\u201d I wondered if he might be on the spectrum, but I knew what he was getting at. We have to start facing our mortality and figure out what, if anything, we can really do about it.<\/p>\n<p data-journey-content=\"true\" data-node-id=\"10\" class=\"css-6wxqfj emevuu60\">That conversation is nothing new. What\u2019s different in 2026 is the existence of all of these diagnostic and preventive protocols that have come to market\u2014a series of predictive tests that aim to detect cancer early enough to hopefully do something about it, like <a href=\"https:\/\/prenuvo.com\/clp?utm_source=google&amp;utm_medium=cpc&amp;utm_campaign=Google_Branded_USA_Exact+Phrase&amp;utm_adgroup=Branded_Proper&amp;utm_content=770633003931&amp;utm_term=prenuvo&amp;utm_device=c&amp;utm_id=22552773961&amp;gad_source=1&amp;gad_campaignid=22552773961&amp;gbraid=0AAAAAC8rmA9YXktyAbc2MYmeFcGZ5yf59&amp;gclid=CjwKCAiAqprNBhB6EiwAMe3yhkmryEi3-MMx4YZ8282hr5tExgpy4gL870HYTwP3dblW8txYnWcLehoC1gIQAvD_BwE\" target=\"_blank\" data-vars-ga-outbound-link=\"https:\/\/prenuvo.com\/clp?utm_source=google&amp;utm_medium=cpc&amp;utm_campaign=Google_Branded_USA_Exact+Phrase&amp;utm_adgroup=Branded_Proper&amp;utm_content=770633003931&amp;utm_term=prenuvo&amp;utm_device=c&amp;utm_id=22552773961&amp;gad_source=1&amp;gad_campaignid=22552773961&amp;gbraid=0AAAAAC8rmA9YXktyAbc2MYmeFcGZ5yf59&amp;gclid=CjwKCAiAqprNBhB6EiwAMe3yhkmryEi3-MMx4YZ8282hr5tExgpy4gL870HYTwP3dblW8txYnWcLehoC1gIQAvD_BwE\" data-vars-ga-ux-element=\"Hyperlink\" data-vars-ga-call-to-action=\"Prenuvo\" data-node-id=\"10.1\" class=\"body-link css-10fnnmt emevuu60\" rel=\"nofollow noopener\">Prenuvo<\/a>, an elective, full-body MRI you may have seen your favorite celebrity post about. (Kim Kardashian, dressed in hospital booties on Instagram, raved, \u201cI recently did this @prenuvo scan and had to tell you all about this life saving machine.\u201d)<\/p>\n<p data-journey-content=\"true\" data-node-id=\"11\" class=\"css-6wxqfj emevuu60\">Elsewhere, a pharmaceutical company called Grail has introduced <a href=\"https:\/\/www.galleri.com\/page\/hcp-cpc-lp1?utm_source=google&amp;utm_medium=cpc&amp;utm_term=galleri&amp;utm_campaign=galleri-hcp-brand&amp;detailrowid=d163878&amp;gclsrc=aw.ds&amp;gad_source=1&amp;gad_campaignid=21362545643&amp;gbraid=0AAAAABZLkwYUmnP8WEFo7C0A6qATtjbLZ&amp;gclid=CjwKCAiAqprNBhB6EiwAMe3yhlnMIjnQjZkvK5rqkFAg-yB3Hq1oLA2xYh-d84bv7drNXQd5BrmIphoCTdMQAvD_BwE\" target=\"_blank\" data-vars-ga-outbound-link=\"https:\/\/www.galleri.com\/page\/hcp-cpc-lp1?utm_source=google&amp;utm_medium=cpc&amp;utm_term=galleri&amp;utm_campaign=galleri-hcp-brand&amp;detailrowid=d163878&amp;gclsrc=aw.ds&amp;gad_source=1&amp;gad_campaignid=21362545643&amp;gbraid=0AAAAABZLkwYUmnP8WEFo7C0A6qATtjbLZ&amp;gclid=CjwKCAiAqprNBhB6EiwAMe3yhlnMIjnQjZkvK5rqkFAg-yB3Hq1oLA2xYh-d84bv7drNXQd5BrmIphoCTdMQAvD_BwE\" data-vars-ga-ux-element=\"Hyperlink\" data-vars-ga-call-to-action=\"Galleri\" data-node-id=\"11.1\" class=\"body-link css-10fnnmt emevuu60\" rel=\"nofollow noopener\">Galleri<\/a>, a blood test that purports to detect cancer long before symptoms arise\u2014an emerging class of multi-cancer early-detection (MCED) tests that are not yet FDA approved or typically covered by insurance. Which, for the MAHA crowd, is probably a selling point.<\/p>\n<p data-journey-content=\"true\" data-node-id=\"12\" class=\"css-6wxqfj emevuu60\">But after losing my brother so quickly\u2014and it was dizzying\u2014I was increasingly paralyzed by the thought that some silent killer was coming for me. Would undergoing these tests help me take control of my health? Or would all of that information (and it was a lot of information) make me crazy? Put another way: What\u2019s the out-of-pocket cost for peace of mind?<\/p>\n<p><img draggable=\"true\" alt=\"divider\" title=\"divider\" loading=\"lazy\" width=\"1596\" height=\"217\" decoding=\"async\" data-nimg=\"1\" style=\"color:transparent;width:100%;height:auto;\"   src=\"https:\/\/www.newsbeep.com\/nz\/wp-content\/uploads\/2026\/03\/divider-mortality-699f20cb61dc8.png\" class=\"css-0 e1g79fud0\"\/><\/p>\n<p data-journey-content=\"true\" data-node-id=\"14\" class=\"css-6wxqfj emevuu60\">PRENUVO WAS FOUNDED in 2018 and offers an hour-long-ish MRI that scans your body for a long list of things that might kill you or, at least, seriously complicate matters: cancer, aneurysms, fatty liver, multiple sclerosis. Like you, I first heard about it when celebrities and fashion designers started posting about their experiences in 2023, prompting The New York Times to declare: \u201cThe New Status Symbol Is a Full-Body MRI.