photopatch<\/a> test results from 10 centres across seven European countries, focusing on reactions to sunscreens, non-steroidal anti-inflammatory drugs (NSAIDs), and other topical agents. Researchers also examined whether occlusion duration prior to irradiation affected outcomes, comparing 24-hour versus 48-hour application periods within the same patients.<\/p>\nAmong participants, 28 photoallergic reactions were identified. Sunscreen agents triggered reactions in 10% of tested individuals (13\/132), while NSAIDs accounted for 9% (9\/101). The most frequently implicated photoallergens included ketoprofen, promethazine, butylmethoxydibenzoylmethane (avobenzone), benzophenone-3 (oxybenzone), and etofenamate. In contrast, classic contact allergies were less common, with only 14 reactions recorded.<\/p>\n
48-Hour Occlusion Significantly Improves Detection Rates<\/p>\n
A key finding of the study was the significant impact of occlusion duration on diagnostic sensitivity. Using a 24-hour occlusion period prior to irradiation resulted in a substantial proportion of missed cases, 53% of sunscreen-related photoallergies and 36% of NSAID-related reactions were not detected compared to the 48-hour protocol. These findings suggest that shorter occlusion times may underestimate the true prevalence of photoallergy.<\/p>\n
No Clear Predictors of Photoallergy Risk Identified<\/p>\n
Participants in the study often had a history of photosensitive dermatitis, suspected reactions to sunscreens or NSAIDs, or underlying photosensitivity disorders. Nearly half also reported pre-existing dermatological conditions. However, the study found no clear clinical predictors that could reliably identify individuals at higher risk of photoallergy, underscoring the broad applicability of photopatch testing.<\/p>\n
Overall, the authors conclude that while the spectrum of topical photoallergens in Europe remains relatively stable, continued vigilance is required. Crucially, they recommend adopting a 48-hour occlusion period, where feasible, to optimise detection rates and improve diagnostic accuracy in clinical practice.<\/p>\n
These findings may prompt a reassessment of current photopatch testing protocols, with implications for both dermatology research and patient care.<\/p>\n
Reference<\/p>\n
Ralph N et al. Prospective multi-centre photopatch test study of photoallergy to sunscreens and NSAIDs in Europe. Br J Dermatol. 2026:doi: 10.1093\/bjd\/ljag085<\/p>\n
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