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Complete removal of sugar from a low-fat diet may trigger unintended metabolic and gut health consequences, according to new research presented at ENDO 2026, the Endocrine Society’s annual meeting in Chicago.<\/p>\n
The preclinical study, conducted by researchers at the Dasman Diabetes Institute in Kuwait, compared mice fed a sucrose-free, low-fat diet with a control group receiving a low-fat diet containing sucrose for 16 weeks.<\/p>\n
Despite maintaining comparable body weights, the sucrose-free group exhibited a range of adverse outcomes, including impaired glucose tolerance, insulin resistance, gut microbiome dysbiosis, intestinal inflammation and markers associated with fatty liver disease.<\/p>\n
“Completely removing sucrose from a low-fat diet may unexpectedly disrupt gut health and promote inflammation and metabolic dysfunction,” said Dr Rasheed Ahmad, principal scientist and Head of the Immunology & Microbiology Department at the Dasman Diabetes Institute.<\/p>\n
Balanced nutrition is more important than simply eliminating sugar.<\/p>\n
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