\u201d It was an amusing headline. Though I wasn\u2019t sure anyone was really getting the test for bragging rights. Like me, they were probably doing it because someone close to them died.<\/p>\n<p data-journey-content=\"true\" data-node-id=\"15\" class=\"css-6wxqfj emevuu60\">Prenuvo is certainly not cheap. The entry-level torso scan (which you might get if you\u2019re particularly concerned about, say, pancreatic cancer) runs to $1,000. But the AI-powered full-body scan costs $2,500. There is also a third tier\u2014an enhanced scan\u2014that includes extensive blood work plus an assessment of your brain health ($4,000 to $4,500). Prenuvo has 26 locations in a bunch of major cities (Chicago, Denver, New York, London) and also one in Buffalo, New York, apparently to capture the Toronto market.<\/p>\n<p data-journey-content=\"true\" data-node-id=\"16\" class=\"css-6wxqfj emevuu60\">More clinics are set to open soon\u2014in Charleston, North Carolina; Nashville; Pittsburgh; Singapore; and Dubai\u2014with a lower-cost tier rumored to be in the works. But I made an appointment at the Pasadena location, which happens to be in the basement of an Erewhon. The proximity to a Hailey Bieber smoothie bar felt a little on the nose, though I will say it\u2019s certainly the only medical office I\u2019ve been to where I was offered multiple brands of bottled water.<\/p>\n<p data-journey-content=\"true\" data-node-id=\"17\" class=\"css-6wxqfj emevuu60\">Prenuvo\u2019s CEO, Andrew Lacy, later hopped on a Zoom call to talk about how his company is empowering customers to take control of their own health care. Lacy just turned 50 in October, and like me, he isn\u2019t a Huberman type either. He\u2019s a serial entrepreneur from Australia who punished his body for years chasing returns. When he heard about a company in Canada that was offering MRIs on demand in 2019, he saw a business opportunity first. \u201cThere is so much wrong with the health system,\u201d he says. \u201cI think you almost need to reimagine it from the very beginning.\u201d<\/p>\n<p data-journey-content=\"true\" data-node-id=\"18\" class=\"css-6wxqfj emevuu60\">MRI technology isn\u2019t new (though Prenuvo\u2019s software is updated monthly, Lacy tells me, including an additional diagnostic to better identify pancreatic cancer). What is new is asking for it. And some doctors think that presents its own problem. According to Ernest Hawk, MD, a vice president and head of the cancer prevention and population sciences division at the University of Texas MD Anderson Cancer Center, \u201cAnytime we subject any population to testing, you\u2019re going to find things you didn\u2019t anticipate.\u201d A nodule, a mysterious lump, whatever. Those tiny abnormalities lurking in your body generally turn out to be nothing. But they may require further (expensive and potentially dangerous) biopsies, turning otherwise healthy people into patients.<\/p>\n<p data-journey-content=\"true\" data-node-id=\"19\" class=\"css-6wxqfj emevuu60\">Dr. Hawk calls these \u201cvoyages\u201d anxiety-inducing and also expensive. I know what he means. If I took my dog to the vet every time I felt a weird bump on his leg, we\u2019d both be sleeping on the floor. Thankfully, my dog can\u2019t Google his symptoms in the middle of the night. Which, come to think of it, is another problem with elective scans. This may sound counterintuitive, but not every cancer is worth treating. In 2012, a study in The New England Journal of Medicine revealed that among men with localized prostate cancer, total removal of the organ did not improve survival rates compared with men who adopted a wait-and-see approach. Those who\u2019d had their prostates removed were maybe cancer-free. But they were now also incontinent. And (worse) couldn\u2019t get hard. Is that empowerment or is it capitalism run amok? (In an adjacent example, doctors are increasingly pushing back on thyroid removal, because most types of the cancer are slow-growing and because removing the gland entirely forces the patient to be on hormone replacement drugs for the rest of their life.)<\/p>\n<p><img draggable=\"true\" alt=\"mri brain scan overlayed with data visuals and a barcode\" title=\"mri brain scan overlayed with data visuals and a barcode\" loading=\"lazy\" width=\"2400\" height=\"1745\" decoding=\"async\" data-nimg=\"1\" style=\"color:transparent;width:100%;height:auto;\"   src=\"https:\/\/www.newsbeep.com\/nz\/wp-content\/uploads\/2026\/03\/hlh099926-an1-mortality-002-699f20fba2627.jpg\" class=\"css-0 e1g79fud0\"\/><\/p>\n<p>Courtesy Mickey Rapkin<\/p>\n<p data-journey-content=\"true\" data-node-id=\"21\" class=\"css-6wxqfj emevuu60\">Perhaps in an attempt to satisfy Prenuvo\u2019s critics, in May 2025 the company released the early findings of its ongoing clinical trial. Prenuvo enrolled 1,011 patients who underwent preemptive full-body scans. Most had no symptoms. But the test turned up potential signs of cancer in about 50 people, who later underwent biopsies. About 20 of those people really did have cancer. The rest merely lost a day of work for a procedure they never needed.