People with\u00a0an\u00a0organ transplant\u00a0who develop or have existing diabetes are more likely to die than\u00a0those\u00a0without diabetes, according to a comprehensive analysis of solid-organ transplant recipients, which is\u00a0being presented\u00a0Saturday\u00a0at ENDO 2026, the Endocrine Society’s annual meeting in Chicago, Ill.<\/p>\n
Diabetes is a common chronic disease affecting\u00a0about 830 million people worldwide.\u00a0Organ transplant recipients have a higher risk of developing and worsening diabetes, which can affect both their lifespan and the success of the transplant.<\/p>\n
<\/p>\n
We studied how diabetes affects longevity in people post solid-organ transplant\u00a0and found both ongoing and new-onset diabetes increased risk of mortality. Until now, the\u00a0magnitude\u00a0of diabetes’ impact on survival has not been compared head-to-head across major organ transplants. This research helps quantify the impact of diabetes across organ transplant types.”<\/p>\n
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<\/p>\n
Mishal Ali, study lead,\u00a0University of Chicago in Chicago, Ill.<\/p>\n
<\/p>\n
The researchers\u00a0looked at more than 800,000 Americans who received a kidney, liver, heart, lung,\u00a0pancreas\u00a0or intestine transplant between 2003 and 2021.\u00a0They\u00a0compared two groups: people who already had diabetes when they received their new organ, and people who got diabetes for the first time after their surgery.<\/p>\n
They found both groups were more likely to die than\u00a0recipients\u00a0without diabetes.\u00a0For people getting a new liver or heart,\u00a0newly developed\u00a0diabetes was about as dangerous as having had diabetes for years. For people getting a new kidney, it was still dangerous, but\u00a0somewhat less\u00a0so than\u00a0having\u00a0diabetes from the start. The association of diabetes diagnosis\u00a0and\u00a0type of organ failure varied almost 7-fold based on organ type.<\/p>\n
In the group of\u00a0recipients\u00a0who already\u00a0had diabetes, kidney recipients\u00a0had the highest risk by far.\u202fHeart and liver recipients had a smaller increase in risk compared to\u00a0kidney. Lung recipients had the smallest increase in risk. The gap was small at\u00a0one\u00a0year, around\u00a0one\u00a0to\u00a0two\u00a0more deaths per 100 patients for kidney,\u00a0liver, and heart and almost no difference for lung recipients. This changed with time: at 10 years after transplant almost 24 more out of every 100 kidney recipients with diabetes had died.<\/p>\n
Among recipients who developed diabetes after surgery, kidney and heart recipients\u00a0had the highest risk\u00a0of death. Liver recipients had a slightly smaller increase, and lung recipients had the smallest risk increase.<\/p>\n
“Transplant providers should\u00a0monitor\u00a0closely for current and new-onset diabetes. Because of the differential effect of diabetes on recipients by organ type, prevention and management will need to be tailored,” said senior author and transplant hepatologist Alan L. Hutchison, M.D., Ph.D., of UChicago Medicine in\u00a0Chicago, Ill. “Patients and their families can ask transplant providers more specific questions about diabetes risk, both before surgery and in the months after, and decide together whether extra check-ups or treatment make sense.”<\/p>\n","protected":false},"excerpt":{"rendered":"People with\u00a0an\u00a0organ transplant\u00a0who develop or have existing diabetes are more likely to die than\u00a0those\u00a0without diabetes, according to a…\n","protected":false},"author":2,"featured_media":27327,"comment_status":"","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[10],"tags":[13448,14416,3535,30124,134,2862,13255,2255,4255,4367,111,139,69,1518,6290,4249],"class_list":["post-477004","post","type-post","status-publish","format-standard","has-post-thumbnail","category-health","tag-chronic","tag-chronic-disease","tag-diabetes","tag-endocrine","tag-health","tag-heart","tag-hormone","tag-kidney","tag-liver","tag-mortality","tag-new-zealand","tag-newzealand","tag-nz","tag-research","tag-surgery","tag-transplant"],"_links":{"self":[{"href":"https:\/\/www.newsbeep.com\/nz\/wp-json\/wp\/v2\/posts\/477004","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.newsbeep.com\/nz\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.newsbeep.com\/nz\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/nz\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/nz\/wp-json\/wp\/v2\/comments?post=477004"}],"version-history":[{"count":0,"href":"https:\/\/www.newsbeep.com\/nz\/wp-json\/wp\/v2\/posts\/477004\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/nz\/wp-json\/wp\/v2\/media\/27327"}],"wp:attachment":[{"href":"https:\/\/www.newsbeep.com\/nz\/wp-json\/wp\/v2\/media?parent=477004"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.newsbeep.com\/nz\/wp-json\/wp\/v2\/categories?post=477004"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.newsbeep.com\/nz\/wp-json\/wp\/v2\/tags?post=477004"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}