Low-dose computed tomography (LDCT) screening \u201csignificantly reduces\u201d lung cancer mortality among patients within non-risk-based populations, according to recent data presented during the 2026 European Lung Cancer Congress (ELCC).<\/p>\n
A team of researchers from China conducted the study and presented their findings during a proffered paper session at ELCC 2026 in Copenhagen, Denmark.<\/p>\n
The investigators explained that the \u201cefficacy\u201d of LDCT screening \u201chas been established in selected populations in Western countries,\u201d but emphasized that \u201cthe distinct epidemiological characteristics\u201d of lung cancer among patients in Asian countries suggests that \u201cthe benefits of LDCT screening in non-risk-based populations warrant further investigation.\u201d<\/p>\n
The \u201cprospective, interventional, non-randomized controlled study\u201d included a \u201cscreened cohort\u201d and a \u201ccomparison cohort.\u201d The investigators explained that the screened cohort included patients who met eligibility criteria and were enrolled in the Lung-Care project, while patients in the comparison cohort were \u201cindividuals from the same geographic region and age range who did not undergo screening and served as a naturally occurring control cohort.\u201d<\/p>\n
The study team analyzed mortality outcomes through the Cox proportional hazards model and compared overall survival (OS) between \u201cscreen-detected and non-screen-detected\u201d cases of lung cancer. They also performed subgroup analyses among scree-detected cases of lung cancer \u201caccording to conventional lung cancer risk factors.\u201d<\/p>\n
According to the results, \u201cduring a median follow-up of 7 years, screening was associated with a significantly lower risk of lung cancer deaths\u201d (hazard ratio [HR], 0.45; 95% CI, 0.32-0.65, P<0.001). The investigators also reported results across \u201csex-stratified\u201d subgroup analyses, which showed that \u201cscreening was associated with reduced mortality in both men (HR 0.55; 95% CI 0.36-0.83; P=0.004) and women (HR 0.28; 95% CI 0.13-0.60; P<0.001).\u201d<\/p>\n
Furthermore, screen-detected cases among patients with lung cancer \u201cdemonstrated significantly better overall survival compared with those detected in the comparison cohort (HR 0.13; 95% CI 0.09-0.19; P<0.001).\u201d However, patients in the screened cohort categorized as \u201chigh risk\u201d per National Comprehensive Cancer Network (NCCN) and Chinese guidelines, \u201chad significantly poorer survival (P<0.001).\u201d<\/p>\n
In reflecting on the impact of additional factors, such as heavy smoking or a history of COPD, the investigators highlighted that both factors were \u201ceach associated with worse outcomes (P<0.001), whereas no significant associations were observed for other factors such as toxic exposures or a personal or family history of cancer.\u201d<\/p>\n
\u201cThese findings highlight the potential benefit of extending screening beyond current risk-based eligibility,\u201d the investigators concluded.<\/p>\n","protected":false},"excerpt":{"rendered":"Low-dose computed tomography (LDCT) screening \u201csignificantly reduces\u201d lung cancer mortality among patients within non-risk-based populations, according to recent…\n","protected":false},"author":2,"featured_media":357573,"comment_status":"","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[10],"tags":[134,111,139,69],"class_list":{"0":"post-357572","1":"post","2":"type-post","3":"status-publish","4":"format-standard","5":"has-post-thumbnail","7":"category-health","8":"tag-health","9":"tag-new-zealand","10":"tag-newzealand","11":"tag-nz"},"_links":{"self":[{"href":"https:\/\/www.newsbeep.com\/nz\/wp-json\/wp\/v2\/posts\/357572","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.newsbeep.com\/nz\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.newsbeep.com\/nz\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/nz\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/nz\/wp-json\/wp\/v2\/comments?post=357572"}],"version-history":[{"count":0,"href":"https:\/\/www.newsbeep.com\/nz\/wp-json\/wp\/v2\/posts\/357572\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/nz\/wp-json\/wp\/v2\/media\/357573"}],"wp:attachment":[{"href":"https:\/\/www.newsbeep.com\/nz\/wp-json\/wp\/v2\/media?parent=357572"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.newsbeep.com\/nz\/wp-json\/wp\/v2\/categories?post=357572"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.newsbeep.com\/nz\/wp-json\/wp\/v2\/tags?post=357572"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}