<\/p>\n<p data-journey-content=\"true\" data-node-id=\"22\" class=\"css-6wxqfj emevuu60\">Thomas C. Kwee, PhD, a radiologist at the University Medical Center Groningen in the Netherlands, complained to The New York Times that this was a \u201cnonrandomized study.\u201d Which maybe isn\u2019t the flex he thinks it is. Because 22 people who didn\u2019t think they had cancer found out they did. And 19 of those people said they had no symptoms. There\u2019s no way to know whether Prenuvo actually saved their lives without the kind of academic study that would satisfy Kwee. But who can afford to wait?<\/p>\n<p data-journey-content=\"true\" data-node-id=\"23\" class=\"css-6wxqfj emevuu60\">Even Sean Clifford, currently suing Prenuvo, admits the test works. (He had a debilitating stroke in March 2024, nearly eight months after Prenuvo declared no adverse findings with regard to the then 37-year-old\u2019s brain health; it turns out his scan showed signs of an arterial narrowing, but he alleges the radiologist misread it.) The case is in early stages, but the defendants have denied the allegations. I tried not to think about any of that as I slid into Prenuvo\u2019s MRI tube, wondering if my brother had felt this alone each time he was wheeled into a room for tests, once emerging from a machine called a Gamma Knife bleeding from the spot where a screw had been drilled into his face to keep him from moving.<\/p>\n<p data-journey-content=\"true\" data-node-id=\"24\" class=\"css-6wxqfj emevuu60\">It would be three long weeks before I got the results.<\/p>\n<p><img draggable=\"true\" alt=\"divider\" title=\"divider\" loading=\"lazy\" width=\"1596\" height=\"217\" decoding=\"async\" data-nimg=\"1\" style=\"color:transparent;width:100%;height:auto;\"   src=\"https:\/\/www.newsbeep.com\/nz\/wp-content\/uploads\/2026\/03\/divider-mortality-699f20cb61dc8.png\" class=\"css-0 e1g79fud0\"\/><\/p>\n<p data-journey-content=\"true\" data-node-id=\"26\" class=\"css-6wxqfj emevuu60\">MANY SUCCESSFUL BUSINESSES are built on consumer insecurity. Without this skin cream, these sneakers, this hot dinner reservation, you\u2019re missing out. Tests like Prenuvo\u2019s\u2014and those of its competitors, such as Ezra, simonONE, and Neko\u2014certainly feed on that FOMO, taking advantage of our creeping sense of mortality. Except the sales pitch is even more compelling because the consequences are potentially life-or-death.<\/p>\n<p data-journey-content=\"true\" data-node-id=\"27\" class=\"css-6wxqfj emevuu60\">Not surprisingly, money is pouring in. Prenuvo (which has completed over 150,000 scans) counts former Google CEO Eric Schmidt, Nest\u2019s founder Tony Fadell, and Casamigos\u2019s Rande Gerber among its investors. The venture capital giant Andreessen Horowitz, meanwhile, has a stake in Function Health, cofounded by Mark Hyman, MD, a company that tests your blood for more than 100 biomarkers that your primary care doctor won\u2019t typically check unless you have underlying symptoms. Dr. Hyman isn\u2019t a fringe figure; in January, Sweetgreen introduced a new menu in collaboration with Function Health across its more than 280 locations.<\/p>\n<p data-journey-content=\"true\" data-node-id=\"28\" class=\"css-6wxqfj emevuu60\">Daniel Ek, cofounder of Spotify, is pushing Neko Health (which does a scan similar to Prenuvo\u2019s and will open its first U.S. location in New York this spring). Meanwhile, Whole Foods cofounder John Mackey opened Love.Life in 2024, a holistic health and wellness center in El Segundo, California; the most popular membership costs $11,400 a year and includes (among other offerings) a longevity screening.<\/p>\n<p data-journey-content=\"true\" data-node-id=\"29\" class=\"css-6wxqfj emevuu60\">\u201cPart of our mission is shifting from sick care into a preventative and well-care model,\u201d says Love.Life cofounder Betsy Foster.<\/p>\n<p data-journey-content=\"true\" data-node-id=\"30\" class=\"css-6wxqfj emevuu60\">I can only imagine demand for services like these will grow as Robert F. Kennedy Jr.