{"id":374911,"date":"2026-04-11T19:07:19","date_gmt":"2026-04-11T19:07:19","guid":{"rendered":"https:\/\/www.newsbeep.com\/nz\/374911\/"},"modified":"2026-04-11T19:07:19","modified_gmt":"2026-04-11T19:07:19","slug":"raul-tirinescu-ctdna-positivity-and-molecular-relapse-before-radiologic-progression","status":"publish","type":"post","link":"https:\/\/www.newsbeep.com\/nz\/374911\/","title":{"rendered":"Raul Tirinescu: ctDNA Positivity and Molecular Relapse Before Radiologic Progression"},"content":{"rendered":"<p>Raul Tirinescu, Oncology Specialist at M Hospital Bucharest shared a post on\u00a0<a href=\"https:\/\/www.linkedin.com\/posts\/raul-tirinescu-549690314_precisiononcology-ctdna-mrd-activity-7448413941975764992--Jvg?utm_source=share&amp;utm_medium=member_desktop&amp;rcm=ACoAAF1uV5kBl8tO2HUf3vDMqR03mtBlko7bkw0\" target=\"_blank\" rel=\"noopener nofollow\">LinkedIn<\/a>:<\/p>\n<p>\u201cctDNA in Clinical Practice: A powerful tool or an open question?<\/p>\n<p>Circulating tumor DNA (ctDNA) assays such as Signatera are increasingly entering clinical discussions in solid tumors, particularly colorectal and breast cancer. Their ability to detect minimal residual disease (MRD) offers a level of sensitivity that conventional imaging cannot achieve.<\/p>\n<p>From a clinical standpoint, the strengths are clear: earlier identification of molecular relapse, refined prognostic stratification, and the potential to guide adjuvant treatment decisions. A persistently negative ctDNA result is reassuring; a positive result often precedes radiologic progression by months.<\/p>\n<p>However, important limitations remain. Pre-analytical variability, assay sensitivity in low-shedding tumors, and the lack of standardized thresholds impact reliability. More importantly, in most settings, ctDNA positivity still does not consistently translate into a validated change in management that improves overall survival. We are often left with actionable anxiety rather than actionable intervention.<\/p>\n<p>At present, ctDNA remains a powerful prognostic tool, but its predictive role is still evolving and not fully integrated into routine decision-making per current guidelines.<\/p>\n<p>The key question for the near future: Are we approaching a point where ctDNA-guided escalation or de-escalation of therapy will become standard practice-or are we still lacking the evidence to act confidently on these results?\u201d<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-medium wp-image-482893\" src=\"https:\/\/www.newsbeep.com\/nz\/wp-content\/uploads\/2026\/04\/1775840267245-800x442.webp.webp\" alt=\"Raul Tirinescu\" width=\"800\" height=\"442\" title=\"Raul Tirinescu: ctDNA Positivity and Molecular Relapse Before Radiologic Progression 2\"  \/><\/p>\n<p>Other articles about <a href=\"https:\/\/oncodaily.com\/tag\/ctdna\" rel=\"nofollow noopener\" target=\"_blank\">ctDNA<\/a> on OncoDaily.<\/p>\n","protected":false},"excerpt":{"rendered":"Raul Tirinescu, Oncology Specialist at M Hospital Bucharest shared a post on\u00a0LinkedIn: \u201cctDNA in Clinical Practice: A powerful&hellip;\n","protected":false},"author":2,"featured_media":374912,"comment_status":"","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[10],"tags":[134,111,139,69],"class_list":{"0":"post-374911","1":"post","2":"type-post","3":"status-publish","4":"format-standard","5":"has-post-thumbnail","7":"category-health","8":"tag-health","9":"tag-new-zealand","10":"tag-newzealand","11":"tag-nz"},"_links":{"self":[{"href":"https:\/\/www.newsbeep.com\/nz\/wp-json\/wp\/v2\/posts\/374911","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.newsbeep.com\/nz\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.newsbeep.com\/nz\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/nz\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/nz\/wp-json\/wp\/v2\/comments?post=374911"}],"version-history":[{"count":0,"href":"https:\/\/www.newsbeep.com\/nz\/wp-json\/wp\/v2\/posts\/374911\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/nz\/wp-json\/wp\/v2\/media\/374912"}],"wp:attachment":[{"href":"https:\/\/www.newsbeep.com\/nz\/wp-json\/wp\/v2\/media?parent=374911"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.newsbeep.com\/nz\/wp-json\/wp\/v2\/categories?post=374911"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.newsbeep.com\/nz\/wp-json\/wp\/v2\/tags?post=374911"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}