\u2019s U.S. Department of Health and Human Services continues to sow distrust, putting the onus on consumers to care for themselves. Which\u2014like everything in this country\u2014is fine if you can afford it. Less so if you\u2019re struggling. (I should say here, we were lucky that my brother and his wife could afford a part-time aide, a Ukrainian refugee who would be a gift to this country.) But in the aftermath of a loss I was powerless to prevent, I could certainly see the appeal of a growing sector that trades on a sense of control.<\/p>\n<p data-journey-content=\"true\" data-node-id=\"31\" class=\"css-6wxqfj emevuu60\">While I waited for the results of my own Prenuvo scan, I signed up for Grail\u2019s Galleri blood test. Introduced in 2021, the test uses a standard blood draw to screen for more than 50 different types of cancer\u2014including some (like pancreatic and liver cancer) that often go undetected until advanced disease progression. The Galleri experience costs $949, is not yet FDA approved, and requires a prescription, which you can get through Grail\u2019s website after answering some basic medical questions. The whole thing took two minutes to fill out, and a few days later, a nurse showed up at my doorstep to draw my blood. It turns out health care is extremely convenient when you\u2019re paying cash.<\/p>\n<p><a>\u201cCONTROL IS AN ILLUSION.<\/a> I learned that the hardest way, by watching my brother <a>BRING A GAMMA KNIFE TO A GUN FIGHT,<\/a> which is the kind of joke he would have laughed at. And we managed to laugh a lot in those 18 months\u2014<a>THE ONE GIFT THAT CAME FROM THIS NIGHTMARE.<\/a>\u201d<\/p>\n<p data-journey-content=\"true\" data-node-id=\"33\" class=\"css-6wxqfj emevuu60\">Grail oncologist Eric Klein, MD, got on the phone to walk me through the science behind the test. Without getting too far into the weeds, he tells me Galleri uses \u201cthe same technology that was used to sequence the human genome,\u201d adding it looks for DNA in the bloodstream that\u2019s been shed by a cancer cell. This DNA \u201ctells us two things,\u201d Dr. Klein says: \u201cIs cancer likely present or absent? And if it\u2019s present\u2014with better than 90 percent accuracy\u2014what kind of cancer is it?\u201d (Tests from Grail competitors such as Singlera Genomics, Burning Rock Dx, and Exact Sciences\u2019 Cancerguard use similar technology.)<\/p>\n<p data-journey-content=\"true\" data-node-id=\"34\" class=\"css-6wxqfj emevuu60\">There\u2019s reason to be optimistic. In October, preliminary results from a major study called Pathfinder 2 were released. This is the kind of legit, large-scale study that might convince skeptical scientists. And the data was pretty convincing: Some 35,000 people had their blood drawn, and according to Dr. Klein, the Galleri test increased the detection of cancers by sevenfold when combined with recommended preventive screenings compared to screenings alone. More than 50 percent of the cancers found by the test were stage I or II, he says, and more important, about 70 percent were stage I, II, or III nonmetastatic\u2014meaning they were potentially curable.<\/p>\n<p data-journey-content=\"true\" data-node-id=\"35\" class=\"css-6wxqfj emevuu60\">Before you go popping the champagne emoji, MD Anderson\u2019s Dr. Hawk threw some water on those early findings. The New York Times reported that the Galleri test missed 60 percent of cancers that went on to be detected within a year. \u201cIt actually kind of found more false negatives than it did true positives,\u201d he says. (For context, Galleri reports a false-positive rate of 0.4 percent, compared with about 10 percent for mammograms, for example).<\/p>\n<p data-journey-content=\"true\" data-node-id=\"36\" class=\"css-6wxqfj emevuu60\">More studies are underway. Results from the largest of its kind on MCED tests recently found that the Galleri test didn\u2019t reduce stage 3 diagnoses. But some doctors don\u2019t think that\u2019s the end of the conversation for this or other MCED tests, as the study was designed to look at only one endpoint and it may still be valuable for detecting some cancers at other stages. But for now, it\u2019s too early for Dr. Hawk\u2014or Memorial Sloan Kettering Cancer Center\u2019s Larry Norton, MD\u2014to endorse these MCED tests. Unlike long-established screenings for breast, skin, colon, and lung cancer, both say, there\u2019s no evidence these tests reduce the risk of death from the cancers they do find.<\/p>\n<p><img draggable=\"true\" alt=\"medical imaging featuring anatomical views alongside heartbeat graphs\" title=\"medical imaging featuring anatomical views alongside heartbeat graphs\" loading=\"lazy\" width=\"2400\" height=\"1829\" decoding=\"async\" data-nimg=\"1\" style=\"color:transparent;width:100%;height:auto;\"   src=\"https:\/\/www.newsbeep.com\/nz\/wp-content\/uploads\/2026\/03\/hlh099926-an1-mortality-003-699f228ba68b4.jpg\" class=\"css-0 e1g79fud0\"\/><\/p>\n<p>Courtesy Mickey Rapkin<\/p>\n<p data-journey-content=\"true\" data-node-id=\"38\" class=\"css-6wxqfj emevuu60\">Dr. Norton likens this whole thing to fighting forest fires. \u201cTo stop a forest fire, you\u2019ve got to find exactly where it is,\u201d he says. (If it\u2019s not obvious, cancer is the fire.) \u201cAnd you have to have the tools to put out the fire. Where we are in this field now is, we\u2019re getting very good at sniffing smoke. But finding out precisely where it is\u2014and finding what to do about it\u2014is an evolution.\u201d<\/p>\n<p data-journey-content=\"true\" data-node-id=\"39\" class=\"css-6wxqfj emevuu60\">And there\u2019s a chance that early detection\u2014without a plan to put out the fire\u2014just gives you more time to worry. To extend the forest fire metaphor, he says, if a patient waited to see flames, Dr. Norton could \u201csend a helicopter with water, and I could put it out. In other words, my intervention would have the same chance of eradicating the problem. It didn\u2019t gain me anything to smell the smoke.\u201d<\/p>\n<p data-journey-content=\"true\" data-node-id=\"40\" class=\"css-6wxqfj emevuu60\">So, those 22 mostly asymptomatic people from the Prenuvo study? They very well might have found their cancers later and had the exact same outcome. Also, if a test reveals you have cancer\u2014but it\u2019s too early to see where that cancer\u2019s coming from\u2014you\u2019ve really just bought yourself more anxiety. And what good is that?<\/p>\n<p data-journey-content=\"true\" data-node-id=\"41\" class=\"css-6wxqfj emevuu60\">Still, I couldn\u2019t shake a conversation I\u2019d had with Roger Royse, a start-up lawyer in Silicon Valley. Royse had read about the Galleri test in a book coauthored by (of all people) Tony Robbins. Royse was 62 at the time and intrigued by this blood test purported to screen for so many cancers. He\u2019d previously had some stomach pains, but after those had lessened, his primary care doctor had basically told him not to worry. But Royse dog-eared the page anyway and scheduled the test.<\/p>\n<p data-journey-content=\"true\" data-node-id=\"42\" class=\"css-6wxqfj emevuu60\">Shortly after his blood draw, Royse got a call from an oncologist telling him the Galleri test had shown a strong signal for pancreatic cancer and that he should seek further testing. An MRI revealed a large mass on Royse\u2019s pancreas, and he was later diagnosed with stage IIB borderline resectable pancreatic cancer.<\/p>\n<p data-journey-content=\"true\" data-node-id=\"43\" class=\"css-6wxqfj emevuu60\">Royse began treatment at Stanford within days, calling his diagnosis a \u201cfour-alarm fire.\u201d He\u2019s in remission now, having beaten the odds. And in September, he testified on Capitol Hill, advocating for tests like Grail\u2019s to be covered by Medicare (which could eventually lead to coverage by other health insurers). Without the Galleri test, \u201cI\u2019d be dead now,\u201d he says plainly. The sad irony, he points out, is that while he beat a notoriously aggressive cancer (thanks to early diagnosis), his brother passed away from a more curable lymphoma after putting off an appointment. Says Royce, \u201cMy brother didn\u2019t know he had cancer until he was wheeled into the emergency room on a stretcher.\u201d<\/p>\n<p data-journey-content=\"true\" data-node-id=\"44\" class=\"css-6wxqfj emevuu60\">When I mention concerns from experts\u2014about unnecessary biopsies and false negatives\u2014Royse doesn\u2019t mince words. \u201cThat is such bullshit,\u201d he says. \u201cWe have the ultimate false-negative test now. When I went to my doctor, he said, \u2018There\u2019s nothing wrong with you. We don\u2019t know why you\u2019ve got stomach pain, but you sure as hell don\u2019t have cancer.\u2019 Talk about a false negative.\u201d<\/p>\n<p><img draggable=\"true\" alt=\"divider\" title=\"divider\" loading=\"lazy\" width=\"1596\" height=\"217\" decoding=\"async\" data-nimg=\"1\" style=\"color:transparent;width:100%;height:auto;\"   src=\"https:\/\/www.newsbeep.com\/nz\/wp-content\/uploads\/2026\/03\/divider-mortality-699f20cb61dc8.png\" class=\"css-0 e1g79fud0\"\/><\/p>\n<p data-journey-content=\"true\" data-node-id=\"46\" class=\"css-6wxqfj emevuu60\">I THINK WE\u2019RE in an era where it\u2019s better to have data than not have data,\u201d says Grail\u2019s Dr. Klein. Considering my own history, I\u2019m certainly not an objective narrator. But I don\u2019t know how anyone over 40 could hear Royse\u2019s story and not want to take the test. Waiting for my own results\u2014and waiting, and waiting\u2014I half-joke to MD Anderson\u2019s Dr. Hawk that there should be a German word for such a convincing anecdote.<\/p>\n<p data-journey-content=\"true\" data-node-id=\"47\" class=\"css-6wxqfj emevuu60\">He laughs. But MSK\u2019s Dr. Norton is less entertained. \u201cYou\u2019re going to hear anecdotes like that,\u201d he says, before countering with his own\u2014about a patient who\u2019d taken a blood test that indicated \u201cpotential kidney cancer.\u201d Subsequent imaging revealed a mass on one of this person\u2019s kidneys, and the organ was removed. But the mass turned out to be benign. \u201cNow the patient\u2019s got one kidney,\u201d Dr. Norton says, adding: \u201cThe term for that is overdiagnosis.\u201d<\/p>\n<p data-journey-content=\"true\" data-node-id=\"48\" class=\"css-6wxqfj emevuu60\">\u201cMore information is not necessarily better than no information,\u201d Dr. Norton adds, \u201cif that more information doesn\u2019t lead to a productive action but leads to excessive anxiety.\u201d<\/p>\n<p><img draggable=\"true\" alt=\"jon rapkin on the new center court in north caldwell, new jersey, march 2025\" title=\"jon rapkin on the new center court in north caldwell, new jersey, march 2025\" loading=\"lazy\" width=\"2400\" height=\"2148\" decoding=\"async\" data-nimg=\"1\" style=\"color:transparent;width:100%;height:auto;\"   src=\"https:\/\/www.newsbeep.com\/nz\/wp-content\/uploads\/2026\/03\/hlh099926-an1-mortality-004-699f2306044f7.jpg\" class=\"css-0 e1g79fud0\"\/>Courtesy Mickey Rapkin<\/p>\n<p>Jon Rapkin on the new center court in North Caldwell, New Jersey, March 2025. The town dedicated the court to Rapkin because he advocated for improving the town\u2019s parks and facilities to provide better recreational opportunities for all.<\/p>\n<p data-journey-content=\"true\" data-node-id=\"50\" class=\"css-6wxqfj emevuu60\">Dr. Hawk has come to the same conclusion, and he takes no pleasure in telling me this. If he were in my shoes, he says, he might be tempted to take a test like Prenuvo\u2019s himself. \u201cWe\u2019re all rooting for these things to work just as they\u2019re marketed right now,\u201d he says. \u201cBut until we really have that solid data showing that more people are benefited than harmed, we\u2019re going to be a little bit reluctant to recommend them to anyone.\u201d<\/p>\n<p data-journey-content=\"true\" data-node-id=\"51\" class=\"css-6wxqfj emevuu60\">On an intellectual level, he is absolutely right. Both doctors are. I hoped that if anything weird turned up in my scan, follow-up testing would reveal it to be nothing. But I also knew that sometimes, that nothing turns out to be a brain stem glioma, and you watch your brother lose his strength and his independence. Soon, he needs help getting dressed and then help going to the bathroom. His speech, meanwhile, becomes harder and harder to understand, despite his intellect remaining perfectly intact, which is maybe worse. He was trapped in his body.<\/p>\n<p data-journey-content=\"true\" data-node-id=\"52\" class=\"css-6wxqfj emevuu60\">I was willing to take the risk.<\/p>\n<p data-journey-content=\"true\" data-node-id=\"53\" class=\"css-6wxqfj emevuu60\">Shortly before the New Year, I got the Galleri results\u2014in an email I almost missed, buried beneath alerts from J.Crew about a year-end sale and instructions from my Airbnb host on what to do with the linens. The report was several pages long, but all I needed was the top line, which read: \u201cNo cancer signal detected.\u201d<\/p>\n<p data-journey-content=\"true\" data-node-id=\"54\" class=\"css-6wxqfj emevuu60\">A week later, I had an hour-long Zoom call with Prenuvo\u2019s Vikash Modi, MD, to go over the results of my MRI. Mercifully, he got right to it: There was no tumor lurking in my brain, no aneurysm, no silent killer. I exhaled deeply.<\/p>\n<p data-journey-content=\"true\" data-node-id=\"55\" class=\"css-6wxqfj emevuu60\">Nothing would bring my brother back. I knew that too. But I couldn\u2019t stop myself from asking: Could these tests have made a difference? Dr. Klein was quick to respond. There\u2019s something called a blood-brain barrier, he explains, and it\u2019s unlikely a blood test would catch a brain tumor. I asked the same of Prenuvo\u2019s Dr. Modi, and he sighed. \u201cThere\u2019s no advantage in playing that game now,\u201d he says kindly. A Prenuvo scan might have revealed the tumor sooner, but because of where it was located, the road was always going to be shit.<\/p>\n<p data-journey-content=\"true\" data-node-id=\"56\" class=\"css-6wxqfj emevuu60\">\u201cThat location is just fucking awful,\u201d he says, apologizing for his language. Frankly, I wish others in the last two years had been so candid. Dr. Modi went on to share some interesting findings from my own scan and blood work (including an asymmetry in my piriformis muscle that I should work on). Halfway through the Zoom call, it occurred to me that I\u2019d spoken with Dr. Modi for longer than I\u2019d spoken with my primary care provider in a decade, which is maybe what you\u2019re also paying for. How do you put a price on compassion?<\/p>\n<p>\u201cSome people are scared to know <a>WHAT\u2019S GOING ON INSIDE THEIR BODY.<\/a> But whether you know or don\u2019t know, <a>IT\u2019S STILL THERE.<\/a> The difference is that knowing allows you to understand how <a>PROACTIVE AND SERIOUS YOUR INTERVENTIONS NEED TO BE.<\/a>\u201d<\/p>\n<p data-journey-content=\"true\" data-node-id=\"58\" class=\"css-6wxqfj emevuu60\">The one thing everyone interviewed for this story can agree on is that the best way to treat cancer is not to get it. And I wasn\u2019t honoring my brother\u2019s memory by ordering a third glass of wine (my preferred carcinogen). Or getting fat\u2014which I had, putting on almost 15 pounds in grief.<\/p>\n<p data-journey-content=\"true\" data-node-id=\"59\" class=\"css-6wxqfj emevuu60\">When it comes to health care, the choose-your-own-adventure approach may be expensive, but it\u2019s nice to feel that you\u2019re part of a team. After getting my Prenuvo results\u2014where my blood work revealed a methylation issue that could be worsening my anxiety\u2014I ordered a vitamin Dr. Modi suggested, and I vowed to do the work. While I don\u2019t have the cash to join Love.Life (I wish), I can afford the $299 it cost to swab my cheek and send the sample to <a href=\"https:\/\/3x4genetics.com\/products\/3x4-health?gad_campaignid=18927039599&amp;gad_source=1&amp;gbraid=0AAAAApD7f3nybgrxeKr3eNTxX1owiYLVX&amp;gclid=CjwKCAiAqprNBhB6EiwAMe3yht7T1pIH2-DXOaRT2x4-D5niRCh5F-9FTkMbpXVHT--Ydq31K6Gy0BoCy7IQAvD_BwE&amp;hsa_acc=9675527449&amp;hsa_ad=696797228865&amp;hsa_cam=18927039599&amp;hsa_grp=142154761143&amp;hsa_kw=3x4+genetics&amp;hsa_mt=p&amp;hsa_net=adwords&amp;hsa_src=g&amp;hsa_tgt=kwd-1215610245260&amp;hsa_ver=3&amp;utm_campaign=GS_BR_Mixed_Core-Brand_US&amp;utm_content=%7B%7Bad.id%7D%7D&amp;utm_medium=ppc&amp;utm_source=adwords&amp;utm_term=3x4+genetics\" target=\"_blank\" data-vars-ga-outbound-link=\"https:\/\/3x4genetics.com\/products\/3x4-health?gad_campaignid=18927039599&amp;gad_source=1&amp;gbraid=0AAAAApD7f3nybgrxeKr3eNTxX1owiYLVX&amp;gclid=CjwKCAiAqprNBhB6EiwAMe3yht7T1pIH2-DXOaRT2x4-D5niRCh5F-9FTkMbpXVHT--Ydq31K6Gy0BoCy7IQAvD_BwE&amp;hsa_acc=9675527449&amp;hsa_ad=696797228865&amp;hsa_cam=18927039599&amp;hsa_grp=142154761143&amp;hsa_kw=3x4+genetics&amp;hsa_mt=p&amp;hsa_net=adwords&amp;hsa_src=g&amp;hsa_tgt=kwd-1215610245260&amp;hsa_ver=3&amp;utm_campaign=GS_BR_Mixed_Core-Brand_US&amp;utm_content=%7B%7Bad.id%7D%7D&amp;utm_medium=ppc&amp;utm_source=adwords&amp;utm_term=3x4+genetics\" data-vars-ga-ux-element=\"Hyperlink\" data-vars-ga-call-to-action=\"3X4 Genetics\" data-node-id=\"59.1\" class=\"body-link css-10fnnmt emevuu60\" rel=\"nofollow noopener\">3X4 Genetics<\/a>, a Seattle-based company that promises to go deep on your DNA, revealing things like how much vitamin D you really need and how well your body tolerates fat and carbs. After reading the data lurking in your code, they\u2019ll upload your results to their app along with personalized health and diet recommendations.<\/p>\n<p data-journey-content=\"true\" data-node-id=\"60\" class=\"css-6wxqfj emevuu60\">While I was waiting for my DNA findings, I scheduled an appointment to try <a href=\"https:\/\/guardanthealth.com\/products\/tests-for-cancer-screening\/\" target=\"_blank\" data-vars-ga-outbound-link=\"https:\/\/guardanthealth.com\/products\/tests-for-cancer-screening\/\" data-vars-ga-ux-element=\"Hyperlink\" data-vars-ga-call-to-action=\"Guardant\u2019s Shield\" data-node-id=\"60.1\" class=\"body-link css-10fnnmt emevuu60\" rel=\"nofollow noopener\">Guardant\u2019s Shield<\/a>, an FDA-approved test for colorectal cancer that can be done with a standard blood draw. Nothing is considered as effective as a traditional colonoscopy, but Shield comes close, and it doesn\u2019t require missing a day of work. (Or a messy clean-out.)<\/p>\n<p data-journey-content=\"true\" data-node-id=\"61\" class=\"css-6wxqfj emevuu60\">Control is an illusion. I learned that the hardest way, by watching my brother bring a Gamma Knife to a gunfight, which is the kind of joke he would have laughed at. And we managed to laugh a lot in those 18 months\u2014the one gift that came from this nightmare, as I put as much work aside as I could, ignoring my friends and my marriage as I just sat with my brother, as he would have done for me if the situation were reversed. And I wish every day that it had been.<\/p>\n<p data-journey-content=\"true\" data-node-id=\"62\" class=\"css-6wxqfj emevuu60\">I\u2019m still wrestling with a cloud of grief, and I would still rather stay home than talk to anyone. But I\u2019d like to see my niece and nephew graduate from college and get married (or not!) and cheer them on, as I promised my brother I would. And for that, I need to be healthy. And I\u2019m starting to see that fear\u2019s only use is motivation.<\/p>\n<p data-journey-content=\"true\" data-node-id=\"63\" class=\"css-6wxqfj emevuu60\">As Jonathan Leary, DC, the founder of Remedy Place, a self-care wellness club\u2014with locations in New York, Boston, and Los Angeles\u2014told me, \u201cSome people are scared to know what\u2019s going on inside their body. But whether you know or don\u2019t know, it\u2019s still there. The difference is that knowing allows you to understand how proactive and serious your interventions need to be.\u201d<\/p>\n<p><img src=\"https:\/\/www.newsbeep.com\/nz\/wp-content\/uploads\/2026\/03\/dc97388f-1bd2-4621-9de4-50c59db232a8_1521573567.jpg\" alt=\"Headshot of Mickey Rapkin\" title=\"Headshot of Mickey Rapkin\" width=\"100%\" height=\"100%\" decoding=\"async\" loading=\"lazy\" class=\"css-o0wq4v ev8dhu53\"\/><\/p>\n<p>Mickey Rapkin is a journalist and screenwriter whose first book, Pitch Perfect, inspired the film series. Previously a senior editor at GQ, he has written for The New York Times, WSJ, and National Geographic. He lives in Los Angeles.<\/p>\n","protected":false},"excerpt":{"rendered":"Mhttps:\/\/guardanthealth.com\/pro&#8230;Y BROTHER&#8217;S EYESIGHT started to fail in February 2024. The problem came on suddenly: Text messages were blurry,&hellip;\n","protected":false},"author":2,"featured_media":311589,"comment_status":"","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[6],"tags":[169532,169526,13507,169513,169518,32532,2535,12690,28404,12240,169535,64609,169522,169523,169530,169521,169520,169514,98716,169516,49286,99803,4532,169533,35791,169527,169524,3698,2047,169528,22349,169517,4367,18698,142634,169529,574,111,139,1374,69,169519,6841,13654,169515,26415,19086,15518,169534,5460,169525,169531,5032,145,2025,3036],"class_list":{"0":"post-311588","1":"post","2":"type-post","3":"status-publish","4":"format-standard","5":"has-post-thumbnail","7":"category-technology","8":"tag-3x4-genetics","9":"tag-ben-sasse","10":"tag-brain-cancer","11":"tag-brain-stem-tumor","12":"tag-cancer-blood-test","13":"tag-caregiving","14":"tag-chemotherapy","15":"tag-clinical-trials","16":"tag-colorectal-cancer","17":"tag-early-detection","18":"tag-el-segundo","19":"tag-eric-dane","20":"tag-eric-klein","21":"tag-ernest-hawk","22":"tag-ezra","23":"tag-false-negatives","24":"tag-false-positives","25":"tag-full-body-mri","26":"tag-function-health","27":"tag-galleri","28":"tag-glioma","29":"tag-grail","30":"tag-grief","31":"tag-guardant-shield","32":"tag-james-van-der-beek","33":"tag-jason-collins","34":"tag-larry-norton","35":"tag-longevity","36":"tag-los-angeles","37":"tag-love-life","38":"tag-lymphoma","39":"tag-mced","40":"tag-mortality","41":"tag-mri","42":"tag-multi-cancer-early-detection","43":"tag-neko-health","44":"tag-new-jersey","45":"tag-new-zealand","46":"tag-newzealand","47":"tag-nhs","48":"tag-nz","49":"tag-overdiagnosis","50":"tag-pancreatic-cancer","51":"tag-pasadena","52":"tag-prenuvo","53":"tag-preventive-screening","54":"tag-pulmonary-fibrosis","55":"tag-radiation","56":"tag-remedy-place","57":"tag-robert-f-kennedy-jr","58":"tag-roger-royse","59":"tag-simonone","60":"tag-stanford","61":"tag-technology","62":"tag-united-kingdom","63":"tag-vision-loss"},"_links":{"self":[{"href":"https:\/\/www.newsbeep.com\/nz\/wp-json\/wp\/v2\/posts\/311588","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.newsbeep.com\/nz\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.newsbeep.com\/nz\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/nz\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/nz\/wp-json\/wp\/v2\/comments?post=311588"}],"version-history":[{"count":0,"href":"https:\/\/www.newsbeep.com\/nz\/wp-json\/wp\/v2\/posts\/311588\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/nz\/wp-json\/wp\/v2\/media\/311589"}],"wp:attachment":[{"href":"https:\/\/www.newsbeep.com\/nz\/wp-json\/wp\/v2\/media?parent=311588"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.newsbeep.com\/nz\/wp-json\/wp\/v2\/categories?post=311588"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.newsbeep.com\/nz\/wp-json\/wp\/v2\/tags?post=311588"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}